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Engevik, M.A., Engevik, K.A., Yacyshyn, M.B., Wang, J., Hassett, D.J., Darien, B., Yacyshyn, B.R., Worrell, R.T., Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile. Am J Physiol Gastrointest Liver Physiol 308 (2015), G497–G509 Studied a potential mechanism of bacterial colonization in organoids by inhibition of NHE3 and modulating microbiota dynamics.
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3:1–6 The first ever in vitro system for the culture of Norovirus in human organoid cultures was developed.
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Ettayebi, K., Crawford, S.E., Murakami, K., Broughman, J.R., Karandikar, U., Tenge, V.R., Neill, F.H., Blutt, S.E., Zeng, X.-L., Qu, L., et al. Replication of human noroviruses in stem cell-derived human enteroids. Science (80) 353 (2016), 1387–1393 3:1–6 The first ever in vitro system for the culture of Norovirus in human organoid cultures was developed.
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39
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Modeling rotavirus infection and antiviral therapy using primary intestinal organoids
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Demonstrated that human organoids support infection of patient-derived rotavirus strains and allow for individualized evaluation of the efficacy of antiviral medications.
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Yin, Y., Bijvelds, M., Dang, W., Xu, L., Van Der Eijk, A.A., Knipping, K., Tuysuz, N., Dekkers, J.F., Wang, Y., De Jonge, J., et al. Modeling rotavirus infection and antiviral therapy using primary intestinal organoids. Antiviral Res 123 (2015), 120–131 Demonstrated that human organoids support infection of patient-derived rotavirus strains and allow for individualized evaluation of the efficacy of antiviral medications.
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Amieva, M., Peek, R.M., Pathobiology of Helicobacter pylori-induced gastric cancer. Gastroenterology 150 (2016), 64–78.
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126–136.e6 Studied the pathogenesis of H. pylori in human gastric organoids. First study to establish the microinjection protocol for adult stem cell derived cultures.
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Bartfeld, S., Bayram, T., Van De Wetering, M., Huch, M., Begthel, H., Kujala, P., Vries, R., Peters, P.J., Clevers, H., In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology, 148, 2015 126–136.e6 Studied the pathogenesis of H. pylori in human gastric organoids. First study to establish the microinjection protocol for adult stem cell derived cultures.
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Bartfeld, S.1
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44
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Using pluripotent stem cells, gastric organoids were developed which modeled H. pylori infection like the in-vivo situation.
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McCracken, K.W., Catá, E.M., Crawford, C.M., Sinagoga, K.L., Schumacher, M., Rockich, B.E., Tsai, Y.-H., Mayhew, C.N., Spence, J.R., Zavros, Y., et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516 (2014), 400–404 Using pluripotent stem cells, gastric organoids were developed which modeled H. pylori infection like the in-vivo situation.
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McCracken, K.W.1
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45
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Reported that Urea secreted by epithelial cells attract H. pylori to the epithelial cells, allowing for co-localization which eventually leads to inflammation and gastric cancer.
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Huang, J.Y., Sweeney, E.G., Sigal, M., Zhang, H.C., Remington, S.J., Cantrell, M.A., Kuo, C.J., Guillemin, K., Amieva, M.R., Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium. Cell Host Microbe 18 (2015), 147–156 Reported that Urea secreted by epithelial cells attract H. pylori to the epithelial cells, allowing for co-localization which eventually leads to inflammation and gastric cancer.
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First ever brain organoids were developed from pluripotent stem cells. These organoids model the fetal brain and can be used for developmental studies and for disease modeling for microcephaly, autism etc.
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Lancaster, M.A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L.S., Hurles, M.E., Homfray, T., Penninger, J.M., Jackson, A.P., Knoblich, J.A., et al. Cerebral organoids model human brain development and microcephaly. Nature 501 (2012), 373–379 First ever brain organoids were developed from pluripotent stem cells. These organoids model the fetal brain and can be used for developmental studies and for disease modeling for microcephaly, autism etc.
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Lancaster, M.A.1
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48
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Show that ZIKV abrogates neurogenesis by targeting human brain cells, reducing their viability and growth as neurospheres and brain organoids.
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Garcez, P.P., Loiola, E.C., Madeiro da Costa, R., Higa, L.M., Trindade, P., Delvecchio, R., Nascimento, J.M., Brindeiro, R., Tanuri, A., Rehen, S.K., Zika virus impairs growth in human neurospheres and brain organoids. Science (80) 352 (2016), 816–818 Show that ZIKV abrogates neurogenesis by targeting human brain cells, reducing their viability and growth as neurospheres and brain organoids.
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Garcez, P.P.1
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49
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Reported the mechanism of halting of neurogenesis leading to decreased number of neurons and thus microcephaly.
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Cugola, F.R., Fernandes, I.R., Russo, F.B., Freitas, B.C., Dias, J.L.M., Guimarães, K.P., Benazzato, C., Almeida, N., Pignatari, G.C., Romero, S., et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature, 2016, 10.1038/nature18296 Reported the mechanism of halting of neurogenesis leading to decreased number of neurons and thus microcephaly.
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Nature
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Cugola, F.R.1
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Russo, F.B.3
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50
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Wells, M.F., Salick, M.R., Wiskow, O., Ho, D.J., Worringer, K.A., Ihry, R.J., Kommineni, S., Bilican, B., Klim, J.R., Hill, E.J., et al. Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection. Cell Stem Cell 19 (2016), 703–708.
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Wells, M.F.1
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Wiskow, O.3
Ho, D.J.4
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51
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Reported a link between the activation of the immune component TLR3 and its association with Zika virus infection leading to microcephaly.
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Dang, J., Tiwari, S.K., Lichinchi, G., Qin, Y., Patil, V.S., Eroshkin, A.M., Rana, T.M., Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3. Cell Stem Cell 19 (2016), 258–265 Reported a link between the activation of the immune component TLR3 and its association with Zika virus infection leading to microcephaly.
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Dang, J.1
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52
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397–406.e5 This article showed that newer strains of ZIKV have a different mode of infection as compared to an older strain. Newer strains induce premature differentiation and death as compared to other strains which abrogated neurogenesis.
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Gabriel, E., Ramani, A., Karow, U., Gottardo, M., Natarajan, K., Gooi, L.M., Goranci-Buzhala, G., Krut, O., Peters, F., Nikolic, M., et al. Recent Zika virus isolates induce premature differentiation of neural progenitors in human brain organoids. Cell Stem Cell, 20, 2017 397–406.e5 This article showed that newer strains of ZIKV have a different mode of infection as compared to an older strain. Newer strains induce premature differentiation and death as compared to other strains which abrogated neurogenesis.
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Cell Stem Cell
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Gabriel, E.1
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53
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Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
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In a one of its kind screen, the study used brain organoids to identify drugs/molecules which could potentially be used to control the replication and spread of ZIKV.
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Xu, M., Lee, E.M., Wen, Z., Cheng, Y., Huang, W.-K., Qian, X., Kouznetsova, J., TCW, J., Ogden, S.C., Hammack, C., et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med 22 (2016), 1101–1107 In a one of its kind screen, the study used brain organoids to identify drugs/molecules which could potentially be used to control the replication and spread of ZIKV.
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Xu, M.1
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54
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Innovative mini-bioreactors were used to develop cerebral organoids which were cost effective and fully functional, mimicking the phenotypes observed in-vivo upon ZIKV infection.
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Qian, X., Nguyen, H.N., Song, M.M., Hadiono, C., Ogden, S.C., Hammack, C., Yao, B., Hamersky, G.R., Jacob, F., Zhong, C., et al. Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 165 (2016), 1238–1254 Innovative mini-bioreactors were used to develop cerebral organoids which were cost effective and fully functional, mimicking the phenotypes observed in-vivo upon ZIKV infection.
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Qian, X.1
Nguyen, H.N.2
Song, M.M.3
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Yao, B.7
Hamersky, G.R.8
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55
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This article showed that Salmonella enterica can promote transformation of genetically predisposed cells, potentially leading to GBC.
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Scanu, T., Spaapen, R.M., Bakker, J.M., Pratap, C.B., Wu, L.en, Hofland, I., Broeks, A., Shukla, V.K., Kumar, M., Janssen, H., et al. Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma. Cell Host Microbe 17 (2015), 763–774 This article showed that Salmonella enterica can promote transformation of genetically predisposed cells, potentially leading to GBC.
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Scanu, T.1
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A landmark study showing the influence of HIV on expansion of HCV virus infection.
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Graham, C.S., Baden, L.R., Yu, E., Mrus, J.M., Carnie, J., Heeren, T., Koziel, M.J., Influence of human immunodeficiency virus infection on the course of Hepatitis C virus infection: a meta-analysis. Clin Infect Dis 33 (2001), 562–569 A landmark study showing the influence of HIV on expansion of HCV virus infection.
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Graham, C.S.1
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Koziel, M.J.7
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