Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes

Journal of Neuroscience

Volumn 35, Issue 13, 2015, Pages 5187-5201

  Petr, Geraldine T ^a,b   Sun, Yan ^a,b   Frederick, Natalie M ^a   Zhou, Yun ^c   Dhamne, Sameer C ^a   Hameed, Mustafa Q ^a   Miranda, Clive ^d   Bedoya, Edward A ^a   Fischer, Kathryn D ^a,b   Armsen, Wencke ^a,b   Wang, Jianlin ^a   Danbolt, Niels C ^c   Rotenberg, Alexander ^a   Aoki, Chiye J ^d   Rosenberg, Paul A ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF OSLO   (Norway)

^d NEW YORK UNIVERSITY   (United States)

Author keywords

Glia; Ischemia; Plasticity; Seizures; Spillover; Transport

Indexed keywords

4 AMINOBUTYRIC ACID; DEXTRO ASPARTIC ACID; EXCITATORY AMINO ACID TRANSPORTER 3; GENOMIC DNA; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; IMMUNOGLOBULIN G; LIPOSOME; NEOMYCIN; PROTEOLIPOSOME; SYNAPSIN I; TAMOXIFEN; THYMIDINE KINASE; VESICULAR GLUTAMATE TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; SLC1A2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DENSITOMETRY; ELECTROENCEPHALOGRAPHY; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; EPILEPSY; FEMALE; GENE DELETION; GENETIC RECOMBINATION; GENOTYPE; GLUTAMATE UPTAKE; IMMUNOASSAY; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOUSE; NONHUMAN; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SENSITIVITY AND SPECIFICITY; SURVIVAL; SYNAPTOSOME; WESTERN BLOTTING; ANIMAL; BODY WEIGHT; BRAIN; CYTOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MORTALITY; NERVE CELL; NERVE ENDING; ULTRASTRUCTURE;

ANIMALS; ASTROCYTES; BODY WEIGHT; BRAIN; ELECTROENCEPHALOGRAPHY; EPILEPSY; EXCITATORY AMINO ACID TRANSPORTER 2; FEMALE; GLUTAMIC ACID; LIPOSOMES; MALE; MICE; MICE, KNOCKOUT; NEURONS; PRESYNAPTIC TERMINALS; SYNAPTOSOMES;

EID: 84929379714     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4255-14.2015     Document Type: Article

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