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Volumn 131, Issue 14, 2017, Pages 1723-1735

Pathogenesis of asthma: Implications for precision medicine

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY REMODELING; ASTHMA; COMORBIDITY; GENETICS; HUMAN; PATHOGENESIS; PERSONALIZED MEDICINE; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; REVIEW; COMPLICATION; EOSINOPHILIA; GENETIC PREDISPOSITION; INFLAMMATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RESPIRATORY HYPERSENSITIVITY;

EID: 85021853693     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20160253     Document Type: Review
Times cited : (119)

References (92)
  • 1
    • 78049457548 scopus 로고    scopus 로고
    • Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma
    • Bousquet, J., Mantzouranis, E., Cruz, A.A., Ait-Khaled, N., Baena-Cagnani, C.E., Bleecker, E.R. et al. (2010) Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J. Allergy. Clin. Immunol. 126, 926-938
    • (2010) J. Allergy. Clin. Immunol , vol.126 , pp. 926-938
    • Bousquet, J.1    Mantzouranis, E.2    Cruz, A.A.3    Ait-Khaled, N.4    Baena-Cagnani, C.E.5    Bleecker, E.R.6
  • 5
    • 84893513577 scopus 로고    scopus 로고
    • International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
    • Chung, K.F., Wenzel, S.E., Brozek, J.L., Bush, A., Castro, M., Sterk, P.J. et al. (2014) International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur. Respir. J. 43, 343-373
    • (2014) Eur. Respir. J , vol.43 , pp. 343-373
    • Chung, K.F.1    Wenzel, S.E.2    Brozek, J.L.3    Bush, A.4    Castro, M.5    Sterk, P.J.6
  • 6
    • 84860679595 scopus 로고    scopus 로고
    • Asthma phenotypes: the evolution from clinical to molecular approaches
    • Wenzel, S.E. (2012) Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 18, 716-725
    • (2012) Nat. Med , vol.18 , pp. 716-725
    • Wenzel, S.E.1
  • 9
    • 85008174139 scopus 로고    scopus 로고
    • New concepts in asthma: clinical phenotypes and pathophysiological mechanisms
    • Koczulla, A.R., Vogelmeier, C.F., Garn, H. and Renz, H. (2017) New concepts in asthma: clinical phenotypes and pathophysiological mechanisms. Drug Discov. Today 22, 388-396
    • (2017) Drug Discov. Today , vol.22 , pp. 388-396
    • Koczulla, A.R.1    Vogelmeier, C.F.2    Garn, H.3    Renz, H.4
  • 12
    • 84866995093 scopus 로고    scopus 로고
    • Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA
    • Ramasamy, A., Kuokkanen, M., Vedantam, S., Gajdos, Z.K., Couto Alves, A., Lyon, H.N. et al. (2012) Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS ONE 7, e44008
    • (2012) PLoS ONE , vol.7
    • Ramasamy, A.1    Kuokkanen, M.2    Vedantam, S.3    Gajdos, Z.K.4    Couto Alves, A.5    Lyon, H.N.6
  • 13
    • 34547216747 scopus 로고    scopus 로고
    • Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    • Moffatt, M.F., Kabesch, M., Liang, L., Dixon, A.L., Strachan, D., Heath, S. et al. (2007) Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448, 470-473
    • (2007) Nature , vol.448 , pp. 470-473
    • Moffatt, M.F.1    Kabesch, M.2    Liang, L.3    Dixon, A.L.4    Strachan, D.5    Heath, S.6
  • 14
    • 84891372721 scopus 로고    scopus 로고
    • A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
    • Bonnelykke, K., Sleiman, P., Nielsen, K., Kreiner-Moller, E., Mercader, J.M., Belgrave, D. et al. (2014) A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat. Genet. 46, 51-55
    • (2014) Nat. Genet , vol.46 , pp. 51-55
    • Bonnelykke, K.1    Sleiman, P.2    Nielsen, K.3    Kreiner-Moller, E.4    Mercader, J.M.5    Belgrave, D.6
  • 15
    • 84865291081 scopus 로고    scopus 로고
    • Genome-wide association study to identify genetic determinants of severe asthma
    • Wan, Y.I., Shrine, N.R., Soler Artigas, M., Wain, L.V., Blakey, J.D., Moffatt, M.F. et al. (2012) Genome-wide association study to identify genetic determinants of severe asthma. Thorax 67, 762-768
    • (2012) Thorax , vol.67 , pp. 762-768
    • Wan, Y.I.1    Shrine, N.R.2    Soler Artigas, M.3    Wain, L.V.4    Blakey, J.D.5    Moffatt, M.F.6
  • 17
    • 0036795111 scopus 로고    scopus 로고
    • Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    • Green, R.H., Brightling, C.E., Woltmann, G., Parker, D., Wardlaw, A.J. and Pavord, I.D. (2002) Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 57, 875-879
    • (2002) Thorax , vol.57 , pp. 875-879
    • Green, R.H.1    Brightling, C.E.2    Woltmann, G.3    Parker, D.4    Wardlaw, A.J.5    Pavord, I.D.6
  • 19
    • 0036310908 scopus 로고    scopus 로고
    • Non-eosinophilic asthma: importance and possible mechanisms
    • Douwes, J., Gibson, P., Pekkanen, J. and Pearce, N. (2002) Non-eosinophilic asthma: importance and possible mechanisms. Thorax 57, 643-648
    • (2002) Thorax , vol.57 , pp. 643-648
    • Douwes, J.1    Gibson, P.2    Pekkanen, J.3    Pearce, N.4
  • 20
    • 84873136114 scopus 로고    scopus 로고
    • Eosinophils as diagnostic tools in chronic lung disease
    • Eltboli, O. and Brightling, C.E. (2013) Eosinophils as diagnostic tools in chronic lung disease. Expert Rev. Respir. Med. 7, 33-42
    • (2013) Expert Rev. Respir. Med , vol.7 , pp. 33-42
    • Eltboli, O.1    Brightling, C.E.2
  • 21
    • 84922273103 scopus 로고    scopus 로고
    • The immunology of asthma
    • Lambrecht, B.N. and Hammad, H. (2015) The immunology of asthma. Nat. Immunol. 16, 45-56
    • (2015) Nat. Immunol , vol.16 , pp. 45-56
    • Lambrecht, B.N.1    Hammad, H.2
  • 22
    • 36249028771 scopus 로고    scopus 로고
    • Repeatability of inflammatory parameters in induced sputum of COPD patients
    • Boorsma, M., Lutter, R., van de Pol, M.A., Out, T.A., Jansen, H.M., Jonkers, R.E. et al. (2007) Repeatability of inflammatory parameters in induced sputum of COPD patients. Copd 4, 321-329
    • (2007) Copd , vol.4 , pp. 321-329
    • Boorsma, M.1    Lutter, R.2    van de Pol, M.A.3    Out, T.A.4    Jansen, H.M.5    Jonkers, R.E.6
  • 24
    • 77953963471 scopus 로고    scopus 로고
    • Eosinophil protein in airway macrophages: a novel biomarker of eosinophilic inflammation in patients with asthma
    • Kulkarni, N.S., Hollins, F., Sutcliffe, A., Saunders, R., Shah, S., Siddiqui, S. et al. (2010) Eosinophil protein in airway macrophages: a novel biomarker of eosinophilic inflammation in patients with asthma. J. Allergy Clin. Immunol. 126, 61.e3-9.e3
    • (2010) J. Allergy Clin. Immunol , vol.126 , pp. 61.e3-69.e3
    • Kulkarni, N.S.1    Hollins, F.2    Sutcliffe, A.3    Saunders, R.4    Shah, S.5    Siddiqui, S.6
  • 25
    • 0033956855 scopus 로고    scopus 로고
    • Changes in sputum eosinophils predict loss of asthma control
    • Jatakanon, A., Lim, S. and Barnes, P.J. (2000) Changes in sputum eosinophils predict loss of asthma control. Am. J. Respir. Crit. Care Med. 161, 64-72
    • (2000) Am. J. Respir. Crit. Care Med , vol.161 , pp. 64-72
    • Jatakanon, A.1    Lim, S.2    Barnes, P.J.3
  • 26
    • 84940733208 scopus 로고    scopus 로고
    • Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies
    • Hanania, N.A., Noonan, M., Corren, J., Korenblat, P., Zheng, Y., Fischer, S.K. et al. (2015) Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies. Thorax 70, 748-756
    • (2015) Thorax , vol.70 , pp. 748-756
    • Hanania, N.A.1    Noonan, M.2    Corren, J.3    Korenblat, P.4    Zheng, Y.5    Fischer, S.K.6
  • 27
    • 84958886796 scopus 로고    scopus 로고
    • Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
    • Heaney, L.G., Djukanovic, R., Woodcock, A., Walker, S., Matthews, J.G., Pavord, I.D. et al. (2016) Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK). Thorax 71, 187-189
    • (2016) Thorax , vol.71 , pp. 187-189
    • Heaney, L.G.1    Djukanovic, R.2    Woodcock, A.3    Walker, S.4    Matthews, J.G.5    Pavord, I.D.6
  • 28
    • 84856759567 scopus 로고    scopus 로고
    • OX40/OX40 ligand interactions in T-cell regulation and asthma
    • Kaur, D. and Brightling, C. (2012) OX40/OX40 ligand interactions in T-cell regulation and asthma. Chest 141, 494-499
    • (2012) Chest , vol.141 , pp. 494-499
    • Kaur, D.1    Brightling, C.2
  • 31
    • 0031756409 scopus 로고    scopus 로고
    • The origins of basophils and eosinophils in allergic inflammation
    • Denburg, J.A. (1998) The origins of basophils and eosinophils in allergic inflammation. J. Allergy Clin. Immunol. 102, S74-S746
    • (1998) J. Allergy Clin. Immunol , vol.102 , pp. S74-S746
    • Denburg, J.A.1
  • 32
    • 0030831869 scopus 로고    scopus 로고
    • Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects A novel marker of progenitor cell commitment towards eosinophilic differentiation
    • Sehmi, R., Wood, L.J., Watson, R., Foley, R., Hamid, Q., O'Byrne, P.M. et al. (1997) Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation. J. Clin. Invest. 100, 2466-2475
    • (1997) J. Clin. Invest , vol.100 , pp. 2466-2475
    • Sehmi, R.1    Wood, L.J.2    Watson, R.3    Foley, R.4    Hamid, Q.5    O'Byrne, P.M.6
  • 34
    • 84953439931 scopus 로고    scopus 로고
    • Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease
    • George, L. and Brightling, C.E. (2016) Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease. Ther. Adv. Chronic Dis. 7, 34-51
    • (2016) Ther. Adv. Chronic Dis , vol.7 , pp. 34-51
    • George, L.1    Brightling, C.E.2
  • 35
    • 84873408369 scopus 로고    scopus 로고
    • Targeting eosinophils in allergy, inflammation and beyond
    • Fulkerson, P.C. and Rothenberg, M.E. (2013) Targeting eosinophils in allergy, inflammation and beyond. Nat. Rev. Drug Discov. 12, 117-129
    • (2013) Nat. Rev. Drug Discov , vol.12 , pp. 117-129
    • Fulkerson, P.C.1    Rothenberg, M.E.2
  • 36
    • 18144392707 scopus 로고    scopus 로고
    • Gradual increase in priming of human eosinophils during extravasation from peripheral blood to the airways in response to allergen challenge
    • Luijk, B., Lindemans, C.A., Kanters, D., van der Heijde, R., Bertics, P., Lammers, J.W. et al. (2005) Gradual increase in priming of human eosinophils during extravasation from peripheral blood to the airways in response to allergen challenge. J. Allergy Clin. Immunol. 115, 997-1003
    • (2005) J. Allergy Clin. Immunol , vol.115 , pp. 997-1003
    • Luijk, B.1    Lindemans, C.A.2    Kanters, D.3    van der Heijde, R.4    Bertics, P.5    Lammers, J.W.6
  • 37
    • 0029685912 scopus 로고    scopus 로고
    • Role of interleukin-4 and vascular cell adhesion molecule-1 in selective eosinophil migration into the airways in allergic asthma
    • Fukuda, T., Fukushima, Y., Numao, T., Ando, N., Arima, M., Nakajima, H. et al. (1996) Role of interleukin-4 and vascular cell adhesion molecule-1 in selective eosinophil migration into the airways in allergic asthma. Am. J. Respir. Cell Mol. Biol. 14, 84-94
    • (1996) Am. J. Respir. Cell Mol. Biol , vol.14 , pp. 84-94
    • Fukuda, T.1    Fukushima, Y.2    Numao, T.3    Ando, N.4    Arima, M.5    Nakajima, H.6
  • 39
    • 0032533215 scopus 로고    scopus 로고
    • Eosinophil tethering to interleukin-4-activated endothelial cells requires both P-selectin and vascular cell adhesion molecule-1
    • Patel, K.D. (1998) Eosinophil tethering to interleukin-4-activated endothelial cells requires both P-selectin and vascular cell adhesion molecule-1. Blood 92, 3904-3911
    • (1998) Blood , vol.92 , pp. 3904-3911
    • Patel, K.D.1
  • 40
    • 0034657274 scopus 로고    scopus 로고
    • Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow
    • Woltmann, G., McNulty, C.A., Dewson, G., Symon, F.A. and Wardlaw, A.J. (2000) Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow. Blood 95, 3146-3152
    • (2000) Blood , vol.95 , pp. 3146-3152
    • Woltmann, G.1    McNulty, C.A.2    Dewson, G.3    Symon, F.A.4    Wardlaw, A.J.5
  • 41
    • 33644883892 scopus 로고    scopus 로고
    • Asthma, allergy and chemokines
    • Pease, J.E. (2006) Asthma, allergy and chemokines. Curr. Drug Targets 7, 3-12
    • (2006) Curr. Drug Targets , vol.7 , pp. 3-12
    • Pease, J.E.1
  • 42
    • 79955733273 scopus 로고    scopus 로고
    • Eosinophils, bronchitis and asthma: pathogenesis of cough and airflow obstruction
    • Brightling, C.E. (2011) Eosinophils, bronchitis and asthma: pathogenesis of cough and airflow obstruction. Pulm. Pharmacol. Ther. 24, 324-327
    • (2011) Pulm. Pharmacol. Ther , vol.24 , pp. 324-327
    • Brightling, C.E.1
  • 43
    • 84865538716 scopus 로고    scopus 로고
    • Cysteinyl leukotriene receptors, old and new; implications for asthma
    • Laidlaw, T.M. and Boyce, J.A. (2012) Cysteinyl leukotriene receptors, old and new; implications for asthma. Clin. Exp. Allergy 42, 1313-1320
    • (2012) Clin. Exp. Allergy , vol.42 , pp. 1313-1320
    • Laidlaw, T.M.1    Boyce, J.A.2
  • 44
    • 84922367959 scopus 로고    scopus 로고
    • D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells
    • Stinson, S.E., Amrani, Y. and Brightling, C.E. (2015) D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells. J. Allergy Clin. Immunol. 135, 395-406
    • (2015) J. Allergy Clin. Immunol , vol.135 , pp. 395-406
    • Stinson, S.E.1    Amrani, Y.2    Brightling, C.E.3
  • 45
    • 0035862329 scopus 로고    scopus 로고
    • Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
    • Hirai, H., Tanaka, K., Yoshie, O., Ogawa, K., Kenmotsu, K., Takamori, Y. et al. (2001) Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 193, 255-261
    • (2001) J. Exp. Med , vol.193 , pp. 255-261
    • Hirai, H.1    Tanaka, K.2    Yoshie, O.3    Ogawa, K.4    Kenmotsu, K.5    Takamori, Y.6
  • 46
    • 84989904460 scopus 로고    scopus 로고
    • Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial
    • Gonem, S., Berair, R., Singapuri, A., Hartley, R., Laurencin, M.F., Bacher, G. et al. (2016) Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial. Lancet Respir. Med. 4, 699-707
    • (2016) Lancet Respir. Med , vol.4 , pp. 699-707
    • Gonem, S.1    Berair, R.2    Singapuri, A.3    Hartley, R.4    Laurencin, M.F.5    Bacher, G.6
  • 48
    • 84908374296 scopus 로고    scopus 로고
    • Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation
    • Beale, J., Jayaraman, A., Jackson, D.J., Macintyre, J.D., Edwards, M.R., Walton, R.P. et al. (2014) Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation. Sci. Transl. Med. 6, 256ra134
    • (2014) Sci. Transl. Med , vol.6
    • Beale, J.1    Jayaraman, A.2    Jackson, D.J.3    Macintyre, J.D.4    Edwards, M.R.5    Walton, R.P.6
  • 49
    • 78649884336 scopus 로고    scopus 로고
    • IL-33 family members and asthma-bridging innate and adaptive immune responses
    • Lloyd, C.M. (2010) IL-33 family members and asthma-bridging innate and adaptive immune responses. Curr. Opin. Immunol. 22, 800-806
    • (2010) Curr. Opin. Immunol , vol.22 , pp. 800-806
    • Lloyd, C.M.1
  • 50
    • 85003698513 scopus 로고    scopus 로고
    • Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma
    • Mitchell, P.D. and O'Byrne, P.M. (2017) Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma. Pharmacol. Ther. 169, 104-112
    • (2017) Pharmacol. Ther , vol.169 , pp. 104-112
    • Mitchell, P.D.1    O'Byrne, P.M.2
  • 51
    • 84922607138 scopus 로고    scopus 로고
    • The biology of innate lymphoid cells
    • Artis, D. and Spits, H. (2015) The biology of innate lymphoid cells. Nature 517, 293-301
    • (2015) Nature , vol.517 , pp. 293-301
    • Artis, D.1    Spits, H.2
  • 53
    • 84989808988 scopus 로고    scopus 로고
    • Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials
    • Hanania, N.A., Korenblat, P., Chapman, K.R., Bateman, E.D., Kopecky, P., Paggiaro, P. et al. (2016) Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir. Med. 4, 781-796
    • (2016) Lancet Respir. Med , vol.4 , pp. 781-796
    • Hanania, N.A.1    Korenblat, P.2    Chapman, K.R.3    Bateman, E.D.4    Kopecky, P.5    Paggiaro, P.6
  • 54
    • 84941182925 scopus 로고    scopus 로고
    • Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial
    • Brightling, C.E., Chanez, P., Leigh, R., O'Byrne, P.M., Korn, S., She, D. et al. (2015) Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Respir. Med. 3, 692-701
    • (2015) Lancet Respir. Med , vol.3 , pp. 692-701
    • Brightling, C.E.1    Chanez, P.2    Leigh, R.3    O'Byrne, P.M.4    Korn, S.5    She, D.6
  • 57
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
    • Pavord, I.D., Korn, S., Howarth, P., Bleecker, E.R., Buhl, R., Keene, O.N. et al. (2012) Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. The Lancet 380, 651-659
    • (2012) The Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3    Bleecker, E.R.4    Buhl, R.5    Keene, O.N.6
  • 59
    • 84929026123 scopus 로고    scopus 로고
    • Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials
    • Castro, M., Zangrilli, J., Wechsler, M.E., Bateman, E.D., Brusselle, G.G., Bardin, P. et al. (2015) Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir. Med. 3, 355-366
    • (2015) Lancet Respir. Med , vol.3 , pp. 355-366
    • Castro, M.1    Zangrilli, J.2    Wechsler, M.E.3    Bateman, E.D.4    Brusselle, G.G.5    Bardin, P.6
  • 60
    • 84994908383 scopus 로고    scopus 로고
    • Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting beta2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial
    • Bleecker, E.R., FitzGerald, J.M., Chanez, P., Papi, A., Weinstein, S.F., Barker, P. et al. (2016) Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting beta2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet 388, 2115-2127
    • (2016) Lancet , vol.388 , pp. 2115-2127
    • Bleecker, E.R.1    FitzGerald, J.M.2    Chanez, P.3    Papi, A.4    Weinstein, S.F.5    Barker, P.6
  • 61
    • 84994910846 scopus 로고    scopus 로고
    • Benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial
    • FitzGerald, J.M., Bleecker, E.R., Nair, P., Korn, S., Ohta, K., Lommatzsch, M. et al. (2016) Benralizumab, an anti-interleukin-5 receptor alpha monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 288, 2128-2141
    • (2016) Lancet , vol.288 , pp. 2128-2141
    • FitzGerald, J.M.1    Bleecker, E.R.2    Nair, P.3    Korn, S.4    Ohta, K.5    Lommatzsch, M.6
  • 63
    • 73149096712 scopus 로고    scopus 로고
    • Qualitative analysis of high-resolution CT scans in severe asthma
    • Gupta, S., Siddiqui, S., Haldar, P., Raj, J.V., Entwisle, J.J., Wardlaw, A.J. et al. (2009) Qualitative analysis of high-resolution CT scans in severe asthma. Chest 136, 1521-1528
    • (2009) Chest , vol.136 , pp. 1521-1528
    • Gupta, S.1    Siddiqui, S.2    Haldar, P.3    Raj, J.V.4    Entwisle, J.J.5    Wardlaw, A.J.6
  • 64
    • 84973551910 scopus 로고    scopus 로고
    • Novel approaches to the management of noneosinophilic asthma
    • Thomson, N.C. (2016) Novel approaches to the management of noneosinophilic asthma. Ther. Adv. Respir. Dis. 10, 211-234
    • (2016) Ther. Adv. Respir. Dis , vol.10 , pp. 211-234
    • Thomson, N.C.1
  • 65
    • 75549087844 scopus 로고    scopus 로고
    • Immune responses of airway neutrophils are impaired in asthma
    • Baines, K.J., Simpson, J.L., Scott, R.J. and Gibson, P.G. (2009) Immune responses of airway neutrophils are impaired in asthma. Exp. Lung Res. 35, 554-569
    • (2009) Exp. Lung Res , vol.35 , pp. 554-569
    • Baines, K.J.1    Simpson, J.L.2    Scott, R.J.3    Gibson, P.G.4
  • 66
    • 84862754513 scopus 로고    scopus 로고
    • Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma
    • Essilfie, A.T., Simpson, J.L., Dunkley, M.L., Morgan, L.C., Oliver, B.G., Gibson, P.G. et al. (2012) Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma. Thorax 67, 588-599
    • (2012) Thorax , vol.67 , pp. 588-599
    • Essilfie, A.T.1    Simpson, J.L.2    Dunkley, M.L.3    Morgan, L.C.4    Oliver, B.G.5    Gibson, P.G.6
  • 67
    • 84875219719 scopus 로고    scopus 로고
    • Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial
    • Brusselle, G.G., Vanderstichele, C., Jordens, P., Deman, R., Slabbynck, H., Ringoet, V. et al. (2013) Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. Thorax 68, 322-329
    • (2013) Thorax , vol.68 , pp. 322-329
    • Brusselle, G.G.1    Vanderstichele, C.2    Jordens, P.3    Deman, R.4    Slabbynck, H.5    Ringoet, V.6
  • 69
    • 78349269946 scopus 로고    scopus 로고
    • Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
    • Doe, C., Bafadhel, M., Siddiqui, S., Desai, D., Mistry, V., Rugman, P. et al. (2010) Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest 138, 1140-1147
    • (2010) Chest , vol.138 , pp. 1140-1147
    • Doe, C.1    Bafadhel, M.2    Siddiqui, S.3    Desai, D.4    Mistry, V.5    Rugman, P.6
  • 70
    • 84890026323 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
    • Busse, W.W., Holgate, S., Kerwin, E., Chon, Y., Feng, J., Lin, J. et al. (2013) Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am. J. Respir. Crit. Care Med. 188, 1294-1302
    • (2013) Am. J. Respir. Crit. Care Med , vol.188 , pp. 1294-1302
    • Busse, W.W.1    Holgate, S.2    Kerwin, E.3    Chon, Y.4    Feng, J.5    Lin, J.6
  • 73
    • 0346216118 scopus 로고    scopus 로고
    • Interleukin-4 and-13 expression is co-localized to mast cells within the airway smooth muscle in asthma
    • Brightling, C.E., Symon, F.A., Holgate, S.T., Wardlaw, A.J., Pavord, I.D. and Bradding, P. (2003) Interleukin-4 and-13 expression is co-localized to mast cells within the airway smooth muscle in asthma. Clin. Exp. Allergy 33, 1711-1716
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 1711-1716
    • Brightling, C.E.1    Symon, F.A.2    Holgate, S.T.3    Wardlaw, A.J.4    Pavord, I.D.5    Bradding, P.6
  • 75
    • 78650650196 scopus 로고    scopus 로고
    • Mast cell fibroblastoid differentiation mediated by airway smooth muscle in asthma
    • Kaur, D., Saunders, R., Hollins, F., Woodman, L., Doe, C., Siddiqui, S. et al. (2010) Mast cell fibroblastoid differentiation mediated by airway smooth muscle in asthma. J. Immunol. 185, 6105-6114
    • (2010) J. Immunol , vol.185 , pp. 6105-6114
    • Kaur, D.1    Saunders, R.2    Hollins, F.3    Woodman, L.4    Doe, C.5    Siddiqui, S.6
  • 76
    • 84856807802 scopus 로고    scopus 로고
    • Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma
    • Sutcliffe, A., Hollins, F., Gomez, E., Saunders, R., Doe, C., Cooke, M. et al. (2012) Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma. Am. J. Respir. Crit. Care Med. 185, 267-274
    • (2012) Am. J. Respir. Crit. Care Med , vol.185 , pp. 267-274
    • Sutcliffe, A.1    Hollins, F.2    Gomez, E.3    Saunders, R.4    Doe, C.5    Cooke, M.6
  • 77
    • 85014126674 scopus 로고    scopus 로고
    • HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4
    • Immunol, in press
    • Di Candia, L., Gomez, E., Venereau, E., Chachi, L., Kaur, D., Bianchi, M.E. et al. (2017) HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. J. Allergy Clin. Immunol, in press, doi:10.1183/13993003.01507-2016
    • (2017) J. Allergy Clin
    • Di Candia, L.1    Gomez, E.2    Venereau, E.3    Chachi, L.4    Kaur, D.5    Bianchi, M.E.6
  • 78
    • 85027928476 scopus 로고    scopus 로고
    • Asthma therapy and its effect on airway remodelling
    • Berair, R. and Brightling, C.E. (2014) Asthma therapy and its effect on airway remodelling. Drugs 74, 1345-1369
    • (2014) Drugs , vol.74 , pp. 1345-1369
    • Berair, R.1    Brightling, C.E.2
  • 80
    • 85019122591 scopus 로고    scopus 로고
    • Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling
    • in press
    • Berair, R., Hartley, R., Mistry, V., Sheshadri, A., Gupta, S., Singapuri, A. et al. (2017) Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling. Eur. Respir. J. 49, in press
    • (2017) Eur. Respir. J , vol.49
    • Berair, R.1    Hartley, R.2    Mistry, V.3    Sheshadri, A.4    Gupta, S.5    Singapuri, A.6
  • 81
    • 77957769295 scopus 로고    scopus 로고
    • Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma
    • Thomas, B., Rutman, A., Hirst, R.A., Haldar, P., Wardlaw, A.J., Bankart, J. et al. (2010) Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma. J. Allergy Clin. Immunol. 126, 722.e2-729.e2
    • (2010) J. Allergy Clin. Immunol , vol.126 , pp. 722.e2-729.e2
    • Thomas, B.1    Rutman, A.2    Hirst, R.A.3    Haldar, P.4    Wardlaw, A.J.5    Bankart, J.6
  • 82
    • 84919360610 scopus 로고    scopus 로고
    • Reduction of airway smooth muscle mass by bronchial thermoplasty in patients with severe asthma
    • Pretolani, M., Dombret, M.C., Thabut, G., Knap, D., Hamidi, F., Debray, M.P. et al. (2014) Reduction of airway smooth muscle mass by bronchial thermoplasty in patients with severe asthma. Am. J. Respir. Crit. Care Med. 190, 1452-1454
    • (2014) Am. J. Respir. Crit. Care Med , vol.190 , pp. 1452-1454
    • Pretolani, M.1    Dombret, M.C.2    Thabut, G.3    Knap, D.4    Hamidi, F.5    Debray, M.P.6
  • 83
    • 84946731979 scopus 로고    scopus 로고
    • Effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in asthma
    • Chakir, J., Haj-Salem, I., Gras, D., Joubert, P., Beaudoin, E.L., Biardel, S. et al. (2015) Effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in asthma. Ann. Am. Thorac. Soc. 12, 1612-1618
    • (2015) Ann. Am. Thorac. Soc , vol.12 , pp. 1612-1618
    • Chakir, J.1    Haj-Salem, I.2    Gras, D.3    Joubert, P.4    Beaudoin, E.L.5    Biardel, S.6
  • 85
    • 85006132133 scopus 로고    scopus 로고
    • Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations
    • Pretolani, M., Bergqvist, A., Thabut, G., Dombret, M.C., Knapp, D., Hamidi, F. et al. (2016) Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations. J. Allergy. Clin. Immunol. 139, 1176-1185
    • (2016) J. Allergy. Clin. Immunol , vol.139 , pp. 1176-1185
    • Pretolani, M.1    Bergqvist, A.2    Thabut, G.3    Dombret, M.C.4    Knapp, D.5    Hamidi, F.6
  • 86
    • 74949090750 scopus 로고    scopus 로고
    • Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial
    • Castro, M., Rubin, A.S., Laviolette, M., Fiterman, J., De Andrade Lima, M., Shah, P.L. et al. (2010) Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am. J. Respir. Crit. Care. Med. 181, 116-124
    • (2010) Am. J. Respir. Crit. Care. Med , vol.181 , pp. 116-124
    • Castro, M.1    Rubin, A.S.2    Laviolette, M.3    Fiterman, J.4    De Andrade Lima, M.5    Shah, P.L.6
  • 89
    • 84937435706 scopus 로고    scopus 로고
    • Airway remodelling in asthma: role for mechanical forces
    • Manuyakorn, W. (2014) Airway remodelling in asthma: role for mechanical forces. Asia Pac. Allergy 4, 19-24
    • (2014) Asia Pac. Allergy , vol.4 , pp. 19-24
    • Manuyakorn, W.1
  • 91
    • 84944455871 scopus 로고    scopus 로고
    • Asthma and metabolic syndrome: Current knowledge and future perspectives
    • Serafino-Agrusa, L., Spatafora, M. and Scichilone, N. (2015) Asthma and metabolic syndrome: Current knowledge and future perspectives. World J. Clin. Cases 3, 285-292
    • (2015) World J. Clin. Cases , vol.3 , pp. 285-292
    • Serafino-Agrusa, L.1    Spatafora, M.2    Scichilone, N.3


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