Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type i IFN Signaling

Cell

Volumn 163, Issue 7, 2015, Pages 1716-1729

  York, Autumn G ^a   Williams, Kevin J ^b   Argus, Joseph P ^a   Zhou, Quan D ^a   Brar, Gurpreet ^a   Vergnes, Laurent ^a   Gray, Elizabeth E ^c   Zhen, Anjie ^a   Wu, Nicholas C ^a,b   Yamada, Douglas H ^g   Cunningham, Cameron R ^b   Tarling, Elizabeth J ^a,b   Wilks, Moses Q ^d   Casero, David ^a   Gray, David H ^b   Yu, Amy K ^a   Wang, Eric S ^a   Brooks, David G ^e,f   Sun, Ren ^a   Kitchen, Scott G ^a   Wu, Ting Ting ^a   Reue, Karen ^a,b   Stetson, Daniel B ^c   Bensinger, Steven J ^a,b   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e PRINCESS MARGARET HOSPITAL   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTERFERON; CHOLESTEROL; INTERFERON; INTERFERON REGULATORY FACTOR 3; LONG CHAIN FATTY ACID; MEVALONIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; GAMMA INTERFERON; INTERFERON BETA SERINE; MEMBRANE PROTEIN; SREBF1 PROTEIN, MOUSE; SREBF2 PROTEIN, MOUSE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE RESPONSE; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; LIPID HOMEOSTASIS; LIPOGENESIS; MACROPHAGE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; NULL CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RNA SEQUENCE; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS INFECTION; VIRUS RESISTANCE; ANIMAL; C57BL MOUSE; METABOLISM; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CHOLESTEROL; HUMANS; IMMUNITY, INNATE; INTERFERON BETA-1B; INTERFERON-GAMMA; MEMBRANE PROTEINS; MEVALONIC ACID; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 84950247027     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.11.045     Document Type: Article

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