Identification of an optimized 2′-O-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8

RNA

Volumn 23, Issue 9, 2017, Pages 1344-1351

  Schmitt, Felix C F ^a,b   Freund, Isabel ^a   Weigand, Markus A ^a   Helm, Mark ^c   Dalpke, Alexander H ^a,b   Eigenbrod, Tatjana ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Partner Site Heidelberg   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

2 O methylation; Immune stimulation; Inhibitory RNA; RNA modification; TLR7; TLR8

Indexed keywords

BACTERIAL RNA; CYTIDINE; NUCLEOTIDE; RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TRANSFER RNA;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; HUMAN; IC50; METABOLISM; METHYLATION; MONONUCLEAR CELL; MUTATION; NUCLEOTIDE MOTIF;

CYTIDINE; HUMANS; INHIBITORY CONCENTRATION 50; LEUKOCYTES, MONONUCLEAR; METHYLATION; MUTATION; NUCLEOTIDE MOTIFS; NUCLEOTIDES; RNA; RNA, BACTERIAL; RNA, TRANSFER; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 85027547981     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.061952.117     Document Type: Article

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