Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages

Nature Communications

Volumn 6, Issue , 2015, Pages

  Jin, Jin ^a   Xiao, Yichuan ^a   Hu, Hongbo ^a   Zou, Qiang ^a   Li, Yanchuan ^a   Gao, Yanpan ^b   Ge, Wei ^b   Cheng, Xuhong ^a   Sun, Shao Cong ^a,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

E3 UBIQUITIN LIGASE CIAP; INTERFERON REGULATORY FACTOR 5; PROTEASOME; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR C REL; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CYTOKINE;

CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNITY; INFECTIOUS DISEASE; PROTEIN; TUMOR;

ABLATION THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; GENE EXPRESSION; INFLAMMATORY BOWEL DISEASE; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; ANIMAL; CHROMATIN IMMUNOPRECIPITATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALIA;

ANIMALS; CHROMATIN IMMUNOPRECIPITATION; COLITIS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOBLOTTING; INFLAMMATORY BOWEL DISEASES; MACROPHAGES; MICE; MICE, KNOCKOUT; PROTEOLYSIS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 2; TOLL-LIKE RECEPTORS;

EID: 84931043753     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6930     Document Type: Article

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