Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes

Cancer Letters

Volumn 317, Issue 2, 2012, Pages 136-143

  Zhao, Zhi Gang ^a   Xu, Wen ^a   Yu, Hai Peng ^a   Fang, Bing Ling ^b   Wu, Shu Hong ^b   Li, Fang ^a   Li, Wei Min ^c   Li, Qiu Bai ^c   Chen, Zhi Chao ^c   Zou, Ping ^c  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS   (United States)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bone marrow; Immunomodulatory; Mesenchymal stem cells; Myelodysplastic syndromes; Support hematopoiesis

Indexed keywords

COLONY STIMULATING FACTOR 1; EPITOPE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 11; INTERLEUKIN 3; INTERLEUKIN 6; SCATTER FACTOR RECEPTOR; STEM CELL FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL STRUCTURE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; HEMATOPOIESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOMODULATION; IN VITRO STUDY; KARYOTYPE; LYMPHOCYTE PROLIFERATION; MESENCHYMAL STEM CELL; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION;

ADULT; AGED; BONE MARROW CELLS; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HEMATOPOIESIS; HUMANS; IMMUNOPHENOTYPING; KARYOTYPE; LYMPHOCYTE ACTIVATION; MALE; MESENCHYMAL STEM CELLS; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES; YOUNG ADULT;

EID: 84862818255     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.08.030     Document Type: Article

References (34)

1. Tse W.T., Pendleton J.D., Beyer W.M., Egalka M.C., Guinan E.C. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003, 75:389-397.
2. Zhang B., Liu R., Shi D., Liu X.X., Chen Y., Dou X.W., Cao X.T. Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population. Blood 2009, 113:46-57.
3. Krampera M., Glennie S., Dyson J., Scott D., Laylor R., Simpson E., Dazzi F. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003, 101:3722-3729.
4. Zhang W., Ge W., Li C., You S., Liao L., Han Q., Deng W., Zhao R.C. Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells. J. Hematoth. Stem Cell 2004, 13:263-271.
5. Jiang X.X., Zhang Y., Liu B., Zhang S.X., Wu Y., Yu X.D., Mao N. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005, 105:4120-4126.
6. Freisinger E., Cramer C., Xia X., Murthy S.N., Slakey D.P., Chiu E., Newsome E.R., Alt E.U., Izadpanah R. Characterization of hematopoietic potential of mesenchymal stem cells. J. Cell. Physiol. 2010, 225:888-897.
7. Nakao N., Nakayama T., Yahata T., Muguruma Y., Saito S., Miyata Y., Yamamoto K., Naoe T. Adipose tissue-derived mesenchymal stem cells facilitate hematopoiesis in vitro and in vivo: advantages over bone marrow-derived mesenchymal stem cells. Am. J. Pathol. 2010, 177:547-554.
8. Flores-Figueroa E., Montesinos J.J., Flores-Guzmán P., Gutiérrez-Espíndola G., Arana-Trejo R.M., Castillo-Medina S., Pérez-Cabrera A., Hernández-Estévez E., Arriaga L., Mayani H. Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cells. Leukemia Res. 2008, 32:1407-1416.
9. Flores-Figueroa E., Arana-Trejo R.M., Gutiérrez-Espíndola G., Pérez-Cabrera A., Mayani H. Mesenchymal stem cells in myelodysplastic syndromes: phenotypic and cytogenetic characterization. Leukemia Res. 2005, 29:215-224.
10. Lopez-Villar O., Garcia J.L., Sanchez-Guijo F.M., Robledo C., Villaron E.M., Hernandez-Campo P., Lopez-Holgado N., Diez-Campelo M., Barbado M.V., Perez-Simon J.A., Herna ́ndez-Rivas J.M., San-Miguel J.F., del Canizo M-C. Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q-syndrome. Leukemia 2009, 23:664-672.
11. Soenen-Cornu V., Tourino C., Marie-Laure B., Guillier M., Flamant S., Kotb R., Bernheim A., Jean-Henri B., Preudhomme C., Fenaux P., Turhan A.G. Mesenchymal cells generated from patients with myelodysplastic syndromes are devoid of chromosomal clonal markers and support short- and long-term hematopoiesis in vitro. Oncogene 2005, 24:2441-2448.
12. Tauro S., Hepburn M.D., Bowen D.T., Pippard M.J. Assessment of stromal function, and its potential contribution to deregulation of hematopoiesis in the myelodysplastic syndromes. Haematologica 2001, 86:1038-1045.
13. Klaus M., Stavroulaki E., Kastrinaki M.C., Fragioudaki P., Giannikou K., Psyllaki M., Pontikoglou C., Tsoukatou D., Mamalaki C., Papadaki H.A. Reserves, functional, immunoregulatory, and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes. Stem Cells Develop. 2010, 19:1043-1054.
14. Guo H., Fang B., Liao L., Zhao Z., Liu J., Chen H., Hsu S.H., Cui Q., Zhao R.C. Hemangioblastic characteristics of fetal bone marrow-derived Flk1+CD32-CD34-cells. Exp. Hematol. 2003, 31:650-658.
15. Reyes M., Lund T., Lenvik T., Aguiar D., Koodie L., Verfaillie C.M. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 2001, 98:2615-2625.
16. Gupta P., Blazar B.R., Gupta K., Verfaillie C.M. Human CD34 bone marrow cells regulate stromal production of interleukin-6 and granulocyte colony-stimulating factor and increase the colony-stimulating activity of stroma. Blood 1998, 91:3724-3733.
17. Zhao Z.G., Liang Y., Li K., Li W.M., Li Q.B., Chen C.Z., Zou P. Phenotypic and functional comparison of mesenchymal stem cells derived from the bone marrow of normal adults and patients with hematologic malignant diseases. Stem Cells Develop. 2007, 16:637-648.
18. Bhatia R., McGlave P.B., Dewald G.W., Blazar B.R., Verfaillie C.M. Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages. Blood 1995, 85:3636-3645.
19. Tennant G.B., Walsh V., Truran L.N., Edwards P., Mills K.I., Burnett A.K. Reduced growth of normal myeloid progenitors on MDS stroma is unrelated to confluence. Br. J. Haematol. 2000, 111:853-862.
20. Noort W.A., Kruisselbrink A.B., in't Anker P.S., Kruger M., van Bezooijen R.L., de Paus R.A., Heemskerk M.H., Löwik C.W., Falkenburg J.H., Willemze R., Fibbe W.E. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp. Hematol. 2002, 30:870-878.
21. Koc O.N., Gerson S.L., Cooper B.W., Dyhouse S.M., Haynesworth S.E., Caplan A.I., Lazarus H.M. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J. Clin. Oncol. 2000, 18:307-316.
22. Najar M., Raicevic G., Id Boufker H., Stamatopoulos B., De Bruyn C., Meuleman N., Bron D., Toungouz M., Lagneaux L. Modulated expression of adhesion molecules and galectin-1: role during mesenchymal stromal cell immunoregulatory functions. Exp. Hematol. 2010, 38:922-932.
23. Aldinucci A., Rizzetto L., Pieri L., Nosi D., Romagnoli P., Biagioli T., Mazzanti B., Saccardi R., Beltrame L., Massacesi L., Cavalieri D., Ballerini C. Inhibition of immune synapse by altered dendritic cell actin distribution: a new pathway of mesenchymal stem cell immune regulation. J. Immunol. 2010, 185:5102-5110.
24. Zangi L., Margalit R., Reich-Zeliger S., Bachar-Lustig E., Beilhack A., Negrin R., Reisner Y. Direct imaging of immune rejection and memory induction by allogeneic mesenchymal stromal cells. Stem Cells 2009, 27:2865-2874.
25. Ren G., Su J., Zhang L., Zhao X., Ling W., L'huillie A., Zhang J., Lu Y., Roberts A.I., Ji W., Zhang H., Rabson A.B., Shi Y. Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells 2009, 27:1954-1962.
26. Di Nicola M., Carlo-Stella C., Magni M., Milanesi M., Longoni P.D., Matteucci P., Grisanti S., Gianni A.M. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002, 99:3838-3843.
27. Zhao Z.G., Li W.M., Chen Z.C., You Y., Zou P. Immunosuppressive properties of mesenchymal stem cells derived from bone marrow of patient with hematological malignant diseases. Leukemia Lymphoma 2008, 49:2187-2195.
28. Wang J., Liu K., Lu D.P. Mesenchymal stem cells in stem cell transplant recipients are damaged and remain of host origin. Int. J. Hematol. 2005, 82:52-158.
29. Albini A., Sporn M.B. The tumour microenvironment as a target for chemoprevention. Nat. Rev. Cancer 2007, 7:139-147.
30. Pinilla S., Alt E., Abdul Khalek F.J., Jotzu C., Muehlberg F., Beckmann C., Song Y.H. Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion. Cancer Lett. 2009, 284:80-85.
31. Corcoran K.E., Trzaska K.A., Fernandes H., Bryan M., Taborga M., Srinivas V., Packman K., Patel P.S., Rameshwar P. Mesenchymal stem cells in early entry of breast cancer into bone marrow. PLoS One 2008, 3:e2563.
32. Sato T., Sakai T., Noguchi Y., Takita M., Hirakawa S., Ito A. Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases. Gynecol. Oncol. 2004, 92:47-56.
33. Zhu W., Xu W., Jiang R., Qian H., Chen M., Hu J., Cao W., Han C., Chen Y. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp. Mol. Pathol. 2006, 80:267-274.
34. Ramasamy R., Lam E.W., Soeiro I., Tisato V., Bonnet D., Dazzi F. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 2007, 21:304-310.