Synergistic activation of Toll-like receptor 8 by two RNA degradation products

Nature Structural and Molecular Biology

Volumn 22, Issue 2, 2015, Pages 99-101

  Geyer, Matthias ^a,b   Pelka, Karin ^a   Latz, Eicke ^a,c,d,e  

^a UNIVERSITY OF BONN   (Germany)

^b CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^e NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

RNA; TOLL LIKE RECEPTOR 8; URIDINE; TLR8 PROTEIN, HUMAN;

CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVATION; INNATE IMMUNITY; ISOTHERMAL TITRATION CALORIMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RNA DEGRADATION; SHORT SURVEY; ANIMAL; CHEMISTRY; HUMAN; METABOLISM;

ANIMALS; HUMANS; RNA; TOLL-LIKE RECEPTOR 8;

EID: 84926376312     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2967     Document Type: Short Survey

References (18)

1. Matzinger, P. Science 296, 301-305 (2002).
2. Akira, S. & Takeda, K. Nat. Rev. Immunol. 4, 499-511 (2004).
3. Heil, F. et al. Science 303, 1526-1529 (2004).
4. Tanji, H. et al. Nat. Struct. Mol. Biol. 22, 109-115 (2015).
5. Tanji, H., Ohto, U., Shibata, T., Miyake, K. & Shimizu, T. Science 339, 1426-1429 (2013).
6. Ohto, U., Tanji, H. & Shimizu, T. Microbes Infect. 16, 273-282 (2014).
7. Gorden, K.K.B. et al. J. Immunol. 177, 8164-8170 (2006).
8. Jurk, M. et al. Eur. J. Immunol. 36, 1815-1826 (2006).
9. Ligoxygakis, P., Pelte, N., Hoffmann, J.A. & Reichhart, J.M. Science 297, 114-116 (2002).
10. Tesar, B.M. et al. Am. J. Transplant. 6, 2622-2635 (2006).
11. Chan, M.P. et al. Nat. Commun. (in the press).
12. Pawaria, S. et al. J. Immunol. (in the press).
13. Horiuchi, T., Horiuchi, S. & Mizuno, D. Nature 183, 1529-1530 (1959).
14. Hausser, E. & Stroun, J. Rev. Med. Suisse Romande 83, 577-586 (1963).
15. White, K.A., Enjuanes, L. & Berkhout, B. RNA Biol. 8, 182-183 (2011).
16. Vogel, J. & Wagner, E.G. Curr. Opin. Microbiol. 10, 262-270 (2007).
17. Hemmi, H. et al. Nat. Immunol. 3, 196-200 (2002).
18. Christensen, S.R. & Shlomchik, M.J. Semin. Immunol. 19, 11-23 (2007).