메뉴 건너뛰기




Volumn 13, Issue , 2012, Pages

A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase; Alternative splicing; Cholesterol; HMG CoA; Statin; Transcription

Indexed keywords

ATORVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA;

EID: 84866298369     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-13-29     Document Type: Article
Times cited : (12)

References (35)
  • 1
    • 0033984436 scopus 로고    scopus 로고
    • Current perspectives on statins
    • 10.1161/01.CIR.101.2.207, 10637210
    • Maron DJ, Fazio S, Linton MF. Current perspectives on statins. Circulation 2000, 101:207-213. 10.1161/01.CIR.101.2.207, 10637210.
    • (2000) Circulation , vol.101 , pp. 207-213
    • Maron, D.J.1    Fazio, S.2    Linton, M.F.3
  • 2
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • 10.1038/343425a0, 1967820
    • Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990, 343:425-430. 10.1038/343425a0, 1967820.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 4
    • 44849131929 scopus 로고    scopus 로고
    • Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase
    • 10.1038/cr.2008.61, 2742364, 18504457
    • DeBose-Boyd RA. Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. Cell Res 2008, 18:609-621. 10.1038/cr.2008.61, 2742364, 18504457.
    • (2008) Cell Res , vol.18 , pp. 609-621
    • DeBose-Boyd, R.A.1
  • 5
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • 150968, 11994399
    • Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002, 109:1125-1131. 150968, 11994399.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 6
    • 79955758640 scopus 로고    scopus 로고
    • Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake
    • 10.1371/journal.pone.0019420, 3084847, 21559365
    • Medina MW, Gao F, Naidoo D, Rudel LL, Temel RE, McDaniel AL, Marshall SM, Krauss RM. Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. PLoS One 2011, 6:e19420. 10.1371/journal.pone.0019420, 3084847, 21559365.
    • (2011) PLoS One , vol.6
    • Medina, M.W.1    Gao, F.2    Naidoo, D.3    Rudel, L.L.4    Temel, R.E.5    McDaniel, A.L.6    Marshall, S.M.7    Krauss, R.M.8
  • 8
    • 49149095635 scopus 로고    scopus 로고
    • Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin
    • 10.1161/CIRCULATIONAHA.108.773267, 2720070, 18559695
    • Medina MW, Gao F, Ruan W, Rotter JI, Krauss RM. Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation 2008, 118:355-362. 10.1161/CIRCULATIONAHA.108.773267, 2720070, 18559695.
    • (2008) Circulation , vol.118 , pp. 355-362
    • Medina, M.W.1    Gao, F.2    Ruan, W.3    Rotter, J.I.4    Krauss, R.M.5
  • 9
    • 0035843962 scopus 로고    scopus 로고
    • Structural mechanism for statin inhibition of HMG-CoA reductase
    • 10.1126/science.1059344, 11349148
    • Istvan ES, Deisenhofer J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 2001, 292:1160-1164. 10.1126/science.1059344, 11349148.
    • (2001) Science , vol.292 , pp. 1160-1164
    • Istvan, E.S.1    Deisenhofer, J.2
  • 10
    • 0034161543 scopus 로고    scopus 로고
    • Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis
    • 10.1093/emboj/19.5.819, 305622, 10698924
    • Istvan ES, Palnitkar M, Buchanan SK, Deisenhofer J. Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J 2000, 19:819-830. 10.1093/emboj/19.5.819, 305622, 10698924.
    • (2000) EMBO J , vol.19 , pp. 819-830
    • Istvan, E.S.1    Palnitkar, M.2    Buchanan, S.K.3    Deisenhofer, J.4
  • 11
    • 71249136025 scopus 로고    scopus 로고
    • The role of HMGCR alternative splicing in statin efficacy
    • 10.1016/j.tcm.2009.10.003, 2805071, 20005478
    • Medina MW, Krauss RM. The role of HMGCR alternative splicing in statin efficacy. Trends Cardiovasc Med 2009, 19:173-177. 10.1016/j.tcm.2009.10.003, 2805071, 20005478.
    • (2009) Trends Cardiovasc Med , vol.19 , pp. 173-177
    • Medina, M.W.1    Krauss, R.M.2
  • 12
    • 84870647022 scopus 로고    scopus 로고
    • UCSC Genome Browser
    • UCSC Genome Browser. http://genome.ucsc.edu/..
  • 13
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000, 132:365-386.
    • (2000) Methods Mol Biol , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 14
    • 77952856143 scopus 로고    scopus 로고
    • Gene expression results in lipopolysaccharide-stimulated monocytes depend significantly on the choice of reference genes
    • 10.1186/1471-2172-11-21, 2884165, 20441576
    • Piehler AP, Grimholt RM, Ovstebo R, Berg JP. Gene expression results in lipopolysaccharide-stimulated monocytes depend significantly on the choice of reference genes. BMC Immunol 2010, 11:21. 10.1186/1471-2172-11-21, 2884165, 20441576.
    • (2010) BMC Immunol , vol.11 , pp. 21
    • Piehler, A.P.1    Grimholt, R.M.2    Ovstebo, R.3    Berg, J.P.4
  • 15
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • 126239, 12184808
    • Vandesompele J, De PK, Pattyn F, Poppe B, Van RN, De PA, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002, 3:RESEARCH0034. 126239, 12184808.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    De, P.K.2    Pattyn, F.3    Poppe, B.4    Van, R.N.5    De, P.A.6    Speleman, F.7
  • 16
    • 84871383556 scopus 로고    scopus 로고
    • GeNorm
    • geNorm. http://medgen.ugent.be/~jvdesomp/genorm/..
  • 17
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • 10.1093/nar/29.9.e45, 55695, 11328886
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:e45. 10.1093/nar/29.9.e45, 55695, 11328886.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 18
    • 84870647668 scopus 로고    scopus 로고
    • Protein knowledgebase (UniProtKB)
    • Protein knowledgebase (UniProtKB). http://www.uniprot.org/..
  • 19
    • 0031755082 scopus 로고    scopus 로고
    • Splice donor site mutations in the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene cause a deficiency of the endoplasmic reticulum 3-hydroxy-3-methylglutaryl coenzyme A reductase protein in UT2 cells
    • Engfelt WH, Masuda KR, Paton VG, Krisans SK. Splice donor site mutations in the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene cause a deficiency of the endoplasmic reticulum 3-hydroxy-3-methylglutaryl coenzyme A reductase protein in UT2 cells. J Lipid Res 1998, 39:2182-2191.
    • (1998) J Lipid Res , vol.39 , pp. 2182-2191
    • Engfelt, W.H.1    Masuda, K.R.2    Paton, V.G.3    Krisans, S.K.4
  • 20
    • 0021913335 scopus 로고
    • Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum
    • Liscum L, Finer-Moore J, Stroud RM, Luskey KL, Brown MS, Goldstein JL. Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. J Biol Chem 1985, 260:522-530.
    • (1985) J Biol Chem , vol.260 , pp. 522-530
    • Liscum, L.1    Finer-Moore, J.2    Stroud, R.M.3    Luskey, K.L.4    Brown, M.S.5    Goldstein, J.L.6
  • 21
    • 0021961770 scopus 로고
    • 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells
    • 10.1073/pnas.82.3.770, 397128, 3883347
    • Keller GA, Barton MC, Shapiro DJ, Singer SJ. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells. Proc Natl Acad Sci U S A 1985, 82:770-774. 10.1073/pnas.82.3.770, 397128, 3883347.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 770-774
    • Keller, G.A.1    Barton, M.C.2    Shapiro, D.J.3    Singer, S.J.4
  • 22
    • 0023030829 scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme A reductase localization in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: quantitative biochemical and immunoelectron microscopical analyses
    • 10.1083/jcb.103.3.875, 2114277, 3745272
    • Keller GA, Pazirandeh M, Krisans S. 3-Hydroxy-3-methylglutaryl coenzyme A reductase localization in rat liver peroxisomes and microsomes of control and cholestyramine-treated animals: quantitative biochemical and immunoelectron microscopical analyses. J Cell Biol 1986, 103:875-886. 10.1083/jcb.103.3.875, 2114277, 3745272.
    • (1986) J Cell Biol , vol.103 , pp. 875-886
    • Keller, G.A.1    Pazirandeh, M.2    Krisans, S.3
  • 23
    • 33947328570 scopus 로고    scopus 로고
    • The hydroxy-methyl-glutaryl CoA reductase promoter polymorphism is associated with Alzheimer's risk and cognitive deterioration
    • 10.1016/j.neulet.2007.01.046, 17284348
    • Porcellini E, Calabrese E, Guerini F, Govoni M, Chiappelli M, Tumini E, Morgan K, Chappell S, Kalsheker N, Franceschi M, et al. The hydroxy-methyl-glutaryl CoA reductase promoter polymorphism is associated with Alzheimer's risk and cognitive deterioration. Neurosci Lett 2007, 416:66-70. 10.1016/j.neulet.2007.01.046, 17284348.
    • (2007) Neurosci Lett , vol.416 , pp. 66-70
    • Porcellini, E.1    Calabrese, E.2    Guerini, F.3    Govoni, M.4    Chiappelli, M.5    Tumini, E.6    Morgan, K.7    Chappell, S.8    Kalsheker, N.9    Franceschi, M.10
  • 24
    • 0034797095 scopus 로고    scopus 로고
    • Purification of brain peroxisomes and localization of 3-hydroxy-3-methylglutaryl coenzyme A reductase
    • 10.1046/j.0014-2956.2001.02409.x, 11559353
    • Kovacs WJ, Faust PL, Keller GA, Krisans SK. Purification of brain peroxisomes and localization of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Eur J Biochem 2001, 268:4850-4859. 10.1046/j.0014-2956.2001.02409.x, 11559353.
    • (2001) Eur J Biochem , vol.268 , pp. 4850-4859
    • Kovacs, W.J.1    Faust, P.L.2    Keller, G.A.3    Krisans, S.K.4
  • 25
    • 0036906509 scopus 로고    scopus 로고
    • A second gene for peroxisomal HMG-CoA reductase? A genomic reassessment
    • 10.1194/jlr.R200010-JLR200, 12454262
    • Breitling R, Krisans SK. A second gene for peroxisomal HMG-CoA reductase? A genomic reassessment. J Lipid Res 2002, 43:2031-2036. 10.1194/jlr.R200010-JLR200, 12454262.
    • (2002) J Lipid Res , vol.43 , pp. 2031-2036
    • Breitling, R.1    Krisans, S.K.2
  • 26
    • 41149149041 scopus 로고    scopus 로고
    • The functional consequences of alternative promoter use in mammalian genomes
    • 10.1016/j.tig.2008.01.008, 18329129
    • Davuluri RV, Suzuki Y, Sugano S, Plass C, Huang TH. The functional consequences of alternative promoter use in mammalian genomes. Trends Genet 2008, 24:167-177. 10.1016/j.tig.2008.01.008, 18329129.
    • (2008) Trends Genet , vol.24 , pp. 167-177
    • Davuluri, R.V.1    Suzuki, Y.2    Sugano, S.3    Plass, C.4    Huang, T.H.5
  • 27
    • 67649652375 scopus 로고    scopus 로고
    • The alternative noncoding exons 1 of aromatase (Cyp19) gene modulate gene expression in a posttranscriptional manner
    • 10.1210/en.2008-1812, 2703541, 19282383
    • Wang H, Li R, Hu Y. The alternative noncoding exons 1 of aromatase (Cyp19) gene modulate gene expression in a posttranscriptional manner. Endocrinology 2009, 150:3301-3307. 10.1210/en.2008-1812, 2703541, 19282383.
    • (2009) Endocrinology , vol.150 , pp. 3301-3307
    • Wang, H.1    Li, R.2    Hu, Y.3
  • 28
    • 69049116283 scopus 로고    scopus 로고
    • Stochastic noise in splicing machinery
    • 10.1093/nar/gkp471, 2724286, 19546110
    • Melamud E, Moult J. Stochastic noise in splicing machinery. Nucleic Acids Res 2009, 37:4873-4886. 10.1093/nar/gkp471, 2724286, 19546110.
    • (2009) Nucleic Acids Res , vol.37 , pp. 4873-4886
    • Melamud, E.1    Moult, J.2
  • 31
    • 47249133453 scopus 로고    scopus 로고
    • Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses
    • 10.1074/jbc.M709841200, 3258881, 18390541
    • Schiefelbein D, Goren I, Fisslthaler B, Schmidt H, Geisslinger G, Pfeilschifter J, Frank S. Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses. J Biol Chem 2008, 283:15479-15490. 10.1074/jbc.M709841200, 3258881, 18390541.
    • (2008) J Biol Chem , vol.283 , pp. 15479-15490
    • Schiefelbein, D.1    Goren, I.2    Fisslthaler, B.3    Schmidt, H.4    Geisslinger, G.5    Pfeilschifter, J.6    Frank, S.7
  • 32
    • 0029936752 scopus 로고    scopus 로고
    • Regulation of gene expression by alternative promoters
    • Ayoubi TA, Van De Ven WJ. Regulation of gene expression by alternative promoters. FASEB J 1996, 10:453-460.
    • (1996) FASEB J , vol.10 , pp. 453-460
    • Ayoubi, T.A.1    Van De Ven, W.J.2
  • 33
    • 77953963028 scopus 로고    scopus 로고
    • A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations
    • Keller L, Murphy C, Wang HX, Fratiglioni L, Olin M, Gafvels M, Bjorkhem I, Graff C, Meaney S. A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations. Brain Res 2010, 1344:185-191.
    • (2010) Brain Res , vol.1344 , pp. 185-191
    • Keller, L.1    Murphy, C.2    Wang, H.X.3    Fratiglioni, L.4    Olin, M.5    Gafvels, M.6    Bjorkhem, I.7    Graff, C.8    Meaney, S.9
  • 34
    • 30044451918 scopus 로고    scopus 로고
    • Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome
    • 1356123, 16344566
    • Cooper SJ, Trinklein ND, Anton ED, Nguyen L, Myers RM. Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome. Genome Res 2006, 16:1-10. 1356123, 16344566.
    • (2006) Genome Res , vol.16 , pp. 1-10
    • Cooper, S.J.1    Trinklein, N.D.2    Anton, E.D.3    Nguyen, L.4    Myers, R.M.5
  • 35
    • 34347384001 scopus 로고    scopus 로고
    • Distinct class of putative " non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes
    • 10.1101/gr.6030107, 1899111, 17567985
    • Tsuritani K, Irie T, Yamashita R, Sakakibara Y, Wakaguri H, Kanai A, Mizushima-Sugano J, Sugano S, Nakai K, Suzuki Y. Distinct class of putative " non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Genome Res 2007, 17:1005-1014. 10.1101/gr.6030107, 1899111, 17567985.
    • (2007) Genome Res , vol.17 , pp. 1005-1014
    • Tsuritani, K.1    Irie, T.2    Yamashita, R.3    Sakakibara, Y.4    Wakaguri, H.5    Kanai, A.6    Mizushima-Sugano, J.7    Sugano, S.8    Nakai, K.9    Suzuki, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.