Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 4, 2008, Pages 1468-1473

  Kamal, Ahmed ^a   Shankaraiah, N ^a   Devaiah, V ^a   Laxma Reddy, K ^a   Juvekar, Aarti ^b   Sen, Subrata ^b   Kurian, Nisha ^b   Zingde, Surekha ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b Research and Education in Cancer   (India)

Author keywords

1,2,3 Triazoles; Anticancer activity; DNA binding affinity; Pyrrolo 2,1 c 1,4 benzodiazepines

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; DOXORUBICIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CHEMISTRY; CONTROLLED STUDY; CROSS LINKING; DNA ALKYLATION; DNA BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PHARMACOPHORE;

ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; CELL LINE, TUMOR; DNA; HUMANS; KINETICS; NEOPLASMS; PYRROLES; TRIAZOLES;

EID: 38949103732     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.063     Document Type: Article

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