Design, synthesis, antiviral activity, and SARs of 13a-substituted phenanthroindolizidine alkaloid derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 13, 2014, Pages 2881-2884

  Su, Bo ^a   Cai, Chunlong ^a   Deng, Meng ^a   Liang, Demin ^a   Wang, Lizhong ^a   Wang, Qingmin ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

Anti TMV; Antiviral activity; Phenanthroindolizidine alkaloid; Structure activity relationship; Tobacco mosaic virus

Indexed keywords

ALKALOID DERIVATIVE; ANTIVIRUS AGENT; NINGNANMYCIN; PHENANTHROINDOLIZIDINE ALKALOID DERIVATIVE; RIBAVIRIN; TYLOPHORINE; UNCLASSIFIED DRUG; ALKALOID; INDOLIZINE DERIVATIVE; PHENANTHROINDOLIZIDINE; PHENANTHROLINE DERIVATIVE; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TOBACCO MOSAIC VIRUS; VIRUS INHIBITION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

TOBACCO MOSAIC VIRUS;

ALKALOIDS; ANTIVIRAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; INDOLIZINES; MICROBIAL SENSITIVITY TESTS; PHENANTHROLINES; RNA, VIRAL; STRUCTURE-ACTIVITY RELATIONSHIP; TOBACCO MOSAIC VIRUS;

EID: 84901795773     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.101     Document Type: Article

References (23)

1. V. Hari, and P. Das Ultra Microscopic Detection of Plant Viruses and Their Gene Products A. Hadidi, R.K. Khetarpal, H. Koganezawa, Plant Disease Virus Control 1998 APS Press St. Paul, MN 417 427
2. L. Bos Trends Microbiol. 8 2000 82
3. G.P. Ouyang, X.J. Cai, Z. Chen, B.A. Song, P.S. Bhadury, S. Yang, L.H. Jin, W. Xue, D.Y. Hu, and S. Zeng J. Agric. Food Chem. 56 2008 10160
4. M. Reichman, Y. Devash, R.J. Suhadolnik, and I. Sela Virology 128 1983 240
5. M.H. Chen, Z. Chen, B.A. Song, P.S. Bhadury, S. Yang, X.J. Cai, D.Y. Hu, W. Xue, and S. Zeng J. Agric. Food Chem. 57 2009 1383
6. Y.M. Li, Z.K. Zhang, Y.T. Jia, Y.M. Shen, H.P. He, R.X. Fang, X.Y. Chen, and X.J. Hao Plant Biotechnol. J. 6 2008 301
7. R.W. Sidwell, J.H. Huffman, G.P. Khare, L.B. Allen, J.T. Witkowski, and R.K. Robins Science 177 1972 705
8. U. Bachrach Amino Acids 33 2007 267
9. C. De Meester Mutat. Res. 339 1995 139
10. X.H. Qian, P.W. Lee, and S. Cao J. Agric. Food Chem. 58 2010 2613
11. J.N. Seiber J. Agric. Food Chem. 59 2011 1
12. E. Gellert J. Nat. Prod. 45 1982 50
13. E. Gellert, and R. Rudzats J. Med. Chem. 7 1964 361
14. A.G. Damu, P.C. Kuo, L.S. Shi, C.Y. Li, C.S. Kuoh, P.L. Wu, and T.S. Wu J. Nat. Prod. 68 2005 1071
15. C.W. Yang, W.L. Chen, P.L. Wu, H.Y. Tseng, and S.J. Lee Mol. Pharmacol. 69 2006 749
16. B. Baumgartner, C.A.J. Erdelmeier, A.D. Wright, T. Rali, and O. Sticher Phytochemistry 29 1990 3327
17. J.Y. Choi, W. Gao, J. Odegard, H.S. Shiah, M. Kashgarian, J.M. McNiff, D.C. Baker, Y.C. Cheng, and J. Craft Arthritis Rheum. 54 2006 3277
18. T.Y. An, R.Q. Huang, Z. Yang, D.K. Zhang, G.R. Li, Y.C. Yao, and J. Gao Phytochemistry 58 2001 1267
19. Z. Xi, R.Y. Zhang, Z.H. Yu, and D. Ouyang Bioorg. Med. Chem. Lett. 16 2006 4300
20. G.R. Pettit, A. Goswami, G.M. Cragg, J.M. Schmit, and J.C. Zou J. Nat. Prod. 47 1984 913
21. K. Wang, B. Su, Z. Wang, M. Wu, Z. Li, Y. Hu, Z. Fan, N. Mi, and Q. Wang J. Agric. Food Chem. 58 2009 2703
22. Z. Wang, L. Wang, S. Ma, Y. Liu, L. Wang, and Q. Wang J. Agric. Food Chem. 60 2012 5825
23. B. Su, C. Cai, and Q. Wang J. Org. Chem. 77 2012 7981