Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Dimicoli, Sophie ^a,c   Wei, Yue ^a   Bueso Ramos, Carlos ^a   Yang, Hui ^a   DiNardo, Courtney ^a   Jia, Yu ^a   Zheng, Hong ^a   Fang, Zhihong ^a   Nguyen, Martin ^a   Pierce, Sherry ^a   Chen, Rui ^b   Wang, Hui ^b   Wu, Chenghua ^b   Garcia Manero, Guillermo ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c HAUT LÉVÊQUE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; INTERLEUKIN 8; MYELOID DIFFERENTIATION FACTOR 88; RNA; TOLL LIKE RECEPTOR;

ADULT; AGE; AGED; ARTICLE; BONE MARROW CELL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ERYTHROID CELL; FEMALE; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; MALE; MYD88 GENE; MYELODYSPLASTIC SYNDROME; PATHOPHYSIOLOGY; PROGNOSIS; SURVIVAL;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIBODIES; ANTIGENS, CD34; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; MUTATION; MYELODYSPLASTIC SYNDROMES; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDES; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TOLL-LIKE RECEPTORS;

EID: 84881600082     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071120     Document Type: Article

References (37)

1. Tefferi A, Vardiman JW, (2009) Myelodysplastic syndromes. N Engl J Med 361: 1872-1885.
2. Bejar R, Stevenson KE, Caughey BA, Abdel-Wahab O, Steensma DP, et al. (2012) Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. J Clin Oncol 30: 3376-3382.
3. Akira S, Uematsu S, Takeuchi O, (2006) Pathogen recognition and innate immunity. Cell 124: 783-801.
4. Kawai T, Akira S, (2006) TLR signaling. Cell Death Differ 13: 816-825.
5. Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, et al. (2006) Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 24: 801-812.
6. Esplin BL, Shimazu T, Welner RS, Garrett KP, Nie L, et al. (2011) Chronic exposure to a TLR ligand injures hematopoietic stem cells. J Immunol 186: 5367-5375.
7. Starczynowski DT, Karsan A, (2010) Innate immune signaling in the myelodysplastic syndromes. Hematol Oncol Clin North Am 24: 343-359.
8. Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, et al. (2010) Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med 16: 49-58.
9. Janssens S, Beyaert R, (2002) A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem Sci 27: 474-482.
10. Puente XS, Pinyol M, Quesada V, Conde L, Ordonez GR, et al. (2011) Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475: 101-105.
11. Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, et al. (2011) Oncogenically active MYD88 mutations in human lymphoma. Nature 470: 115-119.
12. Treon SP, Xu L, Yang G, Zhou Y, Liu X, et al. (2012) MYD88 L265P somatic mutation in Waldenstrom's macroglobulinemia. N Engl J Med 367: 826-833.
13. O'Connell CM, Ionova IA, Quayle AJ, Visintin A, Ingalls RR, (2006) Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen. J Biol Chem 281: 1652-1659.
14. Loiarro M, Sette C, Gallo G, Ciacci A, Fanto N, et al. (2005) Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B. J Biol Chem 280: 15809-15814.
15. Toshchakov VU, Basu S, Fenton MJ, Vogel SN, (2005) Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction. J Immunol 175: 494-500.
16. Ahmed N, Laverick L, Sammons J, Baumforth KR, Hassan HT, (1999) Effect of all-trans retinoic acid on chemotherapy induced apoptosis and down-regulation of Bcl-2 in human myeloid leukaemia CD34 positive cells. Leuk Res 23: 741-749.
17. Koeffler HP, Golde DW, (1978) Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity. Science 200: 1153-1154.
18. Langlet C, Springael C, Johnson J, Thomas S, Flamand V, et al. (2010) PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells. Eur J Immunol 40: 505-515.
19. Kawai T, Takeuchi O, Fujita T, Inoue J, Muhlradt PF, et al. (2001) Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 167: 5887-5894.
20. Filippone C, Franssila R, Kumar A, Saikko L, Kovanen PE, et al. (2010) Erythroid progenitor cells expanded from peripheral blood without mobilization or preselection: molecular characteristics and functional competence. PLoS One 5: e9496.
21. Sato T, Maekawa T, Watanabe S, Tsuji K, Nakahata T, (2000) Erythroid progenitors differentiate and mature in response to endogenous erythropoietin. J Clin Invest 106: 263-270.
22. Weiss MJ, Orkin SH, (1995) Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis. Proc Natl Acad Sci U S A 92: 9623-9627.
23. Galloway JL, Wingert RA, Thisse C, Thisse B, Zon LI, (2005) Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell 8: 109-116.
24. Grass JA, Boyer ME, Pal S, Wu J, Weiss MJ, et al. (2003) GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A 100: 8811-8816.
25. Wang Q, Dziarski R, Kirschning CJ, Muzio M, Gupta D, (2001) Micrococci and peptidoglycan activate TLR2->MyD88->IRAK->TRAF->NIK->IKK->NF-kappaB signal transduction pathway that induces transcription of interleukin-8. Infect Immun 69: 2270-2276.
26. Wei Y, Dimicoli S, Bueso-Ramos C, Chen R, Yang H, et al. (2013) Toll-like receptor alterations in myelodysplastic syndrome. Leukemia.
27. Tye H, Kennedy CL, Najdovska M, McLeod L, McCormack W, et al. (2012) STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation. Cancer Cell 22: 466-478.
28. Fang J, Rhyasen G, Bolanos L, Rasch C, Varney M, et al. (2012) Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood 120: 858-867.
29. Grosjean-Raillard J, Tailler M, Ades L, Perfettini JL, Fabre C, et al. (2009) ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene 28: 1099-1109.
30. da Costa SV, Roela RA, Junqueira MS, Arantes C, Brentani MM, (2010) The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes. Leuk Res 34: 507-512.
31. Wei Y, Chen R, Dimicoli S, Bueso-Ramos C, Neuberg D, et al. (2013) Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells. Leukemia.
32. De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, et al. (2007) The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 130: 1083-1094.
33. Szajnik M, Szczepanski MJ, Czystowska M, Elishaev E, Mandapathil M, et al. (2009) TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer. Oncogene 28: 4353-4363.
34. Swann JB, Vesely MD, Silva A, Sharkey J, Akira S, et al. (2008) Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A 105: 652-656.
35. Je EM, Yoo NJ, Lee SH, (2012) Absence of MYD88 gene mutation in acute leukemias and multiple myelomas. Eur J Haematol 88: 273-274.
36. Maratheftis CI, Andreakos E, Moutsopoulos HM, Voulgarelis M, (2007) Toll-like receptor-4 is up-regulated in hematopoietic progenitor cells and contributes to increased apoptosis in myelodysplastic syndromes. Clin Cancer Res 13: 1154-1160.
37. Kumar MS, Narla A, Nonami A, Mullally A, Dimitrova N, et al. (2011) Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome. Blood 118: 4666-4673.