Chromosomal aberrations in bone marrow mesenchymal stroma cells from patients with myelodysplastic syndrome and acute myeloblastic leukemia

Experimental Hematology

Volumn 35, Issue 2, 2007, Pages 221-229

  Blau, Olga ^a   Hofmann, Wolf Karsten ^a   Baldus, Claudia Dorothea ^a   Thiel, Gundula ^b   Serbent, Verena ^a   Schümann, Elke ^b   Thiel, Eckhard ^a   Blau, Igor Wolfgang ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Out Patients' Clinic   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; CELL ISOLATION; CELL SELECTION; CHROMOSOME ABERRATION; CHROMOSOME MARKER; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; FEMALE; GENETIC SUSCEPTIBILITY; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; KARYOTYPING; MALE; MOLECULAR GENETICS; MONONUCLEAR CELL; MYELODYSPLASTIC SYNDROME; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BONE MARROW CELLS; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 5; CHROMOSOMES, HUMAN, PAIR 7; CYTOGENETIC ANALYSIS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; MALE; MESENCHYMAL STEM CELLS; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PHENOTYPE; PROSPECTIVE STUDIES; STROMAL CELLS;

EID: 33846386176     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2006.10.012     Document Type: Article

References (36)

1. Brunning R., Bennett J., Flandrin G., et al. Myelodysplastic syndromes. In: Jaffe E., Harris N., Stein H., and Vardiman J.W. (Eds). World Health Organization classification of tumor: pathology and genetics of haematopoietic and lymphoid tissues (2001), IARC Press, Lyon, France 61-73
2. + cells from normal and myelodysplastic bone marrow. Blood 100 (2002) 3553-3560
3. Burmeister T., and Thiel E. Molecular genetics in acute and chronic leukemias. J Cancer Res Clin Oncol 127 (2001) 80-90
4. Look A.T. Molecular pathogenesis of MDS. Hematology (2005) 156-160
5. Schoch C., Schnittger S., Kern W., Dugas M., Hiddemann W., and Haferlach T. Acute myeloid leukemia with recurring chromosome abnormalities as defined by the WHO-classification: incidence of subgroups, additional genetic abnormalities, FAB subtypes and age distribution in an unselected series of 1,897 patients with acute myeloid leukemia. Haematologica 88 (2003) 351-352
6. Schoch C., Haferlach T., Haase D., et al. Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients. Br J Haematol 112 (2001) 118-126
7. Schoch C., Kern W., Schnittger S., Hiddemann W., and Haferlach T. Karyotype is an independent prognostic parameter in therapy-related acute myeloid leukemia (t-AML): an analysis of 93 patients with t-AML in comparison to 1091 patients with de novo AML. Leukemia 18 (2004) 120-125
8. Heim S., and Mittelmann F. Cancer Cytogenetics. 2nd ed. (1995), Wiley-Liss, New York
9. Solé F., Espinet B., Sanz G.F., et al. Incidence, characterization and prognostic significance of chromosomal abnormalities in 640 patients with primary myelodysplastic syndromes. Br J Haematol 108 (2000) 346-357
10. Yilmaz Z., Sahin F.I., Kizilkilic E., Karakus S., Boga C., and Ozdogu H. Conventional and molecular cytogenetic findings of myelodysplastic syndrome patients. Clin Exp Med 5 (2005) 55-59
11. Giagounidis A.A., Germing U., Haase S., et al. Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31. Leukemia 18 (2004) 113-119
12. Bene M.C., Bernier M., Casasnovas R.O., et al. Acute myeloid leukaemia MO: haematological, immunophenotypic and cytogenetic characteristics and their prognostic significance: an analysis in 241 patients. Br J Haematol 113 (2001) 737-745
13. Giles F., Keating A., Goldstone A., Avivi I., Willman C., and Kantarjian H. Acute myeloid leukemia. Hematology (2002) 73-110
14. Krug U., Ganser A., and Koeffler H.P. Tumor suppressor genes in normal and malignant hematopoiesis. Oncogene 21 (2002) 3475-3495
15. Bhatia R., McGlave P.B., Dewald G.W., Blazar B.R., and Verfaillie C.M. Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages. Blood 85 (1995) 3636-3645
16. Deeg H.J. Marrow stroma in MDS: culprit or bystander?. Leuk Res 26 (2002) 687-688
17. Mayani H. Composition and function of the hematopoietic microenvironment in human myeloid leukemia. Leukemia 10 (1996) 1041-1047
18. Pittenger M.F., Mackay A.M., Beck S.C., et al. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
19. Deeg H.J., Beckham C., Loken M.R., et al. Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndromes. Leuk Lymphoma 37 (2000) 405-414
20. Charbord P. Microenvironmental cell populations essential for the support of hematopoietic stem cells. In: Zon L.I. (Ed). Hematopoiesis: A Developmental Approach (2001), Oxford University Press, New York, NY 691-701
21. Huss R., and Moosman S. The co-expression of CD117 and osteocalcin in activated bone marrow stem cells in different diseases. Br J Haematol 118 (2002) 305-312
22. Tauro S., Hepburn M.D., Bowen D.T., et al. Assessment of stromal function, and its potential contribution to deregulation of hematopoiesis in the myelodysplastic syndromes. Haematologica 86 (2001) 1038-1045
23. Flores-Figueroa E., Gutiérrez-Espíndola G., Montesinos J.J., et al. In vitro characterization of hematopoietic microenvironment cells from patients with myelodysplastic syndrome. Leuk Res 26 (2002) 677-686
24. Borojevic R., Roela R., Rodarte R., et al. Bone marrow stroma in childhood myelodysplastic syndrome: composition, ability to sustain hematopoiesis in vitro, and altered gene expression. Leuk Res 28 (2004) 831-844
25. Narendran A., Hawkins L., Ganjavi H., et al. Characterization of bone marrow stromal abnormalities in a patient with constitutional trisomy 8 mosaicism and myelodysplastic syndrome. Pediatr Hematol Oncol 21 (2004) 209-221
26. Awaya N., Rupter K., Bryant E., et al. Marrow stromal cells are not derived from the malignant clone in myelodysplastic syndromes (MDS). Blood 98 Suppl 1 (2001) 1487a
27. Soenen V., Korb R., Bonnet M.L., et al. Mesenchymal cells (MC) from patients with myelodysplastic syndromes (MDS) are devoid of cytogenetic abnormalities and support short- and long-term hematopoiesis in vitro. Blood 98 Suppl 1 (2001) 3041a
28. Flores-Figueroa E., Arana-Trejo R.M., Gutiérrez-Espíndola G., Pérez-Cabrera A., and Mayani H. Mesenchymal stem cells in myelodysplastic syndromes: phenotypic and cytogenetic characterization. Leuk Res 29 (2005) 215-224
29. Zhan W., Knieling G., Vohwinkel G., et al. Origin of stroma cells in long-term bone marrow cultures from patients with acute myeloid leukemia. Ann Hematol 78 (1999) 305-324
30. Bennett J.M., Catovsky D., Daniel M.T., et al. Proposals for the classification of the myelodysplastic syndromes. French-American-British (FAB) co-operative group. Br J Haematol 51 (1982) 188-189
31. Bennett J.M., Catovsky D., Daniel M.T., et al. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol 33 (1976) 451-458
32. Bennett J.M. World Health Organization (WHO) classification of the myelodysplastic syndromes. In: List A.F. (Ed). The Myelodysplastic Syndromes: Controversies in Classification and Optimal Look at Treatment Options (2003), The Myelodysplastic Syndromes Foundation, Crosswicks, NJ 11-16
33. Rieger K., Marinets O., Fietz T., et al. Mesenchymal stem cells remain of host origin even a long time after allogeneic peripheral blood stem cell or bone marrow transplantation. Exp Hematol 33 (2005) 605-611
34. Shaffer L.G., and Tommerup N. ISCN (2005): International System for Human Cytogenetic Nomenclature (2005), Karger, Basel
35. Kramer A., Neben K., and Ho A.D. Centrosome replication, genomic instability and cancer. Leukemia 16 (2001) 767-775
36. Reyes M., Lund T., Aguiar D., et al. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood 98 (2001) 2615-2625