-
1
-
-
0031860174
-
Further investigation of phenanthroindolizidine alkaloids from Tylophora tanakae
-
Abe F, Hirokawa M, Yamauchi T, Honda K, Hayashi N, Ishii M, Imagawa S, and Iwahana M (1998) Further investigation of phenanthroindolizidine alkaloids from Tylophora tanakae. Chem Pharm Bull (Tokyo) 46:767-769.
-
(1998)
Chem Pharm Bull (Tokyo)
, vol.46
, pp. 767-769
-
-
Abe, F.1
Hirokawa, M.2
Yamauchi, T.3
Honda, K.4
Hayashi, N.5
Ishii, M.6
Imagawa, S.7
Iwahana, M.8
-
2
-
-
0030791042
-
Transcription factors as activators of gene transcription: AP-1 and NF-kappa B
-
Adcock IM (1997) Transcription factors as activators of gene transcription: AP-1 and NF-kappa B. Monaldi Arch Chest Dis 52:178-186.
-
(1997)
Monaldi Arch Chest Dis
, vol.52
, pp. 178-186
-
-
Adcock, I.M.1
-
3
-
-
4644333142
-
Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets
-
Aikin R, Maysinger D, and Rosenberg L (2004) Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets. Endocrinology 145:4522-4531.
-
(2004)
Endocrinology
, vol.145
, pp. 4522-4531
-
-
Aikin, R.1
Maysinger, D.2
Rosenberg, L.3
-
4
-
-
0031770118
-
Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation
-
Cerezo A, Martinez AC, Lanzarot D, Fischer S, Franke TF, and Rebollo A (1998) Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation. Mol Biol Cell 9:3107-3118.
-
(1998)
Mol Biol Cell
, vol.9
, pp. 3107-3118
-
-
Cerezo, A.1
Martinez, A.C.2
Lanzarot, D.3
Fischer, S.4
Franke, T.F.5
Rebollo, A.6
-
5
-
-
0035132330
-
PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
-
Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, and Evans RM (2001) PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med 7:48-52.
-
(2001)
Nat Med
, vol.7
, pp. 48-52
-
-
Chawla, A.1
Barak, Y.2
Nagy, L.3
Liao, D.4
Tontonoz, P.5
Evans, R.M.6
-
6
-
-
0023057167
-
A theoretical study of anthracene and phenanthrene derivatives acting as A-T specific intercalators
-
Chen KX, Gresh N, and Pullman B (1986) A theoretical study of anthracene and phenanthrene derivatives acting as A-T specific intercalators. Nucleic Acids Res 14:9103-9115.
-
(1986)
Nucleic Acids Res
, vol.14
, pp. 9103-9115
-
-
Chen, K.X.1
Gresh, N.2
Pullman, B.3
-
7
-
-
0032581389
-
Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: Characterization of differences between human and mouse iNOS promoters
-
Chu SC, Marks-Konczalik J, Wu HP, Banks TC, and Moss J (1998) Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters. Biochem Biophys Res Commun 248:871-878.
-
(1998)
Biochem Biophys Res Commun
, vol.248
, pp. 871-878
-
-
Chu, S.C.1
Marks-Konczalik, J.2
Wu, H.P.3
Banks, T.C.4
Moss, J.5
-
8
-
-
0038392976
-
Nitric oxide in inflammatory bowel disease
-
Cross RK and Wilson KT (2003) Nitric oxide in inflammatory bowel disease. Inflamm Bowel Dis 9:179-189.
-
(2003)
Inflamm Bowel Dis
, vol.9
, pp. 179-189
-
-
Cross, R.K.1
Wilson, K.T.2
-
9
-
-
0344643419
-
TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway
-
Funakoshi-Tago M, Tago K, Sonoda Y, Tominaga S, and Kasahara T (2003) TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway. Eur J Biochem 270:1257-1268.
-
(2003)
Eur J Biochem
, vol.270
, pp. 1257-1268
-
-
Funakoshi-Tago, M.1
Tago, K.2
Sonoda, Y.3
Tominaga, S.4
Kasahara, T.5
-
10
-
-
0034769777
-
Inhibition of cellular immune responses by Tylophora indica in experimental models
-
Ganguly T and Sainis KB (2001) Inhibition of cellular immune responses by Tylophora indica in experimental models. Phytomedicine 8:348-355.
-
(2001)
Phytomedicine
, vol.8
, pp. 348-355
-
-
Ganguly, T.1
Sainis, K.B.2
-
11
-
-
1642475128
-
Novel mode of action of tylophorine analogs as antitumor compounds
-
Gao W, Lam W, Zhong S, Kaczmarek C, Baker DC, and Cheng YC (2004) Novel mode of action of tylophorine analogs as antitumor compounds. Cancer Res 64:678-688.
-
(2004)
Cancer Res
, vol.64
, pp. 678-688
-
-
Gao, W.1
Lam, W.2
Zhong, S.3
Kaczmarek, C.4
Baker, D.C.5
Cheng, Y.C.6
-
12
-
-
0035409876
-
NF-κB transcription factor: Role in the pathogenesis of inflammatory, autoimmune and neoplastic diseases and therapy implications
-
Giuliani C, Napolitano G, Bucci I, Montani V, and Monaco F (2001) NF-κB transcription factor: role in the pathogenesis of inflammatory, autoimmune and neoplastic diseases and therapy implications. Clin Ter 152:249-253.
-
(2001)
Clin Ter
, vol.152
, pp. 249-253
-
-
Giuliani, C.1
Napolitano, G.2
Bucci, I.3
Montani, V.4
Monaco, F.5
-
13
-
-
0034813334
-
Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress
-
Go YM, Boo YC, Park H, Maland MC, Patel R, Pritchard KA Jr, Fujio Y, Walsh K, Darley-Usmar V, and Jo H (2001) Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress. J Appl Physiol 91:1574-1581.
-
(2001)
J Appl Physiol
, vol.91
, pp. 1574-1581
-
-
Go, Y.M.1
Boo, Y.C.2
Park, H.3
Maland, M.C.4
Patel, R.5
Pritchard Jr., K.A.6
Fujio, Y.7
Walsh, K.8
Darley-Usmar, V.9
Jo, H.10
-
14
-
-
0018427658
-
Pharmacological investigations of tylophorine, the major alkaloid of Tylophora indica
-
Gopalakrishnan C, Shankaranarayan D, Kameswaran L, and Natarajan S (1979) Pharmacological investigations of tylophorine, the major alkaloid of Tylophora indica. Indian J Med Res 69:513-520.
-
(1979)
Indian J Med Res
, vol.69
, pp. 513-520
-
-
Gopalakrishnan, C.1
Shankaranarayan, D.2
Kameswaran, L.3
Natarajan, S.4
-
15
-
-
0019212312
-
Effect of tylophorine, a major alkaloid of Tylophora indica, on immunopathological and inflammatory reactions
-
Gopalakrishnan C, Shankaranarayanan D, Nazimudeen SK, and Kameswaran L (1980) Effect of tylophorine, a major alkaloid of Tylophora indica, on immunopathological and inflammatory reactions. Indian J Med Res 71:940-948.
-
(1980)
Indian J Med Res
, vol.71
, pp. 940-948
-
-
Gopalakrishnan, C.1
Shankaranarayanan, D.2
Nazimudeen, S.K.3
Kameswaran, L.4
-
16
-
-
0035104119
-
LPS induction of gene expression in human monocytes
-
Guha M and Mackman N (2001) LPS induction of gene expression in human monocytes. Cell Signal 13:85-94.
-
(2001)
Cell Signal
, vol.13
, pp. 85-94
-
-
Guha, M.1
Mackman, N.2
-
17
-
-
0033764392
-
Herbal medicines for asthma: A systematic review
-
Huntley A and Ernst E (2000) Herbal medicines for asthma: a systematic review. Thorax 55:925-929.
-
(2000)
Thorax
, vol.55
, pp. 925-929
-
-
Huntley, A.1
Ernst, E.2
-
18
-
-
0035942524
-
Phenanthroindolizidine alkaloids as cytotoxic substances in a danaid butterfly, Ideopsis similis, against human cancer cells
-
Komatsu H, Watanabe M, Ohyama M, Enya T, Koyama K, Kanazawa T, Kawahara N, Sugimura T, and Wakabayashi K (2001) Phenanthroindolizidine alkaloids as cytotoxic substances in a danaid butterfly, Ideopsis similis, against human cancer cells. J Med Chem 44:1833-1836.
-
(2001)
J Med Chem
, vol.44
, pp. 1833-1836
-
-
Komatsu, H.1
Watanabe, M.2
Ohyama, M.3
Enya, T.4
Koyama, K.5
Kanazawa, T.6
Kawahara, N.7
Sugimura, T.8
Wakabayashi, K.9
-
19
-
-
0028226265
-
Characterization of the human gene (PTGS2) encoding prostaglandin- endoperoxide synthase 2
-
Kosaka T, Miyata A, Ihara H, Hara S, Sugimoto T, Takeda O, Takahashi E, and Tanabe T (1994) Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2. Eur J Biochem 221:889-897.
-
(1994)
Eur J Biochem
, vol.221
, pp. 889-897
-
-
Kosaka, T.1
Miyata, A.2
Ihara, H.3
Hara, S.4
Sugimoto, T.5
Takeda, O.6
Takahashi, E.7
Tanabe, T.8
-
20
-
-
0037283273
-
2/M cell cycle arrest mediated by antofine, a phenanthroindolizidine alkaloid isolated from Cynanchum paniculatum
-
2/M cell cycle arrest mediated by antofine, a phenanthroindolizidine alkaloid isolated from Cynanchum paniculatum. Planta Med 69:21-25.
-
(2003)
Planta Med
, vol.69
, pp. 21-25
-
-
Lee, S.K.1
Nam, K.A.2
Heo, Y.H.3
-
21
-
-
0034672378
-
Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells
-
Levresse V, Butterfield L, Zentrich E, and Heasley LE (2000) Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells. J Neurosci Res 62:799-808.
-
(2000)
J Neurosci Res
, vol.62
, pp. 799-808
-
-
Levresse, V.1
Butterfield, L.2
Zentrich, E.3
Heasley, L.E.4
-
22
-
-
2442434300
-
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
-
Li J, Chen H, Tang MS, Shi X, Amin S, Desai D, Costa M, and Huang C (2004) PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells. J Cell Biol 165:77-86.
-
(2004)
J Cell Biol
, vol.165
, pp. 77-86
-
-
Li, J.1
Chen, H.2
Tang, M.S.3
Shi, X.4
Amin, S.5
Desai, D.6
Costa, M.7
Huang, C.8
-
23
-
-
0035805144
-
Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages
-
Liang YC, Tsai SH, Tsai DC, Lin-Shiau SY, and Lin JK (2001) Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Lett 496:12-18.
-
(2001)
FEBS Lett
, vol.496
, pp. 12-18
-
-
Liang, Y.C.1
Tsai, S.H.2
Tsai, D.C.3
Lin-Shiau, S.Y.4
Lin, J.K.5
-
24
-
-
3843136376
-
Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents
-
Liou JP, Chang YL, Kuo FM, Chang CW, Tseng HY, Wang CC, Yang YN, Chang JY, Lee SJ, and Hsieh HP (2004) Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents. J Med Chem 47:4247-4257.
-
(2004)
J Med Chem
, vol.47
, pp. 4247-4257
-
-
Liou, J.P.1
Chang, Y.L.2
Kuo, F.M.3
Chang, C.W.4
Tseng, H.Y.5
Wang, C.C.6
Yang, Y.N.7
Chang, J.Y.8
Lee, S.J.9
Hsieh, H.P.10
-
25
-
-
0027368278
-
Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
-
Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, and Murphy WJ (1993) Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci USA 90:9730-9734.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9730-9734
-
-
Lowenstein, C.J.1
Alley, E.W.2
Raval, P.3
Snowman, A.M.4
Snyder, S.H.5
Russell, S.W.6
Murphy, W.J.7
-
26
-
-
0037636350
-
Second messenger pathways in pulmonary host defense
-
Monick MM and Hunninghake GW (2003) Second messenger pathways in pulmonary host defense. Annu Rev Physiol 65:643-667.
-
(2003)
Annu Rev Physiol
, vol.65
, pp. 643-667
-
-
Monick, M.M.1
Hunninghake, G.W.2
-
27
-
-
0021721354
-
Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoestes verticillaris
-
Pettit GR, Goswami A, Cragg GM, Schmidt JM, and Zou JC (1984) Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoestes verticillaris. J Nat Prod 47:913-919.
-
(1984)
J Nat Prod
, vol.47
, pp. 913-919
-
-
Pettit, G.R.1
Goswami, A.2
Cragg, G.M.3
Schmidt, J.M.4
Zou, J.C.5
-
28
-
-
0019306479
-
The responsiveness of leukocyte adenyl cyclase to tylophorine in asthmatic subjects
-
Raina V and Raina S (1980) The responsiveness of leukocyte adenyl cyclase to tylophorine in asthmatic subjects. Biochem Biophys Res Commun 94:1074-1077.
-
(1980)
Biochem Biophys Res Commun
, vol.94
, pp. 1074-1077
-
-
Raina, V.1
Raina, S.2
-
29
-
-
0030778093
-
Inhibition of thymidylate synthase and cell growth by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine
-
Rao KN, Bhattacharya RK, and Venkatachalam SR (1997) Inhibition of thymidylate synthase and cell growth by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine. Chem Biol Interact 106:201-212.
-
(1997)
Chem Biol Interact
, vol.106
, pp. 201-212
-
-
Rao, K.N.1
Bhattacharya, R.K.2
Venkatachalam, S.R.3
-
30
-
-
0033997455
-
Inhibition of dihydrofolate reductase and cell growth activity by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine: The in vitro cytotoxicity of these plant alkaloids and their potential as antimicrobial and anticancer agents
-
Rao KN and Venkatachalam SR (2000) Inhibition of dihydrofolate reductase and cell growth activity by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine: the in vitro cytotoxicity of these plant alkaloids and their potential as antimicrobial and anticancer agents. Toxicol In Vitro 14:53-59.
-
(2000)
Toxicol in Vitro
, vol.14
, pp. 53-59
-
-
Rao, K.N.1
Venkatachalam, S.R.2
-
31
-
-
0031886864
-
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
-
Ricote M, Li AC, Willson TM, Kelly CJ, and Glass CK (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature (Lond) 391:79-82.
-
(1998)
Nature (Lond)
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
Kelly, C.J.4
Glass, C.K.5
-
32
-
-
2142756588
-
Cyclooxygenase 2: From inflammation to carcinogenesis
-
Ristimaki A (2004) Cyclooxygenase 2: from inflammation to carcinogenesis. Novartis Found Symp 256:215-226, 259-269.
-
(2004)
Novartis Found Symp
, vol.256
, pp. 215-226
-
-
Ristimaki, A.1
-
33
-
-
0033524740
-
Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons
-
Shimoke K, Yamagishi S, Yamada M, Ikeuchi T, and Hatanaka H (1999) Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain Res Dev Brain Res 112:245-253.
-
(1999)
Brain Res Dev Brain Res
, vol.112
, pp. 245-253
-
-
Shimoke, K.1
Yamagishi, S.2
Yamada, M.3
Ikeuchi, T.4
Hatanaka, H.5
-
34
-
-
17544380761
-
Cytotoxic activity of some phenanthroindolizidine N-oxide alkaloids from Cynanchum vincetoxicum
-
Staerk D, Christensen J, Lemmich E, Duus JO, Olsen CE, and Jaroszewski JW (2000) Cytotoxic activity of some phenanthroindolizidine N-oxide alkaloids from Cynanchum vincetoxicum. J Nat Prod 63:1584-1586.
-
(2000)
J Nat Prod
, vol.63
, pp. 1584-1586
-
-
Staerk, D.1
Christensen, J.2
Lemmich, E.3
Duus, J.O.4
Olsen, C.E.5
Jaroszewski, J.W.6
-
35
-
-
0036743304
-
In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrugresistant cancer cells
-
Staerk D, Lykkeberg AK, Christensen J, Budnik BA, Abe F, and Jaroszewski JW (2002) In vitro cytotoxic activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrugresistant cancer cells. J Nat Prod 65:1299-1302.
-
(2002)
J Nat Prod
, vol.65
, pp. 1299-1302
-
-
Staerk, D.1
Lykkeberg, A.K.2
Christensen, J.3
Budnik, B.A.4
Abe, F.5
Jaroszewski, J.W.6
-
36
-
-
0034712933
-
15-Deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway
-
Straus DS, Pascual G, Li M, Welch JS, Ricote M, Hsiang CH, Sengchanthalangsy LL, Ghosh G, and Glass CK (2000) 15-Deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci USA 97:4844-4849.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4844-4849
-
-
Straus, D.S.1
Pascual, G.2
Li, M.3
Welch, J.S.4
Ricote, M.5
Hsiang, C.H.6
Sengchanthalangsy, L.L.7
Ghosh, G.8
Glass, C.K.9
-
37
-
-
0034650330
-
Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo
-
Thieringer R, Fenyk-Melody JE, Le Grand CB, Shelton BA, Detmers PA, Somers EP, Carbin L, Moller DE, Wright SD, and Berger J (2000) Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivo. J Immunol 164:1046-1054.
-
(2000)
J Immunol
, vol.164
, pp. 1046-1054
-
-
Thieringer, R.1
Fenyk-Melody, J.E.2
Le Grand, C.B.3
Shelton, B.A.4
Detmers, P.A.5
Somers, E.P.6
Carbin, L.7
Moller, D.E.8
Wright, S.D.9
Berger, J.10
-
38
-
-
0242438644
-
Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis
-
Trifan OC and Hla T (2003) Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. J Cell Mol Med 7:207-222.
-
(2003)
J Cell Mol Med
, vol.7
, pp. 207-222
-
-
Trifan, O.C.1
Hla, T.2
-
39
-
-
0031972678
-
Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons
-
Watson A, Eilers A, Lallemand D, Kyriakis J, Rubin LL, and Ham J (1998) Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons. J Neurosci 18:751-762.
-
(1998)
J Neurosci
, vol.18
, pp. 751-762
-
-
Watson, A.1
Eilers, A.2
Lallemand, D.3
Kyriakis, J.4
Rubin, L.L.5
Ham, J.6
-
40
-
-
0036899636
-
Phenanthroindolizidine alkaloids and their cytotoxicity from the leaves of Ficus septica
-
Wu P-L, Rao KV, Su C-H, Kuoh C-S, and Wu T-S (2002) Phenanthroindolizidine alkaloids and their cytotoxicity from the leaves of Ficus septica. Heterocycles 57:2401-2408.
-
(2002)
Heterocycles
, vol.57
, pp. 2401-2408
-
-
Wu, P.-L.1
Rao, K.V.2
Su, C.-H.3
Kuoh, C.-S.4
Wu, T.-S.5
-
41
-
-
0034652581
-
Transcriptional regulation of cyclooxygenase-2 gene expression: Novel effects of nonsteroidal antiinflammatory drugs
-
Yuan CJ, Mandal AK, Zhang Z, and Mukherjee AB (2000) Transcriptional regulation of cyclooxygenase-2 gene expression: novel effects of nonsteroidal antiinflammatory drugs. Cancer Res 60:1084-1091.
-
(2000)
Cancer Res
, vol.60
, pp. 1084-1091
-
-
Yuan, C.J.1
Mandal, A.K.2
Zhang, Z.3
Mukherjee, A.B.4
|