Systematic morphological profiling of human gene and allele function via cell painting

eLife

Volumn 6, Issue , 2017, Pages

  Rohban, Mohammad Hossein ^a   Singh, Shantanu ^a   Wu, Xiaoyun ^a   Berthet, Julia B ^b   Bray, Mark Anthony ^a,c   Shrestha, Yashaswi ^a   Varelas, Xaralabos ^b   Boehm, Jesse S ^a   Carpenter, Anne E ^a  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR YAP1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; WW DOMAIN CONTAINING TRANSCRIPTION REGULATOR 1; FLUORESCENT DYE; HIPPO PROTEIN, HUMAN; HIVEN86A PROTEIN, HUMAN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; PSMD2 PROTEIN, HUMAN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WWTR1 PROTEIN, HUMAN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ALLELE; ARTICLE; CELL PAINTING; CLUSTER ANALYSIS; CONTROLLED STUDY; EPIFLUORESCENCE MICROSCOPY; FUNCTIONAL CONNECTIVITY; FUNCTIONAL MORPHOLOGY; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMAGE PROCESSING; LUCIFERASE ASSAY; OPEN READING FRAME; PHENOTYPE; PHYLOGENETIC TREE; PROTEIN EXPRESSION; PROTEIN INTERACTION; SANGER SEQUENCING; SIGNAL TRANSDUCTION; U2OS CELL LINE; CELL NUCLEUS; CELL TRANSFORMATION; CHEMISTRY; ENDOPLASMIC RETICULUM; FLUORESCENCE IMAGING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GOLGI COMPLEX; METABOLISM; MITOCHONDRION; MULTIGENE FAMILY; OSTEOBLAST; PATHOLOGY; PROCEDURES; STAINING; TUMOR CELL LINE; ULTRASTRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; CELL LINE, TUMOR; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; ENDOPLASMIC RETICULUM; FLUORESCENT DYES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GOLGI APPARATUS; HEK293 CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIA; MULTIGENE FAMILY; NF-KAPPA B; OPTICAL IMAGING; OSTEOBLASTS; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-REL; SIGNAL TRANSDUCTION; STAINING AND LABELING; TNF RECEPTOR-ASSOCIATED FACTOR 2;

EID: 85017449992     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.24060     Document Type: Article

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