Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome

Journal of Biological Chemistry

Volumn 289, Issue 28, 2014, Pages 19571-19584

  Bracey, Nathan A ^a   Gershkovich, Benjamin ^a   Chun, Justin ^b   Vilaysane, Akosua ^b   Meijndert, H Christopher ^a   Wright Jr , James R ^b   Fedak, Paul W ^a   Beck, Paul L ^b   Muruve, Daniel A ^b   Duff, Henry J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CHEMICAL ACTIVATION; DISEASES; FIBROBLASTS; HEART; OXYGEN; PATTERN RECOGNITION; PROFESSIONAL ASPECTS;

CARDIAC FIBROBLASTS; CHRONIC DISEASE; LEUCINE-RICH REPEATS; NUCLEOTIDE-BINDING DOMAIN; PATTERN RECOGNITION RECEPTORS; PROINFLAMMATORY CYTOKINES; PROTEIN SIGNALING; REACTIVE OXYGEN SPECIES;

PROTEINS;

ADENOSINE TRIPHOSPHATE; ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN II; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; CRYOPYRIN; GELATINASE B; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; REACTIVE OXYGEN METABOLITE; RECEPTOR REGULATED SMAD PROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ELEVATED BLOOD PRESSURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MALE; MITOCHONDRION; MOUSE; MYOFIBROBLAST; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION;

FIBROSIS; HEART FAILURE; INFLAMMATION; MYOFIBROBLAST; TRANSFORMING GROWTH FACTOR Β (TGFΒ);

ANGIOTENSIN II; ANIMALS; CARRIER PROTEINS; COLLAGEN TYPE I; FIBROSIS; HEART DISEASES; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MYOCARDIUM; MYOFIBROBLASTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMAD PROTEINS, RECEPTOR-REGULATED; TRANSFORMING GROWTH FACTOR BETA; VASOCONSTRICTOR AGENTS;

EID: 84904214756     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.550624     Document Type: Article

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