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Volumn 8, Issue 2, 2015, Pages 352-361

A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; BACTERIAL PROTEIN; DEFENSIN; MATRILYSIN; PHOP PROTEIN, BACTERIA;

EID: 84922753974     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2014.72     Document Type: Article
Times cited : (131)

References (42)
  • 1
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato, T., et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265 (2009).
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1
  • 2
    • 84878760040 scopus 로고    scopus 로고
    • Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications
    • Sato, T. & Clevers, H. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science 340, 1190-1194 (2013).
    • (2013) Science , vol.340 , pp. 1190-1194
    • Sato, T.1    Clevers, H.2
  • 3
    • 84867198093 scopus 로고    scopus 로고
    • Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury
    • Miyoshi, H., Ajima, R., Luo, C.T., Yamaguchi, T.P. & Stappenbeck, T.S. Wnt5a potentiates TGF-beta signaling to promote colonic crypt regeneration after tissue injury. Science 338, 108-113 (2012).
    • (2012) Science , vol.338 , pp. 108-113
    • Miyoshi, H.1    Ajima, R.2    Luo, C.T.3    Yamaguchi, T.P.4    Stappenbeck, T.S.5
  • 4
    • 0034252293 scopus 로고    scopus 로고
    • Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
    • Ayabe, T., et al. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat. Immunol. 1, 113-118 (2000).
    • (2000) Nat. Immunol. , vol.1 , pp. 113-118
    • Ayabe, T.1
  • 5
    • 79954915318 scopus 로고    scopus 로고
    • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
    • Bevins, C.L. & Salzman, N.H. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat. Rev. Microbiol. 9, 356-368 (2011).
    • (2011) Nat. Rev. Microbiol. , vol.9 , pp. 356-368
    • Bevins, C.L.1    Salzman, N.H.2
  • 7
    • 74049122536 scopus 로고    scopus 로고
    • Enteric defensins are essential regulators of intestinal microbial ecology
    • Salzman, N.H., et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat. Immunol. 11, 76-83 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 76-83
    • Salzman, N.H.1
  • 8
    • 0033214433 scopus 로고    scopus 로고
    • Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
    • Wilson, C.L., et al. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286, 113-117 (1999).
    • (1999) Science , vol.286 , pp. 113-117
    • Wilson, C.L.1
  • 9
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell alpha-defensins in ileal Crohns disease
    • Wehkamp, J., et al. Reduced Paneth cell alpha-defensins in ileal Crohns disease. Proc. Natl. Acad. Sci. USA 102, 18129-18134 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 18129-18134
    • Wehkamp, J.1
  • 10
    • 84870489063 scopus 로고    scopus 로고
    • Primarymouse small intestinal epithelial cell cultures
    • Sato, T. & Clevers, H. Primarymouse small intestinal epithelial cell cultures. Methods Mol. Biol. 945, 319-328 (2013).
    • (2013) Methods Mol. Biol. , vol.945 , pp. 319-328
    • Sato, T.1    Clevers, H.2
  • 11
    • 84873672050 scopus 로고    scopus 로고
    • Paneth cells: Maestros of the small intestinal crypts
    • Clevers, H.C. & Bevins, C.L. Paneth cells: maestros of the small intestinal crypts. Annu. Rev. Physiol. 75, 289-311 (2013).
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 289-311
    • Clevers, H.C.1    Bevins, C.L.2
  • 12
    • 0030914439 scopus 로고    scopus 로고
    • Localization of human intestinal defensin 5 in Paneth cell granules
    • Porter, E.M., Liu, L., Oren, A., Anton, P.A. & Ganz, T. Localization of human intestinal defensin 5 in Paneth cell granules. Infect. Immun. 65, 2389-2395 (1997).
    • (1997) Infect. Immun. , vol.65 , pp. 2389-2395
    • Porter, E.M.1    Liu, L.2    Oren, A.3    Anton, P.A.4    Ganz, T.5
  • 13
    • 78650879096 scopus 로고    scopus 로고
    • Strain-specific polymorphisms in Paneth cell alpha-defensins of C57BL/6 mice and evidence of vestigial myeloid alpha-defensin pseudogenes
    • Shanahan, M.T., Tanabe, H. & Ouellette, A.J. Strain-specific polymorphisms in Paneth cell alpha-defensins of C57BL/6 mice and evidence of vestigial myeloid alpha-defensin pseudogenes. Infect. Immun. 79, 459-473 (2011).
    • (2011) Infect. Immun. , vol.79 , pp. 459-473
    • Shanahan, M.T.1    Tanabe, H.2    Ouellette, A.J.3
  • 14
    • 84859503402 scopus 로고    scopus 로고
    • Alternative luminal activation mechanisms for paneth cell alpha-defensins
    • Mastroianni, J.R., et al. Alternative luminal activation mechanisms for paneth cell alpha-defensins. J. Biol. Chem. 287, 11205-11212 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 11205-11212
    • Mastroianni, J.R.1
  • 15
    • 0025096413 scopus 로고
    • Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium
    • Miller, S.I., Pulkkinen, W.S., Selsted, M.E. & Mekalanos, J.J. Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium. Infect. Immun. 58, 3706-3710 (1990).
    • (1990) Infect. Immun. , vol.58 , pp. 3706-3710
    • Miller, S.I.1    Pulkkinen, W.S.2    Selsted, M.E.3    Mekalanos, J.J.4
  • 16
    • 67650093032 scopus 로고    scopus 로고
    • Salmonella enterica serovar typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cells
    • Lara-Tejero, M. & Galan, J.E. Salmonella enterica serovar typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cells. Infect. Immun. 77, 2635-2642 (2009).
    • (2009) Infect. Immun. , vol.77 , pp. 2635-2642
    • Lara-Tejero, M.1    Galan, J.E.2
  • 17
    • 0037417311 scopus 로고    scopus 로고
    • Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
    • Salzman, N.H., Ghosh, D., Huttner, K.M., Paterson, Y. & Bevins, C.L. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422, 522-526 (2003).
    • (2003) Nature , vol.422 , pp. 522-526
    • Salzman, N.H.1    Ghosh, D.2    Huttner, K.M.3    Paterson, Y.4    Bevins, C.L.5
  • 18
    • 0036079594 scopus 로고    scopus 로고
    • Paneth cell trypsin is the processing enzyme for human defensin-5
    • Ghosh, D., et al. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat. Immunol. 3, 583-590 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 583-590
    • Ghosh, D.1
  • 20
    • 70349468054 scopus 로고    scopus 로고
    • Nod2 is required for the regulation of commensal microbiota in the intestine
    • Petnicki-Ocwieja, T., et al. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc. Natl. Acad. Sci. USA 106, 15813-15818 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 15813-15818
    • Petnicki-Ocwieja, T.1
  • 21
    • 77957047689 scopus 로고    scopus 로고
    • Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
    • Biswas, A., et al. Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Proc. Natl. Acad. Sci. USA 107, 14739-14744 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 14739-14744
    • Biswas, A.1
  • 22
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi, K.S., et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731-734 (2005).
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1
  • 23
    • 84899949037 scopus 로고    scopus 로고
    • Mouse Paneth cell antimicrobial function is independent of Nod2
    • Shanahan, M.T., et al. Mouse Paneth cell antimicrobial function is independent of Nod2. Gut 63, 903-910 (2013).
    • (2013) Gut , vol.63 , pp. 903-910
    • Shanahan, M.T.1
  • 24
    • 20644462344 scopus 로고    scopus 로고
    • Mammalian defensins in the antimicrobial immune response
    • Selsted, M.E. & Ouellette, A.J. Mammalian defensins in the antimicrobial immune response. Nat. Immunol. 6, 551-557 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 551-557
    • Selsted, M.E.1    Ouellette, A.J.2
  • 25
    • 83655193502 scopus 로고    scopus 로고
    • Alpha-Defensins in human innate immunity
    • Lehrer, R.I. & Lu, W. alpha-Defensins in human innate immunity. Immunol. Rev. 245, 84-112 (2012).
    • (2012) Immunol. Rev. , vol.245 , pp. 84-112
    • Lehrer, R.I.1    Lu, W.2
  • 26
    • 84861578826 scopus 로고    scopus 로고
    • Probiotic and postbiotic activity in health and disease: Comparison on a novel polarised ex-vivo organ culture model
    • Tsilingiri, K., et al. Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model. Gut 61, 1007-1015 (2012).
    • (2012) Gut , vol.61 , pp. 1007-1015
    • Tsilingiri, K.1
  • 27
    • 84856490464 scopus 로고    scopus 로고
    • Controlled gene expression in primary Lgr5 organoid cultures
    • Koo, B.K., et al. Controlled gene expression in primary Lgr5 organoid cultures. Nat. Methods 9, 81-83 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 81-83
    • Koo, B.K.1
  • 28
    • 79958816030 scopus 로고    scopus 로고
    • Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease
    • Sun, L., Nava, G.M. & Stappenbeck, T.S. Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease. Curr. Opin. Gastroenterol. 27, 321-327 (2011).
    • (2011) Curr. Opin. Gastroenterol. , vol.27 , pp. 321-327
    • Sun, L.1    Nava, G.M.2    Stappenbeck, T.S.3
  • 29
    • 46349102893 scopus 로고    scopus 로고
    • Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohns disease
    • Simms, L.A., et al. Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohns disease. Gut 57, 903-910 (2008).
    • (2008) Gut , vol.57 , pp. 903-910
    • Simms, L.A.1
  • 30
    • 84902439624 scopus 로고    scopus 로고
    • The cytosolic bacterial peptidoglycan sensor nod2 affords stem cell protection and links microbes togut epithelial regeneration
    • Nigro, G., Rossi, R., Commere, P.H., Jay, P. & Sansonetti, P.J. The cytosolic bacterial peptidoglycan sensor nod2 affords stem cell protection and links microbes togut epithelial regeneration. Cell Host Microbe15, 792-798(2014).
    • (2014) Cell Host Microbe , vol.15 , pp. 792-798
    • Nigro, G.1    Rossi, R.2    Commere, P.H.3    Jay, P.4    Sansonetti, P.J.5
  • 33
    • 0034704102 scopus 로고    scopus 로고
    • Germ-free and colonizedmice generate the same products from enteric prodefensins
    • Putsep, K., et al. Germ-free and colonizedmice generate the same products from enteric prodefensins. J. Biol. Chem. 275, 40478-40482 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 40478-40482
    • Putsep, K.1
  • 34
    • 4444246183 scopus 로고    scopus 로고
    • Increased diversity of intestinal antimicrobial peptides by covalent dimer formation
    • Hornef, M.W., Putsep, K., Karlsson, J., Refai, E. & Andersson, M. Increased diversity of intestinal antimicrobial peptides by covalent dimer formation. Nat. Immunol. 5, 836-843 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 836-843
    • Hornef, M.W.1    Putsep, K.2    Karlsson, J.3    Refai, E.4    Andersson, M.5
  • 35
    • 77951224862 scopus 로고    scopus 로고
    • Elevated expression of paneth cell CRS4C in ileitisprone samp1/YitFc mice: Regional distribution, subcellular localization, and mechanism of action
    • Shanahan, M.T., et al. Elevated expression of paneth cell CRS4C in ileitisprone samp1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. J. Biol. Chem. 285, 7493-7504 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 7493-7504
    • Shanahan, M.T.1
  • 36
    • 84866465328 scopus 로고    scopus 로고
    • Peyers patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts"
    • de Lau, W., et al. Peyers patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Mol. Cell Biol. 32, 3639-3647 (2012).
    • (2012) Mol. Cell Biol. , vol.32 , pp. 3639-3647
    • De Lau, W.1
  • 37
    • 80054857419 scopus 로고    scopus 로고
    • Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barretts epithelium
    • Sato, T., et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barretts epithelium. Gastroenterology 141, 1762-1772 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1762-1772
    • Sato, T.1
  • 38
    • 36749052234 scopus 로고    scopus 로고
    • Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa
    • Kassim, S.Y., et al. Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa. Infect. Immun. 75, 5640-5650 (2007).
    • (2007) Infect. Immun. , vol.75 , pp. 5640-5650
    • Kassim, S.Y.1
  • 39
    • 0041935939 scopus 로고    scopus 로고
    • (U.S. National Institutes of Health, Bethesda, MD, USA, 1997-2014
    • Rasband, W.S. ImageJ. http://rsb.info.nih.gov/ij/ (U.S. National Institutes of Health, Bethesda, MD, USA, 1997-2014).
    • ImageJ.
    • Rasband, W.S.1
  • 40
    • 84863794822 scopus 로고    scopus 로고
    • Critical determinants of human alpha-defensin 5 activity against non-enveloped viruses
    • Gounder, A.P., Wiens, M.E., Wilson, S.S., Lu, W. & Smith, J.G. Critical determinants of human alpha-defensin 5 activity against non-enveloped viruses. J. Biol. Chem. 287, 24554-24562 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 24554-24562
    • Gounder, A.P.1    Wiens, M.E.2    Wilson, S.S.3    Lu, W.4    Smith, J.G.5
  • 41
    • 84855493990 scopus 로고    scopus 로고
    • Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response
    • Stewart, M.K., Cummings, L.A., Johnson, M.L., Berezow, A.B. &Cookson, B.T. Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response. Proc. Natl. Acad. Sci. USA 108, 20742-20747 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 20742-20747
    • Stewart, M.K.1    Cummings, L.A.2    Johnson, M.L.3    Berezow, A.B.4    Cookson, B.T.5
  • 42
    • 33748329474 scopus 로고    scopus 로고
    • In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted
    • Cummings, L.A., Wilkerson, W.D., Bergsbaken, T. & Cookson, B.T. In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted. Mol. Microbiol. 61, 795-809 (2006).
    • (2006) Mol. Microbiol. , vol.61 , pp. 795-809
    • Cummings, L.A.1    Wilkerson, W.D.2    Bergsbaken, T.3    Cookson, B.T.4


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