Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation

Journal of Cell Science

Volumn 126, Issue 17, 2013, Pages 3990-3999

  Elsum, Imogen A ^a   Martin, Claire ^a   Humbert, Patrick O ^a,b,c  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b Department of Oncology ^*  (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

EMT; ERK; Mammary epithelium; Polarity; Scribble; Tight junctions

Indexed keywords

CLAUDIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OCCLUDIN; PROTEIN CRUMBS3; PROTEIN SCRIBBLE; PROTEIN ZO1; TIGHT JUNCTION PROTEIN; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG;

ARTICLE; CELL POLARITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE REPRESSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TIGHT JUNCTION; TRANSCRIPTION REGULATION; UPREGULATION;

EMT; ERK; MAMMARY EPITHELIUM; POLARITY; SCRIBBLE; TIGHT JUNCTIONS;

ANTHRACENES; CHROMONES; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FLAVONOIDS; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIGHT JUNCTIONS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEINS;

EID: 84883267765     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.129387     Document Type: Article

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