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Volumn 7, Issue 2, 2007, Pages 118-129

Myelodysplastic syndromes: The complexity of stem-cell diseases

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALKYLATING AGENT; AMIFOSTINE; AZACITIDINE; CASPASE; CYTARABINE; CYTOKINE; DEPSIPEPTIDE; DOXORUBICIN; ETOPOSIDE; HISTONE DEACETYLASE INHIBITOR; INFLIXIMAB; LBH 589; LENALIDOMIDE; MGCD 0103; PENTOXIFYLLINE; TENIPOSIDE; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; VORINOSTAT;

EID: 33846515640     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc2047     Document Type: Review
Times cited : (285)

References (114)
  • 1
    • 0035375406 scopus 로고    scopus 로고
    • Epidemiological features of myelodysplastic syndromes: Results from regional cancer surveys and hospital-based statistics
    • Aul, C., Giagounidis, A. & Germing, U. Epidemiological features of myelodysplastic syndromes: results from regional cancer surveys and hospital-based statistics. Int. J. Hematol. 73, 405-410 (2001).
    • (2001) Int. J. Hematol , vol.73 , pp. 405-410
    • Aul, C.1    Giagounidis, A.2    Germing, U.3
  • 2
    • 33745847779 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: A view from where the sun rises and where the sun sets
    • Komrokji, R. Myelodysplastic syndromes: a view from where the sun rises and where the sun sets. Leuk. Res. 30, 1067-1068. (2006).
    • (2006) Leuk. Res , vol.30 , pp. 1067-1068
    • Komrokji, R.1
  • 3
    • 25444531973 scopus 로고    scopus 로고
    • Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes
    • Matsuda, A. et al. Difference in clinical features between Japanese and German patients with refractory anemia in myelodysplastic syndromes. Blood 106, 2633-2640 (2005).
    • (2005) Blood , vol.106 , pp. 2633-2640
    • Matsuda, A.1
  • 4
    • 9144232259 scopus 로고    scopus 로고
    • Familial myelodysplastic syndromes, monosomy 7/trisomy 8, and mutator effects
    • Maserati, E. et al. Familial myelodysplastic syndromes, monosomy 7/trisomy 8, and mutator effects. Cancer Genet. Cytogenet. 148, 155-158 (2004).
    • (2004) Cancer Genet. Cytogenet , vol.148 , pp. 155-158
    • Maserati, E.1
  • 5
    • 0035863430 scopus 로고    scopus 로고
    • Familial partial monosomy 7 and myelodysplasia: Different parental origin of the monosomy 7 suggests action of a mutator gene
    • Minelli, A. et al. Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator gene. Cancer Genet. Cytogenet. 124, 147-151 (2001).
    • (2001) Cancer Genet. Cytogenet , vol.124 , pp. 147-151
    • Minelli, A.1
  • 6
    • 0019952276 scopus 로고    scopus 로고
    • Bennett, J. M. et al. Proposals for the classification of the myelodysplastic syndromes. Br. J. Haematol. 51, 189-199 (1982). This 25 year old classification scheme remains popular and widely used.
    • Bennett, J. M. et al. Proposals for the classification of the myelodysplastic syndromes. Br. J. Haematol. 51, 189-199 (1982). This 25 year old classification scheme remains popular and widely used.
  • 7
    • 0036786901 scopus 로고    scopus 로고
    • Vardiman, J. W., Harris, N. L. & Brunning, R. D. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 100, 2292-2302 (2002). The newer international classification scheme for all haematological neoplasms remains similar to the FAB scheme, with a crucial change in the number of blasts that defines AML.
    • Vardiman, J. W., Harris, N. L. & Brunning, R. D. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 100, 2292-2302 (2002). The newer international classification scheme for all haematological neoplasms remains similar to the FAB scheme, with a crucial change in the number of blasts that defines AML.
  • 8
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg, P. et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 89, 2079-2088 (1997).
    • (1997) Blood , vol.89 , pp. 2079-2088
    • Greenberg, P.1
  • 10
    • 32144431895 scopus 로고    scopus 로고
    • Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: A basis for clinical decision making
    • Malcovati, L. et al. Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making. J. Clin. Oncol. 23, 7594-7603 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 7594-7603
    • Malcovati, L.1
  • 12
    • 24344506258 scopus 로고    scopus 로고
    • Cancer stem cells: Lessons from leukemia
    • Wang, J. C. & Dick, J. E. Cancer stem cells: lessons from leukemia. Trends Cell Biol. 15, 494-501 (2005).
    • (2005) Trends Cell Biol , vol.15 , pp. 494-501
    • Wang, J.C.1    Dick, J.E.2
  • 14
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukemia after transplantation into SCID mice
    • Lapidot, T. et al. A cell initiating human acute myeloid leukemia after transplantation into SCID mice. Nature 367, 645-648 (1994).
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1
  • 15
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med. 3, 730-737 (1997).
    • (1997) Nature Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 16
    • 3242754448 scopus 로고    scopus 로고
    • Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
    • Hope, K. J., Jin, L. & Dick, J. E. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nature Immunol. 5, 738-743 (2004).
    • (2004) Nature Immunol , vol.5 , pp. 738-743
    • Hope, K.J.1    Jin, L.2    Dick, J.E.3
  • 17
    • 0032871560 scopus 로고    scopus 로고
    • The prognostic value of in vitro cultures of erythroid and megakaryocyte progenitors in myelodysplastic syndromes
    • Juvonen, E., Aimolahti, A., Volin, L. & Ruutu, T. The prognostic value of in vitro cultures of erythroid and megakaryocyte progenitors in myelodysplastic syndromes. Leuk. Res. 23, 889-894 (1999).
    • (1999) Leuk. Res , vol.23 , pp. 889-894
    • Juvonen, E.1    Aimolahti, A.2    Volin, L.3    Ruutu, T.4
  • 18
    • 0031858306 scopus 로고    scopus 로고
    • Measurement of secondary colony formation after 5 weeks in long-term cultures in patients with myelodysplastic syndrome
    • Sato, T., Kim, S., Selleri, C., Young, N. S. & Maciejewski, J. P. Measurement of secondary colony formation after 5 weeks in long-term cultures in patients with myelodysplastic syndrome. Leukemia 12, 1187-1194 (1998).
    • (1998) Leukemia , vol.12 , pp. 1187-1194
    • Sato, T.1    Kim, S.2    Selleri, C.3    Young, N.S.4    Maciejewski, J.P.5
  • 19
    • 0036659925 scopus 로고    scopus 로고
    • Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8
    • Nilsson, L. et al. Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8. Blood 100, 259-267 (2002).
    • (2002) Blood , vol.100 , pp. 259-267
    • Nilsson, L.1
  • 20
    • 0034665776 scopus 로고    scopus 로고
    • - cells from patients with del(5q) syndrome, with implications for the identity of the MDS stem cell.
    • - cells from patients with del(5q) syndrome, with implications for the identity of the MDS stem cell.
  • 21
    • 0028337826 scopus 로고
    • Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes
    • Asano, H. et al. Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes. Blood 84, 588-594 (1994).
    • (1994) Blood , vol.84 , pp. 588-594
    • Asano, H.1
  • 22
    • 0036493359 scopus 로고    scopus 로고
    • In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: Evidence for Fas-dependent apoptosis
    • Claessens, Y. E. et al. In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis. Blood 99, 1594-1601 (2002).
    • (2002) Blood , vol.99 , pp. 1594-1601
    • Claessens, Y.E.1
  • 23
    • 13244290233 scopus 로고    scopus 로고
    • Campioni, D. et al. Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes. Am. J. Pathol. 166, 557-563 (2005). TNF-related apoptosis probably has an important role in low-risk MDS, although this mechanism has not been validated by anti-TNF agents.
    • Campioni, D. et al. Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes. Am. J. Pathol. 166, 557-563 (2005). TNF-related apoptosis probably has an important role in low-risk MDS, although this mechanism has not been validated by anti-TNF agents.
  • 24
    • 0037400551 scopus 로고    scopus 로고
    • NOD/SCID mice transplanted with marrow from patients with myelodysplastic syndrome (MDS) show long-term propagation of normal but not clonal human precursors
    • Benito, A. I. et al. NOD/SCID mice transplanted with marrow from patients with myelodysplastic syndrome (MDS) show long-term propagation of normal but not clonal human precursors. Leuk. Res. 27, 425-436 (2003).
    • (2003) Leuk. Res , vol.27 , pp. 425-436
    • Benito, A.I.1
  • 25
    • 2542427495 scopus 로고    scopus 로고
    • Engraftment of NOD/SCID-beta2 microglobulin null mice with multilineage neoplastic cells from patients with myelodysplastic syndrome
    • Thanopoulou, E. et al. Engraftment of NOD/SCID-beta2 microglobulin null mice with multilineage neoplastic cells from patients with myelodysplastic syndrome. Blood 103, 4285-4293 (2004).
    • (2004) Blood , vol.103 , pp. 4285-4293
    • Thanopoulou, E.1
  • 26
    • 4644320261 scopus 로고    scopus 로고
    • Kerbauy, D. M., Lesnikov, V., Torok-Storb, B., Bryant, E. & Deeg, H. J. Engraftment of distinct clonal MDS-derived hematopoietic precursors in NOD/SCID-beta2-microglobulin-deficient mice after intramedullary transplantation of hematopoietic and stromal cells. Blood 104, 2202-2203 (2004). References 25 and 26 describe the successful engraftment of clonal MDS cells in a more immunodeficient strain of NOD/SCID mice.
    • Kerbauy, D. M., Lesnikov, V., Torok-Storb, B., Bryant, E. & Deeg, H. J. Engraftment of distinct clonal MDS-derived hematopoietic precursors in NOD/SCID-beta2-microglobulin-deficient mice after intramedullary transplantation of hematopoietic and stromal cells. Blood 104, 2202-2203 (2004). References 25 and 26 describe the successful engraftment of clonal MDS cells in a more immunodeficient strain of NOD/SCID mice.
  • 27
    • 18344410760 scopus 로고    scopus 로고
    • NOD/SCID/γ(c)(null) mouse: An excellent recipient mouse model for engraftment of human cells
    • Ito, M. et al. NOD/SCID/γ(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100, 3175-3182 (2002).
    • (2002) Blood , vol.100 , pp. 3175-3182
    • Ito, M.1
  • 28
    • 20844434966 scopus 로고    scopus 로고
    • Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
    • Shultz, L. D. et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J. Immunol. 174, 6477-6489 (2005).
    • (2005) J. Immunol , vol.174 , pp. 6477-6489
    • Shultz, L.D.1
  • 29
    • 85047694750 scopus 로고    scopus 로고
    • Buonamici, S. et al. EVI1 induces myelodysplastic syndrome in mice. J. Clin. Invest. 114, 713-719 (2004). Although others have modelled high-risk MDS by engrafting primary cells in immunodeficient mouse strains, the mouse model described in this study mimics many of the features found in low-risk MDS.
    • Buonamici, S. et al. EVI1 induces myelodysplastic syndrome in mice. J. Clin. Invest. 114, 713-719 (2004). Although others have modelled high-risk MDS by engrafting primary cells in immunodeficient mouse strains, the mouse model described in this study mimics many of the features found in low-risk MDS.
  • 30
    • 24344437303 scopus 로고    scopus 로고
    • Role of nucleophosmin in embryonic development and tumorigenesis
    • Grisendi, S. et al. Role of nucleophosmin in embryonic development and tumorigenesis. Nature 437, 147-153 (2005).
    • (2005) Nature , vol.437 , pp. 147-153
    • Grisendi, S.1
  • 31
    • 22044450619 scopus 로고    scopus 로고
    • Lin, Y. W., Slape, C., Zhang, Z. & Aplan, P. D. NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood 106, 287-295 (2005). This transgenic mouse model comes closest to reproducing the different stages of MDS progression.
    • Lin, Y. W., Slape, C., Zhang, Z. & Aplan, P. D. NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood 106, 287-295 (2005). This transgenic mouse model comes closest to reproducing the different stages of MDS progression.
  • 32
    • 3042707308 scopus 로고    scopus 로고
    • Compound heterozygosity for Pten and SHIP augments T-dependent humoral immune responses and cytokine production by CD(4+) T cells
    • Moody, J. L. & Jirik, F. R. Compound heterozygosity for Pten and SHIP augments T-dependent humoral immune responses and cytokine production by CD(4+) T cells. Immunology 112, 404-412 (2004).
    • (2004) Immunology , vol.112 , pp. 404-412
    • Moody, J.L.1    Jirik, F.R.2
  • 33
    • 28844463546 scopus 로고    scopus 로고
    • Progression of myelodysplasia to acute lymphoblastic leukaemia: Implications for disease biology
    • Disperati, P. et al. Progression of myelodysplasia to acute lymphoblastic leukaemia: implications for disease biology. Leuk. Res. 30, 233-239 (2006).
    • (2006) Leuk. Res , vol.30 , pp. 233-239
    • Disperati, P.1
  • 34
    • 0038215283 scopus 로고    scopus 로고
    • Refractory anemia in childhood: A retrospective analysis of 67 patients with particular reference to monosomy 7
    • Kardos, G. et al. Refractory anemia in childhood: a retrospective analysis of 67 patients with particular reference to monosomy 7. Blood 102, 1997-2003 (2003).
    • (2003) Blood , vol.102 , pp. 1997-2003
    • Kardos, G.1
  • 35
    • 0029129034 scopus 로고
    • Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
    • Dong, F. et al. Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. N. Engl. J. Med. 333, 487-493 (1995).
    • (1995) N. Engl. J. Med , vol.333 , pp. 487-493
    • Dong, F.1
  • 36
    • 33744481750 scopus 로고    scopus 로고
    • Molecular pathogenesis of Fanconi anemia: Recent progress
    • Taniguchi, T. & D'Andrea, A. D. Molecular pathogenesis of Fanconi anemia: recent progress. Blood 107, 4223-4233 (2006).
    • (2006) Blood , vol.107 , pp. 4223-4233
    • Taniguchi, T.1    D'Andrea, A.D.2
  • 37
  • 38
    • 33745063192 scopus 로고    scopus 로고
    • Ribosomes and marrow failure: Coincidental association or molecular paradigm?
    • Liu, J. M. & Ellis, S. R. Ribosomes and marrow failure: coincidental association or molecular paradigm? Blood 107, 4583-4588 (2006).
    • (2006) Blood , vol.107 , pp. 4583-4588
    • Liu, J.M.1    Ellis, S.R.2
  • 39
    • 27844570832 scopus 로고    scopus 로고
    • Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein
    • Chiocchetti, A. et al. Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein. Haematologica 90, 1453-1462 (2005).
    • (2005) Haematologica , vol.90 , pp. 1453-1462
    • Chiocchetti, A.1
  • 40
    • 26444448463 scopus 로고    scopus 로고
    • The survival kinases Akt and Pim as potential pharmacological targets
    • Amaravadi, R. & Thompson, C. B. The survival kinases Akt and Pim as potential pharmacological targets. J. Clin. Invest. 115, 2618-2624 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 2618-2624
    • Amaravadi, R.1    Thompson, C.B.2
  • 41
    • 0037229094 scopus 로고    scopus 로고
    • Mutations in SBDS are associated with Shwachman-Diamond syndrome
    • Boocock, G. R. et al. Mutations in SBDS are associated with Shwachman-Diamond syndrome. Nature Genet. 33, 97-101 (2003).
    • (2003) Nature Genet , vol.33 , pp. 97-101
    • Boocock, G.R.1
  • 42
    • 32244439352 scopus 로고    scopus 로고
    • The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the pseudopod of Dictyostelium amoebae during chemotaxis
    • Wessels, D. et al. The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the pseudopod of Dictyostelium amoebae during chemotaxis. J. Cell Sci. 119, 370-379 (2006).
    • (2006) J. Cell Sci , vol.119 , pp. 370-379
    • Wessels, D.1
  • 44
    • 0037215566 scopus 로고    scopus 로고
    • Role of neutrophil elastase in bone marrow failure syndromes: Molecular genetic revival of the chalone hypothesis
    • Horwitz, M. et al. Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis. Curr. Opin. Hematol. 10, 49-54 (2003).
    • (2003) Curr. Opin. Hematol , vol.10 , pp. 49-54
    • Horwitz, M.1
  • 45
    • 33749343053 scopus 로고    scopus 로고
    • Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia
    • Ancliff, P. J. et al. Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood 108, 2182-2189 (2006).
    • (2006) Blood , vol.108 , pp. 2182-2189
    • Ancliff, P.J.1
  • 46
    • 0012749633 scopus 로고    scopus 로고
    • Fanconi anaemia syndrome and apoptosis: State of the art
    • Rosselli, F. Fanconi anaemia syndrome and apoptosis: state of the art. Apoptosis 3, 229-236 (1998).
    • (1998) Apoptosis , vol.3 , pp. 229-236
    • Rosselli, F.1
  • 47
    • 33748744175 scopus 로고    scopus 로고
    • Defective ribosomal protein gene expression alters transcription, translation, apoptosis and oncogenic pathways in Diamond-Blackfan anemia
    • Gazda, H. T. et al. Defective ribosomal protein gene expression alters transcription, translation, apoptosis and oncogenic pathways in Diamond-Blackfan anemia. Stem Cells 24, 2034-2044 (2006).
    • (2006) Stem Cells , vol.24 , pp. 2034-2044
    • Gazda, H.T.1
  • 48
    • 2342644211 scopus 로고    scopus 로고
    • The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure
    • Papadaki, H. A. & Eliopoulos, G. D. The role of apoptosis in the pathophysiology of chronic neutropenias associated with bone marrow failure. Cell Cycle 2, 447-451 (2003).
    • (2003) Cell Cycle , vol.2 , pp. 447-451
    • Papadaki, H.A.1    Eliopoulos, G.D.2
  • 49
    • 0035874541 scopus 로고    scopus 로고
    • Shwachman-Diamond syndrome marrow cells show abnormally increased apoptosis mediated through the Fas pathway
    • Dror, Y. & Freedman, M. H. Shwachman-Diamond syndrome marrow cells show abnormally increased apoptosis mediated through the Fas pathway. Blood 97, 3011-3016 (2001).
    • (2001) Blood , vol.97 , pp. 3011-3016
    • Dror, Y.1    Freedman, M.H.2
  • 50
    • 1942521610 scopus 로고    scopus 로고
    • Kostmann syndrome: Severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells
    • Carlsson, G. et al. Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells. Blood 103, 3355-3361 (2004).
    • (2004) Blood , vol.103 , pp. 3355-3361
    • Carlsson, G.1
  • 51
    • 0037428129 scopus 로고    scopus 로고
    • Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification
    • Ruggero, D. et al. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science 299, 259-262 (2003).
    • (2003) Science , vol.299 , pp. 259-262
    • Ruggero, D.1
  • 52
    • 0035360796 scopus 로고    scopus 로고
    • Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system
    • Betti, C. J., Villalobos, M. J., Diaz, M. O. & Vaughan, A. T. Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system. Cancer Res. 61, 4550-4555 (2001).
    • (2001) Cancer Res , vol.61 , pp. 4550-4555
    • Betti, C.J.1    Villalobos, M.J.2    Diaz, M.O.3    Vaughan, A.T.4
  • 53
    • 0037444282 scopus 로고    scopus 로고
    • Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division
    • Betti, C. J., Villalobos, M. J., Diaz, M. O. & Vaughan, A. T. Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division. Cancer Res. 63, 1377-1381 (2003).
    • (2003) Cancer Res , vol.63 , pp. 1377-1381
    • Betti, C.J.1    Villalobos, M.J.2    Diaz, M.O.3    Vaughan, A.T.4
  • 54
    • 0142058040 scopus 로고    scopus 로고
    • Secondary myeloid leukemia and myelodysplastic syndromes in patients treated for Hodgkin's disease: A report from the German Hodgkin's Lymphoma Study Group
    • Josting, A. et al. Secondary myeloid leukemia and myelodysplastic syndromes in patients treated for Hodgkin's disease: a report from the German Hodgkin's Lymphoma Study Group. J. Clin. Oncol. 21, 3440-3446 (2003).
    • (2003) J. Clin. Oncol , vol.21 , pp. 3440-3446
    • Josting, A.1
  • 56
    • 0042914714 scopus 로고    scopus 로고
    • Risk of acute leukemia following epirubicin-based adjuvant chemotherapy: A report from the National Cancer Institute of Canada Clinical Trials Group
    • Crump, M. et al. Risk of acute leukemia following epirubicin-based adjuvant chemotherapy: a report from the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 21, 3066-3071 (2003).
    • (2003) J. Clin. Oncol , vol.21 , pp. 3066-3071
    • Crump, M.1
  • 57
    • 17144366223 scopus 로고    scopus 로고
    • Increasing incidence of late second malignancies after conditioning with cyclophosphamide and total-body irradiation and autologous bone marrow transplantation for non-Hodgkin's lymphoma
    • Brown, J. R. et al. Increasing incidence of late second malignancies after conditioning with cyclophosphamide and total-body irradiation and autologous bone marrow transplantation for non-Hodgkin's lymphoma. J. Clin. Oncol. 23, 2208-2214 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 2208-2214
    • Brown, J.R.1
  • 58
    • 0034778106 scopus 로고    scopus 로고
    • Acute myeloid leukemia in a patient with ataxia-telangiectasia: A case report and review of the literature
    • Viniou, N. et al. Acute myeloid leukemia in a patient with ataxia-telangiectasia: a case report and review of the literature. Leukemia 15, 1668-1670 (2001).
    • (2001) Leukemia , vol.15 , pp. 1668-1670
    • Viniou, N.1
  • 59
    • 0033021504 scopus 로고    scopus 로고
    • Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene
    • Meyn, M. S. Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene. Clin. Genet. 55, 289-304 (1999).
    • (1999) Clin. Genet , vol.55 , pp. 289-304
    • Meyn, M.S.1
  • 60
    • 33645453358 scopus 로고    scopus 로고
    • Spectrum and significance of variants and mutations in the Fanconi anaemia group G gene in children with sporadic acute myeloid leukaemia
    • Meyer, S. et al. Spectrum and significance of variants and mutations in the Fanconi anaemia group G gene in children with sporadic acute myeloid leukaemia. Br. J. Haematol. 133, 284-292 (2006).
    • (2006) Br. J. Haematol , vol.133 , pp. 284-292
    • Meyer, S.1
  • 61
    • 0034486838 scopus 로고    scopus 로고
    • Aberrant Fanconi anaemia protein profiles in acute myeloid leukaemia cells
    • Xie, Y. et al. Aberrant Fanconi anaemia protein profiles in acute myeloid leukaemia cells. Br. J. Haematol. 111, 1057-1064 (2000).
    • (2000) Br. J. Haematol , vol.111 , pp. 1057-1064
    • Xie, Y.1
  • 62
    • 1542373639 scopus 로고    scopus 로고
    • High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia
    • Harada, H. et al. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood 103, 2316-2324 (2004).
    • (2004) Blood , vol.103 , pp. 2316-2324
    • Harada, H.1
  • 63
    • 0037438508 scopus 로고    scopus 로고
    • Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia
    • Harada, H., Harada, Y., Tanaka, H., Kimura, A. & Inaba, T. Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Blood 101, 673-680 (2003).
    • (2003) Blood , vol.101 , pp. 673-680
    • Harada, H.1    Harada, Y.2    Tanaka, H.3    Kimura, A.4    Inaba, T.5
  • 64
    • 0942289903 scopus 로고    scopus 로고
    • Human mismatch repair, drug-induced DNA damage, and secondary cancer
    • Karran, P., Offman, J. & Bignami, M. Human mismatch repair, drug-induced DNA damage, and secondary cancer. Biochimie 85, 1149-1160 (2003).
    • (2003) Biochimie , vol.85 , pp. 1149-1160
    • Karran, P.1    Offman, J.2    Bignami, M.3
  • 65
    • 3242756741 scopus 로고    scopus 로고
    • Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation
    • Offman, J. et al. Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation. Blood 104, 822-828 (2004).
    • (2004) Blood , vol.104 , pp. 822-828
    • Offman, J.1
  • 66
    • 18444395238 scopus 로고    scopus 로고
    • Defective DNA-mismatch repair: A potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia
    • Olipitz, W. et al. Defective DNA-mismatch repair: a potential mediator of leukemogenic susceptibility in therapy-related myelodysplasia and leukemia. Genes Chromosomes Cancer 34, 243-248 (2002).
    • (2002) Genes Chromosomes Cancer , vol.34 , pp. 243-248
    • Olipitz, W.1
  • 67
    • 0035949708 scopus 로고    scopus 로고
    • Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia
    • Allan, J. M. et al. Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc. Natl Acad. Sci. USA 98, 11592-11597 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 11592-11597
    • Allan, J.M.1
  • 68
    • 13144282667 scopus 로고    scopus 로고
    • Association of CYP3A4 genotype with treatment-related leukemia
    • Felix, C. A. et al. Association of CYP3A4 genotype with treatment-related leukemia. Proc. Natl Acad. Sci. USA 95, 13176-13181 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 13176-13181
    • Felix, C.A.1
  • 69
    • 0035892123 scopus 로고    scopus 로고
    • Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: Effects on in vitro hemopoiesis
    • Zang, D. Y., Goodwin, R. G., Loken, M. R., Bryant, E. & Deeg, H. J. Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: effects on in vitro hemopoiesis. Blood 98, 3058-3065 (2001).
    • (2001) Blood , vol.98 , pp. 3058-3065
    • Zang, D.Y.1    Goodwin, R.G.2    Loken, M.R.3    Bryant, E.4    Deeg, H.J.5
  • 70
    • 0032944365 scopus 로고    scopus 로고
    • Biologic characteristics of 164 patients with myelodysplastic syndromes
    • Reza, S. et al. Biologic characteristics of 164 patients with myelodysplastic syndromes. Leuk. Lymphoma 33, 281-287 (1999).
    • (1999) Leuk. Lymphoma , vol.33 , pp. 281-287
    • Reza, S.1
  • 71
    • 0035863757 scopus 로고    scopus 로고
    • Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis
    • Schmidt, M. et al. Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis. J. Immunol. 166, 1344-1351 (2001).
    • (2001) J. Immunol , vol.166 , pp. 1344-1351
    • Schmidt, M.1
  • 72
    • 0037307728 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor inhibits spontaneous cytochrome c release and mitochondria-dependent apoptosis of myelodysplastic syndrome hematopoietic progenitors
    • Tehranchi, R. et al. Granulocyte colony-stimulating factor inhibits spontaneous cytochrome c release and mitochondria-dependent apoptosis of myelodysplastic syndrome hematopoietic progenitors. Blood 101, 1080-1086 (2003).
    • (2003) Blood , vol.101 , pp. 1080-1086
    • Tehranchi, R.1
  • 73
    • 17544385520 scopus 로고    scopus 로고
    • Biological significance of proliferation, apoptosis, cytokines, and monocyte/macrophage cells in bone marrow biopsies of 145 patients with myelodysplastic syndrome
    • Allampallam, K. et al. Biological significance of proliferation, apoptosis, cytokines, and monocyte/macrophage cells in bone marrow biopsies of 145 patients with myelodysplastic syndrome. Int. J. Hematol. 75, 289-297 (2002).
    • (2002) Int. J. Hematol , vol.75 , pp. 289-297
    • Allampallam, K.1
  • 74
    • 0034766727 scopus 로고    scopus 로고
    • Assessment of stromal function, and its potential contribution to deregulation of hematopoiesis in the myelodysplastic syndromes
    • Tauro, S., Hepburn, M. D., Bowen, D. T. & Pippard, M. J. Assessment of stromal function, and its potential contribution to deregulation of hematopoiesis in the myelodysplastic syndromes. Haematologica 86, 1038-1045 (2001).
    • (2001) Haematologica , vol.86 , pp. 1038-1045
    • Tauro, S.1    Hepburn, M.D.2    Bowen, D.T.3    Pippard, M.J.4
  • 75
    • 0036113574 scopus 로고    scopus 로고
    • Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes
    • Tauro, S., Hepburn, M. D., Peddie, C. M., Bowen, D. T. & Pippard, M. J. Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes. Leukemia 16, 785-790 (2002).
    • (2002) Leukemia , vol.16 , pp. 785-790
    • Tauro, S.1    Hepburn, M.D.2    Peddie, C.M.3    Bowen, D.T.4    Pippard, M.J.5
  • 76
    • 0034765667 scopus 로고    scopus 로고
    • Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia
    • Kook, H. et al. Increased cytotoxic T cells with effector phenotype in aplastic anemia and myelodysplasia. Exp. Hematol. 29, 1270-1277 (2001).
    • (2001) Exp. Hematol , vol.29 , pp. 1270-1277
    • Kook, H.1
  • 77
    • 22044434111 scopus 로고    scopus 로고
    • Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes
    • Tehranchi, R. et al. Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes. Blood 106, 247-253 (2005).
    • (2005) Blood , vol.106 , pp. 247-253
    • Tehranchi, R.1
  • 78
    • 0036682997 scopus 로고    scopus 로고
    • Myelodysplastic syndrome is not merely 'preleukemia'
    • Albitar, M. et al. Myelodysplastic syndrome is not merely 'preleukemia'. Blood 100, 791-798 (2002).
    • (2002) Blood , vol.100 , pp. 791-798
    • Albitar, M.1
  • 79
    • 0035100089 scopus 로고    scopus 로고
    • Apoptosis in refractory anaemia with ringed sideroblasts is initiated at the stem cell level and associated with increased activation of caspases
    • Hellstrom-Lindberg, E. et al. Apoptosis in refractory anaemia with ringed sideroblasts is initiated at the stem cell level and associated with increased activation of caspases. Br. J. Haematol. 112, 714-726 (2001).
    • (2001) Br. J. Haematol , vol.112 , pp. 714-726
    • Hellstrom-Lindberg, E.1
  • 80
    • 17744389188 scopus 로고    scopus 로고
    • Expression and activity of caspases 1 and 3 in myelodysplastic syndromes
    • Boudard, D. et al. Expression and activity of caspases 1 and 3 in myelodysplastic syndromes. Leukemia 14, 2045-2051 (2000).
    • (2000) Leukemia , vol.14 , pp. 2045-2051
    • Boudard, D.1
  • 81
    • 0034551738 scopus 로고    scopus 로고
    • The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS
    • Parker, J. E. et al. The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS. Blood 96, 3932-3938 (2000).
    • (2000) Blood , vol.96 , pp. 3932-3938
    • Parker, J.E.1
  • 82
    • 0036848440 scopus 로고    scopus 로고
    • Increased caspase-3 activity in refractory anemias: Lack of evidence for Fas pathway implication
    • Boudard, D. et al. Increased caspase-3 activity in refractory anemias: lack of evidence for Fas pathway implication. Leukemia 16, 2343-2345 (2002).
    • (2002) Leukemia , vol.16 , pp. 2343-2345
    • Boudard, D.1
  • 83
    • 20844462217 scopus 로고    scopus 로고
    • Claessens, Y. E. et al. Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD. Blood 105, 4035-4042 (2005). This study shows that the blockade of CD95 results in the correction of MDS-associated anaemia.
    • Claessens, Y. E. et al. Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD. Blood 105, 4035-4042 (2005). This study shows that the blockade of CD95 results in the correction of MDS-associated anaemia.
  • 84
    • 0033781130 scopus 로고    scopus 로고
    • Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes
    • Shimazaki, K., Ohshima, K., Suzumiya, J., Kawasaki, C. & Kikuchi, M. Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes. Br. J. Haematol. 110, 584-590 (2000).
    • (2000) Br. J. Haematol , vol.110 , pp. 584-590
    • Shimazaki, K.1    Ohshima, K.2    Suzumiya, J.3    Kawasaki, C.4    Kikuchi, M.5
  • 85
    • 0034663046 scopus 로고    scopus 로고
    • Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: Apoptotic cells recovered from high-density fraction of bone marrow aspirates
    • Shetty, V. et al. Intramedullary apoptosis of hematopoietic cells in myelodysplastic syndrome patients can be massive: apoptotic cells recovered from high-density fraction of bone marrow aspirates. Blood 96, 1388-1392 (2000).
    • (2000) Blood , vol.96 , pp. 1388-1392
    • Shetty, V.1
  • 86
    • 0025091773 scopus 로고
    • Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
    • Williams, G. T., Smith, C. A., Spooncer, E., Dexter, T. M. & Taylor, D. R. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343, 76-79 (1990).
    • (1990) Nature , vol.343 , pp. 76-79
    • Williams, G.T.1    Smith, C.A.2    Spooncer, E.3    Dexter, T.M.4    Taylor, D.R.5
  • 87
    • 0037353935 scopus 로고    scopus 로고
    • A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony-stimulating factor: Significant effects on quality of life
    • Hellstrom-Lindberg, E. et al. A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony-stimulating factor: significant effects on quality of life. Br. J. Haematol. 120, 1037-1046 (2003).
    • (2003) Br. J. Haematol , vol.120 , pp. 1037-1046
    • Hellstrom-Lindberg, E.1
  • 88
    • 3142619150 scopus 로고    scopus 로고
    • Health, economic, and quality-of-life effects of erythropoietin and granulocyte colony-stimulating factor for the treatment of myelodysplastic syndromes: A randomized, controlled trial
    • Casadevall, N. et al. Health, economic, and quality-of-life effects of erythropoietin and granulocyte colony-stimulating factor for the treatment of myelodysplastic syndromes: a randomized, controlled trial. Blood 104, 321-327 (2004).
    • (2004) Blood , vol.104 , pp. 321-327
    • Casadevall, N.1
  • 89
    • 0032863499 scopus 로고    scopus 로고
    • Fontenay-Roupie, M. et al. Ineffective erythropoiesis in myelodysplastic syndromes: correlation with Fas expression but not with lack of erythropoietin receptor signal transduction. Br. J. Haematol. 106, 464-473 (1999). First paper to show the importance of CD95 in mediating the ineffective erythropoiesis of MDS.
    • Fontenay-Roupie, M. et al. Ineffective erythropoiesis in myelodysplastic syndromes: correlation with Fas expression but not with lack of erythropoietin receptor signal transduction. Br. J. Haematol. 106, 464-473 (1999). First paper to show the importance of CD95 in mediating the ineffective erythropoiesis of MDS.
  • 90
    • 18344401654 scopus 로고    scopus 로고
    • Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin
    • Hellstrom-Lindberg, E., Kanter-Lewensohn, L. & Ost, A. Morphological changes and apoptosis in bone marrow from patients with myelodysplastic syndromes treated with granulocyte-CSF and erythropoietin. Leuk. Res. 21, 415-425 (1997).
    • (1997) Leuk. Res , vol.21 , pp. 415-425
    • Hellstrom-Lindberg, E.1    Kanter-Lewensohn, L.2    Ost, A.3
  • 91
    • 0033529506 scopus 로고    scopus 로고
    • Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines
    • Silva, M. et al. Erythropoietin can induce the expression of bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines. J. Biol. Chem. 274, 22165-22169 (1999).
    • (1999) J. Biol. Chem , vol.274 , pp. 22165-22169
    • Silva, M.1
  • 92
    • 24344507215 scopus 로고    scopus 로고
    • Antiapoptotic role of growth factors in the myelodysplastic syndromes: Concordance between in vitro and in vivo observations
    • Tehranchi, R. et al. Antiapoptotic role of growth factors in the myelodysplastic syndromes: concordance between in vitro and in vivo observations. Clin. Cancer Res. 11, 6291-6299 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 6291-6299
    • Tehranchi, R.1
  • 93
    • 18044393194 scopus 로고    scopus 로고
    • Thalidomide treatment reduces apoptosis levels in bone marrow cells from patients with myelodysplastic syndromes
    • Invernizzi, R. et al. Thalidomide treatment reduces apoptosis levels in bone marrow cells from patients with myelodysplastic syndromes. Leuk. Res. 29, 641-647 (2005).
    • (2005) Leuk. Res , vol.29 , pp. 641-647
    • Invernizzi, R.1
  • 94
    • 10344264979 scopus 로고    scopus 로고
    • Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-α, IL-1β, and LPS-stimulated human PBMC in a partially IL-10-dependent manner
    • Payvandi, F. et al. Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-α, IL-1β, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cell. Immunol. 230, 81-88 (2004).
    • (2004) Cell. Immunol , vol.230 , pp. 81-88
    • Payvandi, F.1
  • 95
    • 0034254254 scopus 로고    scopus 로고
    • Anti-TNF therapies in rheumatoid arthritis, Crohn's disease, sepsis, and myelodysplastic syndromes
    • Raza, A. Anti-TNF therapies in rheumatoid arthritis, Crohn's disease, sepsis, and myelodysplastic syndromes. Microsc. Res. Tech. 50, 229-235 (2000).
    • (2000) Microsc. Res. Tech , vol.50 , pp. 229-235
    • Raza, A.1
  • 96
    • 4544273958 scopus 로고    scopus 로고
    • Remicade as TNF suppressor in patients with myelodysplastic syndromes
    • Raza, A. et al. Remicade as TNF suppressor in patients with myelodysplastic syndromes. Leuk. Lymphoma 45, 2099-2104 (2004).
    • (2004) Leuk. Lymphoma , vol.45 , pp. 2099-2104
    • Raza, A.1
  • 97
    • 13444256401 scopus 로고    scopus 로고
    • List, A. et al. Efficacy of lenalidomide in myelodysplastic syndromes. N. Engl. J. Med. 352, 549-557 (2005). This paper reports the definitive clinical trial that led to the FDA approval of lenalidomide for MDS.
    • List, A. et al. Efficacy of lenalidomide in myelodysplastic syndromes. N. Engl. J. Med. 352, 549-557 (2005). This paper reports the definitive clinical trial that led to the FDA approval of lenalidomide for MDS.
  • 98
    • 33749438404 scopus 로고    scopus 로고
    • Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
    • List, A. et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N. Engl. J. Med. 355, 1456-1465 (2006).
    • (2006) N. Engl. J. Med , vol.355 , pp. 1456-1465
    • List, A.1
  • 99
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: Past, present and future
    • Yoo, C. B. & Jones, P. A. Epigenetic therapy of cancer: past, present and future. Nature Rev. Drug Discov. 5, 37-50 (2006).
    • (2006) Nature Rev. Drug Discov , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 100
    • 5744248237 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors in myelodysplastic syndrome
    • Silverman, L. R. DNA methyltransferase inhibitors in myelodysplastic syndrome. Best Pract. Res. Clin. Haematol. 17, 585-594 (2004).
    • (2004) Best Pract. Res. Clin. Haematol , vol.17 , pp. 585-594
    • Silverman, L.R.1
  • 102
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
    • Silverman, L. R. et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J. Clin. Oncol. 20, 2429-2440 (2002).
    • (2002) J. Clin. Oncol , vol.20 , pp. 2429-2440
    • Silverman, L.R.1
  • 103
    • 85186723749 scopus 로고    scopus 로고
    • Kantarjian, H. et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 106, 1794-803 (2006). References 102 and 103 comprise the definitive clinical trials that led to the FDA approval of two hypomethylating agents for MDS.
    • Kantarjian, H. et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 106, 1794-803 (2006). References 102 and 103 comprise the definitive clinical trials that led to the FDA approval of two hypomethylating agents for MDS.
  • 104
    • 21044439177 scopus 로고    scopus 로고
    • Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes
    • Kaminskas, E. et al. Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes. Clin. Cancer Res. 11, 3604-3608 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 3604-3608
    • Kaminskas, E.1
  • 105
    • 33846011361 scopus 로고    scopus 로고
    • Results of a randomized study of three schedules of low-dose decitabine in higher risk myelodysplastic syndrome and chronic myelomonocytic leukemia
    • Kantarjian, H. et al. Results of a randomized study of three schedules of low-dose decitabine in higher risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 109, 52-57 (2007).
    • (2007) Blood , vol.109 , pp. 52-57
    • Kantarjian, H.1
  • 106
    • 29744454120 scopus 로고    scopus 로고
    • The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia
    • Kuendgen, A. et al. The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia. Cancer 106, 112-119 (2006).
    • (2006) Cancer , vol.106 , pp. 112-119
    • Kuendgen, A.1
  • 107
    • 33750530675 scopus 로고    scopus 로고
    • Phase I/II study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero, G. et al. Phase I/II study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia. Blood 108, 3271-3279 (2006).
    • (2006) Blood , vol.108 , pp. 3271-3279
    • Garcia-Manero, G.1
  • 108
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore, S. D. et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res. 66, 6361-6369 (2006).
    • (2006) Cancer Res , vol.66 , pp. 6361-6369
    • Gore, S.D.1
  • 109
    • 0036893544 scopus 로고    scopus 로고
    • Clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure syndrome
    • Wang, H., Chuhjo, T., Yasue, S., Omine, M. & Nakao, S. Clinical significance of a minor population of paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure syndrome. Blood 100, 3897-3902 (2002).
    • (2002) Blood , vol.100 , pp. 3897-3902
    • Wang, H.1    Chuhjo, T.2    Yasue, S.3    Omine, M.4    Nakao, S.5
  • 110
    • 10244227886 scopus 로고    scopus 로고
    • Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities
    • Chen, G. et al. Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities. Blood 104, 4210-4218 (2004).
    • (2004) Blood , vol.104 , pp. 4210-4218
    • Chen, G.1
  • 111
    • 0033967640 scopus 로고    scopus 로고
    • A hypothesis for the pathogenesis of myelodysplastic syndromes: Implications for new therapies
    • Rosenfeld, C. & List, A. A hypothesis for the pathogenesis of myelodysplastic syndromes: implications for new therapies. Leukemia 14, 2-8 (2000).
    • (2000) Leukemia , vol.14 , pp. 2-8
    • Rosenfeld, C.1    List, A.2
  • 112
    • 0032408713 scopus 로고    scopus 로고
    • Apoptosis and its role in the myelodysplastic syndromes: Implications for disease natural history and treatment
    • Greenberg, P. L. Apoptosis and its role in the myelodysplastic syndromes: implications for disease natural history and treatment. Leuk. Res. 22, 1123-1136 (1998).
    • (1998) Leuk. Res , vol.22 , pp. 1123-1136
    • Greenberg, P.L.1
  • 114
    • 3543010174 scopus 로고    scopus 로고
    • The hematopoietic stem cell in myelodysplasia
    • Liesveld, J. L., Jordan, C. T. & Phillips, G. L., II. The hematopoietic stem cell in myelodysplasia. Stem Cells 22, 590-599 (2004).
    • (2004) Stem Cells , vol.22 , pp. 590-599
    • Liesveld, J.L.1    Jordan, C.T.2    Phillips II, G.L.3


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