The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis

Journal of Biological Chemistry

Volumn 292, Issue 23, 2017, Pages 9830-9839

  Kim, Hyoung Tae ^a   Goldberg, Alfred L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ENZYMES; FIBROBLASTS; PURIFICATION;

DE-UBIQUITINATING ACTIVITY; DEUBIQUITINATING ENZYMES; EMBRYONIC FIBROBLASTS; MOUSE EMBRYONIC FIBROBLASTS; PROTEASOMAL DEGRADATION; PROTEIN DEGRADATION; REGULATORY PROPERTIES; UBIQUITINATED PROTEINS;

PROTEOLYSIS;

ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE TRIPHOSPHATE; DEUBIQUITINASE; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG; USP14 PROTEIN; ATP DEPENDENT 26S PROTEASE; PSMD14 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; UBIQUITIN THIOLESTERASE; UBIQUITINATED PROTEIN; USP14 PROTEIN, HUMAN; USP14 PROTEIN, MOUSE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SPECIFICITY; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN HYDROLYSIS; UBIQUITINATION; WILD TYPE MOUSE; ANIMAL; CELL CULTURE; ENZYMOLOGY; GENETICS; HUMAN; KNOCKOUT MOUSE; MAMMALIAN EMBRYO; METABOLISM; MUTATION; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; CELLS, CULTURED; EMBRYO, MAMMALIAN; FIBROBLASTS; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; TRANS-ACTIVATORS; UBIQUITIN; UBIQUITIN THIOLESTERASE; UBIQUITINATED PROTEINS; UBIQUITINATION;

EID: 85019612188     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.763128     Document Type: Article

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