A Ubiquitin Stress Response Induces Altered Proteasome Composition

Cell

Volumn 129, Issue 4, 2007, Pages 747-759

  Hanna, John ^a   Meides, Alice ^a   Zhang, Dan Phoebe ^a   Finley, Daniel ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CHEMBIO; PROTEINS

Indexed keywords

MUTANT PROTEIN; PROTEASOME; PROTEIN; UBIQUITIN; UBP6 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; HOMEOSTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN FUNCTION; STRESS; UPREGULATION;

EID: 34249007126     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2007.03.042     Document Type: Article

References (30)

1. Amerik A.Y., Swaminathan S., Krantz B.A., Wilkinson K.D., and Hochstrasser M. In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome. EMBO J. 16 (1997) 4826-4838
2. Arnason T., and Ellison M.J. Stress resistance in Saccharomyces cerevisiae is strongly correlated with assembly of a novel type of multiubiquitin chain. Mol. Cell. Biol. 14 (1994) 7876-7883
3. Borodovsky A., Kessler B.M., Casagrande R., Overkleeft H.S., Wilkinson K.D., and Ploegh H.L. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J. 20 (2001) 5187-5196
4. Chen Y., and Piper P.W. Consequences of the overexpression of ubiquitin in yeast: elevated tolerances of osmostress, ethanol and canavanine, yet reduced tolerances of cadmium, arsenite and paromomycin. Biochim. Biophys. Acta 1268 (1995) 59-64
5. Chernova T.A., Allen K.D., Wesoloski L.M., Shanks J.R., Chernoff Y.O., and Wilkinson K.D. Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool. J. Biol. Chem. 278 (2003) 52102-52115
6. Finley D., Ozkaynak E., and Varshavsky A. The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses. Cell 48 (1987) 1035-1046
7. Glickman M.H., Rubin D.M., Fried V.A., and Finley D. The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol. Cell. Biol. 18 (1998) 3149-3162
8. Haas A.L., and Bright P.M. The dynamics of ubiquitin pools within cultured human lung fibroblasts. J. Biol. Chem. 262 (1987) 345-351
9. Hanna J., Leggett D.S., and Finley D. Ubiquitin depletion as a key mediator of toxicity by translational inhibitors. Mol. Cell. Biol. 23 (2003) 9251-9261
10. Hanna J., Hathaway N.A., Tone Y., Crosas B., Elsasser S., Kirkpatrick D.S., Leggett D.S., Gygi S.P., King R.W., and Finley D. Deubiquitinating enzyme ubp6 functions noncatalytically to delay proteasomal degradation. Cell 127 (2006) 99-111
11. Hiroi Y., and Rechsteiner M. Ubiquitin metabolism in HeLa cells starved of amino acids. FEBS Lett. 307 (1992) 156-161
12. Johnson E.S., Ma P.C., Ota I.M., and Varshavsky A. A proteolytic pathway that recognizes ubiquitin as a degradation signal. J. Biol. Chem. 270 (1995) 17442-17456
13. Ju D., Wang L., Mao X., and Xie Y. Homeostatic regulation of the proteasome via an Rpn4-dependent feedback circuit. Biochem. Biophys. Res. Commun. 321 (2004) 51-57
14. Leggett D.S., Hanna J., Borodovsky A., Crosas B., Schmidt M., Baker R.T., Walz T., Ploegh H., and Finley D. Multiple associated proteins regulate proteasome structure and function. Mol. Cell 10 (2002) 495-507
15. Lenkinski R.E., Chen D.M., Glickson J.D., and Goldstein G. Nuclear magnetic resonance studies of the denaturation of ubiquitin. Biochim. Biophys. Acta 494 (1977) 126-130
16. London M.K., Keck B.I., Ramos P.C., and Dohmen R.J. Regulatory mechanisms controlling biogenesis of ubiquitin and the proteasome. FEBS Lett. 567 (2004) 259-264
17. Mannhaupt G., Schnall R., Karpov V., Vetter I., and Feldmann H. Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast. FEBS Lett. 450 (1999) 27-34
18. Meiners S., Heyken D., Weller A., Ludwig A., Stangl K., Kloetzel P.M., and Kruger E. Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes. J. Biol. Chem. 278 (2003) 21517-21525
19. Mimnaugh E.G., Chen H.Y., Davie J.R., Celis J.E., and Neckers L. Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response. Biochemistry 36 (1997) 14418-14429
20. Osaka H., Wang Y.L., Takada K., Takizawa S., Setsuie R., Li H., Sato Y., Nishikawa K., Sun Y.J., Sakurai M., et al. Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum. Mol. Genet. 12 (2003) 1945-1958
21. Ozkaynak E., Finley D., Solomon M.J., and Varshavsky A. The yeast ubiquitin genes: a family of natural gene fusions. EMBO J. 6 (1987) 1429-1439
22. Rose I.A., and Warms J.V. A specific endpoint assay for ubiquitin. Proc. Natl. Acad. Sci. USA 84 (1987) 1477-1481
23. Ryu K.Y., Baker R.T., and Kopito R.R. Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimens. Anal. Biochem. 353 (2006) 153-155
24. Saigoh K., Wang Y.L., Suh J.G., Yamanishi T., Sakai Y., Kiyosawa H., Harada T., Ichihara N., Wakana S., Kikuchi T., and Wada K. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. Nat. Genet. 23 (1999) 47-51
25. Simon J.R., Treger J.M., and McEntee K. Multiple independent regulatory pathways control UBI4 expression after heat shock in Saccharomyces cerevisiae. Mol. Microbiol. 31 (1999) 823-832
26. Swaminathan S., Amerik A.Y., and Hochstrasser M. The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast. Mol. Biol. Cell 10 (1999) 2583-2594
27. Verma R., Chen S., Feldman R., Schieltz D., Yates J., Dohmen J., and Deshaies R.J. Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Mol. Biol. Cell 11 (2000) 3425-3439
28. Watt R., and Piper P.W. UBI4, the polyubiquitin gene of Saccharomyces cerevisiae, is a heat shock gene that is also subject to catabolite derepression control. Mol. Gen. Genet. 253 (1997) 439-447
29. Wilson S.M., Bhattacharyya B., Rachel R.A., Coppola V., Tessarollo L., Householder D.B., Fletcher C.F., Miller R.J., Copeland N.G., and Jenkins N.A. Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat. Genet. 32 (2002) 420-425
30. Xie Y., and Varshavsky A. RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit. Proc. Natl. Acad. Sci. USA 98 (2001) 3056-3061