메뉴 건너뛰기




Volumn 102, Issue 2, 2017, Pages 209-219

Success in bone marrow failure? Novel therapeutic directions based on the immune environment of myelodysplastic syndromes

Author keywords

Cancer; Inflammation; Leukemogenesis; Myeloid cells

Indexed keywords

CRYOPYRIN; DNA METHYLTRANSFERASE 3A; INTERFERON; MICRORNA 145; MICRORNA 146A; TOLL LIKE RECEPTOR 4;

EID: 85026736953     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.5RI0317-083R     Document Type: Review
Times cited : (13)

References (124)
  • 3
    • 77950526605 scopus 로고    scopus 로고
    • The epidemiology of myelodysplastic syndromes
    • Sekeres, M. A. (2010) The epidemiology of myelodysplastic syndromes. Hematol. Oncol. Clin. North Am. 24, 287–294.
    • (2010) Hematol. Oncol. Clin. North Am. , vol.24 , pp. 287-294
    • Sekeres, M.A.1
  • 4
    • 84908056225 scopus 로고    scopus 로고
    • Relative risk of myelodysplastic syndromes in patients with autoimmune disorders in the general practice research database
    • Wilson, A. B., Neogi, T., Prout, M., Jick, S. (2014) Relative risk of myelodysplastic syndromes in patients with autoimmune disorders in the general practice research database. Cancer Epidemiol. 38, 544–549.
    • (2014) Cancer Epidemiol , vol.38 , pp. 544-549
    • Wilson, A.B.1    Neogi, T.2    Prout, M.3    Jick, S.4
  • 5
    • 27644448871 scopus 로고    scopus 로고
    • Risk factors of myelodysplastic syndromes: A case-control study
    • Strom, S. S., Gu, Y., Gruschkus, S. K., Pierce, S. A., Estey, E. H. (2005) Risk factors of myelodysplastic syndromes: a case-control study. Leukemia 19, 1912–1918.
    • (2005) Leukemia , vol.19 , pp. 1912-1918
    • Strom, S.S.1    Gu, Y.2    Gruschkus, S.K.3    Pierce, S.A.4    Estey, E.H.5
  • 9
    • 84865368678 scopus 로고    scopus 로고
    • Analyzing transformation of myelodysplastic syndrome to secondary acute myeloid leukemia using a large patient database
    • Shukron, O., Vainstein, V., Kündgen, A., Germing, U., Agur, Z. (2012) Analyzing transformation of myelodysplastic syndrome to secondary acute myeloid leukemia using a large patient database. Am. J. Hematol. 87, 853–860.
    • (2012) Am. J. Hematol. , vol.87 , pp. 853-860
    • Shukron, O.1    Vainstein, V.2    Kündgen, A.3    Germing, U.4    Agur, Z.5
  • 10
    • 70350755818 scopus 로고    scopus 로고
    • Myelodysplastic syndromes
    • Tefferi, A., Vardiman, J. W. (2009) Myelodysplastic syndromes. N. Engl. J. Med. 361, 1872–1885.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1872-1885
    • Tefferi, A.1    Vardiman, J.W.2
  • 11
    • 84866609437 scopus 로고    scopus 로고
    • Systemic mastocytosis: Disease overview, pathogenesis, and treatment
    • Pardanani, A. (2012) Systemic mastocytosis: disease overview, pathogenesis, and treatment. Hematol. Oncol. Clin. North Am. 26, 1117–1128.
    • (2012) Hematol. Oncol. Clin. North Am. , vol.26 , pp. 1117-1128
    • Pardanani, A.1
  • 12
    • 79953074952 scopus 로고    scopus 로고
    • Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemia
    • Bacher, U., Haferlach, T., Schnittger, S., Kreipe, H., Kröger, N. (2011) Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemia. Br. J. Haematol. 153, 149–167.
    • (2011) Br. J. Haematol. , vol.153 , pp. 149-167
    • Bacher, U.1    Haferlach, T.2    Schnittger, S.3    Kreipe, H.4    Kröger, N.5
  • 13
    • 84903268944 scopus 로고    scopus 로고
    • Myelodysplastic syndromes
    • Adès, L., Itzykson, R., Fenaux, P. (2014) Myelodysplastic syndromes. Lancet 383, 2239–2252.
    • (2014) Lancet , vol.383 , pp. 2239-2252
    • Adès, L.1    Itzykson, R.2    Fenaux, P.3
  • 14
    • 84898488422 scopus 로고    scopus 로고
    • Chronic myelomonocytic leukaemia: A concise clinical and pathophysiological review
    • Patnaik, M. M., Parikh, S. A., Hanson, C. A., Tefferi, A. (2014) Chronic myelomonocytic leukaemia: a concise clinical and pathophysiological review. Br. J. Haematol. 165, 273–286.
    • (2014) Br. J. Haematol. , vol.165 , pp. 273-286
    • Patnaik, M.M.1    Parikh, S.A.2    Hanson, C.A.3    Tefferi, A.4
  • 16
    • 84870221419 scopus 로고    scopus 로고
    • The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes
    • Raza, A., Galili, N. (2012) The genetic basis of phenotypic heterogeneity in myelodysplastic syndromes. Nat. Rev. Cancer 12, 849–859.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 849-859
    • Raza, A.1    Galili, N.2
  • 17
    • 0034551738 scopus 로고    scopus 로고
    • The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS
    • Parker, J. E., Mufti, G. J., Rasool, F., Mijovic, A., Devereux, S., Pagliuca, A. (2000) The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood 96, 3932–3938.
    • (2000) Blood , vol.96 , pp. 3932-3938
    • Parker, J.E.1    Mufti, G.J.2    Rasool, F.3    Mijovic, A.4    Devereux, S.5    Pagliuca, A.6
  • 22
    • 84902194619 scopus 로고    scopus 로고
    • Disease progression in myelodysplastic syndromes: Do mesenchymal cells pave the way?
    • Raaijmakers, M. H. (2014) Disease progression in myelodysplastic syndromes: do mesenchymal cells pave the way? Cell Stem Cell 14, 695–697.
    • (2014) Cell Stem Cell , vol.14 , pp. 695-697
    • Raaijmakers, M.H.1
  • 26
    • 34249740754 scopus 로고    scopus 로고
    • Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood 109, 4816–4824. 27. Takeuchi, O., Akira, S. (2010) Pattern recognition receptors and inflammation
    • Epling-Burnette, P. K., Bai, F., Painter, J. S., Rollison, D. E., Salih, H. R., Krusch, M., Zou, J., Ku, E., Zhong, B., Boulware, D., Moscinski, L., Wei, S., Djeu, J. Y., List, A. F. (2007) Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood 109, 4816–4824.
    • (2007) Cell , vol.140 , pp. 805-820
    • Epling-Burnette, P.K.1    Bai, F.2    Painter, J.S.3    Rollison, D.E.4    Salih, H.R.5    Krusch, M.6    Zou, J.7    Ku, E.8    Zhong, B.9    Boulware, D.10    Moscinski, L.11    Wei, S.12    Djeu, J.Y.13    List, A.F.14
  • 27
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi, O., Akira, S. (2010) Pattern recognition receptors and inflammation. Cell 140, 805–820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 28
    • 33947255107 scopus 로고    scopus 로고
    • Toll-like receptor-4 is up-regulated in hematopoietic progenitor cells and contributes to increased apoptosis in myelodysplastic syndromes
    • Maratheftis, C. I., Andreakos, E., Moutsopoulos, H. M., Voulgarelis, M. (2007) Toll-like receptor-4 is up-regulated in hematopoietic progenitor cells and contributes to increased apoptosis in myelodysplastic syndromes. Clin. Cancer Res. 13, 1154–1160.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1154-1160
    • Maratheftis, C.I.1    Andreakos, E.2    Moutsopoulos, H.M.3    Voulgarelis, M.4
  • 29
    • 77950629227 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 9 in bone marrow cells of myelodysplastic syndromes is down-regulated during transformation to overt leukemia
    • Kuninaka, N., Kurata, M., Yamamoto, K., Suzuki, S., Umeda, S., Kirimura, S., Arai, A., Nakagawa, Y., Suzuki, K., Kitagawa, M. (2010) Expression of Toll-like receptor 9 in bone marrow cells of myelodysplastic syndromes is down-regulated during transformation to overt leukemia. Exp. Mol. Pathol. 88, 293–298.
    • (2010) Exp. Mol. Pathol. , vol.88 , pp. 293-298
    • Kuninaka, N.1    Kurata, M.2    Yamamoto, K.3    Suzuki, S.4    Umeda, S.5    Kirimura, S.6    Arai, A.7    Nakagawa, Y.8    Suzuki, K.9    Kitagawa, M.10
  • 31
    • 0037111773 scopus 로고    scopus 로고
    • Characterization of gene expression of CD34 cells from normal and myelodysplastic bone marrow
    • Hofmann, W. K., de Vos, S., Komor, M., Hoelzer, D., Wachsman, W., Koeffler, H. P. (2002) Characterization of gene expression of CD34 cells from normal and myelodysplastic bone marrow. Blood 100, 3553–3560.
    • (2002) Blood , vol.100 , pp. 3553-3560
    • Hofmann, W.K.1    De Vos, S.2    Komor, M.3    Hoelzer, D.4    Wachsman, W.5    Koeffler, H.P.6
  • 33
    • 38949123096 scopus 로고    scopus 로고
    • Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML
    • Gondek, L. P., Tiu, R., O’Keefe, C. L., Sekeres, M. A., Theil, K. S., Maciejewski, J. P. (2008) Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML. Blood 111, 1534–1542.
    • (2008) Blood , vol.111 , pp. 1534-1542
    • Gondek, L.P.1    Tiu, R.2    O’Keefe, C.L.3    Sekeres, M.A.4    Theil, K.S.5    Maciejewski, J.P.6
  • 34
    • 84880982508 scopus 로고    scopus 로고
    • Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production
    • Velegraki, M., Papakonstanti, E., Mavroudi, I., Psyllaki, M., Tsatsanis, C., Oulas, A., Iliopoulos, I., Katonis, P., Papadaki, H. A. (2013) Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production. Haematologica 98, 1206–1215.
    • (2013) Haematologica , vol.98 , pp. 1206-1215
    • Velegraki, M.1    Papakonstanti, E.2    Mavroudi, I.3    Psyllaki, M.4    Tsatsanis, C.5    Oulas, A.6    Iliopoulos, I.7    Katonis, P.8    Papadaki, H.A.9
  • 41
    • 79960709287 scopus 로고    scopus 로고
    • Chronic immune stimulation might act as a trigger for the development of acute myeloid leukemia or myelodysplastic syndromes
    • Kristinsson, S. Y., Björkholm, M., Hultcrantz, M., Derolf, A. R., Landgren, O., Goldin, L. R. (2011) Chronic immune stimulation might act as a trigger for the development of acute myeloid leukemia or myelodysplastic syndromes. J. Clin. Oncol. 29, 2897–2903.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2897-2903
    • Kristinsson, S.Y.1    Björkholm, M.2    Hultcrantz, M.3    Derolf, A.R.4    Landgren, O.5    Goldin, L.R.6
  • 43
    • 65449178870 scopus 로고    scopus 로고
    • Simultaneous occurrence of inflammatory bowel disease and myelodysplastic syndrome due to chromosomal abnormalities in bone marrow cells
    • Nakamura, F., Watanabe, T., Hori, K., Ohara, Y., Yamashita, K., Tsuji, Y., Ueda, Y., Mikami, S., Nakase, H., Chiba, T. (2009) Simultaneous occurrence of inflammatory bowel disease and myelodysplastic syndrome due to chromosomal abnormalities in bone marrow cells. Digestion 79, 215–219.
    • (2009) Digestion , vol.79 , pp. 215-219
    • Nakamura, F.1    Watanabe, T.2    Hori, K.3    Ohara, Y.4    Yamashita, K.5    Tsuji, Y.6    Ueda, Y.7    Mikami, S.8    Nakase, H.9    Chiba, T.10
  • 45
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight?
    • Filipowicz, W., Bhattacharyya, S. N., Sonenberg, N. (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat. Rev. Genet. 9, 102–114.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 46
    • 33747608638 scopus 로고    scopus 로고
    • NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • Taganov, K. D., Boldin, M. P., Chang, K. J., Baltimore, D. (2006) NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. USA 103, 12481–12486.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 47
    • 68149165370 scopus 로고    scopus 로고
    • MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2
    • Hou, J., Wang, P., Lin, L., Liu, X., Ma, F., An, H., Wang, Z., Cao, X. (2009) MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J. Immunol. 183, 2150–2158.
    • (2009) J. Immunol. , vol.183 , pp. 2150-2158
    • Hou, J.1    Wang, P.2    Lin, L.3    Liu, X.4    Ma, F.5    An, H.6    Wang, Z.7    Cao, X.8
  • 50
    • 42649108339 scopus 로고    scopus 로고
    • Monocyte-mediated defense against microbial pathogens
    • Serbina, N. V., Jia, T., Hohl, T. M., Pamer, E. G. (2008) Monocyte-mediated defense against microbial pathogens. Annu. Rev. Immunol. 26, 421–452.
    • (2008) Annu. Rev. Immunol. , vol.26 , pp. 421-452
    • Serbina, N.V.1    Jia, T.2    Hohl, T.M.3    Pamer, E.G.4
  • 53
    • 58149347630 scopus 로고    scopus 로고
    • Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes
    • Martin, A. P., Rankin, S., Pitchford, S., Charo, I. F., Furtado, G. C., Lira, S. A. (2008) Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes. Diabetes 57, 3025–3033.
    • (2008) Diabetes , vol.57 , pp. 3025-3033
    • Martin, A.P.1    Rankin, S.2    Pitchford, S.3    Charo, I.F.4    Furtado, G.C.5    Lira, S.A.6
  • 55
    • 50949089311 scopus 로고    scopus 로고
    • Erythroblastic islands: Niches for erythropoiesis
    • Chasis, J. A., Mohandas, N. (2008) Erythroblastic islands: niches for erythropoiesis. Blood 112, 470–478.
    • (2008) Blood , vol.112 , pp. 470-478
    • Chasis, J.A.1    Mohandas, N.2
  • 57
    • 0034919938 scopus 로고    scopus 로고
    • Dendritic cell lineage, plasticity and cross-regulation
    • Liu, Y. J., Kanzler, H., Soumelis, V., Gilliet, M. (2001) Dendritic cell lineage, plasticity and cross-regulation. Nat. Immunol. 2, 585–589.
    • (2001) Nat. Immunol. , vol.2 , pp. 585-589
    • Liu, Y.J.1    Kanzler, H.2    Soumelis, V.3    Gilliet, M.4
  • 58
    • 0027635984 scopus 로고
    • Increase in number of bone marrow macrophages in patients with myelodysplastic syndromes
    • Kitagawa, M., Kamiyama, R., Kasuga, T. (1993) Increase in number of bone marrow macrophages in patients with myelodysplastic syndromes. Eur. J. Haematol. 51, 56–58.
    • (1993) Eur. J. Haematol. , vol.51 , pp. 56-58
    • Kitagawa, M.1    Kamiyama, R.2    Kasuga, T.3
  • 59
  • 60
    • 84931560522 scopus 로고    scopus 로고
    • The molecular pathogenesis of the myelodysplastic syndromes
    • Pellagatti, A., Boultwood, J. (2015) The molecular pathogenesis of the myelodysplastic syndromes. Eur. J. Haematol. 95, 3–15.
    • (2015) Eur. J. Haematol. , vol.95 , pp. 3-15
    • Pellagatti, A.1    Boultwood, J.2
  • 62
    • 84905383217 scopus 로고    scopus 로고
    • Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
    • Turner, M. D., Nedjai, B., Hurst, T., Pennington, D. J. (2014) Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease. Biochim. Biophys. Acta 1843, 2563–2582.
    • (2014) Biochim. Biophys. Acta , vol.1843 , pp. 2563-2582
    • Turner, M.D.1    Nedjai, B.2    Hurst, T.3    Pennington, D.J.4
  • 63
    • 77954537848 scopus 로고    scopus 로고
    • Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages
    • Díaz-Muñoz, M. D., Osma-García, I. C., Cacheiro-Llaguno, C., Fresno, M., Iñiguez, M. A. (2010) Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages. Cell. Signal. 22, 1427–1436.
    • (2010) Cell. Signal. , vol.22 , pp. 1427-1436
    • Díaz-Muñoz, M.D.1    Osma-García, I.C.2    Cacheiro-Llaguno, C.3    Fresno, M.4    Iñiguez, M.A.5
  • 72
    • 84936891896 scopus 로고    scopus 로고
    • Inflammasomes: Mechanism of action, role in disease, and therapeutics
    • Guo, H., Callaway, J. B., Ting, J. P. (2015) Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21, 677–687.
    • (2015) Nat. Med. , vol.21 , pp. 677-687
    • Guo, H.1    Callaway, J.B.2    Ting, J.P.3
  • 73
    • 84893822649 scopus 로고    scopus 로고
    • S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-kB(1
    • Simard, J. C., Cesaro, A., Chapeton-Montes, J., Tardif, M., Antoine, F., Girard, D., Tessier, P. A. (2013) S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-kB(1.). PLoS One 8, e72138.
    • (2013) Plos One , vol.8
    • Simard, J.C.1    Cesaro, A.2    Chapeton-Montes, J.3    Tardif, M.4    Antoine, F.5    Girard, D.6    Tessier, P.A.7
  • 75
    • 80052179138 scopus 로고    scopus 로고
    • Caspase-1-induced pyroptotic cell death
    • Miao, E. A., Rajan, J. V., Aderem, A. (2011) Caspase-1-induced pyroptotic cell death. Immunol. Rev. 243, 206–214.
    • (2011) Immunol. Rev. , vol.243 , pp. 206-214
    • Miao, E.A.1    Rajan, J.V.2    Aderem, A.3
  • 76
    • 84988420388 scopus 로고    scopus 로고
    • RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs
    • Höckendorf, U., Yabal, M., Jost, P. J. (2016) RIPK3-dependent cell death and inflammasome activation in FLT3-ITD expressing LICs. Oncotarget 7, 57483–57484.
    • (2016) Oncotarget , vol.7 , pp. 57483-57484
    • Höckendorf, U.1    Yabal, M.2    Jost, P.J.3
  • 78
    • 84890034242 scopus 로고    scopus 로고
    • Murine xenogeneic models of myelodysplastic syndrome: An essential role for stroma cells
    • Li, X., Deeg, H. J. (2014) Murine xenogeneic models of myelodysplastic syndrome: an essential role for stroma cells. Exp. Hematol. 42, 4–10.
    • (2014) Exp. Hematol. , vol.42 , pp. 4-10
    • Li, X.1    Deeg, H.J.2
  • 80
    • 66149114386 scopus 로고    scopus 로고
    • Trafficking and differentiation of mesenchymal stem cells
    • Liu, Z. J., Zhuge, Y., Velazquez, O. C. (2009) Trafficking and differentiation of mesenchymal stem cells. J. Cell. Biochem. 106, 984–991.
    • (2009) J. Cell. Biochem. , vol.106 , pp. 984-991
    • Liu, Z.J.1    Zhuge, Y.2    Velazquez, O.C.3
  • 83
    • 33846386176 scopus 로고    scopus 로고
    • Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia
    • Blau, O., Hofmann, W. K., Baldus, C. D., Thiel, G., Serbent, V., Schümann, E., Thiel, E., Blau, I. W. (2007) Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia. Exp. Hematol. 35, 221–229.
    • (2007) Exp. Hematol. , vol.35 , pp. 221-229
    • Blau, O.1    Hofmann, W.K.2    Baldus, C.D.3    Thiel, G.4    Serbent, V.5    Schümann, E.6    Thiel, E.7    Blau, I.W.8
  • 84
    • 0031979845 scopus 로고    scopus 로고
    • Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia
    • Kitagawa, M., Yamaguchi, S., Takahashi, M., Tanizawa, T., Hirokawa, K., Kamiyama, R. (1998) Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia. Leukemia 12, 486–492.
    • (1998) Leukemia , vol.12 , pp. 486-492
    • Kitagawa, M.1    Yamaguchi, S.2    Takahashi, M.3    Tanizawa, T.4    Hirokawa, K.5    Kamiyama, R.6
  • 85
    • 84862818255 scopus 로고    scopus 로고
    • Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes
    • Zhao, Z. G., Xu, W., Yu, H. P., Fang, B. L., Wu, S. H., Li, F., Li, W. M., Li, Q. B., Chen, Z. C., Zou, P. (2012) Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes. Cancer Lett. 317, 136–143.
    • (2012) Cancer Lett , vol.317 , pp. 136-143
    • Zhao, Z.G.1    Xu, W.2    Yu, H.P.3    Fang, B.L.4    Wu, S.H.5    Li, F.6    Li, W.M.7    Li, Q.B.8    Chen, Z.C.9    Zou, P.10
  • 86
    • 18544371666 scopus 로고    scopus 로고
    • Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
    • Jiang, X. X., Zhang, Y., Liu, B., Zhang, S. X., Wu, Y., Yu, X. D., Mao, N. (2005) Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 105, 4120–4126.
    • (2005) Blood , vol.105 , pp. 4120-4126
    • Jiang, X.X.1    Zhang, Y.2    Liu, B.3    Zhang, S.X.4    Wu, Y.5    Yu, X.D.6    Mao, N.7
  • 87
    • 2942562525 scopus 로고    scopus 로고
    • Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells
    • Zhang, W., Ge, W., Li, C., You, S., Liao, L., Han, Q., Deng, W., Zhao, R. C. (2004) Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells. Stem Cells Dev. 13, 263–271.
    • (2004) Stem Cells Dev , vol.13 , pp. 263-271
    • Zhang, W.1    Ge, W.2    Li, C.3    You, S.4    Liao, L.5    Han, Q.6    Deng, W.7    Zhao, R.C.8
  • 88
    • 84874639295 scopus 로고    scopus 로고
    • The different immunoregulatory functions on dendritic cells between mesenchymal stem cells derived from bone marrow of patients with low-risk or high-risk myelodysplastic syndromes
    • Wang, Z., Tang, X., Xu, W., Cao, Z., Sun, L., Li, W., Li, Q., Zou, P., Zhao, Z. (2013) The different immunoregulatory functions on dendritic cells between mesenchymal stem cells derived from bone marrow of patients with low-risk or high-risk myelodysplastic syndromes. PLoS One 8, e57470.
    • (2013) Plos One , vol.8
    • Wang, Z.1    Tang, X.2    Xu, W.3    Cao, Z.4    Sun, L.5    Li, W.6    Li, Q.7    Zou, P.8    Zhao, Z.9
  • 89
    • 85014873549 scopus 로고    scopus 로고
    • The influence of macrophages on mesenchymal stromal cell therapy: Passive or aggressive agents?
    • Carty, F., Mahon, B. P., English, K. (2017) The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents? Clin. Exp. Immunol. 188, 1–11.
    • (2017) Clin. Exp. Immunol. , vol.188 , pp. 1-11
    • Carty, F.1    Mahon, B.P.2    English, K.3
  • 90
    • 34250777773 scopus 로고    scopus 로고
    • Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond
    • Mohty, M. (2007) Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond. Leukemia 21, 1387–1394.
    • (2007) Leukemia , vol.21 , pp. 1387-1394
    • Mohty, M.1
  • 99
    • 0033168605 scopus 로고    scopus 로고
    • Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha
    • Corral, L. G., Haslett, P. A., Muller, G. W., Chen, R., Wong, L. M., Ocampo, C. J., Patterson, R. T., Stirling, D. I., Kaplan, G. (1999) Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha. J. Immunol. 163, 380–386.
    • (1999) J. Immunol. , vol.163 , pp. 380-386
    • Corral, L.G.1    Haslett, P.A.2    Muller, G.W.3    Chen, R.4    Wong, L.M.5    Ocampo, C.J.6    Patterson, R.T.7    Stirling, D.I.8    Kaplan, G.9
  • 102
    • 43949136445 scopus 로고    scopus 로고
    • Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
    • Stresemann, C., Lyko, F. (2008) Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int. J. Cancer 123, 8–13.
    • (2008) Int. J. Cancer , vol.123 , pp. 8-13
    • Stresemann, C.1    Lyko, F.2
  • 103
  • 106
    • 84939547558 scopus 로고    scopus 로고
    • Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury
    • Thangavel, J., Samanta, S., Rajasingh, S., Barani, B., Xuan, Y. T., Dawn, B., Rajasingh, J. (2015) Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury. J. Cell Sci. 128, 3094–3105.
    • (2015) J. Cell Sci , vol.128 , pp. 3094-3105
    • Thangavel, J.1    Samanta, S.2    Rajasingh, S.3    Barani, B.4    Xuan, Y.T.5    Dawn, B.6    Rajasingh, J.7
  • 107
    • 84914132768 scopus 로고    scopus 로고
    • Inhibiting DNA methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation
    • Cao, Q., Wang, X., Jia, L., Mondal, A. K., Diallo, A., Hawkins, G. A., Das, S. K., Parks, J. S., Yu, L., Shi, H., Shi, H., Xue, B. (2014) Inhibiting DNA methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology 155, 4925–4938.
    • (2014) Endocrinology , vol.155 , pp. 4925-4938
    • Cao, Q.1    Wang, X.2    Jia, L.3    Mondal, A.K.4    Diallo, A.5    Hawkins, G.A.6    Das, S.K.7    Parks, J.S.8    Yu, L.9    Shi, H.10    Shi, H.11    Xue, B.12
  • 109
    • 0037326224 scopus 로고    scopus 로고
    • Editorial: Sulfonylureas differ in effects on ischemic preconditioning–is it time to retire glyburide?
    • Riddle, M. C. (2003) Editorial: sulfonylureas differ in effects on ischemic preconditioning–is it time to retire glyburide? J. Clin. Endocrinol. Metab. 88, 528–530.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 528-530
    • Riddle, M.C.1
  • 114
    • 4744363912 scopus 로고    scopus 로고
    • Expression of P2X7 in human hematopoietic cell lines and leukemia patients
    • Zhang, X. J., Zheng, G. G., Ma, X. T., Yang, Y. H., Li, G., Rao, Q., Nie, K., Wu, K. F. (2004) Expression of P2X7 in human hematopoietic cell lines and leukemia patients. Leuk. Res. 28, 1313–1322.
    • (2004) Leuk. Res. , vol.28 , pp. 1313-1322
    • Zhang, X.J.1    Zheng, G.G.2    Ma, X.T.3    Yang, Y.H.4    Li, G.5    Rao, Q.6    Nie, K.7    Wu, K.F.8
  • 117
    • 33846665846 scopus 로고    scopus 로고
    • Bortezomib is an effective agent for MDS/MPD syndrome with 5q- anomaly and thrombocytosis
    • Terpos, E., Verrou, E., Banti, A., Kaloutsi, V., Lazaridou, A., Zervas, K. (2007) Bortezomib is an effective agent for MDS/MPD syndrome with 5q- anomaly and thrombocytosis. Leuk. Res. 31, 559–562.
    • (2007) Leuk. Res. , vol.31 , pp. 559-562
    • Terpos, E.1    Verrou, E.2    Banti, A.3    Kaloutsi, V.4    Lazaridou, A.5    Zervas, K.6
  • 119
    • 84907880426 scopus 로고    scopus 로고
    • Suppression of the pro-inflammatory NLRP3/interleukin-1β pathway in macrophages by the thioredoxin reductase inhibitor auranofin
    • Isakov, E., Weisman-Shomer, P., Benhar, M. (2014) Suppression of the pro-inflammatory NLRP3/interleukin-1β pathway in macrophages by the thioredoxin reductase inhibitor auranofin. Biochim. Biophys. Acta 1840, 3153–3161.
    • (2014) Biochim. Biophys. Acta , vol.1840 , pp. 3153-3161
    • Isakov, E.1    Weisman-Shomer, P.2    Benhar, M.3
  • 120
    • 84891917420 scopus 로고    scopus 로고
    • 3,4-Methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome
    • He, Y., Varadarajan, S., Muñoz-Planillo, R., Burberry, A., Nakamura, Y., Núñez, G. (2014) 3,4-Methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. J. Biol. Chem. 289, 1142–1150.
    • (2014) J. Biol. Chem. , vol.289 , pp. 1142-1150
    • He, Y.1    Varadarajan, S.2    Muñoz-Planillo, R.3    Burberry, A.4    Nakamura, Y.5    Núñez, G.6
  • 121
    • 84924565877 scopus 로고    scopus 로고
    • The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes
    • Maier, N. K., Leppla, S. H., Moayeri, M. (2015) The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. J. Immunol. 194, 2776–2785.
    • (2015) J. Immunol. , vol.194 , pp. 2776-2785
    • Maier, N.K.1    Leppla, S.H.2    Moayeri, M.3
  • 122
    • 84055182560 scopus 로고    scopus 로고
    • The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes
    • Coll, R. C., Robertson, A., Butler, M., Cooper, M., O’Neill, L. A. (2011) The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS One 6, e29539.
    • (2011) Plos One , vol.6
    • Coll, R.C.1    Robertson, A.2    Butler, M.3    Cooper, M.4    O’Neill, L.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.