Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes

Diabetes

Volumn 57, Issue 11, 2008, Pages 3025-3033

  Martin, Andrea P ^a   Rankin, Sara ^b   Pitchford, Simon ^b   Charo, Israel F ^c   Furtado, Glaucia C ^a   Lira, Sergio A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL INFILTRATION; CELL STRESS; CONTROLLED STUDY; GENE OVEREXPRESSION; GLUCOSE TOLERANCE TEST; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSGENIC MOUSE; ANIMAL; BLOOD; BONE MARROW; CELL MOTION; CYTOLOGY; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; B-LYMPHOCYTES; BONE MARROW; CELL MOVEMENT; CHEMOKINE CCL2; DIABETES MELLITUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLUCOSE TOLERANCE TEST; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; MONOCYTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 58149347630     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0625     Document Type: Article

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