DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target

PLoS Pathogens

Volumn 13, Issue 4, 2017, Pages

  Soto Acosta, Rubén ^a,b   Bautista Carbajal, Patricia ^a   Cervantes Salazar, Margot ^a   Angel Ambrocio, Antonio H ^a   del Angel, Rosa M ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE (NADPH); HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; METFORMIN; MEVINOLIN; NONSTRUCTURAL PROTEIN 1; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; VIRAL PROTEIN; ANTIVIRUS AGENT; HMGCR PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELL VIABILITY ASSAY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENGUE; DENGUE VIRUS; DOWN REGULATION; ENZYMATIC ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE INACTIVATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LIPID METABOLISM; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; VIRUS REPLICATION; WESTERN BLOTTING; ANIMAL; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; TRANSCRIPTION INITIATION; VIROLOGY; VIRUS GENOME;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DENGUE; DENGUE VIRUS; GENOME, VIRAL; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; PHOSPHORYLATION; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; VIRUS REPLICATION;

EID: 85018291520     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1006257     Document Type: Article

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