Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture

Aging Cell

Volumn 10, Issue 1, 2011, Pages 103-113

  Mohmmad Abdul, Hafiz ^a   Baig, Irfan ^a   LeVine, Harry ^a   Guttmann, Rodney P ^a,b   Norris, Christopher M ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer's disease; Amyloid; Ca2+; Calcineurin; Calpain; Mild cognitive impairment; NMDA receptors

Indexed keywords

CALCINEURIN; CALPAIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOSOLIC FRACTION; DEMENTIA; ENZYME ACTIVATION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MILD COGNITIVE IMPAIRMENT; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CALCINEURIN; CALCIUM; CALPAIN; CASE-CONTROL STUDIES; CELL CULTURE TECHNIQUES; CELL FRACTIONATION; COGNITION DISORDERS; DISEASE PROGRESSION; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; GLUTAMIC ACID; HIPPOCAMPUS; HUMANS; MALE; PEPTIDE FRAGMENTS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RETROSPECTIVE STUDIES; SIGNAL TRANSDUCTION;

RATTUS;

EID: 78651349580     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2010.00645.x     Document Type: Article

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