Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells

Journal of Pathology

Volumn 230, Issue 3, 2013, Pages 336-346

  Lo, Angela Kwok Fung ^a,b,d   Lo, Kwok Wai ^b   Ko, Chun Wai ^b   Young, Lawrence S ^c   Dawson, Christopher W ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF WARWICK   (United Kingdom)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

AMPK; Epstein Barr virus; LKB1; LMP1; nasopharyngeal carcinoma

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; FLUOROURACIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LATENT MEMBRANE PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE LKB1;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL TRANSFORMATION; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME REACTIVATION; EPITHELIUM CELL; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NASOPHARYNX; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; EPSTEIN-BARR VIRUS INFECTIONS; FLUOROURACIL; HERPESVIRUS 4, HUMAN; HUMANS; MAP KINASE SIGNALING SYSTEM; NASOPHARYNGEAL NEOPLASMS; NASOPHARYNX; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; VIRAL MATRIX PROTEINS;

EID: 84878810801     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4201     Document Type: Article

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