Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells)

Journal of Neuroscience

Volumn 30, Issue 28, 2010, Pages 9641-9646

  Nagamoto Combs, Kumi ^a   Combs, Colin K ^a  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CYTOKINE RELEASE; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; MICROGLIA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYTOKINES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; MICE; MICROGLIA; NFATC TRANSCRIPTION FACTORS; PHENOTYPE; PROTEIN ISOFORMS; T-LYMPHOCYTES;

EID: 77954755219     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0828-10.2010     Document Type: Article

References (40)

1. Abdul HM, Sama MA, Furman JL, Mathis DM, Beckett TL, Weidner AM, Patel ES, Baig I, Murphy MP, LeVine H 3rd, Kraner SD, Norris CM (2009) Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. J Neurosci 29:12957-12969.
2. Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A (1999) Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 285:2129-2133. (Pubitemid 29451431)
3. Bao Y, Li R, Jiang J, Cai B, Gao J, Le K, Zhang F, Chen S, Liu P (2008) Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiac hypertrophy via the calcineurin/NFAT signaling pathway. Mol Cell Biochem 317:189-196.
4. Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A (2005) The transcription factor NFAT3 mediates neuronal survival. J Biol Chem 280:2818-2825. (Pubitemid 40189389)
5. Best JA, Chen Y, Piech KM, Tank AW (1995) The response of the tyrosine hydroxylase gene to cyclic AMP is mediated by two cyclic AMP-response elements. J Neurochem 65:1934-1943.
6. Boise LH, Petryniak B, Mao X, June CH, Wang CY, Lindsten T, Bravo R, Kovary K, Leiden JM, Thompson CB (1993) The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol Cell Biol 13:1911-1919. (Pubitemid 23068131)
7. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
8. Brooks H, Lebleu B, Vivès E (2005) Tat peptide-mediated cellular delivery: back to basics. Adv Drug Deliv Rev 57:559-577. (Pubitemid 40255561)
9. Canellada A, Ramirez BG, Minami T, Redondo JM, Cano E (2008) Calcium/ calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes. Glia 56:709-722.
10. Ferrari D, Stroh C, Schulze-Osthoff K (1999) P2X7/P2Z Purinoreceptor-mediated activation of transcription factorNFATin microglial cells. J Biol Chem 274:13205-13210.
11. Fisher WG, Yang PC, Medikonduri RK, Jafri MS (2006) NFAT and NFkappaB activation in T lymphocytes: a model of differential activation of gene expression. Ann Biomed Eng 34:1712-1728. (Pubitemid 44704826)
12. Floden AM, Li S, Combs CK (2005) Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J Neurosci 25:2566-2575.
13. Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR (2003) Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell 113:657-670.
14. Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T, Rao A (1993) The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365:352-355. (Pubitemid 23288978)
15. Kataoka A, Tozaki-Saitoh H, Koga Y, Tsuda M, Inoue K (2009) Activation of P2X〈sub〉7〈/sub〉 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J Neurochem 108:115-125.
16. Kuriyama M, Matsushita M, Tateishi A, Moriwaki A, Tomizawa K, Ishino K, Sano S, Matsui H (2006) A cell-permeable NFAT inhibitor peptide prevents pressure-overload cardiac hypertrophy. Chem Biol Drug Des 67:238-243.
17. Lee CG, Kang KH, So JS, Kwon HK, Son JS, Song MK, Sahoo A, Yi HJ, Hwang KC, Matsuyama T, Yui K, Im SH (2009) A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol 46:613-621.
18. Lopez-Rodríguez C, Aramburu J, Rakeman AS, Rao A (1999) NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc Natl Acad Sci U S A 96:7214-7219. (Pubitemid 29299641)
19. Luoma JI, Zirpel L (2008) Deafferentation-induced activation of NFAT (nuclear factor of activated T-cells) in cochlear nucleus neurons during a developmental critical period: a role for NFATc4-dependent apoptosis in the CNS. J Neurosci 28:3159-3169.
20. Macian F (2005) NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 5:472-484.
21. Masuda ES, Imamura R, Amasaki Y, Arai K, Arai N (1998) Signalling into the T-cell nucleus: NFAT regulation. Cell Signal 10:599-611.
22. Miyakawa H, Woo SK, Dahl SC, Handler JS, Kwon HM (1999) Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity. Proc Natl Acad Sci U S A 96:2538-2542.
23. Nagamoto-Combs K, Piech KM, Best JA, Sun B, Tank AW (1997) Tyrosine hydroxylase gene promoter activity is regulated by both cyclic AMP-responsive element and AP1 sites following calcium influx. Evidence for cyclic amp-responsive element binding protein-independent regulation. J Biol Chem 272:6051-6058.
24. Noguchi H, Matsushita M, Okitsu T, Moriwaki A, Tomizawa K, Kang S, Li ST, Kobayashi N, Matsumoto S, Tanaka K, Tanaka N, Matsui H (2004) A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat Med 10:305-309.
25. Pérez-Ortiz JM, Serrano-Pérez MC, Pastor MD, Martín ED, Calvo S, Rincón M, Tranque P (2008) Mechanical lesion activates newly identified NFATc1 in primary astrocytes: implication of ATP and purinergic receptors. Eur J Neurosci 27:2453-2465.
26. Putt ME, Hannenhalli S, Lu Y, Haines P, Chandrupatla HR, Morrisey EE, Margulies KB, Cappola TP (2009) Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure. Circ Cardiovasc Genet 2:212-219.
27. Rao A, Luo C, Hogan PG (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15:707-747.
28. Sama MA, Mathis DM, Furman JL, Abdul HM, Artiushin IA, Kraner SD, Norris CM (2008) Interleukin-1beta-dependent signaling between astrocytes and neurons depends critically on astrocytic calcineurin/NFAT activity. J Biol Chem 283:21953-21964.
29. Sareneva T, Matikainen S, Vanhatalo J, Melén K, Pelkonen J, Julkunen I (1998) Kinetics of cytokine and NFAT gene expression in human interleukin-2-dependent T lymphoblasts stimulated via T-cell receptor. Immunology 93:350-357.
30. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF (1999) In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285:1569-1572.
31. Shaw JP, Utz PJ, Durand DB, Toole JJ, Emmel EA, Crabtree GR (1988) Identification of a putative regulator of early T cell activation genes. Science 241:202-205.
32. Shaw KT, Ho AM, Raghavan A, Kim J, Jain J, Park J, Sharma S, Rao A, Hogan PG (1995) Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc Natl Acad Sci U S A 92:11205-11209.
33. Sondag CM, Combs CK (2004) Amyloid precursor protein mediates proinflammatory activation of monocytic lineage cells. J Biol Chem 279:14456-14463.
34. Sondag CM, Dhawan G, Combs CK (2009) Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia. J Neuroinflammation 6:1.
35. Vashishta A, Habas A, Pruunsild P, Zheng JJ, Timmusk T, HetmanM (2009) Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. J Neurosci 29:15331-15340.
36. Vieira AS, Rezende AC, Grigoletto J, Rogério F, Velloso LA, Skaper SD, Negro A, Langone F (2009) Ciliary neurotrophic factor infused intracerebroventricularly shows reduced catabolic effects when linked to the TAT protein transduction domain. J Neurochem 110:1557-1566.
37. Vihma H, Pruunsild P, Timmusk T (2008) Alternative splicing and expression of human and mouse NFAT genes. Genomics 92:279-291.
38. Vives E (2005) Present and future of cell-penetrating peptide mediated delivery systems: "Is the Trojan horse too wild to go only to Troy?" J Control Release 109:77-85.
39. Wang Q, Gou X, Jin W, Xiong L, Hou L, Chen S, Zhang H, Zhu X, Xu L (2009) TAT-mediated protein transduction of Nogo extracellular peptide 1-40 and its biological activity. Cell Mol Neurobiol 29:97-108.
40. Yang XY, Wang LH, Chen T, Hodge DR, Resau JH, DaSilva L, Farrar WL (2000) Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPAR-gamma co-association with transcription factor NFAT. J Biol Chem 275: 4541-4544.