메뉴 건너뛰기




Volumn 74, Issue 6, 2013, Pages 730-737

Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12

Author keywords

[No Author keywords available]

Indexed keywords

KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; RECEPTOR; TREM 2 RECEPTOR; UNCLASSIFIED DRUG;

EID: 84877036833     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2013.02.003     Document Type: Article
Times cited : (83)

References (76)
  • 1
    • 77956419470 scopus 로고    scopus 로고
    • ITAM-mediated signaling by the T-cell antigen receptor
    • Love P.E., Hayes S.M. ITAM-mediated signaling by the T-cell antigen receptor. Cold Spring Harb Perspect Biol 2010, 2:a002485.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Love, P.E.1    Hayes, S.M.2
  • 3
    • 33750714007 scopus 로고    scopus 로고
    • DAP12: an adapter protein with dual functionality
    • Takaki R., Watson S.R., Lanier L.L. DAP12: an adapter protein with dual functionality. Immunol Rev 2006, 214:118-129.
    • (2006) Immunol Rev , vol.214 , pp. 118-129
    • Takaki, R.1    Watson, S.R.2    Lanier, L.L.3
  • 4
    • 20844439274 scopus 로고    scopus 로고
    • KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions
    • Tomasello E., Vivier E. KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions. Eur J Immunol 2005, 35:1670-1677.
    • (2005) Eur J Immunol , vol.35 , pp. 1670-1677
    • Tomasello, E.1    Vivier, E.2
  • 6
    • 33746875981 scopus 로고    scopus 로고
    • Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
    • Hamerman J.A., Jarjoura J.R., Humphrey M.B., Nakamura M.C., Seaman W.E., Lanier L.L. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol 2006, 177:2051-2055.
    • (2006) J Immunol , vol.177 , pp. 2051-2055
    • Hamerman, J.A.1    Jarjoura, J.R.2    Humphrey, M.B.3    Nakamura, M.C.4    Seaman, W.E.5    Lanier, L.L.6
  • 9
    • 0037316580 scopus 로고    scopus 로고
    • DAP12 signaling: from immune cells to bone modeling and brain myelination
    • Colonna M. DAP12 signaling: from immune cells to bone modeling and brain myelination. J Clin Invest 2003, 111:313-314.
    • (2003) J Clin Invest , vol.111 , pp. 313-314
    • Colonna, M.1
  • 10
    • 38449106692 scopus 로고    scopus 로고
    • The enigmatic function of TREM-2 in osteoclastogenesis
    • Colonna M., Turnbull I., Klesney-Tait J. The enigmatic function of TREM-2 in osteoclastogenesis. Adv Exp Med Biol 2007, 602:97-105.
    • (2007) Adv Exp Med Biol , vol.602 , pp. 97-105
    • Colonna, M.1    Turnbull, I.2    Klesney-Tait, J.3
  • 11
    • 0033930245 scopus 로고    scopus 로고
    • DAP12 and KAP10 (DAP10)-novel transmembrane adapter proteins of the CD3ζ family
    • Wilson M.J., Lindquist J.A., Trowsdale J. DAP12 and KAP10 (DAP10)-novel transmembrane adapter proteins of the CD3ζ family. Immunol Res 2000, 22:21-42.
    • (2000) Immunol Res , vol.22 , pp. 21-42
    • Wilson, M.J.1    Lindquist, J.A.2    Trowsdale, J.3
  • 12
    • 33846562134 scopus 로고    scopus 로고
    • Activating and inhibitory function of DAP12
    • Turnbull I.R., Colonna M. Activating and inhibitory function of DAP12. Nat Rev Immunol 2007, 7:155-161.
    • (2007) Nat Rev Immunol , vol.7 , pp. 155-161
    • Turnbull, I.R.1    Colonna, M.2
  • 13
    • 0032709773 scopus 로고    scopus 로고
    • Cutting egde: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties
    • Chang C., et al. Cutting egde: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J Immunol 1999, 163:4651-4654.
    • (1999) J Immunol , vol.163 , pp. 4651-4654
    • Chang, C.1
  • 14
    • 70350414455 scopus 로고    scopus 로고
    • The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells
    • Hamerman J.A., Ni M., Killebrew J.R., Chu C.L., Lowell C.A. The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells. Immunol Rev 2009, 232:42-58.
    • (2009) Immunol Rev , vol.232 , pp. 42-58
    • Hamerman, J.A.1    Ni, M.2    Killebrew, J.R.3    Chu, C.L.4    Lowell, C.A.5
  • 15
    • 78649815100 scopus 로고    scopus 로고
    • The conundrum of inhibitory signaling by ITAM-containg immunoreceptors: potential molecular mechanisms
    • Waterman P.M., Cambier J.C. The conundrum of inhibitory signaling by ITAM-containg immunoreceptors: potential molecular mechanisms. FEBS Lett 2010, 584:4878-4882.
    • (2010) FEBS Lett , vol.584 , pp. 4878-4882
    • Waterman, P.M.1    Cambier, J.C.2
  • 16
    • 0032510146 scopus 로고    scopus 로고
    • Immunoreceptor DAP12 bearing a tyrosine-based activation motifs is involved in activating NK cells
    • Lanier L.L., Corliss B.C., Wu J., Leong C., Philips J.H. Immunoreceptor DAP12 bearing a tyrosine-based activation motifs is involved in activating NK cells. Nature 1998, 391:703-707.
    • (1998) Nature , vol.391 , pp. 703-707
    • Lanier, L.L.1    Corliss, B.C.2    Wu, J.3    Leong, C.4    Philips, J.H.5
  • 17
    • 77958153191 scopus 로고    scopus 로고
    • The structural basis for intramembrane assembly of an activating immunoreceptor complex
    • Call M.E., Wucherpfennig K.W., Chou J.J. The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol 2010, 11:1023-1029.
    • (2010) Nat Immunol , vol.11 , pp. 1023-1029
    • Call, M.E.1    Wucherpfennig, K.W.2    Chou, J.J.3
  • 18
    • 58049200736 scopus 로고    scopus 로고
    • DAP10- and DAP12-associated receptors in innate immunity
    • Lanier L.L. DAP10- and DAP12-associated receptors in innate immunity. Immunol Rev 2009, 227:150-160.
    • (2009) Immunol Rev , vol.227 , pp. 150-160
    • Lanier, L.L.1
  • 19
    • 12244274375 scopus 로고    scopus 로고
    • Role of DAP12 in innate and adaptive immune responses
    • Aoki N., Kimura S., Xing Z. Role of DAP12 in innate and adaptive immune responses. Curr Pharm Design 2003, 9:7-10.
    • (2003) Curr Pharm Design , vol.9 , pp. 7-10
    • Aoki, N.1    Kimura, S.2    Xing, Z.3
  • 20
    • 0035887503 scopus 로고    scopus 로고
    • A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
    • Bouchon A., Hernandez-Munain C., Cella M., Colonna M. A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J Exp Med 2001, 194:1111-1122.
    • (2001) J Exp Med , vol.194 , pp. 1111-1122
    • Bouchon, A.1    Hernandez-Munain, C.2    Cella, M.3    Colonna, M.4
  • 21
    • 78649410484 scopus 로고    scopus 로고
    • The tortoise and the hare: slowly evolving T-cell responses take hastily evolving KIR
    • van Bergen J., Koning F. The tortoise and the hare: slowly evolving T-cell responses take hastily evolving KIR. Immunology 2010, 131:301-309.
    • (2010) Immunology , vol.131 , pp. 301-309
    • van Bergen, J.1    Koning, F.2
  • 22
    • 67650099148 scopus 로고    scopus 로고
    • Deletion polymorphism of SIGLEC14 and its functional implications
    • Yamanaka M., Kato Y., Angata T., Narimatsu H. Deletion polymorphism of SIGLEC14 and its functional implications. Glycobiology 2009, 19:841-846.
    • (2009) Glycobiology , vol.19 , pp. 841-846
    • Yamanaka, M.1    Kato, Y.2    Angata, T.3    Narimatsu, H.4
  • 24
    • 33747806633 scopus 로고    scopus 로고
    • Molecular and functional characterization of Cd300b, a new activating immunoglobulin receptor able to transducer signals through two different pathways
    • Martinez-Barriocanal A., Sayos J. Molecular and functional characterization of Cd300b, a new activating immunoglobulin receptor able to transducer signals through two different pathways. J Immunol 2006, 177:2819-2830.
    • (2006) J Immunol , vol.177 , pp. 2819-2830
    • Martinez-Barriocanal, A.1    Sayos, J.2
  • 25
    • 51149102498 scopus 로고    scopus 로고
    • SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans
    • Cao H., Lanker U., de Bono B., Traherne J.A., Trwosdale J., Barrow A.D. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. Eur J Immunol 2008, 38:2303-2315.
    • (2008) Eur J Immunol , vol.38 , pp. 2303-2315
    • Cao, H.1    Lanker, U.2    de Bono, B.3    Traherne, J.A.4    Trwosdale, J.5    Barrow, A.D.6
  • 26
    • 0037331539 scopus 로고    scopus 로고
    • The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44
    • Allcock R.J.N., Barrow A.D., Forbes S., Beck S., Trowsdale J. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol 2003, 33:567-577.
    • (2003) Eur J Immunol , vol.33 , pp. 567-577
    • Allcock, R.J.N.1    Barrow, A.D.2    Forbes, S.3    Beck, S.4    Trowsdale, J.5
  • 27
    • 33846316333 scopus 로고    scopus 로고
    • The TREM receptor family and signal integration
    • Klesney-Tait J., Turnbull I.R., Colonna M. The TREM receptor family and signal integration. Nat Immunol 2007, 7:1266-1273.
    • (2007) Nat Immunol , vol.7 , pp. 1266-1273
    • Klesney-Tait, J.1    Turnbull, I.R.2    Colonna, M.3
  • 28
    • 77449150146 scopus 로고    scopus 로고
    • The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells
    • Whittaker G.C., et al. The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells. J Biol Chem 2010, 285:2976-2985.
    • (2010) J Biol Chem , vol.285 , pp. 2976-2985
    • Whittaker, G.C.1
  • 29
    • 42149188248 scopus 로고    scopus 로고
    • TREM-2 binds to lipopolisaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells
    • Quan D.N., Cooper M.D., Potter J.L., Roberts M.H., Cheng H., Jarvis G.A. TREM-2 binds to lipopolisaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells. Mucosal Immunol 2008, 1:229-238.
    • (2008) Mucosal Immunol , vol.1 , pp. 229-238
    • Quan, D.N.1    Cooper, M.D.2    Potter, J.L.3    Roberts, M.H.4    Cheng, H.5    Jarvis, G.A.6
  • 30
    • 62749164849 scopus 로고    scopus 로고
    • Triggering receptor expressed on myeloid cells (TREM) family and the application of its antagonist
    • Molloy E.J. Triggering receptor expressed on myeloid cells (TREM) family and the application of its antagonist. Recent Pat Antiinfect Drug Discov 2009, 4:51-56.
    • (2009) Recent Pat Antiinfect Drug Discov , vol.4 , pp. 51-56
    • Molloy, E.J.1
  • 31
    • 0034657890 scopus 로고    scopus 로고
    • Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    • Bouchon A., Dietrich J., Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 2000, 164:4991-4995.
    • (2000) J Immunol , vol.164 , pp. 4991-4995
    • Bouchon, A.1    Dietrich, J.2    Colonna, M.3
  • 32
    • 64049095240 scopus 로고    scopus 로고
    • TREM and TREM-like receptors in inflammation and disease
    • Ford J.W., McVicar D.W. TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 2009, 21:38-46.
    • (2009) Curr Opin Immunol , vol.21 , pp. 38-46
    • Ford, J.W.1    McVicar, D.W.2
  • 33
    • 0037805700 scopus 로고    scopus 로고
    • TREMS in the immune system and beyond
    • Colonna M. TREMS in the immune system and beyond. Nat Rev Immunol 2003, 3:1-9.
    • (2003) Nat Rev Immunol , vol.3 , pp. 1-9
    • Colonna, M.1
  • 34
    • 67650859937 scopus 로고    scopus 로고
    • Pattern of DAP12 expression in leukocytes from both healthy and systemic lupus erythematosus patients
    • Schleinitz N., et al. Pattern of DAP12 expression in leukocytes from both healthy and systemic lupus erythematosus patients. PLoS ONE 2009, 4:e6264.
    • (2009) PLoS ONE , vol.4
    • Schleinitz, N.1
  • 35
    • 0035086799 scopus 로고    scopus 로고
    • Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family
    • Daws M.R., Lanier L.L., Seaman W.E., Ryan J.C. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol 2001, 31:783-791.
    • (2001) Eur J Immunol , vol.31 , pp. 783-791
    • Daws, M.R.1    Lanier, L.L.2    Seaman, W.E.3    Ryan, J.C.4
  • 36
    • 84855221945 scopus 로고    scopus 로고
    • TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR
    • Ito H., Hamerman J.A. TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR. Eur J Immunol 2012, 42:176-185.
    • (2012) Eur J Immunol , vol.42 , pp. 176-185
    • Ito, H.1    Hamerman, J.A.2
  • 37
    • 33746875981 scopus 로고    scopus 로고
    • Cutting edge: inhibition of TLR and FcR resposnes in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
    • Hamerman J.A., Jarjoura J.R., Humphrey M.B., Nakamura M.C., Seaman W.E., Lanier L.L. Cutting edge: inhibition of TLR and FcR resposnes in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol 2006, 177:2051-2055.
    • (2006) J Immunol , vol.177 , pp. 2051-2055
    • Hamerman, J.A.1    Jarjoura, J.R.2    Humphrey, M.B.3    Nakamura, M.C.4    Seaman, W.E.5    Lanier, L.L.6
  • 38
    • 33748517428 scopus 로고    scopus 로고
    • Cutting edge: TREM-2 attenuates macrophage activation
    • Turnbull I.R., et al. Cutting edge: TREM-2 attenuates macrophage activation. J Immunol 2006, 177:3520-3524.
    • (2006) J Immunol , vol.177 , pp. 3520-3524
    • Turnbull, I.R.1
  • 39
    • 0041419697 scopus 로고    scopus 로고
    • DAP12/TREM-2 deficiency results in impired osteoclast differentiation and osteoporotic features
    • Paloneva J., et al. DAP12/TREM-2 deficiency results in impired osteoclast differentiation and osteoporotic features. J Exp Med 2003, 198:669-675.
    • (2003) J Exp Med , vol.198 , pp. 669-675
    • Paloneva, J.1
  • 41
    • 9644307970 scopus 로고    scopus 로고
    • Distribution and signaling of TREM-2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia
    • Sessa G., et al. Distribution and signaling of TREM-2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. Eur J Neurosci 2004, 20:2617-2628.
    • (2004) Eur J Neurosci , vol.20 , pp. 2617-2628
    • Sessa, G.1
  • 42
    • 34250679758 scopus 로고    scopus 로고
    • Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis
    • Piccio L., et al. Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. Eur J Immunol 2007, 37:1290-1301.
    • (2007) Eur J Immunol , vol.37 , pp. 1290-1301
    • Piccio, L.1
  • 43
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • Guha M., Mackman N. The phosphatidylinositol 3-kinase-akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002, 277:32124-32132.
    • (2002) J Biol Chem , vol.277 , pp. 32124-32132
    • Guha, M.1    Mackman, N.2
  • 44
    • 53649103519 scopus 로고    scopus 로고
    • Metastasis and AKT activation
    • Qiao M., Sheng S., Pardee A.B. Metastasis and AKT activation. Cell Cycle 2008, 7:2991-2996.
    • (2008) Cell Cycle , vol.7 , pp. 2991-2996
    • Qiao, M.1    Sheng, S.2    Pardee, A.B.3
  • 47
    • 79952704606 scopus 로고    scopus 로고
    • A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation and autoimmunity
    • Fuller D.M., Zhu M., Ou-Yang C.W., Sullivan S.A., Zhang W. A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation and autoimmunity. Immunol Res 2011, 49:97-108.
    • (2011) Immunol Res , vol.49 , pp. 97-108
    • Fuller, D.M.1    Zhu, M.2    Ou-Yang, C.W.3    Sullivan, S.A.4    Zhang, W.5
  • 48
    • 0345743609 scopus 로고    scopus 로고
    • LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways
    • Sommers C.L., Samelson L.E., Love P.E. LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways. BioEssays 2004, 26:61-67.
    • (2004) BioEssays , vol.26 , pp. 61-67
    • Sommers, C.L.1    Samelson, L.E.2    Love, P.E.3
  • 49
    • 79251572954 scopus 로고    scopus 로고
    • LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?
    • Orr S.J., McVicar D.W. LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?. J Leukoc Biol 2011, 89:11-19.
    • (2011) J Leukoc Biol , vol.89 , pp. 11-19
    • Orr, S.J.1    McVicar, D.W.2
  • 51
    • 1842631103 scopus 로고    scopus 로고
    • Jurkat T cells and development of the T-cell receptor signaling paradigm
    • Abraham R.T., Weiss A. Jurkat T cells and development of the T-cell receptor signaling paradigm. Nat Rev Immunol 2004, 4:301-308.
    • (2004) Nat Rev Immunol , vol.4 , pp. 301-308
    • Abraham, R.T.1    Weiss, A.2
  • 52
    • 33846621025 scopus 로고    scopus 로고
    • Antigen receptor signaling: a distinctive role for the p110δ isoform of PI3K
    • Okkenhaug K., Ali K., Vanhaesebroeck B. Antigen receptor signaling: a distinctive role for the p110δ isoform of PI3K. Trends Immunol 2007, 28:80-87.
    • (2007) Trends Immunol , vol.28 , pp. 80-87
    • Okkenhaug, K.1    Ali, K.2    Vanhaesebroeck, B.3
  • 53
    • 7244252807 scopus 로고    scopus 로고
    • Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL
    • Volna P., et al. Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med 2004, 200:1001-1013.
    • (2004) J Exp Med , vol.200 , pp. 1001-1013
    • Volna, P.1
  • 54
    • 0037307394 scopus 로고    scopus 로고
    • The role of Tec family kinases in T cell development and function
    • Lucas J.A., Miller A.T., Atherly L.O., Berg L.J. The role of Tec family kinases in T cell development and function. Immunol Rev 2003, 191:119-138.
    • (2003) Immunol Rev , vol.191 , pp. 119-138
    • Lucas, J.A.1    Miller, A.T.2    Atherly, L.O.3    Berg, L.J.4
  • 55
    • 62849123774 scopus 로고    scopus 로고
    • Cross-regulation of signaling by ITAM-associated receptors
    • Ivashkiv L.B. Cross-regulation of signaling by ITAM-associated receptors. Nat Immunol 2009, 10:340-347.
    • (2009) Nat Immunol , vol.10 , pp. 340-347
    • Ivashkiv, L.B.1
  • 56
    • 20644443886 scopus 로고    scopus 로고
    • Enhanced toll-like receptor responses in the absence of signaling adapter DAP12
    • Hamerman J.A., Tchao N.K., Lowell C.A., Lanier L.L. Enhanced toll-like receptor responses in the absence of signaling adapter DAP12. Nat Immunol 2005, 6:579-586.
    • (2005) Nat Immunol , vol.6 , pp. 579-586
    • Hamerman, J.A.1    Tchao, N.K.2    Lowell, C.A.3    Lanier, L.L.4
  • 57
    • 33646908228 scopus 로고    scopus 로고
    • Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling
    • Kagan J.C., Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling. Cell 2006, 125:943-955.
    • (2006) Cell , vol.125 , pp. 943-955
    • Kagan, J.C.1    Medzhitov, R.2
  • 59
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on toll-like receptors
    • Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol 2010, 11:373-384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 62
    • 2142652249 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of toll-like receptor 2-stimulated neutrophils
    • Strassheim D., et al. Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of toll-like receptor 2-stimulated neutrophils. J Immunol 2004, 172:5727-5733.
    • (2004) J Immunol , vol.172 , pp. 5727-5733
    • Strassheim, D.1
  • 63
    • 55749094156 scopus 로고    scopus 로고
    • Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation
    • Piccio L., et al. Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain 2008, 131:3081-3091.
    • (2008) Brain , vol.131 , pp. 3081-3091
    • Piccio, L.1
  • 64
    • 65449139593 scopus 로고    scopus 로고
    • CARD9 versus CARMA1 in innate and adaptive immunity
    • Hara H., Saito T. CARD9 versus CARMA1 in innate and adaptive immunity. Trends Immunol 2009, 30:234-242.
    • (2009) Trends Immunol , vol.30 , pp. 234-242
    • Hara, H.1    Saito, T.2
  • 65
    • 0141532262 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira S. Toll-like receptor signaling. J Biol Chem 2003, 278:38105-38108.
    • (2003) J Biol Chem , vol.278 , pp. 38105-38108
    • Akira, S.1
  • 66
    • 60849109512 scopus 로고    scopus 로고
    • TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria
    • N'Diaye E.N., Branda C.S., Branda S.S., Nevarez L., et al. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol 2009, 184:215-223.
    • (2009) J Cell Biol , vol.184 , pp. 215-223
    • N'Diaye, E.N.1    Branda, C.S.2    Branda, S.S.3    Nevarez, L.4
  • 67
    • 0033662295 scopus 로고    scopus 로고
    • Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice
    • Tomasello E., et al. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 2000, 13:355-364.
    • (2000) Immunity , vol.13 , pp. 355-364
    • Tomasello, E.1
  • 68
    • 58149195670 scopus 로고    scopus 로고
    • Essential role of DAP12 signaling in macrophage programming into a fusion-competent state
    • Helming L., et al. Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Sci Signal 2008, 1:ra11.
    • (2008) Sci Signal , vol.1
    • Helming, L.1
  • 69
    • 71849093985 scopus 로고    scopus 로고
    • TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells
    • Radhakrishnan S., et al. TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells. J Immunol 2008, 181:7863-7872.
    • (2008) J Immunol , vol.181 , pp. 7863-7872
    • Radhakrishnan, S.1
  • 70
    • 75749091859 scopus 로고    scopus 로고
    • IL-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of NFATc1 and suppressing proximal RANK signaling
    • Kalliolias G.D., Zhao B., Triantafyllopoulou A., Park-Min K.H., Ivashkiv L.B. IL-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of NFATc1 and suppressing proximal RANK signaling. Arthritis Rheum 2010, 62:402.
    • (2010) Arthritis Rheum , vol.62 , pp. 402
    • Kalliolias, G.D.1    Zhao, B.2    Triantafyllopoulou, A.3    Park-Min, K.H.4    Ivashkiv, L.B.5
  • 71
    • 0037314230 scopus 로고    scopus 로고
    • Osteopetrosis and thalamic hypomyelinosis with synaptic degradation in DAP12-deficient mice
    • Kaifu T., et al. Osteopetrosis and thalamic hypomyelinosis with synaptic degradation in DAP12-deficient mice. J Clin Invest 2003, 111:323-332.
    • (2003) J Clin Invest , vol.111 , pp. 323-332
    • Kaifu, T.1
  • 72
    • 1642526619 scopus 로고    scopus 로고
    • The signaling adapter protein DAP12 regulates multinucleation during osteoclast development
    • Humphrey M.B., et al. The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J Bone Miner Res 2004, 19:224-234.
    • (2004) J Bone Miner Res , vol.19 , pp. 224-234
    • Humphrey, M.B.1
  • 73
    • 33144467142 scopus 로고    scopus 로고
    • TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function
    • Humphery M.B., et al. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res 2006, 21:237-345.
    • (2006) J Bone Miner Res , vol.21 , pp. 237-345
    • Humphery, M.B.1
  • 74
    • 64649084316 scopus 로고    scopus 로고
    • Lymphocytes and the DAP12 adaptor are key regulators of osteoclast activation associated with gonadal failure
    • Anginot A., Dacquin R., Mazzorana M., Jurdic P. Lymphocytes and the DAP12 adaptor are key regulators of osteoclast activation associated with gonadal failure. PLoS One 2007, 7:e585.
    • (2007) PLoS One , vol.7
    • Anginot, A.1    Dacquin, R.2    Mazzorana, M.3    Jurdic, P.4
  • 75
    • 14244268775 scopus 로고    scopus 로고
    • Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
    • Takahashi K., Rochford C.D., Neumann H. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med 2005, 201:647-657.
    • (2005) J Exp Med , vol.201 , pp. 647-657
    • Takahashi, K.1    Rochford, C.D.2    Neumann, H.3
  • 76
    • 46249131907 scopus 로고    scopus 로고
    • The innate immune response to Salmonella by macrophages is dependent on TREM2-DAP12
    • Charles J.F., et al. The innate immune response to Salmonella by macrophages is dependent on TREM2-DAP12. Infect Immun 2008, 76:2439-2447.
    • (2008) Infect Immun , vol.76 , pp. 2439-2447
    • Charles, J.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.