NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Luo, Beibei ^a   Li, Bo ^a   Wang, Wenke ^a   Liu, Xiangjuan ^a   Xia, Yanfei ^a   Zhang, Cheng ^a   Zhang, Mingxiang ^a   Zhang, Yun ^a   An, Fengshuang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MICRORNA; NUCLEAR PROTEIN; PROCASPASE 1; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STREPTOZOCIN; THIOREDOXIN INTERACTING PROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CARRIER PROTEIN; INFLAMMASOME; NOD-LIKE RECEPTOR 3, RAT; PYCARD PROTEIN, RAT; TXNIP PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDITIS; CELL ACTIVATION; CELL DEATH; CELL STRAIN; CELL STRAIN H9C2; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DISEASE SEVERITY; ENZYME ACTIVATION; GENE ACTIVATION; GENE SILENCING; GENE THERAPY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; METABOLIC DISORDER; NLRP3 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; PYROPTOSIS; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SYSTEMIC DISEASE; TRANSCRIPTION REGULATION; TRANSTHORACIC ECHOCARDIOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; COMPLICATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; GENE EXPRESSION REGULATION; GENETICS; LIPID DIET; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CASPASE 1; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; DIET, HIGH-FAT; GENE EXPRESSION REGULATION; GENE SILENCING; INFLAMMASOMES; INTERLEUKIN-1BETA; MYOCYTES, CARDIAC; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 84927700592     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104771     Document Type: Article

References (49)

1. Boudina S, Abel ED (2010) Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord 11: 31-39.
2. Falcao-Pires I, Leite-Moreira AF (2012) Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart Fail Rev 17: 325-344.
3. Cai L (2006) Suppression of nitrative damage by metallothionein in diabetic heart contributes to the prevention of cardiomyopathy. Free Radic Biol Med 41: 851-861.
4. Cai L, Wang Y, Zhou G, Chen T, Song Y, et al. (2006) Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. J Am Coll Cardiol 48: 1688-1697. (Pubitemid 44528172)
5. Tsai KH, Wang WJ, Lin CW, Pai P, Lai TY, et al. (2012) NADPH oxidase-derived superoxide anion-induced apoptosis is mediated via the JNK-dependent activation of NF-kappaB in cardiomyocytes exposed to high glucose. J Cell Physiol 227: 1347-1357.
6. Devi TS, Lee I, Huttemann M, Kumar A, Nantwi KD, et al. (2012) TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy. Exp Diabetes Res 2012: 438238.
7. Bryant C, Fitzgerald KA (2009) Molecular mechanisms involved in inflammasome activation. Trends Cell Biol 19: 455-464.
8. Lee HM, Kim JJ, Kim HJ, Shong M, Ku BJ, et al. (2013) Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes 62: 194-204.
9. Wang C, Pan Y, Zhang QY, Wang FM, Kong LD (2012) Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. PLoS One 7: e38285.
10. Franchi L, Munoz-Planillo R, Nunez G (2012) Sensing and reacting to microbes through the inflammasomes. Nat Immunol 13: 325-332.
11. Schroder K, Zhou R, Tschopp J (2010) The NLRP3 inflammasome: a sensor for metabolic danger? Science 327: 296-300.
12. Schroder K, Tschopp J (2010) The inflammasomes. Cell 140: 821-832.
13. Lamkanfi M, Kanneganti TD (2010) Nlrp3: an immune sensor of cellular stress and infection. Int J Biochem Cell Biol 42: 792-795.
14. Bujak M, Frangogiannis NG (2009) The role of IL-1 in the pathogenesis of heart disease. Arch Immunol Ther Exp (Warsz) 57: 165-176.
15. Coll NS, Epple P, Dangl JL (2011) Programmed cell death in the plant immune system. Cell Death Differ 18: 1247-1256.
16. Guarda G, So A (2010) Regulation of inflammasome activity. Immunology 130: 329-336.
17. Miao EA, Rajan JV, Aderem A (2011) Caspase-1-induced pyroptotic cell death. Immunol Rev 243: 206-214.
18. Lin J, Shou X, Mao X, Dong J, Mohabeer N, et al. (2013) Oxidized low density lipoprotein induced caspase-1 mediated pyroptotic cell death in macrophages: implication in lesion instability? PLoS One 8: e62148.
19. Fink SL, Bergsbaken T, Cookson BT (2008) Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc Natl Acad Sci U S A 105: 4312-4317. (Pubitemid 351754377)
20. Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, et al. (2010) Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 11: 1136-1142.
21. Lian LH, Milora KA, Manupipatpong KK, Jensen LE (2012) The double-stranded RNA analogue polyinosinic-polycytidylic acid induces keratinocyte pyroptosis and release of IL-36gamma. J Invest Dermatol 132: 1346-1353.
22. Chung SD, Lai TY, Chien CT, Yu HJ (2012) Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney. PLoS One 7: e47299.
23. Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, et al. (2013) NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation and fibrosis. Hepatology.
24. Shen X, Zheng S, Metreveli NS, Epstein PN (2006) Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy. Diabetes 55: 798-805. (Pubitemid 43343239)
25. Van Linthout S, Spillmann F, Riad A, Trimpert C, Lievens J, et al. (2008) Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy. Circulation 117: 1563-1573. (Pubitemid 351444665)
26. Yu W, Wu J, Cai F, Xiang J, Zha W, et al. (2012) Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One 7: e52013.
27. Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, et al. (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183: 787-791.
28. Simard JC, Cesaro A, Chapeton-Montes J, Tardif M, Antoine F, et al. (2013) S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-kappaB(1.). PLoS One 8: e72138.
29. Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J (2010) Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 11: 136-140.
30. Lacombe VA, Viatchenko-Karpinski S, Terentyev D, Sridhar A, Emani S, et al. (2007) Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol 293: R1787-1797. (Pubitemid 350085654)
31. Ti Y, Xie GL, Wang ZH, Bi XL, Ding WY, et al. (2011) TRB3 gene silencing alleviates diabetic cardiomyopathy in a type 2 diabetic rat model. Diabetes 60: 2963-2974.
32. Maeda H, Nagai H, Takemura G, Shintani-Ishida K, Komatsu M, et al. (2013) Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart. Biochim Biophys Acta 1832: 1159-1166.
33. Liu X, Li B, Wang W, Zhang C, Zhang M, et al. (2012) Effects of HMG-CoA reductase inhibitor on experimental autoimmune myocarditis. Cardiovasc Drugs Ther 26: 121-130.
34. Luo B, Wang F, Li B, Dong Z, Liu X, et al. (2013) Association of nucleotide-binding oligomerization domain-like receptor 3 inflammasome and adverse clinical outcomes in patients with idiopathic dilated cardiomyopathy. Clin Chem Lab Med 51: 1521-1528.
35. Liu L, Ding WY, Zhao J, Wang ZH, Zhong M, et al. (2013) Activin receptor-like kinase 7 mediates high glucose-induced H9c2 cardiomyoblast apoptosis through activation of Smad2/3. Int J Biochem Cell Biol 45: 2027-2035.
36. Dong Z, An F, Wu T, Zhang C, Zhang M, et al. (2011) PTX3, a key component of innate immunity, is induced by SAA via FPRL1-mediated signaling in HAECs. J Cell Biochem 112: 2097-2105.
37. Bell DS (2008) Diabetes: a cardiac condition manifesting as hyperglycemia. Endocr Pract 14: 924-932.
38. Devereux RB, Roman MJ, Paranicas M, O'Grady MJ, Lee ET, et al. (2000) Impact of diabetes on cardiac structure and function: the strong heart study. Circulation 101: 2271-2276. (Pubitemid 30317129)
39. McCoy AJ, Koizumi Y, Higa N, Suzuki T (2010) Differential regulation of caspase-1 activation via NLRP3/NLRC4 inflammasomes mediated by aerolysin and type III secretion system during Aeromonas veronii infection. J Immunol 185: 7077-7084.
40. Yang JR, Yao FH, Zhang JG, Ji ZY, Li KL, et al. (2013) Ischemia/Reperfusion Induces Renal Tubule Pyroptosis via the CHOP-Caspase-11 Pathway. Am J Physiol Renal Physiol.
41. Fink SL, Cookson BT (2006) Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol 8: 1812-1825. (Pubitemid 44530672)
42. van de Weijer T, Schrauwen-Hinderling VB, Schrauwen P (2011) Lipotoxicity in type 2 diabetic cardiomyopathy. Cardiovasc Res 92: 10-18.
43. Asbun J, Villarreal FJ (2006) The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. J Am Coll Cardiol 47: 693-700. (Pubitemid 43243087)
44. Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, et al. (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320: 674-677. (Pubitemid 351928351)
45. Liao PC, Chao LK, Chou JC, Dong WC, Lin CN, et al. (2013) Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1beta secretion. Inflamm Res 62: 89-96.
46. Corsini E, Galbiati V, Nikitovic D, Tsatsakis AM (2013) Role of oxidative stress in chemical allergens induced skin cells activation. Food Chem Toxicol.
47. Martinon F (2010) Signaling by ROS drives inflammasome activation. Eur J Immunol 40: 616-619.
48. Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, et al. (2010) Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat Immunol 11: 897-904.
49. Mohamed IN, Hafez SS, Fairaq A, Ergul A, Imig JD, et al. (2014) Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet. Diabetologia 57: 413-423.