Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

Epigenetics and Chromatin

Volumn 10, Issue 1, 2017, Pages

  Okada, Masahiro ^a   Kanamori, Mitsuhiro ^a   Someya, Kazue ^a   Nakatsukasa, Hiroko ^a   Yoshimura, Akihiko ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

CRISPR; dCas9; Epigenome editing; Foxp3; p300; TET1; Treg

Indexed keywords

CONSERVED NON CODING DNA SEQUENCES 2; CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN 9; DIOXYGENASE; DNA; E1A ASSOCIATED P300 PROTEIN; GUIDE RNA; HISTONE ACETYLTRANSFERASE; HYBRID PROTEIN; METHYLCYTOSINE DIOXYGENASE; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSLOCATION DIOXYGENASE 1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; EP300 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; ONCOPROTEIN; TET1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DNA SEQUENCE; EMBRYO; ENHANCER REGION; ENZYME ACTIVE SITE; EPIGENETICS; FOXP3 GENE; GENE; GENE EDITING; GENE EXPRESSION; GENE LOCUS; GENE REPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; REGULATORY T LYMPHOCYTE; T CELL CULTURE; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; CRISPR CAS SYSTEM; DNA METHYLATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROMOTER REGION;

ANIMALS; CRISPR-CAS SYSTEMS; DNA METHYLATION; DNA-BINDING PROTEINS; E1A-ASSOCIATED P300 PROTEIN; EPIGENOMICS; FORKHEAD TRANSCRIPTION FACTORS; GENE EDITING; GENE EXPRESSION REGULATION; MICE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 85019038328     PISSN: None     EISSN: 17568935     Source Type: Journal    
DOI: 10.1186/s13072-017-0129-1     Document Type: Article

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