메뉴 건너뛰기




Volumn 23, Issue 5, 2017, Pages 393-410

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

Author keywords

cancer; CFTR; infectious disease; microbiota; organoid; personalized medicine; stem cells

Indexed keywords

ADULT STEM CELL; CANCER MODEL; CELL CULTURE TECHNIQUE; CYSTIC FIBROSIS; CYTOPLASM; DISEASE MODEL; EMBRYONIC STEM CELL; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; INFECTION; NONHUMAN; PERSONALIZED MEDICINE; PLURIPOTENT STEM CELL; REVIEW; STEM CELL; ANIMAL; CYTOLOGY; METABOLISM; NEOPLASM; ORGANOID; PHYSIOLOGY;

EID: 85015718933     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2017.02.007     Document Type: Review
Times cited : (583)

References (112)
  • 1
    • 84914441871 scopus 로고
    • Cystic organoid teratoma; report of a case
    • 1 Smith, E., Cochrane, W.J., Cystic organoid teratoma; report of a case. Can. Med. Assoc. J., 55, 1946, 151.
    • (1946) Can. Med. Assoc. J. , vol.55 , pp. 151
    • Smith, E.1    Cochrane, W.J.2
  • 2
    • 84868206007 scopus 로고    scopus 로고
    • Self-formation of layered neural structures in three-dimensional culture of ES cells
    • 2 Eiraku, M., Sasai, Y., Self-formation of layered neural structures in three-dimensional culture of ES cells. Curr. Opin. Neurobiol. 22 (2012), 768–777.
    • (2012) Curr. Opin. Neurobiol. , vol.22 , pp. 768-777
    • Eiraku, M.1    Sasai, Y.2
  • 3
    • 79953749322 scopus 로고    scopus 로고
    • Self-organizing optic-cup morphogenesis in three-dimensional culture
    • 3 Eiraku, M., et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 472 (2011), 51–56.
    • (2011) Nature , vol.472 , pp. 51-56
    • Eiraku, M.1
  • 4
    • 84884414984 scopus 로고    scopus 로고
    • Cerebral organoids model human brain development and microcephaly
    • 4 Lancaster, M.A., et al. Cerebral organoids model human brain development and microcephaly. Nature 501 (2013), 373–379.
    • (2013) Nature , vol.501 , pp. 373-379
    • Lancaster, M.A.1
  • 5
    • 84979790139 scopus 로고    scopus 로고
    • Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons
    • 5 Jo, J., et al. Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons. Cell Stem Cell 19 (2016), 248–257.
    • (2016) Cell Stem Cell , vol.19 , pp. 248-257
    • Jo, J.1
  • 6
    • 84925459906 scopus 로고    scopus 로고
    • In vitro generation of human pluripotent stem cell derived lung organoids
    • 6 Dye, B.R., et al. In vitro generation of human pluripotent stem cell derived lung organoids. eLife, 4, 2015, e05098.
    • (2015) eLife , vol.4 , pp. e05098
    • Dye, B.R.1
  • 7
    • 84945283561 scopus 로고    scopus 로고
    • Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
    • 7 Takasato, M., et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526 (2015), 564–568.
    • (2015) Nature , vol.526 , pp. 564-568
    • Takasato, M.1
  • 8
    • 84881184980 scopus 로고    scopus 로고
    • Vascularized and functional human liver from an iPSC-derived organ bud transplant
    • 8 Takebe, T., et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499 (2013), 481–484.
    • (2013) Nature , vol.499 , pp. 481-484
    • Takebe, T.1
  • 9
    • 84877624830 scopus 로고    scopus 로고
    • Regeneration and experimental orthotopic transplantation of a bioengineered kidney
    • 9 Song, J.J., et al. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat. Med. 19 (2013), 646–651.
    • (2013) Nat. Med. , vol.19 , pp. 646-651
    • Song, J.J.1
  • 10
    • 84906865436 scopus 로고    scopus 로고
    • An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts
    • 10 Bredenkamp, N., et al. An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts. Nat. Cell Biol. 16 (2014), 902–908.
    • (2014) Nat. Cell Biol. , vol.16 , pp. 902-908
    • Bredenkamp, N.1
  • 11
    • 84962050518 scopus 로고    scopus 로고
    • Retinal organoids from pluripotent stem cells efficiently recapitulate retinogenesis
    • 11 Volkner, M., et al. Retinal organoids from pluripotent stem cells efficiently recapitulate retinogenesis. Stem Cell Rep. 6 (2016), 525–538.
    • (2016) Stem Cell Rep. , vol.6 , pp. 525-538
    • Volkner, M.1
  • 12
    • 84900327361 scopus 로고    scopus 로고
    • Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice
    • 12 Assawachananont, J., et al. Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Rep. 2 (2014), 662–674.
    • (2014) Stem Cell Rep. , vol.2 , pp. 662-674
    • Assawachananont, J.1
  • 13
    • 84948127936 scopus 로고    scopus 로고
    • Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid
    • 13 Aihara, E., et al. Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid. Sci. Rep., 5, 2015, 17185.
    • (2015) Sci. Rep. , vol.5 , pp. 17185
    • Aihara, E.1
  • 14
    • 84950316779 scopus 로고    scopus 로고
    • Generating inner ear organoids from mouse embryonic stem cells
    • 14 Longworth-Mills, E., et al. Generating inner ear organoids from mouse embryonic stem cells. Methods Mol. Biol. 1341 (2016), 391–406.
    • (2016) Methods Mol. Biol. , vol.1341 , pp. 391-406
    • Longworth-Mills, E.1
  • 15
    • 79551686425 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • 15 Spence, J.R., et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470 (2011), 105–109.
    • (2011) Nature , vol.470 , pp. 105-109
    • Spence, J.R.1
  • 16
    • 84892149549 scopus 로고    scopus 로고
    • Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
    • 16 Huang, S.X., et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat. Biotechnol. 32 (2014), 84–91.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 84-91
    • Huang, S.X.1
  • 17
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • 17 Evans, M.J., Kaufman, M.H., Establishment in culture of pluripotential cells from mouse embryos. Nature 292 (1981), 154–156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 18
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • 18 Thomson, J.A., et al. Embryonic stem cell lines derived from human blastocysts. Science 282 (1998), 1145–1147.
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1
  • 19
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • 19 Barker, N., et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449 (2007), 1003–1007.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1
  • 20
    • 47549099591 scopus 로고    scopus 로고
    • The intestinal stem cell
    • 20 Barker, N., et al. The intestinal stem cell. Genes & Dev. 22 (2008), 1856–1864.
    • (2008) Genes & Dev. , vol.22 , pp. 1856-1864
    • Barker, N.1
  • 21
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche
    • 21 Sato, T., et al. Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche. Nature 459 (2009), 262–265.
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 22
    • 80054857419 scopus 로고    scopus 로고
    • Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
    • 22 Sato, T., et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology 141 (2011), 1762–1772.
    • (2011) Gastroenterology , vol.141 , pp. 1762-1772
    • Sato, T.1
  • 23
    • 73049116186 scopus 로고    scopus 로고
    • +ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
    • +ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 6 (2010), 25–36.
    • (2010) Cell Stem Cell , vol.6 , pp. 25-36
    • Barker, N.1
  • 24
    • 84873712443 scopus 로고    scopus 로고
    • + liver stem cells induced by Wnt-driven regeneration
    • + liver stem cells induced by Wnt-driven regeneration. Nature 494 (2013), 247–250.
    • (2013) Nature , vol.494 , pp. 247-250
    • Huch, M.1
  • 25
    • 84885846800 scopus 로고    scopus 로고
    • Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
    • 25 Huch, M., et al. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. The EMBO J. 32 (2013), 2708–2721.
    • (2013) The EMBO J. , vol.32 , pp. 2708-2721
    • Huch, M.1
  • 26
    • 84920989984 scopus 로고    scopus 로고
    • Long-term culture of genome-stable bipotent stem cells from adult human liver
    • 26 Huch, M., et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 160 (2015), 299–312.
    • (2015) Cell , vol.160 , pp. 299-312
    • Huch, M.1
  • 27
    • 84920983131 scopus 로고    scopus 로고
    • Organoid models of human and mouse ductal pancreatic cancer
    • 27 Boj, S.F., et al. Organoid models of human and mouse ductal pancreatic cancer. Cell 160 (2015), 324–338.
    • (2015) Cell , vol.160 , pp. 324-338
    • Boj, S.F.1
  • 28
    • 84907552531 scopus 로고    scopus 로고
    • Identification of multipotent luminal progenitor cells in human prostate organoid cultures
    • 28 Karthaus, W.R., et al. Identification of multipotent luminal progenitor cells in human prostate organoid cultures. Cell 159 (2014), 163–175.
    • (2014) Cell , vol.159 , pp. 163-175
    • Karthaus, W.R.1
  • 29
    • 84922875352 scopus 로고    scopus 로고
    • In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection
    • 29 Bartfeld, S., et al. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148 (2015), 126–136.
    • (2015) Gastroenterology , vol.148 , pp. 126-136
    • Bartfeld, S.1
  • 30
    • 84949504069 scopus 로고    scopus 로고
    • The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
    • 30 Kessler, M., et al. The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Nat. Commun., 6, 2015, 8989.
    • (2015) Nat. Commun. , vol.6 , pp. 8989
    • Kessler, M.1
  • 31
    • 84961332993 scopus 로고    scopus 로고
    • Organoid culture systems for prostate epithelial and cancer tissue
    • 31 Drost, J., et al. Organoid culture systems for prostate epithelial and cancer tissue. Nat. Protoc. 11 (2016), 347–358.
    • (2016) Nat. Protoc. , vol.11 , pp. 347-358
    • Drost, J.1
  • 32
    • 84917734391 scopus 로고    scopus 로고
    • Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo
    • 32 Ren, W., et al. Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo. Proc. Natl. Acad. Sci. U.S.A. 111 (2014), 16401–16406.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 16401-16406
    • Ren, W.1
  • 33
    • 84889563027 scopus 로고    scopus 로고
    • Establishment of a novel lingual organoid culture system: generation of organoids having mature keratinized epithelium from adult epithelial stem cells
    • 33 Hisha, H., et al. Establishment of a novel lingual organoid culture system: generation of organoids having mature keratinized epithelium from adult epithelial stem cells. Sci. Rep., 3, 2013, 3224.
    • (2013) Sci. Rep. , vol.3 , pp. 3224
    • Hisha, H.1
  • 34
    • 69149106207 scopus 로고    scopus 로고
    • Basal cells as stem cells of the mouse trachea and human airway epithelium
    • 34 Rock, J.R., et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc. Natl. Acad. Sci. U.S.A. 106 (2009), 12771–12775.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 12771-12775
    • Rock, J.R.1
  • 35
    • 79952126043 scopus 로고    scopus 로고
    • Copy number variation and selection during reprogramming to pluripotency
    • 35 Hussein, S.M., et al. Copy number variation and selection during reprogramming to pluripotency. Nature 471 (2011), 58–62.
    • (2011) Nature , vol.471 , pp. 58-62
    • Hussein, S.M.1
  • 36
    • 78650971216 scopus 로고    scopus 로고
    • Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    • 36 Laurent, L.C., et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 8 (2011), 106–118.
    • (2011) Cell Stem Cell , vol.8 , pp. 106-118
    • Laurent, L.C.1
  • 37
    • 84862777784 scopus 로고    scopus 로고
    • + stem cell
    • + stem cell. Nat. Med. 18 (2012), 618–623.
    • (2012) Nat. Med. , vol.18 , pp. 618-623
    • Yui, S.1
  • 38
    • 84856490464 scopus 로고    scopus 로고
    • Controlled gene expression in primary Lgr5 organoid cultures
    • 38 Koo, B.K., et al. Controlled gene expression in primary Lgr5 organoid cultures. Nat. Methods 9 (2011), 81–83.
    • (2011) Nat. Methods , vol.9 , pp. 81-83
    • Koo, B.K.1
  • 39
    • 84941201582 scopus 로고    scopus 로고
    • Single-cell messenger RNA sequencing reveals rare intestinal cell types
    • 39 Grun, D., et al. Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature 525 (2015), 251–255.
    • (2015) Nature , vol.525 , pp. 251-255
    • Grun, D.1
  • 40
    • 85014751112 scopus 로고    scopus 로고
    • Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
    • 40 Broutier, L., et al. Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation. Nat. Protoc. 11 (2016), 1724–1743.
    • (2016) Nat. Protoc. , vol.11 , pp. 1724-1743
    • Broutier, L.1
  • 41
    • 84992426980 scopus 로고    scopus 로고
    • The promises and challenges of human brain organoids as models of neuropsychiatric disease
    • 41 Quadrato, G., et al. The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat. Med. 22 (2016), 1220–1228.
    • (2016) Nat. Med. , vol.22 , pp. 1220-1228
    • Quadrato, G.1
  • 42
    • 84991669713 scopus 로고    scopus 로고
    • Tissue-specific mutation accumulation in human adult stem cells during life
    • 42 Blokzijl, F., et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature 538 (2016), 260–264.
    • (2016) Nature , vol.538 , pp. 260-264
    • Blokzijl, F.1
  • 43
    • 84952674076 scopus 로고    scopus 로고
    • Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
    • 43 Camp, J.G., et al. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc. Natl. Acad. Sci. U.S.A. 112 (2015), 15672–15677.
    • (2015) Proc. Natl. Acad. Sci. U.S.A. , vol.112 , pp. 15672-15677
    • Camp, J.G.1
  • 44
    • 84945246096 scopus 로고    scopus 로고
    • Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
    • 44 Freedman, B.S., et al. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids. Nat. Commun., 6, 2015, 8715.
    • (2015) Nat. Commun. , vol.6 , pp. 8715
    • Freedman, B.S.1
  • 45
    • 84960870493 scopus 로고    scopus 로고
    • Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals
    • 45 Williams, K.E., et al. Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals. Proc. Natl. Acad. Sci. U.S.A. 113 (2016), E1343–1351.
    • (2016) Proc. Natl. Acad. Sci. U.S.A. , vol.113 , pp. E1343-1351
    • Williams, K.E.1
  • 46
    • 84959357347 scopus 로고    scopus 로고
    • Organoids as an in vitro model of human development and disease
    • 46 Fatehullah, A., et al. Organoids as an in vitro model of human development and disease. Nat. Cell Biol. 18 (2016), 246–254.
    • (2016) Nat. Cell Biol. , vol.18 , pp. 246-254
    • Fatehullah, A.1
  • 47
    • 84929103936 scopus 로고    scopus 로고
    • Sequential cancer mutations in cultured human intestinal stem cells
    • 47 Drost, J., et al. Sequential cancer mutations in cultured human intestinal stem cells. Nature 521 (2015), 43–47.
    • (2015) Nature , vol.521 , pp. 43-47
    • Drost, J.1
  • 48
    • 84890033064 scopus 로고    scopus 로고
    • Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
    • 48 Schwank, G., et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 13 (2013), 653–658.
    • (2013) Cell Stem Cell , vol.13 , pp. 653-658
    • Schwank, G.1
  • 49
    • 84986224423 scopus 로고    scopus 로고
    • The generation of organoids for studying Wnt signaling
    • 49 Drost, J., et al. The generation of organoids for studying Wnt signaling. Methods Mol. Biol. 1481 (2016), 141–159.
    • (2016) Methods Mol. Biol. , vol.1481 , pp. 141-159
    • Drost, J.1
  • 50
    • 84924422753 scopus 로고    scopus 로고
    • Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids
    • 50 Matano, M., et al. Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids. Nat. Med. 21 (2015), 256–262.
    • (2015) Nat. Med. , vol.21 , pp. 256-262
    • Matano, M.1
  • 51
    • 84949431975 scopus 로고    scopus 로고
    • Organoids as model for infectious diseases: culture of human and murine stomach organoids and microinjection of Helicobacter pylori
    • Published online November 12, 2015
    • 51 Bartfeld, S., Clevers, H., Organoids as model for infectious diseases: culture of human and murine stomach organoids and microinjection of Helicobacter pylori. J. Vis. Exp., 2015, 10.3791/53359 Published online November 12, 2015.
    • (2015) J. Vis. Exp.
    • Bartfeld, S.1    Clevers, H.2
  • 52
    • 85000607350 scopus 로고    scopus 로고
    • Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection
    • 52 Wells, M.F., et al. Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection. Cell Stem Cell 19 (2016), 703–708.
    • (2016) Cell Stem Cell , vol.19 , pp. 703-708
    • Wells, M.F.1
  • 53
    • 84962798328 scopus 로고    scopus 로고
    • Zika virus impairs growth in human neurospheres and brain organoids
    • 53 Garcez, P.P., et al. Zika virus impairs growth in human neurospheres and brain organoids. Science 352 (2016), 816–818.
    • (2016) Science , vol.352 , pp. 816-818
    • Garcez, P.P.1
  • 54
    • 84971568586 scopus 로고    scopus 로고
    • The Brazilian Zika virus strain causes birth defects in experimental models
    • 54 Cugola, F.R., et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 534 (2016), 267–271.
    • (2016) Nature , vol.534 , pp. 267-271
    • Cugola, F.R.1
  • 55
    • 84919478713 scopus 로고    scopus 로고
    • Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function
    • 55 Leslie, J.L., et al. Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function. Infect. Immun. 83 (2015), 138–145.
    • (2015) Infect. Immun. , vol.83 , pp. 138-145
    • Leslie, J.L.1
  • 56
    • 84964619895 scopus 로고    scopus 로고
    • Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure
    • 56 Qian, X., et al. Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 165 (2016), 1238–1254.
    • (2016) Cell , vol.165 , pp. 1238-1254
    • Qian, X.1
  • 57
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • 57 Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144 (2011), 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 58
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial–mesenchymal transition: at the crossroads of development and tumor metastasis
    • 58 Yang, J., Weinberg, R.A., Epithelial–mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell 14 (2008), 818–829.
    • (2008) Dev. Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 59
    • 84964240053 scopus 로고    scopus 로고
    • Biological and therapeutic impact of intratumor heterogeneity in cancer evolution
    • 59 McGranahan, N., Swanton, C., Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell 27 (2015), 15–26.
    • (2015) Cancer Cell , vol.27 , pp. 15-26
    • McGranahan, N.1    Swanton, C.2
  • 60
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: premises, promises and challenges
    • 60 Clevers, H., The cancer stem cell: premises, promises and challenges. Nat. Med. 17 (2011), 313–319.
    • (2011) Nat. Med. , vol.17 , pp. 313-319
    • Clevers, H.1
  • 61
    • 84891404742 scopus 로고    scopus 로고
    • Organoid cultures for the analysis of cancer phenotypes
    • 61 Sachs, N., Clevers, H., Organoid cultures for the analysis of cancer phenotypes. Curr. Opin. Genet. Dev. 24 (2014), 68–73.
    • (2014) Curr. Opin. Genet. Dev. , vol.24 , pp. 68-73
    • Sachs, N.1    Clevers, H.2
  • 62
    • 79951691421 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations in pancreatic carcinogenesis
    • 62 Delpu, Y., et al. Genetic and epigenetic alterations in pancreatic carcinogenesis. Curr. Genom. 12 (2011), 15–24.
    • (2011) Curr. Genom. , vol.12 , pp. 15-24
    • Delpu, Y.1
  • 63
    • 84946215806 scopus 로고    scopus 로고
    • Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids
    • 63 Huang, L., et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nat. Med. 21 (2015), 1364–1371.
    • (2015) Nat. Med. , vol.21 , pp. 1364-1371
    • Huang, L.1
  • 64
    • 84964414260 scopus 로고    scopus 로고
    • Modeling pancreatic cancer with organoids
    • 64 Baker, L.A., et al. Modeling pancreatic cancer with organoids. Trends Cancer 2 (2016), 176–190.
    • (2016) Trends Cancer , vol.2 , pp. 176-190
    • Baker, L.A.1
  • 65
    • 84988649860 scopus 로고    scopus 로고
    • Building pancreatic organoids to aid drug development
    • 65 Wills, E.S., Drenth, J.P., Building pancreatic organoids to aid drug development. Gut 66 (2016), 393–394.
    • (2016) Gut , vol.66 , pp. 393-394
    • Wills, E.S.1    Drenth, J.P.2
  • 66
    • 84907554319 scopus 로고    scopus 로고
    • Organoid cultures derived from patients with advanced prostate cancer
    • 66 Gao, D., et al. Organoid cultures derived from patients with advanced prostate cancer. Cell 159 (2014), 176–187.
    • (2014) Cell , vol.159 , pp. 176-187
    • Gao, D.1
  • 67
    • 84969599540 scopus 로고    scopus 로고
    • A three-dimensional organoid culture system derived from human glioblastomas recapitulates the hypoxic gradients and cancer stem cell heterogeneity of tumors found in vivo
    • 67 Hubert, C.G., et al. A three-dimensional organoid culture system derived from human glioblastomas recapitulates the hypoxic gradients and cancer stem cell heterogeneity of tumors found in vivo. Cancer Res. 76 (2016), 2465–2477.
    • (2016) Cancer Res. , vol.76 , pp. 2465-2477
    • Hubert, C.G.1
  • 68
    • 84928974420 scopus 로고    scopus 로고
    • Prospective derivation of a living organoid biobank of colorectal cancer patients
    • 68 van de Wetering, M., et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161 (2015), 933–945.
    • (2015) Cell , vol.161 , pp. 933-945
    • van de Wetering, M.1
  • 69
    • 84971516758 scopus 로고    scopus 로고
    • A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis
    • 69 Fujii, M., et al. A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis. Cell Stem Cell 18 (2016), 827–838.
    • (2016) Cell Stem Cell , vol.18 , pp. 827-838
    • Fujii, M.1
  • 70
    • 0024424270 scopus 로고
    • Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
    • 70 Riordan, J.R., et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245 (1989), 1066–1073.
    • (1989) Science , vol.245 , pp. 1066-1073
    • Riordan, J.R.1
  • 71
    • 0028982894 scopus 로고
    • CFTR as a cAMP-dependent regulator of sodium channels
    • 71 Stutts, M.J., et al. CFTR as a cAMP-dependent regulator of sodium channels. Science 269 (1995), 847–850.
    • (1995) Science , vol.269 , pp. 847-850
    • Stutts, M.J.1
  • 72
    • 6344231597 scopus 로고    scopus 로고
    • Clinical manifestations of cystic fibrosis among patients with diagnosis in adulthood
    • 72 Gilljam, M., et al. Clinical manifestations of cystic fibrosis among patients with diagnosis in adulthood. Chest 126 (2004), 1215–1224.
    • (2004) Chest , vol.126 , pp. 1215-1224
    • Gilljam, M.1
  • 73
    • 0033069576 scopus 로고    scopus 로고
    • Digestive alterations in cystic fibrosis. Retrospective study of a series of 46 adult patients
    • (in Spanish)
    • 73 Perez-Aguilar, F., et al. Digestive alterations in cystic fibrosis. Retrospective study of a series of 46 adult patients. Gastroenterol. Hepatol. 22 (1999), 72–78 (in Spanish).
    • (1999) Gastroenterol. Hepatol. , vol.22 , pp. 72-78
    • Perez-Aguilar, F.1
  • 74
    • 84959358838 scopus 로고    scopus 로고
    • Cystic fibrosis from the gastroenterologist's perspective
    • 74 Ooi, C.Y., Durie, P.R., Cystic fibrosis from the gastroenterologist's perspective. Nat. Rev. Gastroenterol. Hepatol. 13 (2016), 175–185.
    • (2016) Nat. Rev. Gastroenterol. Hepatol. , vol.13 , pp. 175-185
    • Ooi, C.Y.1    Durie, P.R.2
  • 75
    • 84927176500 scopus 로고    scopus 로고
    • Cystic fibrosis genetics: from molecular understanding to clinical application
    • 75 Cutting, G.R., Cystic fibrosis genetics: from molecular understanding to clinical application. Nat. Rev. Genet. 16 (2015), 45–56.
    • (2015) Nat. Rev. Genet. , vol.16 , pp. 45-56
    • Cutting, G.R.1
  • 76
    • 84880292828 scopus 로고    scopus 로고
    • A functional CFTR assay using primary cystic fibrosis intestinal organoids
    • 76 Dekkers, J.F., et al. A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nat. Med. 19 (2013), 939–945.
    • (2013) Nat. Med. , vol.19 , pp. 939-945
    • Dekkers, J.F.1
  • 77
    • 84975464759 scopus 로고    scopus 로고
    • Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
    • 77 Dekkers, J.F., et al. Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Sci. Transl. Med., 8, 2016, 344ra384.
    • (2016) Sci. Transl. Med. , vol.8 , pp. 344ra384
    • Dekkers, J.F.1
  • 78
    • 84987917122 scopus 로고    scopus 로고
    • Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling
    • Published online September 15, 2016
    • 78 Hohwieler, M., et al. Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling. Gut, 2016, 10.1136/gutjnl-2016-312423 Published online September 15, 2016.
    • (2016) Gut
    • Hohwieler, M.1
  • 79
    • 84940793000 scopus 로고    scopus 로고
    • Functional gene correction for cystic fibrosis in lung epithelial cells generated from patient iPSCs
    • 79 Firth, A.L., et al. Functional gene correction for cystic fibrosis in lung epithelial cells generated from patient iPSCs. Cell Rep. 12 (2015), 1385–1390.
    • (2015) Cell Rep. , vol.12 , pp. 1385-1390
    • Firth, A.L.1
  • 80
    • 84994719204 scopus 로고    scopus 로고
    • Modeling infectious diseases and host–microbe interactions in gastrointestinal organoids
    • 80 Bartfeld, S., Modeling infectious diseases and host–microbe interactions in gastrointestinal organoids. Devel. Biol. 420 (2016), 262–270.
    • (2016) Devel. Biol. , vol.420 , pp. 262-270
    • Bartfeld, S.1
  • 81
    • 84971557656 scopus 로고    scopus 로고
    • Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3
    • 81 Dang, J., et al. Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3. Cell Stem Cell 19 (2016), 258–265.
    • (2016) Cell Stem Cell , vol.19 , pp. 258-265
    • Dang, J.1
  • 82
    • 84926039213 scopus 로고    scopus 로고
    • Generation of cerebral organoids from human pluripotent stem cells
    • 82 Lancaster, M.A., Knoblich, J.A., Generation of cerebral organoids from human pluripotent stem cells. Nat. Protoc. 9 (2014), 2329–2340.
    • (2014) Nat. Protoc. , vol.9 , pp. 2329-2340
    • Lancaster, M.A.1    Knoblich, J.A.2
  • 83
    • 84962118425 scopus 로고    scopus 로고
    • Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells
    • 83 Nowakowski, T.J., et al. Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells. Cell Stem Cell 18 (2016), 591–596.
    • (2016) Cell Stem Cell , vol.18 , pp. 591-596
    • Nowakowski, T.J.1
  • 84
    • 17044383351 scopus 로고    scopus 로고
    • A millennium update on pediatric diarrheal illness in the developing world
    • 84 O'Ryan, M., et al. A millennium update on pediatric diarrheal illness in the developing world. Semin. Pediatr. Infect. Dis. 16 (2005), 125–136.
    • (2005) Semin. Pediatr. Infect. Dis. , vol.16 , pp. 125-136
    • O'Ryan, M.1
  • 85
    • 0038748139 scopus 로고    scopus 로고
    • Viruses causing gastroenteritis
    • 85 Wilhelmi, I., et al. Viruses causing gastroenteritis. Clin. Microbiol. Infect. 9 (2003), 247–262.
    • (2003) Clin. Microbiol. Infect. , vol.9 , pp. 247-262
    • Wilhelmi, I.1
  • 86
    • 84865798086 scopus 로고    scopus 로고
    • Stem cell-derived human intestinal organoids as an infection model for rotaviruses
    • 86 Finkbeiner, S.R., et al. Stem cell-derived human intestinal organoids as an infection model for rotaviruses. mBio 3 (2012), e00159–00112.
    • (2012) mBio , vol.3 , pp. e00159-00112
    • Finkbeiner, S.R.1
  • 87
    • 84942784008 scopus 로고    scopus 로고
    • Modeling rotavirus infection and antiviral therapy using primary intestinal organoids
    • 87 Yin, Y., et al. Modeling rotavirus infection and antiviral therapy using primary intestinal organoids. Antiviral Res. 123 (2015), 120–131.
    • (2015) Antiviral Res. , vol.123 , pp. 120-131
    • Yin, Y.1
  • 88
    • 84986332708 scopus 로고    scopus 로고
    • Replication of human noroviruses in stem cell-derived human enteroids
    • 88 Ettayebi, K., et al. Replication of human noroviruses in stem cell-derived human enteroids. Science 353 (2016), 1387–1393.
    • (2016) Science , vol.353 , pp. 1387-1393
    • Ettayebi, K.1
  • 89
    • 84866597864 scopus 로고    scopus 로고
    • Stem cell-derived cell cultures and organoids for protozoan parasite propagation and studying host–parasite interaction
    • 89 Klotz, C., et al. Stem cell-derived cell cultures and organoids for protozoan parasite propagation and studying host–parasite interaction. Int. J. Med. Microbiol. 302 (2012), 203–209.
    • (2012) Int. J. Med. Microbiol. , vol.302 , pp. 203-209
    • Klotz, C.1
  • 90
    • 84992391514 scopus 로고    scopus 로고
    • Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
    • 90 Tao, L., et al. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature 538 (2016), 350–355.
    • (2016) Nature , vol.538 , pp. 350-355
    • Tao, L.1
  • 91
    • 84930999403 scopus 로고    scopus 로고
    • Interaction of Salmonella enterica serovar Typhimurium with intestinal organoids derived from human induced pluripotent stem cells
    • 91 Forbester, J.L., et al. Interaction of Salmonella enterica serovar Typhimurium with intestinal organoids derived from human induced pluripotent stem cells. Infect. Immun. 83 (2015), 2926–2934.
    • (2015) Infect. Immun. , vol.83 , pp. 2926-2934
    • Forbester, J.L.1
  • 92
    • 85009424076 scopus 로고    scopus 로고
    • Salmonella-infected crypt-derived intestinal organoid culture system for host–bacterial interactions
    • 92 Zhang, Y.G., et al. Salmonella-infected crypt-derived intestinal organoid culture system for host–bacterial interactions. Physiol. Rep., 2, 2014, e12147.
    • (2014) Physiol. Rep. , vol.2 , pp. e12147
    • Zhang, Y.G.1
  • 93
    • 84930016564 scopus 로고    scopus 로고
    • Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma
    • 93 Scanu, T., et al. Salmonella manipulation of host signaling pathways provokes cellular transformation associated with gallbladder carcinoma. Cell Host Microbe 17 (2015), 763–774.
    • (2015) Cell Host Microbe , vol.17 , pp. 763-774
    • Scanu, T.1
  • 94
    • 84942991269 scopus 로고    scopus 로고
    • Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium
    • 94 Huang, J.Y., et al. Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium. Cell Host Microbe 18 (2015), 147–156.
    • (2015) Cell Host Microbe , vol.18 , pp. 147-156
    • Huang, J.Y.1
  • 95
    • 84952683442 scopus 로고    scopus 로고
    • Pathobiology of Helicobacter pylori-induced gastric cancer
    • 95 Amieva, M., Peek, R.M. Jr., Pathobiology of Helicobacter pylori-induced gastric cancer. Gastroenterology 150 (2016), 64–78.
    • (2016) Gastroenterology , vol.150 , pp. 64-78
    • Amieva, M.1    Peek, R.M.2
  • 96
    • 84918561297 scopus 로고    scopus 로고
    • Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
    • 96 McCracken, K.W., et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516 (2014), 400–404.
    • (2014) Nature , vol.516 , pp. 400-404
    • McCracken, K.W.1
  • 97
    • 84978863785 scopus 로고    scopus 로고
    • Emerging technologies for gut microbiome research
    • 97 Arnold, J.W., et al. Emerging technologies for gut microbiome research. Trends Microbiol. 24 (2016), 887–901.
    • (2016) Trends Microbiol. , vol.24 , pp. 887-901
    • Arnold, J.W.1
  • 98
    • 84902439624 scopus 로고    scopus 로고
    • The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration
    • 98 Nigro, G., et al. The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe 15 (2014), 792–798.
    • (2014) Cell Host Microbe , vol.15 , pp. 792-798
    • Nigro, G.1
  • 99
    • 84908293710 scopus 로고    scopus 로고
    • Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids
    • e01438–14
    • 99 Lukovac, S., et al. Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids. mBio, 5, 2014 e01438–14.
    • (2014) mBio , vol.5
    • Lukovac, S.1
  • 100
    • 84971616810 scopus 로고    scopus 로고
    • Promotion of intestinal epithelial cell turnover by commensal bacteria: role of short-chain fatty acids
    • 100 Park, J.H., et al. Promotion of intestinal epithelial cell turnover by commensal bacteria: role of short-chain fatty acids. PloS One, 11, 2016, e0156334.
    • (2016) PloS One , vol.11 , pp. e0156334
    • Park, J.H.1
  • 101
    • 84887577062 scopus 로고    scopus 로고
    • Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth
    • 101 Engevik, M.A., et al. Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth. Am. J. Physiol. Gastrointest. Liver Physiol. 305 (2013), G697–711.
    • (2013) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.305 , pp. G697-711
    • Engevik, M.A.1
  • 102
    • 85050808739 scopus 로고    scopus 로고
    • The colonic crypt protects stem cells from microbiota-derived metabolites
    • 102 Kaiko, G.E., et al. The colonic crypt protects stem cells from microbiota-derived metabolites. Cell, 167, 2016, 1137.
    • (2016) Cell , vol.167 , pp. 1137
    • Kaiko, G.E.1
  • 103
    • 84908075358 scopus 로고    scopus 로고
    • Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen
    • 103 Pham, T.A., et al. Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen. Cell Host Microbe 16 (2014), 504–516.
    • (2014) Cell Host Microbe , vol.16 , pp. 504-516
    • Pham, T.A.1
  • 104
    • 84903794978 scopus 로고    scopus 로고
    • Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-gamma
    • 104 Farin, H.F., et al. Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-gamma. J. Exp. Med. 211 (2014), 1393–1405.
    • (2014) J. Exp. Med. , vol.211 , pp. 1393-1405
    • Farin, H.F.1
  • 105
    • 85016162669 scopus 로고    scopus 로고
    • Designer matrices for intestinal stem cell and organoid culture
    • 105 Gjorevski, N., et al. Designer matrices for intestinal stem cell and organoid culture. Nature 539 (2016), 560–564.
    • (2016) Nature , vol.539 , pp. 560-564
    • Gjorevski, N.1
  • 106
    • 84937212591 scopus 로고    scopus 로고
    • FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders
    • 106 Mariani, J., et al. FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders. Cell 162 (2015), 375–390.
    • (2015) Cell , vol.162 , pp. 375-390
    • Mariani, J.1
  • 107
    • 84994885304 scopus 로고    scopus 로고
    • Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis
    • Published online November 1, 2016
    • 107 Dotti, I., et al. Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis. Gut, 2016, 10.1136/gutjnl-2016-312609 Published online November 1, 2016.
    • (2016) Gut
    • Dotti, I.1
  • 108
    • 85043357916 scopus 로고    scopus 로고
    • Long-term inflammation transforms intestinal epithelial cells of colonic organoids
    • Published online October 11, 2016
    • 108 Hibiya, S., et al. Long-term inflammation transforms intestinal epithelial cells of colonic organoids. J. Crohns Colitis, 2016, 10.1093/ecco-jcc/jjw186 Published online October 11, 2016.
    • (2016) J. Crohns Colitis
    • Hibiya, S.1
  • 109
    • 84967110135 scopus 로고    scopus 로고
    • Understanding how Zika virus enters and infects neural target cells
    • 109 Miner, J.J., Diamond, M.S., Understanding how Zika virus enters and infects neural target cells. Cell Stem Cell 18 (2016), 559–560.
    • (2016) Cell Stem Cell , vol.18 , pp. 559-560
    • Miner, J.J.1    Diamond, M.S.2
  • 110
    • 84984662505 scopus 로고    scopus 로고
    • Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
    • 110 Xu, M., et al. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat. Med. 22 (2016), 1101–1107.
    • (2016) Nat. Med. , vol.22 , pp. 1101-1107
    • Xu, M.1
  • 111
    • 84952640112 scopus 로고    scopus 로고
    • Model organoids provide new research opportunities for ductal pancreatic cancer
    • 111 Boj, S.F., et al. Model organoids provide new research opportunities for ductal pancreatic cancer. Mol. Cell. Oncol., 3, 2016, e1014757.
    • (2016) Mol. Cell. Oncol. , vol.3 , pp. e1014757
    • Boj, S.F.1
  • 112
    • 84991085076 scopus 로고    scopus 로고
    • Molecular obstacles to clinical translation of iPSCs
    • 112 Tapia, N., Scholer, H.R., Molecular obstacles to clinical translation of iPSCs. Cell Stem Cell 19 (2016), 298–309.
    • (2016) Cell Stem Cell , vol.19 , pp. 298-309
    • Tapia, N.1    Scholer, H.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.