Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA

Immunity

Volumn 45, Issue 4, 2016, Pages 737-748

  Zhang, Zhikuan ^a   Ohto, Umeharu ^a   Shibata, Takuma ^a   Krayukhina, Elena ^b   Taoka, Masato ^c   Yamauchi, Yoshio ^c   Tanji, Hiromi ^a   Isobe, Toshiaki ^c   Uchiyama, Susumu ^b,d   Miyake, Kensuke ^a   Shimizu, Toshiyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN UNIVERSITY   (Japan)

^d OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

Author keywords

guanosine innate immunity; pattern recognition receptor; single stranded RNA; synergistic effect; Toll like receptor 7; X ray crystallography

Indexed keywords

DIMER; GUANOSINE; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; URIDINE; LIGAND; RNA;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DIMERIZATION; LIGAND BINDING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; CELL LINE; CHEMISTRY; DROSOPHILA; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; RHESUS MONKEY;

ANIMALS; BINDING SITES; CELL LINE; DROSOPHILA; GUANOSINE; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; LIGANDS; MACACA MULATTA; RNA; TOLL-LIKE RECEPTOR 7;

EID: 84994908842     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.09.011     Document Type: Article

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