Cysteinyl leukotriene receptors, old and new; implications for asthma

Clinical and Experimental Allergy

Volumn 42, Issue 9, 2012, Pages 1313-1320

  Laidlaw, T M ^a   Boyce, J A ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CLOPIDOGREL; G PROTEIN COUPLED RECEPTOR; INDOMETACIN; LEUKOTRIENE C4; LEUKOTRIENE RECEPTOR; PEPTIDOLEUKOTRIENE; RHO KINASE INHIBITOR;

ASPERGILLUS FUMIGATUS; ASPIRIN EXACERBATED RESPIRATORY DISEASE; ASTHMA; BASOPHIL; CELL PROLIFERATION; CHO CELL; DISEASE EXACERBATION; EOSINOPHIL; HEMATOPOIETIC CELL; HUMAN; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; LOEFFLER PNEUMONIA; LUNG DISEASE; LUNG FUNCTION; MACROPHAGE; MAST CELL; MYELOID DENDRITIC CELL; NONHUMAN; NOSE POLYP; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; TH2 CELL;

ALLERGENS; ANIMALS; ASTHMA; CHO CELLS; CRICETINAE; CYSTEINE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LEUKOTRIENES; MICE; RECEPTORS, LEUKOTRIENE; TH2 CELLS;

EID: 84865538716     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2012.03982.x     Document Type: Review

References (65)

1. Drazen JM. Inhalation challenge with sulfidopeptide leukotrienes in human subjects. Chest 1986; 89:414-9.
2. Drazen JM, O'Brien J, Sparrow D et al. Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis 1992; 146:104-8.
3. Riccioni G, Back M, Capra V. Leukotrienes and atherosclerosis. Curr Drug Targets 2010; 11:882-7.
4. Magnusson C, Mezhybovska M, Lorinc E, Fernebro E, Nilbert M, Sjolander A. Low expression of CysLT1R and high expression of CysLT2R mediate good prognosis in colorectal cancer. Eur J Cancer 2010; 46:826-35.
5. Beller TC, Friend DS, Maekawa A, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Proc Natl Acad Sci U S A 2004; 101:3047-52.
6. Machado ER, Ueta MT, Lourenco EV et al. Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis. J Immunol 2005; 175:3892-9.
7. Israel E, Cohn J, Dube L, Drazen JM. Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. JAMA 1996; 275:931-6.
8. Knorr B, Matz J, Bernstein JA et al. Montelukast for chronic asthma in 6- to 14-year-old children: a randomized, double-blind trial. Pediatric Montelukast Study Group. JAMA 1998; 279:1181-6.
9. Israel E, Chervinsky PS, Friedman B et al. Effects of montelukast and beclomethasone on airway function and asthma control. J Allergy Clin Immunol 2002; 110:847-54.
10. Drazen JM, Silverman EK, Lee TH. Heterogeneity of therapeutic responses in asthma. Br Med Bull 2000; 56:1054-70.
11. Capra V, Ravasi S, Accomazzo MR et al. CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. J Cell Sci 2005; 118:5625-36.
12. Jiang Y, Borrelli L, Bacskai BJ, Kanaoka Y, Boyce JA. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol 2009; 182:1129-37.
13. Jiang Y, Borrelli LA, Kanaoka Y, Bacskai BJ, Boyce JA. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood 2007; 110:3263-70.
14. Maekawa A, Balestrieri B, Austen KF, Kanaoka Y. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proc Natl Acad Sci U S A 2009; 106:11685-90.
15. Maekawa A, Kanaoka Y, Xing W, Austen KF. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. Proc Natl Acad Sci U S A 2008; 105:16695-700.
16. Paruchuri S, Jiang Y, Feng C, Francis SA, Plutzky J, Boyce JA. Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. J Biol Chem 2008; 283:16477-87.
17. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J Immunol 2004; 173:1503-10.
18. Malaviya R, Malaviya R, Jakschik BA. Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation. J Biol Chem 1993; 268:4939-44.
19. Lam BK, Penrose JF, Freeman GJ, Austen KF. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc Natl Acad Sci U S A 1994; 91:7663-7.
20. Lam BK, Owen WF Jr, Austen KF, Soberman RJ. The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils. J Biol Chem 1989; 264:12885-9.
21. Carter BZ, Shi ZZ, Barrios R, Lieberman MW. gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. J Biol Chem 1998; 273:28277-85.
22. Lee CW, Lewis RA, Corey EJ, Austen KF. Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes. Immunology 1983; 48:27-35.
23. Maclouf J, Antoine C, Henson PM, Murphy RC. Leukotriene C4 formation by transcellular biosynthesis. Ann N Y Acad Sci 1994; 714:143-50.
24. Laidlaw TM, Kidder MS, Bhattacharyya N et al. Cysteinyl leukotriene overproduction in aspirin exacerbated respiratory disease is driven by platelet-adherent leukocytes. Blood 2012; 119:3790-8.
25. Christie PE, Tagari P, Ford-Hutchinson AW et al. Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. Am Rev Respir Dis 1991; 143:1025-9.
26. Liu MC, Dube LM, Lancaster J. Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group. J Allergy Clin Immunol 1996; 98:859-71.
27. Berges-Gimeno MP, Simon RA, Stevenson DD. The effect of leukotriene-modifier drugs on aspirin-induced asthma and rhinitis reactions. Clin Exp Allergy 2002; 32:1491-6.
28. Soter NA, Lewis RA, Corey EJ, Austen KF. Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4, and LTB4) in human skin. J Invest Dermatol 1983; 80:115-9.
29. Griffin M, Weiss JW, Leitch AG et al. Effects of leukotriene D on the airways in asthma. N Engl J Med 1983; 308:436-9.
30. Weiss JW, Drazen JM, Coles N et al. Bronchoconstrictor effects of leukotriene C in humans. Science 1982; 216:196-8.
31. Drazen JM, Venugopalan CS, Austen KF, Brion F, Corey EJ. Effects of leukotriene E on pulmonary mechanics in the guinea pig. Am Rev Respir Dis 1982; 125:290-4.
32. Lee TH, Austen KF, Corey EJ, Drazen JM. Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. Proc Natl Acad Sci U S A 1984; 81:4922-5.
33. Jacques CA, Spur BW, Johnson M, Lee TH. The mechanism of LTE4-induced histamine hyperresponsiveness in guinea-pig tracheal and human bronchial smooth muscle, in vitro. Br J Pharmacol 1991; 104:859-66.
34. Weiss JW, Drazen JM, McFaddenx ER Jr et al. Comparative bronchoconstrictor effects of histamine, leukotriene C, and leukotriene D in normal human volunteers. Trans Assoc Am Physicians 1982; 95:30-5.
35. Weiss JW, Drazen JM, McFadden ER Jr et al. Airway constriction in normal humans produced by inhalation of leukotriene D Potency, time course, and effect of aspirin therapy. JAMA 1983; 249:2814-7.
36. Davidson AB, Lee TH, Scanlon PD et al. Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects. Am Rev Respir Dis 1987; 135:333-7.
37. Christie PE, Schmitz-Schumann M, Spur BW, Lee TH. Airway responsiveness to leukotriene C4 (LTC4), leukotriene E4 (LTE4) and histamine in aspirin-sensitive asthmatic subjects. Eur Respir J 1993; 6:1468-73.
38. Gauvreau GM, Parameswaran KN, Watson RM, O'Byrne PM. Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma. Am J Respir Crit Care Med 2001; 164:1495-500.
39. Christie PE, Hawksworth R, Spur BW, Lee TH. Effect of indomethacin on leukotriene4-induced histamine hyperresponsiveness in asthmatic subjects. Am Rev Respir Dis 1992; 146:1506-10.
40. Heise CE, O'Dowd BF, Figueroa DJ et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem 2000; 275:30531-6.
41. Lynch KR, O'Neill GP, Liu Q et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 1999; 399:789-93.
42. Mollerup J, Jorgensen ST, Hougaard C, Hoffmann EK. Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes. Biochim Biophys Acta 2001; 1517:455-9.
43. Hui Y, Yang G, Galczenski H et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. J Biol Chem 2001; 276:47489-95.
44. Mellor EA, Maekawa A, Austen KF, Boyce JA. Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc Natl Acad Sci U S A 2001; 98:7964-9.
45. Jiang Y, Kanaoka Y, Feng C, Nocka K, Rao S, Boyce JA. Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. J Immunol 2006; 177:2755-9.
46. Mellor EA, Austen KF, Boyce JA. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. J Exp Med 2002; 195:583-92.
47. Evans JF. Cysteinyl leukotriene receptors. Prostaglandins Other Lipid Mediat 2002; 69:587-97.
48. Mellor EA, Frank N, Soler D et al. Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: functional distinction from CysLT1R. Proc Natl Acad Sci U S A 2003; 100:11589-93.
49. Franco R, Casado V, Cortes A et al. Basic concepts in G-protein-coupled receptor homo- and heterodimerization. ScientificWorldJournal 2007; 7:48-57.
50. Ciana P, Fumagalli M, Trincavelli ML et al. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J 2006; 25:4615-27.
51. Maekawa A, Xing W, Austen KF, Kanaoka Y. GPR17 regulates immune pulmonary inflammation induced by house dust mites. J Immunol 2010; 185:1846-54.
52. 2 immunity through the generation of cysteinyl leukotrienes. J Exp Med 2011; 208:593-604.
53. Paruchuri S, Tashimo H, Feng C et al. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med 2009; 206:2543-55.
54. Nonaka Y, Hiramoto T, Fujita N. Identification of endogenous surrogate ligands for human P2Y12 receptors by in silico and in vitro methods. Biochem Biophys Res Commun 2005; 337:281-8.
55. Savi P, Zachayus JL, Delesque-Touchard N et al. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A 2006; 103:11069-74.
56. Martin TR, Gerard NP, Galli SJ, Drazen JM. Pulmonary responses to bronchoconstrictor agonists in the mouse. J Appl Physiol 1988; 64:2318-23.
57. Park JS, Chang HS, Park CS et al. Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. Pharmacogenet Genomics 2005; 15:483-92.
58. Mamedova L, Capra V, Accomazzo MR et al. CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors. Biochem Pharmacol 2005; 71:115-25.
59. Malmstrom K, Rodriguez-Gomez G, Guerra J et al. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast/Beclomethasone Study Group. Ann Intern Med 1999; 130:487-95.
60. Arm JP, O'Hickey SP, Spur BW, Lee TH. Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma. Am Rev Respir Dis 1989; 140:148-53.
61. Kim SH, Choi JH, Park HS et al. Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. Clin Exp Allergy 2005; 35:585-90.
62. Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol 2009; 182:1119-28.
63. Thompson MD, Capra V, Takasaki J et al. A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate. Pharmacogenet Genomics 2007; 17:539-49.
64. Thompson MD, Storm van's GK, Galczenski H et al. A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. Pharmacogenetics 2003; 13:641-9.
65. Acevedo N, Vergara C, Mercado D, Jimenez S, Caraballo L. The A-444C polymorphism of leukotriene C4 synthase gene is associated with IgE antibodies to Dermatophagoides pteronyssinus in a Colombian population. J Allergy Clin Immunol 2007; 119:505-7.