Antisense knockdown of the glial glutamate transporter GLT-1 exacerbates hippocampal neuronal damage following traumatic injury to rat brain

European Journal of Neuroscience

Volumn 13, Issue 1, 2001, Pages 119-128

  Rao, Vemuganti L Raghavendra ^a,b   Dogan, Aclan ^a   Bowen, Kellie K ^a   Todd, Kathryn G ^d   Dempsey, Robert J ^a,c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b University of Wisconsin Cardiovascular Research Center   (United States)

^c WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Antisense ODN; Controlled cortical impact injury; Glutamate uptake; Hippocampus; Knockdown; Neuronal death

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GLUTAMATE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; MALE; MORTALITY; NERVE CELL LESION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BRAIN INJURIES; DOWN-REGULATION; HIPPOCAMPUS; MALE; MOTOR ACTIVITY; NEUROGLIA; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; WOUNDS, NONPENETRATING;

EID: 0035176824     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2001.01367.x     Document Type: Article

References (63)

1. Traumatic brain damage prevented by the non-N-methyl-D-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f] quinoxaline
2. Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes
3. The excitotoxic concept
4. GDNF induces an increase in EAAT2 (GLT-1) expression
5. Properties and localization of glutamate transporters
6. Fluid percussion brain injury exacerbates glutamate-induced focal damage in the rat
7. One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats
8. Histological markers of neuronal, axonal and astrocytic changes after lateral rigid impact traumatic brain injury
9. The neurotransmitter amino acid transport systems. A fresh outlook on an old problem
10. Differential expression of glycine transporter 1 and three glutamate transporter mRNA in the hippocampus of gerbils with transient forebrain ischemia
11. Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury
12. Pituitary adenylate cyclase-activating polypeptide (PACAP), a neuron-derived peptide regulating glial glutamate transport and metabolism
13. Enhancement of AMPA-mediated current after traumatic injury in cortical neurons
14. Astrocytes are the major source of nerve growth factor upregulation following traumatic brain injury in the rat
15. The high-affinity glutamate transporter family
16. Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury
17. Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure
18. Relationship between excitatory amino acid release and outcome after severe human head injury
19. Continuous administration of the glutamate uptake inhibitor L-transpyrrolidine-2,4-dicarboxylate produces striatal lesion
20. Protein measurement with the Folin-phenol reagent
21. 3H-glutamate uptake with different potencies in rodent central nervous system regions expressing different transporters subtypes
22. Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum
23. Glutamate uptake impairment and neuronal damage in young and aged rats in vivo
24. Glycolysis inhibition exacerbates neuronal damage induced by glutamate transporter inhibition in vivo
25. Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: An in vivo microdialysis study
26. Novel pharmacologic strategies in the treatment of experimental traumatic brain injury
27. Alterations in glutamate transporter protein levels in kindling-induced epilepsy
28. Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury
29. Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats
30. High extracellular glutamate and neuronal death in neurological disorders. Cause, contribution or consequence?
31. Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model
32. Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats
33. Cloning and expression of a rat brain L-glutamate transporter
34. Traumatic brain injury down-regulates glial glutamate transporter (GLT-1 and GLAST) proteins in rat brain
35. 3H]nitroarginine binding
36. Antisense knockout of glial glutamate transporter GLT-1 exacerbates ischemic neuronal damage
37. Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death and activation of astrocytes and microglia in rat thalamus
38. Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia
39. The family of sodium-dependent glutamate transporters: A focus on the GLT1/EAAT2 subtype
40. Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia
41. Glutamate release in severe brain ischaemia is mainly by reversed uptake
42. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
43. Transient inhibition of glutamate uptake in vivo induces neurodegeneration when energy metabolism is impaired
44. Morris water maze deficits in rats following traumatic brain injury: Lateral controlled cortical impact
45. Excitatory amino acid transporters: A family in flux
46. Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker
47. PACAP protects hippocampal neurons against apoptosis: Involvement of JNK/SAPK signaling pathway
48. Antisense knockdown of glutamate transporters alters the subfield selectivity of kainate-induced ceil death in rat hippocampal slice cultures
49. Improvement of cognitive deficits and decreased cholinergic neuronal cell loss and apoptotic cell death following neurotrophin infusion after experimental traumatic brain injury
50. Progressive atrophy and neuron death for one year following brain trauma in the rat
51. Structure, expression, and functional analysis of a Na(+)-dependent glutamate/ aspartate transporter from rat brain
52. Pretreatment with antisense oligodeoxynucleotides directed against the NMDA-R1 receptor enhances survival and behavioral recovery following traumatic brain injury in rats
53. Exacerbation of traumatic brain injury in mice lacking the glutamate transporter GLT-1
54. Acidosis causes failure of astrocyte glutamate uptake during hypoxia
55. Neuronal regulation of glutamate transporter subtype expression in astrocytes
56. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1
57. Peroxynitrite inhibits glutamate transporter subtypes
58. Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-typ calcium channel antagonist (SNX-111)
59. Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: A microdialysis study
60. Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats
61. Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex
62. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury