3,4-Methylenedioxy-β'-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome

Journal of Biological Chemistry

Volumn 289, Issue 2, 2014, Pages 1142-1150

  He, Yuan ^a   Varadarajan, Saranyaraajan ^a   Muñoz Planillo, Raúl ^a   Burberry, Aaron ^a   Nakamura, Yuumi ^a   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-ASE ACTIVITY; CRITICAL COMPONENT; INFLAMMASOME; INFLAMMATORY DISEASE; INNATE IMMUNE SYSTEMS; NITROSTYRENE;

BIOCHEMISTRY;

BIOLOGY;

3,4 METHYLENEDIOXY BETA NITROSTYRENE; ABSENT IN MELANOMA 2; CHEMOKINE; CRYOPYRIN; INFLAMMASOME; PROTEIN INHIBITOR; PROTEIN KINASE SYK; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MOUSE; MUTATION; NONHUMAN; OLIGOMERIZATION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN ACTIVATION; PROTEIN MODIFICATION; PROTEIN SYNTHESIS INHIBITION;

CASPASE; INFLAMMATION; INNATE IMMUNITY; MACROPHAGES; NOD-LIKE RECEPTOR (NLR);

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELLS, CULTURED; DIOXOLANES; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; PROTEIN-TYROSINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84891917420     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.515080     Document Type: Article

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