메뉴 건너뛰기




Volumn 30, Issue 15, 2016, Pages 1718-1730

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin

Author keywords

Akt; Autophagy; Beclin 1; USP14

Indexed keywords

BECLIN 1; CELL PROTEIN; K63 PROTEIN; PROTEASOME; PROTEIN KINASE B; PROTEOME; UBIQUITIN; UNCLASSIFIED DRUG; USP14 PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; UBIQUITIN THIOLESTERASE; USP14 PROTEIN, HUMAN;

EID: 84983371822     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.285122.116     Document Type: Article
Times cited : (98)

References (35)
  • 1
    • 28844503115 scopus 로고    scopus 로고
    • Application and analysis of the GFPu family of ubiquitin-proteasome system reporters
    • Bence NF, Bennett EJ, Kopito RR. 2005. Application and analysis of the GFPu family of ubiquitin-proteasome system reporters. Method Enzymol 399: 481–490.
    • (2005) Method Enzymol , vol.399 , pp. 481-490
    • Bence, N.F.1    Bennett, E.J.2    Kopito, R.R.3
  • 2
    • 0035903538 scopus 로고    scopus 로고
    • A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14
    • Borodovsky A, Kessler BM, Casagrande R, Overkleeft HS, Wilkinson KD, Ploegh HL. 2001. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J 20: 5187–5196.
    • (2001) EMBO J , vol.20 , pp. 5187-5196
    • Borodovsky, A.1    Kessler, B.M.2    Casagrande, R.3    Overkleeft, H.S.4    Wilkinson, K.D.5    Ploegh, H.L.6
  • 3
    • 0029160069 scopus 로고
    • Protein kinase B (C-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering BM, Coffer PJ. 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376: 599–602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 4
    • 84989284335 scopus 로고    scopus 로고
    • Degradation of misfolded proteins in neurodegenerative diseases: Therapeutic targets and strategies
    • Ciechanover A, Kwon YT. 2015. Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies. Exp Mol Med 47: e147.
    • (2015) Exp Mol Med , pp. 47
    • Ciechanover, A.1    Kwon, Y.T.2
  • 5
    • 57449099865 scopus 로고    scopus 로고
    • MaxQuant enables high peptide identification rates, individualized p.P.b.-range mass accuracies and proteome-wide protein quantification
    • Cox J, Mann M. 2008. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 26: 1367–1372.
    • (2008) Nat Biotechnol , vol.26 , pp. 1367-1372
    • Cox, J.1    Mann, M.2
  • 6
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727–736.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.N.8
  • 8
    • 59249089394 scopus 로고    scopus 로고
    • Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
    • Itakura E, Kishi C, Inoue K, Mizushima N. 2008. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 19: 5360–5372.
    • (2008) Mol Biol Cell , vol.19 , pp. 5360-5372
    • Itakura, E.1    Kishi, C.2    Inoue, K.3    Mizushima, N.4
  • 11
    • 41649091606 scopus 로고    scopus 로고
    • Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome
    • Koulich E, Li X, DeMartino GN. 2008. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Mol Biol Cell 19: 1072–1082.
    • (2008) Mol Biol Cell , vol.19 , pp. 1072-1082
    • Koulich, E.1    Li, X.2    Demartino, G.N.3
  • 14
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine B, Klionsky DJ. 2004. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463–477.
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 15
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. 2008. Autophagy in the pathogenesis of disease. Cell 132: 27–42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 16
    • 77954898129 scopus 로고    scopus 로고
    • A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions
    • Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, et al. 2010. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell 18: 1041–1052.
    • (2010) Dev Cell , vol.18 , pp. 1041-1052
    • Lipinski, M.M.1    Hoffman, G.2    Ng, A.3    Zhou, W.4    Py, B.F.5    Hsu, E.6    Liu, X.7    Eisenberg, J.8    Liu, J.9    Blenis, J.10
  • 17
    • 80053501671 scopus 로고    scopus 로고
    • Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
    • Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, et al. 2011. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147: 223–234.
    • (2011) Cell , vol.147 , pp. 223-234
    • Liu, J.1    Xia, H.2    Kim, M.3    Xu, L.4    Li, Y.5    Zhang, L.6    Cai, Y.7    Norberg, H.V.8    Zhang, T.9    Furuya, T.10
  • 19
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B. 2010. Methods in mammalian autophagy research. Cell 140: 313–326.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 20
    • 34548851476 scopus 로고    scopus 로고
    • Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
    • Olzmann JA, Li L, Chudaev MV, Chen J, Perez FA, Palmiter RD, Chin LS. 2007. Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol 178: 1025–1038.
    • (2007) J Cell Biol , vol.178 , pp. 1025-1038
    • Olzmann, J.A.1    Li, L.2    Chudaev, M.V.3    Chen, J.4    Perez, F.A.5    Palmiter, R.D.6    Chin, L.S.7
  • 25
    • 38349114036 scopus 로고    scopus 로고
    • Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases
    • Tan JM, Wong ES, Kirkpatrick DS, Pletnikova O, Ko HS, Tay SP, Ho MW, Troncoso J, Gygi SP, Lee MK, et al. 2008. Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum Mol Genet 17: 431–439.
    • (2008) Hum Mol Genet , vol.17 , pp. 431-439
    • Tan, J.M.1    Wong, E.S.2    Kirkpatrick, D.S.3    Pletnikova, O.4    Ko, H.S.5    Tay, S.P.6    Ho, M.W.7    Troncoso, J.8    Gygi, S.P.9    Lee, M.K.10
  • 26
    • 84897022669 scopus 로고    scopus 로고
    • A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
    • Tian Z, D’Arcy P, Wang X, Ray A, Tai YT, Hu Y, Carrasco RD, Richardson P, Linder S, Chauhan D, et al. 2014. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood 123: 706–716.
    • (2014) Blood , vol.123 , pp. 706-716
    • Tian, Z.1    D’Arcy, P.2    Wang, X.3    Ray, A.4    Tai, Y.T.5    Hu, Y.6    Carrasco, R.D.7    Richardson, P.8    Linder, S.9    Chauhan, D.10
  • 30
    • 84919883904 scopus 로고    scopus 로고
    • Ubiquitin-specific protease 14 (USP14) regulates cellular proliferation and apoptosis in epithelial ovarian cancer
    • Wang Y, Wang J, Zhong J, Deng Y, Xi Q, He S, Yang S, Jiang L, Huang M, Tang C, et al. 2015. Ubiquitin-specific protease 14 (USP14) regulates cellular proliferation and apoptosis in epithelial ovarian cancer. Med Oncol 32: 379.
    • (2015) Med Oncol , vol.32 , pp. 379
    • Wang, Y.1    Wang, J.2    Zhong, J.3    Deng, Y.4    Xi, Q.5    He, S.6    Yang, S.7    Jiang, L.8    Huang, M.9    Tang, C.10
  • 31
    • 84878208622 scopus 로고    scopus 로고
    • Over-expression of deubiquitinating enzyme USP14 in lung adenocarcinoma promotes proliferation through the accumulation of β-catenin
    • Wu N, Liu C, Bai C, Han YP, Cho WC, Li Q. 2013. Over-expression of deubiquitinating enzyme USP14 in lung adenocarcinoma promotes proliferation through the accumulation of β-catenin. Int J Mol Sci 14: 10749–10760.
    • (2013) Int J Mol Sci , vol.14 , pp. 10749-10760
    • Wu, N.1    Liu, C.2    Bai, C.3    Han, Y.P.4    Cho, W.C.5    Li, Q.6
  • 32
    • 84955281129 scopus 로고    scopus 로고
    • Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system
    • Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L, et al. 2015a. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. Elife 4: e10510.
    • (2015) Elife , pp. 4
    • Xu, D.1    Shan, B.2    Lee, B.H.3    Zhu, K.4    Zhang, T.5    Sun, H.6    Liu, M.7    Shi, L.8    Liang, W.9    Qian, L.10
  • 33
    • 84946848015 scopus 로고    scopus 로고
    • Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
    • Xu D, Zhang T, Xiao J, Zhu K, Wei R, Wu Z, Meng H, Li Y, Yuan J. 2015b. Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon. Autophagy 11: 617–628.
    • (2015) Autophagy , vol.11 , pp. 617-628
    • Xu, D.1    Zhang, T.2    Xiao, J.3    Zhu, K.4    Wei, R.5    Wu, Z.6    Meng, H.7    Li, Y.8    Yuan, J.9
  • 34
    • 37649024076 scopus 로고    scopus 로고
    • Small molecule regulators of autophagy identified by an image-based high-throughput screen
    • Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, et al. 2007. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci 104: 19023–19028.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 19023-19028
    • Zhang, L.1    Yu, J.2    Pan, H.3    Hu, P.4    Hao, Y.5    Cai, W.6    Zhu, H.7    Yu, A.D.8    Xie, X.9    Ma, D.10
  • 35
    • 64049113909 scopus 로고    scopus 로고
    • Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidyli-nositol-3-kinase complex
    • Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, Heintz N, Yue Z. 2009. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidyli-nositol-3-kinase complex. Nat Cell Biol 11: 468–476.
    • (2009) Nat Cell Biol , vol.11 , pp. 468-476
    • Zhong, Y.1    Wang, Q.J.2    Li, X.3    Yan, Y.4    Backer, J.M.5    Chait, B.T.6    Heintz, N.7    Yue, Z.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.