Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition

Journal of the American Chemical Society

Volumn 125, Issue 11, 2003, Pages 3192-3193

  Wang, Qian ^a   Chan, Timothy R ^a   Hilgraf, Robert ^a   Fokin, Valery V ^a   Sharpless, K Barry ^a   Finn, M G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE; AMINE; AZIDE; COPPER; PHOSPHINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ARTICLE; BIOCONJUGATION; CATALYSIS; CONJUGATION; CYCLOADDITION; LIGATION; MOSAIC VIRUS; NONHUMAN; PH; PROTEIN FOLDING; REACTION ANALYSIS; TECHNIQUE;

ALKYNES; AZIDES; AZOLES; CAPSID PROTEINS; CATALYSIS; COMOVIRUS; COPPER; HYDROGEN-ION CONCENTRATION;

EID: 0037454346     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja021381e     Document Type: Article

References (20)

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13. We were alerted to the beneficial effects of tris(triazolyl)amine ligands by the observation of accelerating reaction rates (autocatalysis) during their preparation by the copper-catalyzed cycloaddition. Compound 6 was designed based on this observation and is a particularly powerful facilitator of this process. A full account of the development, coordination chemistry, and applications of multidentate triazoles and related ligands will be presented elsewhere.
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