Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3820-3831

  Kamal, Ahmed ^a   Prabhakar, S ^a   Janaki Ramaiah, M ^a   Venkat Reddy, P ^a   Ratna Reddy, Ch ^a   Mallareddy, A ^a   Shankaraiah, Nagula ^b   Lakshmi Narayan Reddy, T ^a   Pushpavalli, S N C V L ^a   Pal Bhadra, Manika ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

1,2,3 Triazoles; Anticancer activity; Apoptosis; Cdk4; Chalcones; Cyclin D1; NF kB; Pyrrolo 2,1 c 1,4 benzodiazepines

Indexed keywords

1 (2 HYDROXYPHENYL) 3 [3 METHOXY 4 (PROP 2 YNYLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (2 HYDROXYPHENYL) 3 [3 METHOXY 4 (PROP 2 YNYLOXY)PHENYL]PROP EN 1 ONE; 3 [4 (3 AZIDOPROPOXY) 3 METHOXYPHENYL] 1 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 [4 (3 AZIDOPROPOXY) 3 METHOXYPHENYL] 1 (5 CHLORO 2HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 [4 (3 AZIDOPROPYLOXY) 3 METHOXYPHENYL] 1 (2 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 [4 (4 AZIDOBUTYLOXY) 3 METHOXYPHENYL] 1 (2 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 [4 (4 AZIDOBUTYLOXY) 3 METHOXYPHENYL] 1 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 [4 (4 AZIDOBUTYLOXY) 3 METHOXYPHENYL] 1 (5 CHLORO 2HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 [4 (5 AZIDOPENTYLOXY) 3 METHOXYPHENYL] 1 (2 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 [4 (5 AZIDOPENTYLOXY) 3 METHOXYPHENYL] 1 (5 CHLORO 2 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 [4 (5 AZIDOPENTYLOXY)3 METHOXYPHENYL] 1 (4 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 [4 (AZIDOALKYLOXY) 3 METHOXYPHENYL] 1 (SUBSTITUTE PHENYL)PROP 2 EN 1 ONE; 3 METHOXY 4 (PROP 2 YNYLOXY)BENZALDEHYDE; 4 (3 AZIDOPROPYLOXY) 3 METHOXYBENZALDEHYDE; 4 (4 AZIDOBUTYLOXY) 3 METHOXYBENZALDEHYDE; 4 (5 AZIDOPENTYLOXY) 3 METHOXYBENZALDEHYDE; ANTINEOPLASTIC AGENT; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N[4 (PROP 2 YNYLOXY) 5 METHOXY 2 NITROBENZOYL]PYRROLIDINE 2 CARBOX ALDEHYDE DIETHYLTHIOACETAL; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE ACTIVATED CELL SORTING; PHARMACOPHORE; PROTEIN FUNCTION;

ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; CELL LINE, TUMOR; CHALCONES; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; NF-KAPPA B; PYRROLES; TRIAZOLES;

EID: 80052948673     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.050     Document Type: Article

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