A single naturally occurring 2′-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Jung, Stephanie ^a   Von Thülen, Tina ^a   Laukemper, Viktoria ^a   Pigisch, Stephanie ^b   Hangel, Doris ^b   Wagner, Hermann ^b   Kaufmann, Andreas ^a   Bauer, Stefan ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; DINUCLEOTIDE; GUANOSINE; INTERLEUKIN 16; RNA 18S; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; INTERLEUKIN 6; LIGAND; RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE CONVERSION; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMACYTOID DENDRITIC CELL; RNA METHYLATION; RNA SEQUENCE; ANIMAL; BIOSYNTHESIS; CHEMISTRY; ENZYME SPECIFICITY; HEK293 CELL LINE; METABOLISM; METHYLATION; SECRETION (PROCESS);

ANIMALS; HEK293 CELLS; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-6; LIGANDS; METHYLATION; MICE; RNA; RNA, RIBOSOMAL, 18S; SUBSTRATE SPECIFICITY; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 84925436673     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120498     Document Type: Article

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