Design and synthesis of 1,2,3-triazolo-phenanthrene hybrids as cytotoxic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 27, Issue 11, 2017, Pages 2369-2376

  Kumar, Niggula Praveen ^a   Nekkanti, Shalini ^a   Sujana Kumari, S ^a   Sharma, Pankaj ^a   Shankaraiah, Nagula ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

1,2,3 Triazoles; Click reaction; Cytotoxicity; DNA interaction; Phenanthrene

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 4',6 DIAMIDINO 2 PHENYLINDOLE; CYTOTOXIC AGENT; FLUOROURACIL; PHENANTHRENE DERIVATIVE; REACTIVE OXYGEN METABOLITE; 2-((1-((2,3,6,7-TETRAMETHOXYPHENANTHREN-9-YL)METHYL)-1H-1,2,3-TRIAZOL-4-YL)METHYL)-1H-BENZO(DE)ISOQUINOLINE-1,3(2H)-DIONE; ANTINEOPLASTIC AGENT; FLUORESCENT DYE; INDOLE DERIVATIVE; INTERCALATING AGENT; NAPHTHALIMIDE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG DESIGN; DRUG DNA BINDING; DRUG SYNTHESIS; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; G1 PHASE CELL CYCLE CHECKPOINT; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; LUNG CANCER CELL LINE; MALE; MDA-MB-231 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DOCKING; PHASE CONTRAST MICROSCOPY; PROSTATE CANCER CELL LINE; VISCOMETRY; VISCOSITY; APOPTOSIS; CYCLOADDITION; DRUG EFFECTS; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CYCLOADDITION REACTION; FLUORESCENT DYES; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INDOLES; INTERCALATING AGENTS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, PHASE-CONTRAST; MOLECULAR DOCKING SIMULATION; NAPHTHALIMIDES; PHENANTHRENES; REACTIVE OXYGEN SPECIES; TRIAZOLES; VISCOSITY;

EID: 85017531389     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2017.04.022     Document Type: Article

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