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Volumn 8, Issue JUL, 2017, Pages

NLRP3 inflammasome as a molecular marker in diabetic cardiomyopathy

Author keywords

Diabetic cardiomyopathy; Inflammation; NLRP3 inflammasome; Pyroptosis; Thioredoxin interacting inhibiting protein

Indexed keywords

CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; MOLECULAR MARKER; REACTIVE OXYGEN METABOLITE; THIOREDOXIN INTERACTING PROTEIN;

EID: 85025809100     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2017.00519     Document Type: Review
Times cited : (178)

References (73)
  • 1
    • 84975492597 scopus 로고    scopus 로고
    • Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue
    • Ahmad, F., Chung, Y. W., Tang, Y., Hockman, S. C., Liu, S., Khan, Y., et al. (2016). Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci. Rep. 6:28056. doi: 10.1038/srep28056
    • (2016) Sci. Rep. , vol.6 , pp. 28056
    • Ahmad, F.1    Chung, Y.W.2    Tang, Y.3    Hockman, S.C.4    Liu, S.5    Khan, Y.6
  • 2
    • 64049111768 scopus 로고    scopus 로고
    • The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
    • Allen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., et al. (2009). The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30, 556-565. doi: 10.1016/j.immuni.2009.02.005
    • (2009) Immunity , vol.30 , pp. 556-565
    • Allen, I.C.1    Scull, M.A.2    Moore, C.B.3    Holl, E.K.4    McElvania-TeKippe, E.5    Taxman, D.J.6
  • 3
    • 46649091330 scopus 로고    scopus 로고
    • IL-1 cytokines in cardiovascular disease: diagnostic, prognostic and therapeutic implications
    • Apostolakis, S., Vogiatzi, K., Krambovitis, E., and Spandidos, D. A. (2008). IL-1 cytokines in cardiovascular disease: diagnostic, prognostic and therapeutic implications. Cardiovasc. Hematol. Agents Med. Chem. 6, 150-158. doi: 10.2174/187152508783955006
    • (2008) Cardiovasc. Hematol. Agents Med. Chem. , vol.6 , pp. 150-158
    • Apostolakis, S.1    Vogiatzi, K.2    Krambovitis, E.3    Spandidos, D.A.4
  • 4
    • 58449083290 scopus 로고    scopus 로고
    • Pyroptosis: host cell death and inflammation
    • Bergsbaken, T., Fink, S. L., and Cookson, B. T. (2009). Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7, 99-109. doi: 10.1038/nrmicro2070
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 99-109
    • Bergsbaken, T.1    Fink, S.L.2    Cookson, B.T.3
  • 6
    • 84904214756 scopus 로고    scopus 로고
    • Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome
    • Bracey, N. A., Gershkovich, B., Chun, J., Vilaysane, A., Meijndert, H. C., Wright, J. R. Jr., et al. (2014). Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome. J. Biol. Chem. 289, 19571-19584. doi: 10.1074/jbc.M114.550624
    • (2014) J. Biol. Chem. , vol.289 , pp. 19571-19584
    • Bracey, N.A.1    Gershkovich, B.2    Chun, J.3    Vilaysane, A.4    Meijndert, H.C.5    Wright, J.R.6
  • 7
    • 43549099569 scopus 로고    scopus 로고
    • Biomarkers in heart failure
    • Braunwald, E. (2008). Biomarkers in heart failure. N. Engl. J. Med. 358, 2148-2159. doi: 10.1056/NEJMra0800239
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2148-2159
    • Braunwald, E.1
  • 8
    • 69549119940 scopus 로고    scopus 로고
    • Molecular mechanisms involved in inflammasome activation
    • Bryant, C., and Fitzgerald, K. A. (2009). Molecular mechanisms involved in inflammasome activation. Trends Cell Biol. 19, 455-464. doi: 10.1016/j.tcb.2009.06.002
    • (2009) Trends Cell Biol. , vol.19 , pp. 455-464
    • Bryant, C.1    Fitzgerald, K.A.2
  • 9
    • 84943585944 scopus 로고    scopus 로고
    • The importance of NLRP3 inflammasome in heart failure
    • Butts, B., Gary, R. A., Dunbar, S. B., and Butler, J. (2015). The importance of NLRP3 inflammasome in heart failure. J. Card. Fail. 21, 586-593. doi: 10.1016/j.cardfail.2015.04.014
    • (2015) J. Card. Fail. , vol.21 , pp. 586-593
    • Butts, B.1    Gary, R.A.2    Dunbar, S.B.3    Butler, J.4
  • 10
    • 79960210750 scopus 로고    scopus 로고
    • Programmed cell death in the plant immune system
    • Coll, N. S., Epple, P., and Dangl, J. L. (2011). Programmed cell death in the plant immune system. Cell Death Differ. 18, 1247-1256. doi: 10.1038/cdd.2011.37
    • (2011) Cell Death Differ. , vol.18 , pp. 1247-1256
    • Coll, N.S.1    Epple, P.2    Dangl, J.L.3
  • 11
    • 84888820105 scopus 로고    scopus 로고
    • Role of oxidative stress in chemical allergens induced skin cells activation
    • Corsini, E., Galbiati, V., Nikitovic, D., and Tsatsakis, A. M. (2013). Role of oxidative stress in chemical allergens induced skin cells activation. Food Chem. Toxicol. 61, 74-81. doi: 10.1016/j.fct.2013.02.038
    • (2013) Food Chem. Toxicol. , vol.61 , pp. 74-81
    • Corsini, E.1    Galbiati, V.2    Nikitovic, D.3    Tsatsakis, A.M.4
  • 13
    • 84978419608 scopus 로고    scopus 로고
    • Pore-forming activity and structural autoinhibition of the gasdermin family
    • Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., et al. (2016). Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535, 111-116. doi: 10.1038/nature18590
    • (2016) Nature , vol.535 , pp. 111-116
    • Ding, J.1    Wang, K.2    Liu, W.3    She, Y.4    Sun, Q.5    Shi, J.6
  • 14
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath, M. Y., and Shoelson, S. E. (2011). Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 11, 98-107. doi: 10.1038/nri2925
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 15
    • 77952488104 scopus 로고    scopus 로고
    • Cytokine production by islets in health and diabetes: cellular origin, regulation and function
    • Donath, M. Y., Boni-Schnetzler, M., Ellingsgaard, H., Halban, P. A., and Ehses, J. A. (2010). Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endocrinol. Metab. 21, 261-267. doi: 10.1016/j.tem.2009.12.010
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 261-267
    • Donath, M.Y.1    Boni-Schnetzler, M.2    Ellingsgaard, H.3    Halban, P.A.4    Ehses, J.A.5
  • 16
    • 84858677223 scopus 로고    scopus 로고
    • Sensing and reacting to microbes through the inflammasomes
    • Franchi, L., Munoz-Planillo, R., and Nunez, G. (2012). Sensing and reacting to microbes through the inflammasomes. Nat. Immunol. 13, 325-332. doi: 10.1038/ni.2231
    • (2012) Nat. Immunol. , vol.13 , pp. 325-332
    • Franchi, L.1    Munoz-Planillo, R.2    Nunez, G.3
  • 17
    • 77953488157 scopus 로고    scopus 로고
    • Regulation of inflammasome activity
    • Guarda, G., and So, A. (2010). Regulation of inflammasome activity. Immunology 130, 329-336. doi: 10.1111/j.1365-2567.2010.03283.x
    • (2010) Immunology , vol.130 , pp. 329-336
    • Guarda, G.1    So, A.2
  • 18
    • 84949091051 scopus 로고    scopus 로고
    • Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
    • He, W. T., Wan, H., Hu, L., Chen, P., Wang, X., Huang, Z., et al. (2015). Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res. 25, 1285-1298. doi: 10.1038/cr.2015.139
    • (2015) Cell Res. , vol.25 , pp. 1285-1298
    • He, W.T.1    Wan, H.2    Hu, L.3    Chen, P.4    Wang, X.5    Huang, Z.6
  • 19
    • 84882614243 scopus 로고    scopus 로고
    • Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation
    • Iyer, S. S., He, Q., Janczy, J. R., Elliott, E. I., Zhong, Z., Olivier, A. K., et al. (2013). Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity 39, 311-323. doi: 10.1016/j.immuni.2013.08.001
    • (2013) Immunity , vol.39 , pp. 311-323
    • Iyer, S.S.1    He, Q.2    Janczy, J.R.3    Elliott, E.I.4    Zhong, Z.5    Olivier, A.K.6
  • 20
    • 84945244832 scopus 로고    scopus 로고
    • Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells
    • Jang, Y., Lee, A. Y., Jeong, S. H., Park, K. H., Paik, M. K., Cho, N. J., et al. (2015). Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells. Toxicology 338, 37-46. doi: 10.1016/j.tox.2015.09.006
    • (2015) Toxicology , vol.338 , pp. 37-46
    • Jang, Y.1    Lee, A.Y.2    Jeong, S.H.3    Park, K.H.4    Paik, M.K.5    Cho, N.J.6
  • 21
    • 84939803969 scopus 로고    scopus 로고
    • Oral infections, metabolic inflammation, genetics, and cardiometabolic diseases
    • Janket, S. J., Javaheri, H., Ackerson, L. K., Ayilavarapu, S., and Meurman, J. H. (2015). Oral infections, metabolic inflammation, genetics, and cardiometabolic diseases. J. Dent. Res. 94(9 Suppl.), 119S-127S. doi: 10.1177/0022034515580795
    • (2015) J. Dent. Res. , vol.94 , Issue.9 , pp. 119S-127S
    • Janket, S.J.1    Javaheri, H.2    Ackerson, L.K.3    Ayilavarapu, S.4    Meurman, J.H.5
  • 22
    • 84881192566 scopus 로고    scopus 로고
    • Innate sensors of pathogen and stress: linking inflammation to obesity
    • Jin, C., and Flavell, R. A. (2013). Innate sensors of pathogen and stress: linking inflammation to obesity. J. Allergy Clin. Immunol. 132, 287-294. doi: 10.1016/j.jaci.2013.06.022
    • (2013) J. Allergy Clin. Immunol. , vol.132 , pp. 287-294
    • Jin, C.1    Flavell, R.A.2
  • 23
    • 84959917649 scopus 로고    scopus 로고
    • Molecular mechanisms regulating NLRP3 inflammasome activation
    • Jo, E. K., Kim, J. K., Shin, D. M., and Sasakawa, C. (2016). Molecular mechanisms regulating NLRP3 inflammasome activation. Cell. Mol. Immunol. 13, 148-159. doi: 10.1038/cmi.2015.95
    • (2016) Cell. Mol. Immunol. , vol.13 , pp. 148-159
    • Jo, E.K.1    Kim, J.K.2    Shin, D.M.3    Sasakawa, C.4
  • 24
    • 84942856523 scopus 로고    scopus 로고
    • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
    • Kayagaki, N., Stowe, I. B., Lee, B. L., O'Rourke, K., Anderson, K., Warming, S., et al. (2015). Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666-671. doi: 10.1038/nature15541
    • (2015) Nature , vol.526 , pp. 666-671
    • Kayagaki, N.1    Stowe, I.B.2    Lee, B.L.3    O'Rourke, K.4    Anderson, K.5    Warming, S.6
  • 25
    • 34848908421 scopus 로고    scopus 로고
    • Apoptosis in patients with dilated cardiomyopathy and diabetes: a feature of diabetic cardiomyopathy?
    • Kuethe, F., Sigusch, H. H., Bornstein, S. R., Hilbig, K., Kamvissi, V., and Figulla, H. R. (2007). Apoptosis in patients with dilated cardiomyopathy and diabetes: a feature of diabetic cardiomyopathy? Horm. Metab. Res. 39, 672-676. doi: 10.1055/s-2007-985823
    • (2007) Horm. Metab. Res. , vol.39 , pp. 672-676
    • Kuethe, F.1    Sigusch, H.H.2    Bornstein, S.R.3    Hilbig, K.4    Kamvissi, V.5    Figulla, H.R.6
  • 26
    • 84879744608 scopus 로고    scopus 로고
    • Multiple antioxidants improve cardiac complications and inhibit cardiac cell death in streptozotocin-induced diabetic rats
    • Kumar, S., Prasad, S., and Sitasawad, S. L. (2013). Multiple antioxidants improve cardiac complications and inhibit cardiac cell death in streptozotocin-induced diabetic rats. PLoS ONE 8:e67009. doi: 10.1371/journal.pone.0067009
    • (2013) PLoS ONE , vol.8
    • Kumar, S.1    Prasad, S.2    Sitasawad, S.L.3
  • 27
    • 84901310586 scopus 로고    scopus 로고
    • Mechanisms and functions of inflammasomes
    • Lamkanfi, M., and Dixit, V. M. (2014). Mechanisms and functions of inflammasomes. Cell 157, 1013-1022. doi: 10.1016/j.cell.2014.04.007
    • (2014) Cell , vol.157 , pp. 1013-1022
    • Lamkanfi, M.1    Dixit, V.M.2
  • 29
    • 84908164212 scopus 로고    scopus 로고
    • Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes
    • Legrand-Poels, S., Esser, N., L'Homme, L., Scheen, A., Paquot, N., and Piette, J. (2014). Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes. Biochem. Pharmacol. 92, 131-141. doi: 10.1016/j.bcp.2014.08.013
    • (2014) Biochem. Pharmacol. , vol.92 , pp. 131-141
    • Legrand-Poels, S.1    Esser, N.2    L'Homme, L.3    Scheen, A.4    Paquot, N.5    Piette, J.6
  • 30
    • 84864682160 scopus 로고    scopus 로고
    • IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress
    • Lerner, A. G., Upton, J. P., Praveen, P. V., Ghosh, R., Nakagawa, Y., Igbaria, A., et al. (2012). IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 16, 250-264. doi: 10.1016/j.cmet.2012.07.007
    • (2012) Cell Metab. , vol.16 , pp. 250-264
    • Lerner, A.G.1    Upton, J.P.2    Praveen, P.V.3    Ghosh, R.4    Nakagawa, Y.5    Igbaria, A.6
  • 31
    • 84872290052 scopus 로고    scopus 로고
    • Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion
    • Liao, P. C., Chao, L. K., Chou, J. C., Dong, W. C., Lin, C. N., Lin, C. Y., et al. (2013). Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion. Inflamm. Res. 62, 89-96. doi: 10.1007/s00011-012-0555-2
    • (2013) Inflamm. Res. , vol.62 , pp. 89-96
    • Liao, P.C.1    Chao, L.K.2    Chou, J.C.3    Dong, W.C.4    Lin, C.N.5    Lin, C.Y.6
  • 32
    • 84885143547 scopus 로고    scopus 로고
    • Activin receptor-like kinase 7 mediates high glucose-induced H9c2 cardiomyoblast apoptosis through activation of Smad2/3
    • Liu, L., Ding, W. Y., Zhao, J., Wang, Z. H., Zhong, M., Zhang, W., et al. (2013). Activin receptor-like kinase 7 mediates high glucose-induced H9c2 cardiomyoblast apoptosis through activation of Smad2/3. Int. J. Biochem. Cell Biol. 45, 2027-2035. doi: 10.1016/j.biocel.2013.06.018
    • (2013) Int. J. Biochem. Cell Biol. , vol.45 , pp. 2027-2035
    • Liu, L.1    Ding, W.Y.2    Zhao, J.3    Wang, Z.H.4    Zhong, M.5    Zhang, W.6
  • 33
    • 84978374487 scopus 로고    scopus 로고
    • Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
    • Liu, X., Zhang, Z., Ruan, J., Pan, Y., Magupalli, V. G., Wu, H., et al. (2016). Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature 535, 153-158. doi: 10.1038/nature18629
    • (2016) Nature , vol.535 , pp. 153-158
    • Liu, X.1    Zhang, Z.2    Ruan, J.3    Pan, Y.4    Magupalli, V.G.5    Wu, H.6
  • 34
    • 84988726167 scopus 로고    scopus 로고
    • Effects of berberine on NLRP3 and IL-1β expressions in monocytic THP-1 cells with monosodium urate crystals-induced inflammation
    • Liu, Y. F., Wen, C. Y., Chen, Z., Wang, Y., Huang, Y., and Tu, S. H. (2016). Effects of berberine on NLRP3 and IL-1β expressions in monocytic THP-1 cells with monosodium urate crystals-induced inflammation. Biomed Res. Int. 2016:2503703. doi: 10.1155/2016/2503703
    • (2016) Biomed Res. Int. , vol.2016
    • Liu, Y.F.1    Wen, C.Y.2    Chen, Z.3    Wang, Y.4    Huang, Y.5    Tu, S.H.6
  • 35
    • 84940205401 scopus 로고    scopus 로고
    • Inhibition of caspase-1 activation in endothelial cells improves angiogenesis: a novel therapeutic potential for ischemia
    • Lopez-Pastrana, J., Ferrer, L. M., Li, Y. F., Xiong, X., Xi, H., Cueto, R., et al. (2015). Inhibition of caspase-1 activation in endothelial cells improves angiogenesis: a novel therapeutic potential for ischemia. J. Biol. Chem. 290, 17485-17494. doi: 10.1074/jbc.M115.641191
    • (2015) J. Biol. Chem. , vol.290 , pp. 17485-17494
    • Lopez-Pastrana, J.1    Ferrer, L.M.2    Li, Y.F.3    Xiong, X.4    Xi, H.5    Cueto, R.6
  • 36
    • 0035226546 scopus 로고    scopus 로고
    • Interleukin-1 and related proteins in cardiovascular disease in adults and children
    • Loppnow, H., Westphal, E., Buchhorn, R., Wessel, A., and Werdan, K. (2001). Interleukin-1 and related proteins in cardiovascular disease in adults and children. Shock 16(Suppl. 1), 3-9. doi: 10.1097/00024382-200116001-00002
    • (2001) Shock , vol.16 , pp. 3-9
    • Loppnow, H.1    Westphal, E.2    Buchhorn, R.3    Wessel, A.4    Werdan, K.5
  • 37
    • 84865511926 scopus 로고    scopus 로고
    • Novel role of PKR in inflammasome activation and HMGB1 release
    • Lu, B., Nakamura, T., Inouye, K., Li, J., Tang, Y., Lundback, P., et al. (2012). Novel role of PKR in inflammasome activation and HMGB1 release. Nature 488, 670-674. doi: 10.1038/nature11290
    • (2012) Nature , vol.488 , pp. 670-674
    • Lu, B.1    Nakamura, T.2    Inouye, K.3    Li, J.4    Tang, Y.5    Lundback, P.6
  • 38
    • 84898831401 scopus 로고    scopus 로고
    • Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model
    • Luo, B., Li, B., Wang, W., Liu, X., Liu, X., Xia, Y., et al. (2014a). Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model. Cardiovasc. Drugs Ther. 28, 33-43. doi: 10.1007/s10557-013-6498-1
    • (2014) Cardiovasc. Drugs Ther. , vol.28 , pp. 33-43
    • Luo, B.1    Li, B.2    Wang, W.3    Liu, X.4    Liu, X.5    Xia, Y.6
  • 39
    • 84927700592 scopus 로고    scopus 로고
    • NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model
    • Luo, B., Li, B., Wang, W., Liu, X., Xia, Y., Zhang, C., et al. (2014b). NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model. PLoS ONE 9:e104771. doi: 10.1371/journal.pone.0104771
    • (2014) PLoS ONE , vol.9
    • Luo, B.1    Li, B.2    Wang, W.3    Liu, X.4    Xia, Y.5    Zhang, C.6
  • 40
    • 77749304032 scopus 로고    scopus 로고
    • Signaling by ROS drives inflammasome activation
    • Martinon, F. (2010). Signaling by ROS drives inflammasome activation. Eur. J. Immunol. 40, 616-619. doi: 10.1002/eji.200940168
    • (2010) Eur. J. Immunol. , vol.40 , pp. 616-619
    • Martinon, F.1
  • 41
    • 84953924429 scopus 로고    scopus 로고
    • Maladaptive modulations of NLRP3 inflammasome and cardioprotective pathways are involved in diet-induced exacerbation of myocardial ischemia/reperfusion injury in mice
    • Mastrocola, R., Collino, M., Penna, C., Nigro, D., Chiazza, F., Fracasso, V., et al. (2016a). Maladaptive modulations of NLRP3 inflammasome and cardioprotective pathways are involved in diet-induced exacerbation of myocardial ischemia/reperfusion injury in mice. Oxid. Med. Cell. Longev. 2016:3480637. doi: 10.1155/2016/3480637
    • (2016) Oxid. Med. Cell. Longev. , vol.2016
    • Mastrocola, R.1    Collino, M.2    Penna, C.3    Nigro, D.4    Chiazza, F.5    Fracasso, V.6
  • 42
    • 85008873287 scopus 로고    scopus 로고
    • Pharmacological inhibition of NLRP3 inflammasome attenuates myocardial ischemia/reperfusion injury by activation of RISK and mitochondrial pathways
    • Mastrocola, R., Penna, C., Tullio, F., Femmino, S., Nigro, D., Chiazza, F., et al. (2016b). Pharmacological inhibition of NLRP3 inflammasome attenuates myocardial ischemia/reperfusion injury by activation of RISK and mitochondrial pathways. Oxid. Med. Cell. Longev. 2016:5271251. doi: 10.1155/2016/5271251
    • (2016) Oxid. Med. Cell. Longev. , vol.2016
    • Mastrocola, R.1    Penna, C.2    Tullio, F.3    Femmino, S.4    Nigro, D.5    Chiazza, F.6
  • 43
    • 80052179138 scopus 로고    scopus 로고
    • Caspase-1-induced pyroptotic cell death
    • Miao, E. A., Rajan, J. V., and Aderem, A. (2011). Caspase-1-induced pyroptotic cell death. Immunol. Rev. 243, 206-214. doi: 10.1111/j.1600-065X.2011.01044.x
    • (2011) Immunol. Rev. , vol.243 , pp. 206-214
    • Miao, E.A.1    Rajan, J.V.2    Aderem, A.3
  • 44
    • 0029793103 scopus 로고    scopus 로고
    • Salmonella typhimurium invasion induces apoptosis in infected macrophages
    • Monack, D. M., Raupach, B., Hromockyj, A. E., and Falkow, S. (1996). Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proc. Natl. Acad. Sci. U.S.A. 93, 9833-9838. doi: 10.1073/pnas.93.18.9833
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 9833-9838
    • Monack, D.M.1    Raupach, B.2    Hromockyj, A.E.3    Falkow, S.4
  • 45
    • 79951642032 scopus 로고    scopus 로고
    • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    • Nakahira, K., Haspel, J. A., Rathinam, V. A., Lee, S. J., Dolinay, T., Lam, H. C., et al. (2011). Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222-230. doi: 10.1038/ni.1980
    • (2011) Nat. Immunol. , vol.12 , pp. 222-230
    • Nakahira, K.1    Haspel, J.A.2    Rathinam, V.A.3    Lee, S.J.4    Dolinay, T.5    Lam, H.C.6
  • 46
    • 84944061375 scopus 로고    scopus 로고
    • Molecular interactions governing autoantigen presentation in type 1 diabetes
    • Nakayama, M., Simmons, K. M., and Michels, A. W. (2015). Molecular interactions governing autoantigen presentation in type 1 diabetes. Curr. Diab. Rep. 15, 113. doi: 10.1007/s11892-015-0689-z
    • (2015) Curr. Diab. Rep. , vol.15 , pp. 113
    • Nakayama, M.1    Simmons, K.M.2    Michels, A.W.3
  • 47
    • 84937976664 scopus 로고    scopus 로고
    • Type-2 diabetes: current understanding and future perspectives
    • Pandey, A., Chawla, S., and Guchhait, P. (2015). Type-2 diabetes: current understanding and future perspectives. IUBMB Life 67, 506-513. doi: 10.1002/iub.1396
    • (2015) IUBMB Life , vol.67 , pp. 506-513
    • Pandey, A.1    Chawla, S.2    Guchhait, P.3
  • 48
    • 84870066624 scopus 로고    scopus 로고
    • Effect of interleukin 1β inhibition in cardiovascular disease
    • Qamar, A., and Rader, D. J. (2012). Effect of interleukin 1β inhibition in cardiovascular disease. Curr. Opin. Lipidol. 23, 548-553. doi: 10.1097/MOL.0b013e328359b0a6
    • (2012) Curr. Opin. Lipidol. , vol.23 , pp. 548-553
    • Qamar, A.1    Rader, D.J.2
  • 49
    • 84862807232 scopus 로고    scopus 로고
    • TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages
    • Qiao, Y., Wang, P., Qi, J., Zhang, L., and Gao, C. (2012). TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages. FEBS Lett. 586, 1022-1026. doi: 10.1016/j.febslet.2012.02.045
    • (2012) FEBS Lett. , vol.586 , pp. 1022-1026
    • Qiao, Y.1    Wang, P.2    Qi, J.3    Zhang, L.4    Gao, C.5
  • 50
    • 84978766925 scopus 로고    scopus 로고
    • p38delta MAPK: a novel regulator of NLRP3 inflammasome activation with increased expression in coronary atherogenesis
    • Rajamaki, K., Mayranpaa, M. I., Risco, A., Tuimala, J., Nurmi, K., Cuenda, A., et al. (2016). p38delta MAPK: a novel regulator of NLRP3 inflammasome activation with increased expression in coronary atherogenesis. Arterioscler. Thromb. Vasc. Biol. 36, 1937-1946. doi: 10.1161/ATVBAHA.115.307312
    • (2016) Arterioscler. Thromb. Vasc. Biol. , vol.36 , pp. 1937-1946
    • Rajamaki, K.1    Mayranpaa, M.I.2    Risco, A.3    Tuimala, J.4    Nurmi, K.5    Cuenda, A.6
  • 51
    • 84899140315 scopus 로고    scopus 로고
    • Inflammasomes and metabolic disorders: old genes in modern diseases
    • Robbins, G. R., Wen, H., and Ting, J. P. (2014). Inflammasomes and metabolic disorders: old genes in modern diseases. Mol. Cell 54, 297-308. doi: 10.1016/j.molcel.2014.03.029
    • (2014) Mol. Cell , vol.54 , pp. 297-308
    • Robbins, G.R.1    Wen, H.2    Ting, J.P.3
  • 52
    • 84901350078 scopus 로고    scopus 로고
    • High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling
    • Santiago, J. J., McNaughton, L. J., Koleini, N., Ma, X., Bestvater, B., Nickel, B. E., et al. (2014). High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling. PLoS ONE 9:e97281. doi: 10.1371/journal.pone.0097281
    • (2014) PLoS ONE , vol.9
    • Santiago, J.J.1    McNaughton, L.J.2    Koleini, N.3    Ma, X.4    Bestvater, B.5    Nickel, B.E.6
  • 53
    • 74549184092 scopus 로고    scopus 로고
    • The NLRP3 inflammasome: a sensor for metabolic danger?
    • Schroder, K., Zhou, R., and Tschopp, J. (2010). The NLRP3 inflammasome: a sensor for metabolic danger? Science 327, 296-300. doi: 10.1126/science.1184003
    • (2010) Science , vol.327 , pp. 296-300
    • Schroder, K.1    Zhou, R.2    Tschopp, J.3
  • 54
    • 84923119242 scopus 로고    scopus 로고
    • Old, new and emerging functions of caspases
    • Shalini, S., Dorstyn, L., Dawar, S., and Kumar, S. (2015). Old, new and emerging functions of caspases. Cell Death Differ. 22, 526-539. doi: 10.1038/cdd.2014.216
    • (2015) Cell Death Differ. , vol.22 , pp. 526-539
    • Shalini, S.1    Dorstyn, L.2    Dawar, S.3    Kumar, S.4
  • 55
    • 84949742300 scopus 로고    scopus 로고
    • NLRP3 inflammasome and its inhibitors: a review
    • Shao, B. Z., Xu, Z. Q., Han, B. Z., Su, D. F., and Liu, C. (2015). NLRP3 inflammasome and its inhibitors: a review. Front. Pharmacol. 6:262. doi: 10.3389/fphar.2015.00262
    • (2015) Front. Pharmacol. , vol.6 , pp. 262
    • Shao, B.Z.1    Xu, Z.Q.2    Han, B.Z.3    Su, D.F.4    Liu, C.5
  • 56
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • Shaw, J. E., Sicree, R. A., and Zimmet, P. Z. (2010). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87, 4-14. doi: 10.1016/j.diabres.2009.10.007
    • (2010) Diabetes Res. Clin. Pract. , vol.87 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 57
    • 84860225554 scopus 로고    scopus 로고
    • GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals
    • Shenoy, A. R., Wellington, D. A., Kumar, P., Kassa, H., Booth, C. J., Cresswell, P., et al. (2012). GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science 336, 481-485. doi: 10.1126/science.1217141
    • (2012) Science , vol.336 , pp. 481-485
    • Shenoy, A.R.1    Wellington, D.A.2    Kumar, P.3    Kassa, H.4    Booth, C.J.5    Cresswell, P.6
  • 58
    • 84936985489 scopus 로고    scopus 로고
    • Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress
    • Shi, H., Zhang, Z., Wang, X., Li, R., Hou, W., Bi, W., et al. (2015). Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress. Biochem. Biophys. Res. Commun. 463, 1071-1076. doi: 10.1016/j.bbrc.2015.06.060
    • (2015) Biochem. Biophys. Res. Commun. , vol.463 , pp. 1071-1076
    • Shi, H.1    Zhang, Z.2    Wang, X.3    Li, R.4    Hou, W.5    Bi, W.6
  • 59
    • 85007439966 scopus 로고    scopus 로고
    • Pyroptosis: gasdermin-mediated programmed necrotic cell death
    • Shi, J., Gao, W., and Shao, F. (2017). Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem. Sci. 42, 245-254. doi: 10.1016/j.tibs.2016.10.004
    • (2017) Trends Biochem. Sci. , vol.42 , pp. 245-254
    • Shi, J.1    Gao, W.2    Shao, F.3
  • 60
    • 84942892037 scopus 로고    scopus 로고
    • Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
    • Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., et al. (2015). Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660-665. doi: 10.1038/nature15514
    • (2015) Nature , vol.526 , pp. 660-665
    • Shi, J.1    Zhao, Y.2    Wang, K.3    Shi, X.4    Wang, Y.5    Huang, H.6
  • 61
    • 84898799055 scopus 로고    scopus 로고
    • The NLRP3 inflammasome and diabetic cardiomyopathy: editorial to: "Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model" by Beibei Luo et al
    • Singh, L. P. (2014). The NLRP3 inflammasome and diabetic cardiomyopathy: editorial to: "Rosuvastatin alleviates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome and MAPK pathways in a type 2 diabetes rat model" by Beibei Luo et al. Cardiovasc. Drugs Ther. 28, 5-6. doi: 10.1007/s10557-013-6501-x
    • (2014) Cardiovasc. Drugs Ther. , vol.28 , pp. 5-6
    • Singh, L.P.1
  • 62
    • 84938505204 scopus 로고    scopus 로고
    • Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2
    • Somanna, N. K., Yariswamy, M., Garagliano, J. M., Siebenlist, U., Mummidi, S., Valente, A. J., et al. (2015). Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2. Cell. Signal. 27, 1928-1938. doi: 10.1016/j.cellsig.2015.07.001
    • (2015) Cell. Signal. , vol.27 , pp. 1928-1938
    • Somanna, N.K.1    Yariswamy, M.2    Garagliano, J.M.3    Siebenlist, U.4    Mummidi, S.5    Valente, A.J.6
  • 63
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar, B., Youm, Y. H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., et al. (2011). The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188. doi: 10.1038/nm.2279
    • (2011) Nat. Med. , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3    Galgani, J.E.4    Stadler, K.5    Mynatt, R.L.6
  • 64
    • 85025842565 scopus 로고    scopus 로고
    • Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice
    • [Epub ahead of print]
    • Wang, R., Wang, Y., Mu, N., Lou, X., Li, W., Chen, Y., et al. (2017). Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice. Lab. Invest. doi: 10.1038/labinvest.2017.30. [Epub ahead of print].
    • (2017) Lab. Invest
    • Wang, R.1    Wang, Y.2    Mu, N.3    Lou, X.4    Li, W.5    Chen, Y.6
  • 65
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen, H., Gris, D., Lei, Y., Jha, S., Zhang, L., Huang, M. T., et al. (2011). Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol. 12, 408-415. doi: 10.1038/ni.2022
    • (2011) Nat. Immunol. , vol.12 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3    Jha, S.4    Zhang, L.5    Huang, M.T.6
  • 67
    • 84964199632 scopus 로고    scopus 로고
    • Suppression of plasma free fatty acids reduces myocardial lipid content and systolic function in type 2 diabetes
    • Wolf, P., Winhofer, Y., Krssak, M., Smajis, S., Harreiter, J., Kosi-Trebotic, L., et al. (2016). Suppression of plasma free fatty acids reduces myocardial lipid content and systolic function in type 2 diabetes. Nutr. Metab. Cardiovasc. Dis. 26, 387-392. doi: 10.1016/j.numecd.2016.03.012
    • (2016) Nutr. Metab. Cardiovasc. Dis. , vol.26 , pp. 387-392
    • Wolf, P.1    Winhofer, Y.2    Krssak, M.3    Smajis, S.4    Harreiter, J.5    Kosi-Trebotic, L.6
  • 68
    • 84896709837 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice
    • Wree, A., Eguchi, A., McGeough, M. D., Pena, C. A., Johnson, C. D., Canbay, A., et al. (2014). NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology 59, 898-910. doi: 10.1002/hep.26592
    • (2014) Hepatology , vol.59 , pp. 898-910
    • Wree, A.1    Eguchi, A.2    McGeough, M.D.3    Pena, C.A.4    Johnson, C.D.5    Canbay, A.6
  • 69
    • 84927924699 scopus 로고    scopus 로고
    • Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis: the role of NLRP3 inflammasome activation
    • Zhang, W., Xu, X., Kao, R., Mele, T., Kvietys, P., Martin, C. M., et al. (2014). Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis: the role of NLRP3 inflammasome activation. PLoS ONE 9:e107639. doi: 10.1371/journal.pone.0107639
    • (2014) PLoS ONE , vol.9
    • Zhang, W.1    Xu, X.2    Kao, R.3    Mele, T.4    Kvietys, P.5    Martin, C.M.6
  • 70
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou, R., Tardivel, A., Thorens, B., Choi, I., and Tschopp, J. (2010). Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136-140. doi: 10.1038/ni.1831
    • (2010) Nat. Immunol. , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 71
    • 84959180301 scopus 로고    scopus 로고
    • Lipotoxicity in obesity and diabetes-related cardiac dysfunction
    • Zlobine, I., Gopal, K., and Ussher, J. R. (2016). Lipotoxicity in obesity and diabetes-related cardiac dysfunction. Biochim. Biophys. Acta 1861, 1555-1568. doi: 10.1016/j.bbalip.2016.02.011
    • (2016) Biochim. Biophys. Acta , vol.1861 , pp. 1555-1568
    • Zlobine, I.1    Gopal, K.2    Ussher, J.R.3
  • 72
    • 84929868515 scopus 로고    scopus 로고
    • The mitochondrial Na+/Ca2+ exchanger may reduce high glucose-induced oxidative stress and nucleotide-binding oligomerization domain receptor 3 inflammasome activation in endothelial cells
    • Zu, Y., Wan, L. J., Cui, S. Y., Gong, Y. P., and Li, C. L. (2015). The mitochondrial Na+/Ca2+ exchanger may reduce high glucose-induced oxidative stress and nucleotide-binding oligomerization domain receptor 3 inflammasome activation in endothelial cells. J. Geriatr. Cardiol. 12, 270-278. doi: 10.11909/j.issn.1671-5411.2015.03.003
    • (2015) J. Geriatr. Cardiol. , vol.12 , pp. 270-278
    • Zu, Y.1    Wan, L.J.2    Cui, S.Y.3    Gong, Y.P.4    Li, C.L.5
  • 73
    • 0026635783 scopus 로고
    • Shigella flexneri induces apoptosis in infected macrophages
    • Zychlinsky, A., Prevost, M. C., and Sansonetti, P. J. (1992). Shigella flexneri induces apoptosis in infected macrophages. Nature 358, 167-169. doi: 10.1038/358167a0
    • (1992) Nature , vol.358 , pp. 167-169
    • Zychlinsky, A.1    Prevost, M.C.2    Sansonetti, P.J.3


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