Macrophages recognize streptococci through bacterial single-stranded RNA

EMBO Reports

Volumn 12, Issue 1, 2011, Pages 71-76

  Deshmukh, Sachin D ^a   Kremer, Bernhard ^a   Freudenberg, Marina ^b   Bauer, Stefan ^c   Golenbock, Douglas T ^d   Henneke, Philipp ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

bacterial infection; phagocytosis; RNA; signal transduction

Indexed keywords

BACTERIAL RNA; CYTOKINE; MYELOID DIFFERENTIATION FACTOR 88; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL INFECTION; CONTROLLED STUDY; GRAM POSITIVE BACTERIUM; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; STREPTOCOCCUS AGALACTIAE;

ANIMALS; BASE SEQUENCE; CYTOKINES; HOST-PATHOGEN INTERACTIONS; HUMANS; INFANT, NEWBORN; MACROPHAGES; MEMBRANE TRANSPORT PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MYELOID DIFFERENTIATION FACTOR 88; RNA, BACTERIAL; STREPTOCOCCUS AGALACTIAE;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS SP. 'GROUP B';

EID: 78650859153     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2010.189     Document Type: Article

References (28)

1. Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagawi M, Nakanishi K, Akira S (1998) Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9: 143-150
2. Bauer S et al (2010) A major role for TLR8 in the recognition of vaccinia viral DNA by murine pDC? Proc Natl Acad Sci USA 107: E139
3. Biondo C, Midiri A, Messina L, Tomasello F, Garufi G, Catania MR, Bombaci M, Beninati C, Teti G, Mancuso G (2005) MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans. Eur J. Immunol 35: 870-878
4. Blander JM, Medzhitov R (2004) Regulation of phagosome maturation by signals from Toll-like receptors. Science 304: 1014-1018
5. Boller T, He SY (2009) Innate immunity in plants: an arms race between pattern recognition receptors in plants and effectors in microbial pathogens. Science 324: 742-744
6. Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM (2007) The interaction between the ER membrane protein UNC-93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol 177: 265-275
7. Charrel-Dennis M, Latz E, Halmen KA, Trieu-Cuot P, Fitzgerald KA, Kasper DL, Golenbock DT (2008) TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA. Cell Host Microbe 4: 543-554
8. D'Alessio G, Riordan JF (1997) Ribonucleases: Structure and Function. New York and London: Academic
9. Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM (2008) The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 456: 658-662
10. Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, Miyake K (2009) UNC-93B biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med 206: 1339-1350
11. Gratz N et al (2008) Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9. J Biol Chem 283: 19879-19887
12. Gust AA et al (2007) Bacteria-derived peptidoglycans constitute pathogen-associated molecular patterns triggering innate immunity in Arabidopsis. J Biol Chem 282: 32338-32348
13. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526-1529
14. Henneke P et al (2008) Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis. J Immunol 180: 6149-6158
15. Henneke P, Golenbock DT (2001) TIRAP: how Toll receptors fraternize. Nat Immunol 2: 828-830
16. Henneke P, Golenbock DT (2002) Innate immune recognition of lipopolysaccharide by endothelial cells. Crit Care Med 30: S207-S213
17. Henneke P et al (2005) Role of lipoteichoic acid in the phagocyte response to group B streptococcus. J Immunol 174: 6449-6455
18. Kenzel S, Santos-Sierra S, Deshmukh SD, Moeller I, Ergin B, Fitzgerald KA, Lien E, Akira S, Golenbock DT, Henneke P (2009) Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus. Infect Immun 77: 2474-2481
19. Kim YM, Brinkmann MM, Paquet ME, Ploegh HL (2008) UNC-93B delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature 452: 234-238
20. Lembo A, Kalis C, Kirschning CJ, Mitolo V, Jirillo E, Wagner H, Galanos C, Freudenberg MA (2003) Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice. Infect Immun 71: 6058-6062
21. Mancuso G, Gambuzza M, Midiri A, Biondo C, Papasergi S, Akira S, Teti G, Beninati C (2009) Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells. Nat Immunol 10: 587-594
22. Martinez J, Huang X, Yang Y (2010) Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA. Proc Natl Acad Sci USA 107: 6442-6447
23. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397
24. Prithiviraj B, Bais HP, Jha AK, Vivanco JM (2005) Staphylococcus aureus pathogenicity on Arabidopsis thaliana is mediated either by a direct effect of salicylic acid on the pathogen or by SA-dependent, NPR1-independent host responses. Plant J 42: 417-432
25. Tabeta K et al (2006) The UNC-93B mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 7: 156-164
26. Takeuchi O, Hashino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-451
27. Talati AJ, Kim HJ, Kim YI, Yi AK, English BK (2008) Role of bacterial DNA in macrophage activation by group B streptococci. Microbes Infect 10: 1106-1113
28. Valenti-Weigand P, Benkel P, Rohde M, Chhatwal GS (1996) Entry and intracellular survival of group B streptococci in J774 macrophages. Infect Immun 64: 2467-2473