Synthesis of 2,3,6,7-tetramethoxyphenanthren-9-amine: An efficient precursor to access new 4-aza-2,3-dihydropyridophenanthrenes as apoptosis inducing agents

European Journal of Medicinal Chemistry

Volumn 127, Issue , 2017, Pages 305-317

  Kumar, Niggula Praveen ^a   Sharma, Pankaj ^a   Reddy, T Srinivasa ^b   Nekkanti, Shalini ^a   Shankaraiah, Nagula ^a   Lalita, Guntuku ^a   Sujanakumari, S ^a   Bhargava, Suresh K ^b   Naidu, V G M ^a   Kamal, Ahmed ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b RMIT UNIVERSITY   (Australia)

Author keywords

2,3,6,7 Tetramethoxyphenanthren 9 amine; 4 Aza 2,3 dihydropyridophenanthrenes; Apoptosis; Cytotoxicity; Multi component reaction; Perkin condensation

Indexed keywords

13 (2 FLUOROPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (2,4 DIFLUOROPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (3 BROMOPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (3 HYDROXYPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (3,4 DIHYDROXYPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (3,4 DIMETHOXYPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (4 BROMOPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (4 CHLOROPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (4 FLUOROPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (4 HYDROXY 3,5 DIMETHOXYPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 13 (4 ISOPROPYLPHENYL) 2,3,6,7 TETRAMETHOXY 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 2,3,6,7 TETRAMETHOXY 13 (3 METHOXYPHENYL) 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 2,3,6,7 TETRAMETHOXY 13 (3,4,5 TRIMETHOXYPHENYL) 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 2,3,6,7 TETRAMETHOXY 13 (4 METHOXYPHENYL) 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 2,3,6,7 TETRAMETHOXY 13 (NAPHTHALEN 1 YL) 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 2,3,6,7 TETRAMETHOXY 13 (THIOPHEN 2 YL) 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 2,3,6,7 TETRAMETHOXY 13 4 TOLYL 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 2,3,6,7 TETRAMETHOXY 13 PHENYL 10,13 DIHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 12(9H) ONE; 2,3,6,7 TETRAMETHOXY PHENANTHREN 9 AMINE; 2,3,6,7 TETRAMETHOXYPHENANTHREN 9 AMINE; 4 (2,3,6,7 TETRAMETHOXY 12 OXO 9,10,12,13 TETRAHYDRODIBENZO[F,H]FURO[3,4 B]QUINOLIN 13 YL)BENZONITRILE; 4 AZA 2,3 DIHYDROPYRIDOPHENANTHRENE; ACRIDINE ORANGE; APOPTOSIS INDUCING FACTOR; BENZYL 2,3,6,7 TETRAMETHOXYPHENANTHREN 9 YL CARBAMATE; ETHIDIUM BROMIDE; F ACTIN; LIPOCORTIN 5; PHENANTHRENE DERIVATIVE; TETRONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PHENANTHRENE;

4T1 CELL LINE; A-549 CELL LINE; ACTIN POLYMERIZATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING ASSAY; BREAST CANCER CELL LINE; CACO-2 CELL LINE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE PROGRESSION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; CURTIUS REARRANGEMENT; CYCLIZATION; CYTOSKELETON; DIAZOTIZATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; DU145 CELL LINE; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; GASTRIC CANCER CELL LINE; HELA CELL LINE; HGC-27 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MDA-MB-231 CELL LINE; METASTASIS; MIGRATION INHIBITION; MITOCHONDRIAL MEMBRANE POTENTIAL; PC-3 CELL LINE; PRECURSOR; PROSTATE CANCER CELL LINE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION OPTIMIZATION; STAINING; CELL CYCLE; CELL MOTION; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PHENANTHRENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85008674886     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2017.01.001     Document Type: Article

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