One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH2SO3H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 19, 2015, Pages 4239-4244

  Shankaraiah, Nagula ^a   Kumar, Niggula Praveen ^a,b   Amula, Suresh Babu ^a   Nekkanti, Shalini ^a   Jeengar, Manish Kumar ^a   Naidu, V G M ^a   Reddy, T Srinivasa ^b   Kamal, Ahmed ^a,b  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Azido reduction; Cell cycle analysis; Cytotoxicity; Molecular modeling; Podophyllotoxin; Sodium iodide; Sulfamic acid; Thiourea; Topoisomerase II inhibition

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; GYRASE INHIBITOR; ISOTHIOCYANIC ACID DERIVATIVE; PODOPHYLLOTOXIN DERIVATIVE; THIOUREA DERIVATIVE; AMIDE; ANTINEOPLASTIC AGENT; PODOPHYLLOTOXIN; SODIUM IODIDE; SULFUR OXIDE; SULFUR TRIOXIDE; THIOUREA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SAFETY; ENZYME INHIBITION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MALE; MOLECULAR DOCKING; ONE POT SYNTHESIS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

AMIDES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PODOPHYLLOTOXIN; SODIUM IODIDE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR OXIDES; THIOUREA; TOPOISOMERASE II INHIBITORS;

EID: 84945490153     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.07.100     Document Type: Article

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