Thymidylate synthase activity in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia and its inhibition by phenanthroindolizidine alkaloids pergularinine and tylophorinidine

Cancer Letters

Volumn 128, Issue 2, 1998, Pages 183-188

  Narasimha Rao, K ^a   Bhattacharya, R K ^a   Venkatachalam, S R ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Antitumor compounds; Inhibition; Leukemia; Pergularinine; Thymidylate synthase; Tylophorinidine

Indexed keywords

ANTILEUKEMIC AGENT; INDOLIZIDINE ALKALOID; PERGULARININE; THYMIDYLATE SYNTHASE; TYLOPHORINE; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CANCER CHEMOTHERAPY; CHILD; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; HERB; HUMAN; HUMAN CELL; LEUKOCYTE; MALE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHILD; CHILD, PRESCHOOL; ENZYME INHIBITORS; FEMALE; HUMANS; ISOQUINOLINES; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID, CHRONIC; LEUKOCYTES; MALE; MIDDLE AGED; THYMIDYLATE SYNTHASE;

PERGULARIA; PERGULARIA PALLIDA;

EID: 0001755858     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00061-5     Document Type: Article

References (40)

1. Bertino J.R., Silber R., Freeman M., Alenty A., Albrecht M., Gabrio B.W., Huennekens F.M. Studies on normal and leukemic leukocytes. IV. Tetrahydrofolate-dependent enzyme systems and dihydrofolic reductase. J. Clin. Invest. 42:1963;1899-1907.
2. I.R.C. Bick, W. Sinchai, Phenanthroindolizidine and phenanthroquinolizidine alkaloids, in: R.G.A. Rodrigo (Ed.), The Alkaloids: Chemistry and Physiology, Vol. XIX, Academic Press, New York, 1981, pp. 193-220.
3. R.L. Blakley, Pteridines in the metabolism of purines, pyrimidines and their derivatives, in: A. Neuberger, E.L. Tatum (Eds.), The Biochemistry of Folic Acid and Related Pteridines, North-Holland, Amsterdam, 1969, pp. 219-266.
4. Bray G.A. A simple efficient liquid scintillation for counting aqueous solutions in a liquid scintillation counter. Anal. Biochem. 1:1960;279-285.
5. Carreras C.W., Santi D.V. The catalytic mechanism and structure of thymidylate synthase. Annu. Rev. Biochem. 64:1995;721-762.
6. Crusberg T.C., Leary R., Kisliuk R.L. Properties of thymidylate synthetase from dichloromethotrexate-resistant Lactobacillus casei. J. Biol. Chem. 245:1970;5292-5296.
7. Danenberg P.V. Thymidylate synthetase - A target enzyme in cancer chemotherapy. Biochim. Biophys. Acta. 473:1977;73-92.
8. Dolnick B.J., Cheng Y.-c. Human thymidylate synthetase derived from blast cells of patients with acute myelocytic leukemia. J. Biol. Chem. 252:1977;7697-7703.
9. Donaldson G.R., Atkinson M.R., Murray A.W. Inhibition of protein synthesis in Ehrlich ascites tumor cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cytopleurine. Biochem. Biophys. Res. Commun. 31:1968;104-109.
10. Dunlap R.B., Harding R.G.L., Huennekens F.M. Thymidylate synthetase from amethopterin-resistant Lactobacillus casei. Biochemistry. 10:1971;88-97.
11. M. Friedkin, Thymidylate synthetase, in: A. Meister (Ed.), Advances in Enzymology and Related Areas of Molecular Biology, Vol. 38, Wiley, New York, 1973, pp. 235-292.
12. Gellert E., Rudzats R. Antileukemia activity of tylocrebrine. J. Med. Chem. 7:1964;361-362.
13. Grant P., Sanchez L., Jimenez A. Cryptopleurine resistance: genetic locus for a 40S ribosomal component in Saccharomyces cerevisae. J. Bacteriol. 120:1974;1308-1314.
14. 2-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma. Leuk. Lymphoma. 22:1996;439-447.
15. K.R. Harrap, R.C. Jackson, Biochemical mechanisms of resistance to antimetabolites, in: F.M. Schabel (Ed.), Fundamentals in Cancer Chemotherapy: Antibodies and Chemotherapy, Vol. 23, Karger, Basel, 1978, pp. 228-237.
16. Herzfeld A., Raper S.M. Relative activities of thymidylate synthetase and thymidine kinase in rat tissues. Cancer Res. 40:1980;744-750.
17. Huang M.-T., Grollman A.P. Mode of action of tylocrebrine: effects on protein and nucleic acid synthesis. Mol. Pharmacol. 8:1972;538-550.
18. A. Kornberg, T.A. Baker, Biosynthesis of DNA precursors, in: DNA Replication, second ed., W.H. Freeman, New York, pp. 53-100.
19. Langenbach R. Thymidylate synthetase of in vitro chemically and virally transformed rat cells. Biochim. Biophys. Acta. 422:1976;295-301.
20. Larsson P.-A., Carlsson G., Gustavsson B., Spears C.P. Thymidylate synthase in advanced gastrointestinal and breast cancers. Acta Oncol. 35:1996;469-472.
21. Lehtinen M., Wigren T., Lehtinen T., Kallioniemi O.P., Aine R., Aaran R.K., Ojala A. Correlation between serum tumor marker levels and tumor proliferation in small cell lung cancer. Tumor Biol. 9:1988;287-292.
22. Lockshin A., Moran R.G., Danenberg P.V. Thymidylate synthetase purified to homogeneity from human leukemic cells. Proc. Natl. Acad. Sci. USA. 76:1979;750-754.
23. 3H. J. Biol. Chem. 242:1967;109-113.
24. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
25. Mulchandani N.B., Venkatachalam S.R. Alkaloids of Pergularia pallida. Phytochemistry. 15:1976;1561-1563.
26. Narasimha Rao K., Kisliuk R.L. Association of RNA with thymidylate synthase from methotrexate-resistant Streptococcus faecium. Proc. Natl. Acad. Sci. USA. 80:1983;916-920.
27. K. Narasimha Rao, R.L. Kisliuk, Y. Gaumont, R. Deschenes, K. Vestal, M. Karasik, G.F. Maley, M.G. Nair, C.M. Baugh, Properties of thymidylate synthase from Streptococcus faecium, in: J.A. Blair (Ed.), Chemistry and Biology of Pteridines, Gruyter, Berlin, 1983, pp. 375-379.
28. Narasimha Rao K., Kisliuk R.L. RNA association with thymidylate synthase, thymidine kinase and dihydrofolate reductase. Indian J. Microbiol. 26:1986;105-110.
29. Narasimha Rao K. Purification, relative molecular mass and subunits of thymidylate synthase from Lactobacillus leichmannii. Indian J. Biochem. Biophys. 30:1993;26-35.
30. K. Narasimha Rao, R.K. Bhattacharya, S.R. Venkatachalam, Inhibition of thymidylate synthase by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine, Presented in part at the Indian Society of Cell Biology: XIX All India Cell Biology Conference and Cell Biology Symposia Proceedings, PNA-20, Calcutta, 1996, pp. 68-69.
31. Narasimha Rao K. Ternary complex formation with 5-fluoro-2′-deoxyuridylate and the kinetic properties of thymidylate synthase from Lactobacillus leichmannii. Indian J. Biochem. Biophys. 30:1993;103-110.
32. Navalgund L.G., Rossana C., Muench A.J., Johnson L.E. Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts. J. Biol. Chem. 255:1980;7386-7390.
33. Rao K.V., Wilson R.A., Cummings B. Alkaloids of Tylophora III: new alkaloids of Tylophora indica (Burn) Merrill and Tylophora dalzellii Hook f. J. Pharm. Sci. 60:1971;1725-1726.
34. Santi D.V., McHenry C.S., Sommer H. Mechanism of interaction of thymidylate synthetase with 5-flourodeoxyuridylate. Biochemistry. 13:1974;471-481.
35. Silber R., Gabrio B.W., Huennekens F.M. Studies on normal and leukemic leukocytes. VI. Thymidylate synthetase and deoxycytidylate deaminase. J. Clin. Invest. 42:1963;1913-1921.
36. Shoichet B.K., Stroud R.M., Santi D.V., Kuntz I.D., Perry K.M. Structure-based discovery of inhibitors of thymidylate synthase. Science. 259:1993;1445-1450.
37. Takemura Y., Jackman A.L. Folate-based thymidylate synthase inhibitors in cancer chemotherapy. Anti-Cancer Drugs. 8:1997;3-16.
38. Tourotoglou N., Pazdur R. Thymidylate synthase inhibitors. Clin. Cancer Res. 2:1996;227-243.
39. Wahba A.J., Friedkin M. The enzymatic synthesis of thymidylate: 1. Early steps in the purification of thymidylate synthetase of Escherichia coli. J. Biol. Chem. 237:1962;3794-3801.
40. Weber G. Biochemical strategy of cancer cells and the design of chemotherapy: G.H.A. Clowes memorial lecture. Cancer Res. 43:1983;3466-3492.