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Volumn 12, Issue , 2012, Pages

Myeloid malignancies: Mutations, models and management

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CBL PROTEIN; CD135 ANTIGEN; DNA METHYLTRANSFERASE 3A; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; JANUS KINASE 2; RAS PROTEIN; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR RUNX1;

EID: 84865161055     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-304     Document Type: Review
Times cited : (114)

References (137)
  • 1
    • 72949114887 scopus 로고    scopus 로고
    • Leukaemogenesis: more than mutant genes
    • Chen J, Odenike O, Rowley JD. Leukaemogenesis: more than mutant genes. Nat Rev Cancer 2010, 10:23-36.
    • (2010) Nat Rev Cancer , vol.10 , pp. 23-36
    • Chen, J.1    Odenike, O.2    Rowley, J.D.3
  • 7
    • 80053545678 scopus 로고    scopus 로고
    • Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy
    • Fathi AT, Abdel-Wahab O. Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy. Adv Hematol 2012, 2012:469592.
    • (2012) Adv Hematol , vol.2012 , pp. 469592
    • Fathi, A.T.1    Abdel-Wahab, O.2
  • 10
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications
    • Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011, 29:475-486.
    • (2011) J Clin Oncol , vol.29 , pp. 475-486
    • Marcucci, G.1    Haferlach, T.2    Dohner, H.3
  • 12
    • 61849118935 scopus 로고    scopus 로고
    • Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F
    • Schaub FX, Jager R, Looser R, Hao-Shen H, Hermouet S, Girodon F, Tichelli A, Gisslinger H, Kralovics R, Skoda RC. Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F. Blood 2009, 113:2022-2027.
    • (2009) Blood , vol.113 , pp. 2022-2027
    • Schaub, F.X.1    Jager, R.2    Looser, R.3    Hao-Shen, H.4    Hermouet, S.5    Girodon, F.6    Tichelli, A.7    Gisslinger, H.8    Kralovics, R.9    Skoda, R.C.10
  • 13
    • 80052836966 scopus 로고    scopus 로고
    • Current findings for recurring mutations in acute myeloid leukemia
    • Takahashi S. Current findings for recurring mutations in acute myeloid leukemia. J Hematol Oncol 2011, 4:36.
    • (2011) J Hematol Oncol , vol.4 , pp. 36
    • Takahashi, S.1
  • 14
    • 79960262592 scopus 로고    scopus 로고
    • Mutations galore in myeloproliferative neoplasms: Would the real Spartacus please stand up?
    • Tefferi A. Mutations galore in myeloproliferative neoplasms: Would the real Spartacus please stand up?. Leukemia 2011, 25:1059-1063.
    • (2011) Leukemia , vol.25 , pp. 1059-1063
    • Tefferi, A.1
  • 19
    • 57749114621 scopus 로고    scopus 로고
    • 250 K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies
    • Dunbar AJ, Gondek LP, O'Keefe CL, Makishima H, Rataul MS, Szpurka H, Sekeres MA, Wang XF, McDevitt MA, Maciejewski JP. 250 K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. Cancer Res 2008, 68:10349-10357.
    • (2008) Cancer Res , vol.68 , pp. 10349-10357
    • Dunbar, A.J.1    Gondek, L.P.2    O'Keefe, C.L.3    Makishima, H.4    Rataul, M.S.5    Szpurka, H.6    Sekeres, M.A.7    Wang, X.F.8    McDevitt, M.A.9    Maciejewski, J.P.10
  • 34
    • 33645400695 scopus 로고    scopus 로고
    • X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis
    • Levine RL, Belisle C, Wadleigh M, Zahrieh D, Lee S, Chagnon P, Gilliland DG, Busque L. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood 2006, 107:4139-4141.
    • (2006) Blood , vol.107 , pp. 4139-4141
    • Levine, R.L.1    Belisle, C.2    Wadleigh, M.3    Zahrieh, D.4    Lee, S.5    Chagnon, P.6    Gilliland, D.G.7    Busque, L.8
  • 43
    • 84856405146 scopus 로고    scopus 로고
    • Mutational determinants of epigenetic instability in myeloid malignancies
    • Jankowska AM, Szpurka H. Mutational determinants of epigenetic instability in myeloid malignancies. Semin Oncol 2012, 39:80-96.
    • (2012) Semin Oncol , vol.39 , pp. 80-96
    • Jankowska, A.M.1    Szpurka, H.2
  • 44
    • 84859647446 scopus 로고    scopus 로고
    • Deletion of the tumor-suppressor gene NF1 occurs in 5 % of myeloid malignancies and is accompanied by a mutation in the remaining allele in half of the cases
    • Haferlach C, Grossmann V, Kohlmann A, Schindela S, Kern W, Schnittger S, Haferlach T. Deletion of the tumor-suppressor gene NF1 occurs in 5 % of myeloid malignancies and is accompanied by a mutation in the remaining allele in half of the cases. Leukemia 2011, 26:834-839.
    • (2011) Leukemia , vol.26 , pp. 834-839
    • Haferlach, C.1    Grossmann, V.2    Kohlmann, A.3    Schindela, S.4    Kern, W.5    Schnittger, S.6    Haferlach, T.7
  • 56
    • 24944476696 scopus 로고    scopus 로고
    • Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndrome
    • Brakensiek K, Langer F, Schlegelberger B, Kreipe H, Lehmann U. Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndrome. Br J Haematol 2005, 130:209-217.
    • (2005) Br J Haematol , vol.130 , pp. 209-217
    • Brakensiek, K.1    Langer, F.2    Schlegelberger, B.3    Kreipe, H.4    Lehmann, U.5
  • 57
    • 84856366956 scopus 로고    scopus 로고
    • Clinical applications of epigenetic markers and epigenetic profiling in myeloid malignancies
    • McDevitt MA. Clinical applications of epigenetic markers and epigenetic profiling in myeloid malignancies. Semin Oncol 2012, 39:109-122.
    • (2012) Semin Oncol , vol.39 , pp. 109-122
    • McDevitt, M.A.1
  • 64
    • 79957798663 scopus 로고    scopus 로고
    • Transcriptional and epigenetic networks in haematological malignancy
    • Cheung N, So CW. Transcriptional and epigenetic networks in haematological malignancy. FEBS Lett 2011, 585:2100-2111.
    • (2011) FEBS Lett , vol.585 , pp. 2100-2111
    • Cheung, N.1    So, C.W.2
  • 65
    • 79952109988 scopus 로고    scopus 로고
    • Epigenetic mechanisms in acute myeloid leukemia
    • Peters AH, Schwaller J. Epigenetic mechanisms in acute myeloid leukemia. Prog Drug Res 2011, 67:197-219.
    • (2011) Prog Drug Res , vol.67 , pp. 197-219
    • Peters, A.H.1    Schwaller, J.2
  • 72
    • 80052303426 scopus 로고    scopus 로고
    • TET family proteins and their role in stem cell differentiation and transformation
    • Cimmino L, Abdel-Wahab O, Levine RL, Aifantis I. TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell 2011, 9:193-204.
    • (2011) Cell Stem Cell , vol.9 , pp. 193-204
    • Cimmino, L.1    Abdel-Wahab, O.2    Levine, R.L.3    Aifantis, I.4
  • 73
    • 80052461558 scopus 로고    scopus 로고
    • Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
    • Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y. Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine. Science 2011, 233:1300-1303.
    • (2011) Science , vol.233 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3    Wu, S.C.4    Collins, L.B.5    Swenberg, J.A.6    He, C.7    Zhang, Y.8
  • 82
    • 53549127289 scopus 로고    scopus 로고
    • CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop
    • Li T, Hu JF, Qiu X, Ling J, Chen H, Wang S, Hou A, Vu TH, Hoffman AR. CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop. Mol Cell Biol 2008, 28:6473-6482.
    • (2008) Mol Cell Biol , vol.28 , pp. 6473-6482
    • Li, T.1    Hu, J.F.2    Qiu, X.3    Ling, J.4    Chen, H.5    Wang, S.6    Hou, A.7    Vu, T.H.8    Hoffman, A.R.9
  • 84
    • 78751590899 scopus 로고    scopus 로고
    • Silencing chromatin: comparing modes and mechanisms
    • Beisel C, Paro R. Silencing chromatin: comparing modes and mechanisms. Nat Rev Genet 2011, 12:123-135.
    • (2011) Nat Rev Genet , vol.12 , pp. 123-135
    • Beisel, C.1    Paro, R.2
  • 85
    • 84856747744 scopus 로고    scopus 로고
    • Da RV, Tang Z, Siegle J, Asp P, Hadler M, Rigo I, Keersmaecker KD, Patel J, Huynh T, Utro F, Poglio S, Samon JB, Paietta E, Racevskis J, Rowe JM, Rabadan R, Levine RL, Brown S, Pflumio F, Dominguez M, Ferrando A, Aifantis I: Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
    • Ntziachristos P, Tsirigos A, Vlierberghe PV, Nedjic J, Trimarchi T, Flaherty MS, Ferres-Marco D. da RV, Tang Z, Siegle J, Asp P, Hadler M, Rigo I, Keersmaecker KD, Patel J, Huynh T, Utro F, Poglio S, Samon JB, Paietta E, Racevskis J, Rowe JM, Rabadan R, Levine RL, Brown S, Pflumio F, Dominguez M, Ferrando A, Aifantis I: Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med 2012, 18:298-303.
    • (2012) Nat Med , vol.18 , pp. 298-303
    • Ntziachristos, P.1    Tsirigos, A.2    Vlierberghe, P.V.3    Nedjic, J.4    Trimarchi, T.5    Flaherty, M.S.6    Ferres-Marco, D.7
  • 88
    • 70349469565 scopus 로고    scopus 로고
    • Mechanisms of polycomb gene silencing: knowns and unknowns
    • Simon JA, Kingston RE. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol 2009, 10:697-708.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 697-708
    • Simon, J.A.1    Kingston, R.E.2
  • 91
    • 78650027929 scopus 로고    scopus 로고
    • Haplo-insufficiency: a driving force in cancer
    • Berger AH, Pandolfi PP. Haplo-insufficiency: a driving force in cancer. J Pathol 2011, 223:137-146.
    • (2011) J Pathol , vol.223 , pp. 137-146
    • Berger, A.H.1    Pandolfi, P.P.2
  • 92
    • 74249103981 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: lost between two states?
    • Acquaviva C, Gelsi-Boyer V, Birnbaum D. Myelodysplastic syndromes: lost between two states?. Leukemia 2010, 24:1-5.
    • (2010) Leukemia , vol.24 , pp. 1-5
    • Acquaviva, C.1    Gelsi-Boyer, V.2    Birnbaum, D.3
  • 93
    • 14644431836 scopus 로고    scopus 로고
    • Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
    • Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H. Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev 2005, 19:536-541.
    • (2005) Genes Dev , vol.19 , pp. 536-541
    • Isono, K.1    Mizutani-Koseki, Y.2    Komori, T.3    Schmidt-Zachmann, M.S.4    Koseki, H.5
  • 96
    • 77958021645 scopus 로고    scopus 로고
    • LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations
    • Pardanani A, Lasho T, Finke C, Oh ST, Gotlib J, Tefferi A. LNK mutation studies in blast-phase myeloproliferative neoplasms, and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations. Leukemia 2010, 24:1713-1718.
    • (2010) Leukemia , vol.24 , pp. 1713-1718
    • Pardanani, A.1    Lasho, T.2    Finke, C.3    Oh, S.T.4    Gotlib, J.5    Tefferi, A.6
  • 98
    • 54349105660 scopus 로고    scopus 로고
    • Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias
    • Abbas S, Rotmans G, Lowenberg B, Valk PJ. Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias. Haematologica 2008, 93:1595-1597.
    • (2008) Haematologica , vol.93 , pp. 1595-1597
    • Abbas, S.1    Rotmans, G.2    Lowenberg, B.3    Valk, P.J.4
  • 103
    • 80054694786 scopus 로고    scopus 로고
    • Point mutations in myelodysplastic syndromes
    • Damm F, Fontenay M, Bernard OA. Point mutations in myelodysplastic syndromes. N Engl J Med 2011, 365:1154-1155.
    • (2011) N Engl J Med , vol.365 , pp. 1154-1155
    • Damm, F.1    Fontenay, M.2    Bernard, O.A.3
  • 104
    • 77956152948 scopus 로고    scopus 로고
    • Murine models of human acute myeloid leukemia
    • Fortier JM, Graubert TA. Murine models of human acute myeloid leukemia. Cancer Treat Res 2010, 145:183-196.
    • (2010) Cancer Treat Res , vol.145 , pp. 183-196
    • Fortier, J.M.1    Graubert, T.A.2
  • 105
    • 18644384085 scopus 로고    scopus 로고
    • Animal models of acute myelogenous leukaemia - development, application and future perspectives
    • McCormack E, Bruserud O, Gjertsen BT. Animal models of acute myelogenous leukaemia - development, application and future perspectives. Leukemia 2005, 19:687-706.
    • (2005) Leukemia , vol.19 , pp. 687-706
    • McCormack, E.1    Bruserud, O.2    Gjertsen, B.T.3
  • 108
    • 0141483064 scopus 로고    scopus 로고
    • Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
    • Passegue E, Jamieson CH, Ailles LE, Weissman IL. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?. Proc Natl Acad Sci U S A 2003, 100(Suppl 1):11842-11849.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.SUPPL. 1 , pp. 11842-11849
    • Passegue, E.1    Jamieson, C.H.2    Ailles, L.E.3    Weissman, I.L.4
  • 109
    • 70449497349 scopus 로고    scopus 로고
    • In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm
    • Lambert JR, Everington T, Linch DC, Gale RE. In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm. Blood 2009, 114:3018-3023.
    • (2009) Blood , vol.114 , pp. 3018-3023
    • Lambert, J.R.1    Everington, T.2    Linch, D.C.3    Gale, R.E.4
  • 110
    • 0036814971 scopus 로고    scopus 로고
    • Molecular genetics of human leukemias: new insights into therapy
    • Gilliland DG. Molecular genetics of human leukemias: new insights into therapy. Semin Hematol 2002, 39:6-11.
    • (2002) Semin Hematol , vol.39 , pp. 6-11
    • Gilliland, D.G.1
  • 112
    • 79952164235 scopus 로고    scopus 로고
    • Unraveling the molecular pathophysiology of myelodysplastic syndromes
    • Bejar R, Levine R, Ebert BL. Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol 2011, 29:504-515.
    • (2011) J Clin Oncol , vol.29 , pp. 504-515
    • Bejar, R.1    Levine, R.2    Ebert, B.L.3
  • 117
    • 73649110641 scopus 로고    scopus 로고
    • Van PW, Skrabanek L, Campagne F, Mazumdar M, Greally JM, Valk PJ, Lowenberg B, Delwel R, Melnick A: DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
    • Figueroa ME, Lugthart S, Li Y, Erpelinck-Verschueren C, Deng X, Christos PJ, Schifano E, Booth J. van PW, Skrabanek L, Campagne F, Mazumdar M, Greally JM, Valk PJ, Lowenberg B, Delwel R, Melnick A: DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell 2010, 17:13-27.
    • (2010) Cancer Cell , vol.17 , pp. 13-27
    • Figueroa, M.E.1    Lugthart, S.2    Li, Y.3    Erpelinck-Verschueren, C.4    Deng, X.5    Christos, P.J.6    Schifano, E.7    Booth, J.8
  • 121
    • 80053629571 scopus 로고    scopus 로고
    • Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes
    • Stein BL, Williams DM, O'Keefe C, Rogers O, Ingersoll RG, Spivak JL, Verma A, Maciejewski JP, McDevitt MA, Moliterno AR. Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes. Haematologica 2011, 96:1462-1469.
    • (2011) Haematologica , vol.96 , pp. 1462-1469
    • Stein, B.L.1    Williams, D.M.2    O'Keefe, C.3    Rogers, O.4    Ingersoll, R.G.5    Spivak, J.L.6    Verma, A.7    Maciejewski, J.P.8    McDevitt, M.A.9    Moliterno, A.R.10
  • 127
    • 79952042862 scopus 로고    scopus 로고
    • Targeting myeloproliferative neoplasms with JAK inhibitors
    • Pardanani A, Tefferi A. Targeting myeloproliferative neoplasms with JAK inhibitors. Curr Opin Hematol 2011, 18:105-110.
    • (2011) Curr Opin Hematol , vol.18 , pp. 105-110
    • Pardanani, A.1    Tefferi, A.2
  • 131
    • 80052924863 scopus 로고    scopus 로고
    • Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors
    • Pollyea DA, Raval A, Kusler B, Gotlib JR, Alizadeh AA, Mitchell BS. Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors. Hematol Oncol 2010, 29:157-160.
    • (2010) Hematol Oncol , vol.29 , pp. 157-160
    • Pollyea, D.A.1    Raval, A.2    Kusler, B.3    Gotlib, J.R.4    Alizadeh, A.A.5    Mitchell, B.S.6
  • 135
    • 80055023013 scopus 로고    scopus 로고
    • Managing resistance in chronic myeloid leukemia
    • Roychowdhury S, Talpaz M. Managing resistance in chronic myeloid leukemia. Blood Rev 2011, 25:279-290.
    • (2011) Blood Rev , vol.25 , pp. 279-290
    • Roychowdhury, S.1    Talpaz, M.2
  • 136
    • 79955592811 scopus 로고    scopus 로고
    • Harnessing synthetic lethal interactions in anticancer drug discovery
    • Chan DA, Giaccia AJ. Harnessing synthetic lethal interactions in anticancer drug discovery. Nat Rev Drug Discov 2011, 10:351-364.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 351-364
    • Chan, D.A.1    Giaccia, A.J.2
  • 137
    • 0033227499 scopus 로고    scopus 로고
    • Hypothesis: more mutations to cure cancer?
    • Eisinger F, Sobol H, Birnbaum D. Hypothesis: more mutations to cure cancer?. Oncol Rep 1999, 6:1189-1190.
    • (1999) Oncol Rep , vol.6 , pp. 1189-1190
    • Eisinger, F.1    Sobol, H.2    Birnbaum, D.3


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