TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-β production via a TAK1-IKKβ-IRF5 signaling pathway

Journal of Immunology

Volumn 195, Issue 3, 2015, Pages 1100-1111

  Bergstrøm, Bjarte ^a   Aune, Marie H ^a   Awuh, Jane A ^a   Kojen, June F ^a   Blix, Kjetil J ^a   Ryan, Liv ^a   Flo, Trude H ^a   Mollnes, Tom E ^a,b,c,d,e   Espevik, Terje ^a   Stenvik, Jørgen ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d NORDLAND HOSPITAL   (Norway)

^e UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL RNA; BETA INTERFERON; I KAPPA B KINASE BETA; INTERFERON REGULATORY FACTOR 5; MYELOID DIFFERENTIATION FACTOR 88; PATTERN RECOGNITION RECEPTOR; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 8; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; INTERFERON REGULATORY FACTOR; INTERLEUKIN 12; IRF5 PROTEIN, HUMAN; MAP KINASE KINASE KINASE 7; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; MPYS PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; TBK1 PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN; TLR7 PROTEIN, HUMAN; TLR8 PROTEIN, HUMAN; TNF PROTEIN, HUMAN; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; BIOSYNTHESIS; ENZYME ACTIVATION; GENETICS; IMMUNOLOGY; MICROBIOLOGY; RNA INTERFERENCE; STAPHYLOCOCCUS INFECTION;

ENZYME ACTIVATION; HUMANS; I-KAPPA B KINASE; INTERFERON REGULATORY FACTORS; INTERFERON-BETA; INTERLEUKIN-12; MACROPHAGES; MAP KINASE KINASE KINASES; MEMBRANE PROTEINS; MONOCYTES; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, BACTERIAL; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84937718727     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1403176     Document Type: Article

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