-
1
-
-
70849112486
-
Cell signaling in space and time: Where proteins come together and when they're apart
-
Scott JD, Pawson T (2009) Cell signaling in space and time: Where proteins come together and when they're apart. Science 326(5957): 1220-1224.
-
(2009)
Science
, vol.326
, Issue.5957
, pp. 1220-1224
-
-
Scott, J.D.1
Pawson, T.2
-
2
-
-
38449087529
-
Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer
-
Bhola NE, Grandis JR (2008) Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer. Front Biosci 13: 1857-1865.
-
(2008)
Front Biosci
, vol.13
, pp. 1857-1865
-
-
Bhola, N.E.1
Grandis, J.R.2
-
4
-
-
1342322686
-
Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion
-
Schäfer B, Gschwind A, Ullrich A (2004) Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion. Oncogene 23(4): 991-999.
-
(2004)
Oncogene
, vol.23
, Issue.4
, pp. 991-999
-
-
Schäfer, B.1
Gschwind, A.2
Ullrich, A.3
-
5
-
-
36448956774
-
GPCR-jacking: From a new route in RTK signalling to a new concept in GPCR activation
-
Delcourt N, Bockaert J, Marin P (2007) GPCR-jacking: From a new route in RTK signalling to a new concept in GPCR activation. Trends Pharmacol Sci 28(12): 602-607.
-
(2007)
Trends Pharmacol Sci
, vol.28
, Issue.12
, pp. 602-607
-
-
Delcourt, N.1
Bockaert, J.2
Marin, P.3
-
6
-
-
33846474121
-
G-protein-coupled receptors and cancer
-
Dorsam RT, Gutkind JS (2007) G-protein-coupled receptors and cancer. Nat Rev Cancer 7(2): 79-94.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.2
, pp. 79-94
-
-
Dorsam, R.T.1
Gutkind, J.S.2
-
7
-
-
38149061122
-
Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for drug design
-
Taylor SS, et al. (2008) Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for drug design. Biochim Biophys Acta 1784(1): 16-26.
-
(2008)
Biochim Biophys Acta
, vol.1784
, Issue.1
, pp. 16-26
-
-
Taylor, S.S.1
-
8
-
-
84856983194
-
Structure and allostery of the PKA RIIβ tetrameric holoenzyme
-
Zhang P, et al. (2012) Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science 335(6069): 712-716.
-
(2012)
Science
, vol.335
, Issue.6069
, pp. 712-716
-
-
Zhang, P.1
-
9
-
-
1842866233
-
AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes
-
Malbon CC, Tao J, Wang HY (2004) AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes. Biochem J 379(Pt 1): 1-9.
-
(2004)
Biochem J
, vol.379
, Issue.PART 1
, pp. 1-9
-
-
Malbon, C.C.1
Tao, J.2
Wang, H.Y.3
-
10
-
-
10044253425
-
AKAP signalling complexes: Focal points in space and time
-
Wong W, Scott JD (2004) AKAP signalling complexes: Focal points in space and time. Nat Rev Mol Cell Biol 5(12): 959-970.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, Issue.12
, pp. 959-970
-
-
Wong, W.1
Scott, J.D.2
-
11
-
-
46849106085
-
Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility
-
Gerits N, Kostenko S, Shiryaev A, Johannessen M, Moens U (2008) Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility. Cell Signal 20(9): 1592-1607.
-
(2008)
Cell Signal
, vol.20
, Issue.9
, pp. 1592-1607
-
-
Gerits, N.1
Kostenko, S.2
Shiryaev, A.3
Johannessen, M.4
Moens, U.5
-
12
-
-
22544463087
-
Integrating signals between cAMP and the RAS/RAF/MEK/ ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels
-
Dumaz N, Marais R (2005) Integrating signals between cAMP and the RAS/RAF/MEK/ ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS J 272(14): 3491-3504.
-
(2005)
FEBS J
, vol.272
, Issue.14
, pp. 3491-3504
-
-
Dumaz, N.1
Marais, R.2
-
13
-
-
0036607064
-
Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation
-
Stork PJ, Schmitt JM (2002) Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 12(6): 258-266.
-
(2002)
Trends Cell Biol
, vol.12
, Issue.6
, pp. 258-266
-
-
Stork, P.J.1
Schmitt, J.M.2
-
14
-
-
34248563299
-
Role of mitogen-activated protein kinase kinase kinases in signal integration
-
Cuevas BD, Abell AN, Johnson GL (2007) Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene 26(22): 3159-3171.
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3159-3171
-
-
Cuevas, B.D.1
Abell, A.N.2
Johnson, G.L.3
-
15
-
-
0036488510
-
RHO-GTPases and cancer
-
Sahai E, Marshall CJ (2002) RHO-GTPases and cancer. Nat Rev Cancer 2(2): 133-142.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.2
, pp. 133-142
-
-
Sahai, E.1
Marshall, C.J.2
-
16
-
-
77953480305
-
Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo
-
Wang Z, et al. (2010) Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo. Oncogene 29(23): 3362-3373.
-
(2010)
Oncogene
, vol.29
, Issue.23
, pp. 3362-3373
-
-
Wang, Z.1
-
17
-
-
0037417890
-
Beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi
-
Baillie GS, et al. (2003) beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proc Natl Acad Sci USA 100(3): 940-945.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.3
, pp. 940-945
-
-
Baillie, G.S.1
-
18
-
-
84455180792
-
PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades
-
Stefan E, et al. (2011) PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades. Nat Commun 2:598.
-
(2011)
Nat Commun
, vol.2
, pp. 598
-
-
Stefan, E.1
-
19
-
-
0028124505
-
Mechanism of inhibition of Raf-1 by protein kinase A
-
Häfner S, et al. (1994) Mechanism of inhibition of Raf-1 by protein kinase A. Mol Cell Biol 14(10): 6696-6703.
-
(1994)
Mol Cell Biol
, vol.14
, Issue.10
, pp. 6696-6703
-
-
Häfner, S.1
-
20
-
-
0027716596
-
Inhibition by cAMP of Ras-dependent activation of Raf
-
Cook SJ, McCormick F (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science 262(5136): 1069-1072.
-
(1993)
Science
, vol.262
, Issue.5136
, pp. 1069-1072
-
-
Cook, S.J.1
McCormick, F.2
-
21
-
-
78649832811
-
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade
-
Smith FD, et al. (2010) AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol 12(12): 1242-1249.
-
(2010)
Nat Cell Biol
, vol.12
, Issue.12
, pp. 1242-1249
-
-
Smith, F.D.1
-
22
-
-
0033558010
-
The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579
-
Hoffmann R, Baillie GS, MacKenzie SJ, Yarwood SJ, Houslay MD (1999) The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579. EMBO J 18(4): 893-903.
-
(1999)
EMBO J
, vol.18
, Issue.4
, pp. 893-903
-
-
Hoffmann, R.1
Baillie, G.S.2
MacKenzie, S.J.3
Yarwood, S.J.4
Houslay, M.D.5
-
23
-
-
1642414254
-
Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: Dynamics and subcellular location
-
Nika K, et al. (2004) Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: Dynamics and subcellular location. Biochem J 378(Pt 2): 335-342.
-
(2004)
Biochem J
, vol.378
, Issue.PART 2
, pp. 335-342
-
-
Nika, K.1
-
24
-
-
33746851955
-
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
-
Thaker PH, et al. (2006) Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12(8): 939-944.
-
(2006)
Nat Med
, vol.12
, Issue.8
, pp. 939-944
-
-
Thaker, P.H.1
-
25
-
-
27944479854
-
Rho GTPases: Biochemistry and biology
-
Jaffe AB, Hall A (2005) Rho GTPases: Biochemistry and biology. Annu Rev Cell Dev Biol 21: 247-269.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
26
-
-
67651097663
-
PAK signaling in oncogenesis
-
Molli PR, Li DQ, Murray BW, Rayala SK, Kumar R (2009) PAK signaling in oncogenesis. Oncogene 28(28): 2545-2555.
-
(2009)
Oncogene
, vol.28
, Issue.28
, pp. 2545-2555
-
-
Molli, P.R.1
Li, D.Q.2
Murray, B.W.3
Rayala, S.K.4
Kumar, R.5
-
27
-
-
14844293207
-
PAK and other Rho-associated kinases - Effectors with surprisingly diverse mechanisms of regulation
-
Zhao ZS, Manser E (2005) PAK and other Rho-associated kinases - effectors with surprisingly diverse mechanisms of regulation. Biochem J 386(Pt 2): 201-214.
-
(2005)
Biochem J
, vol.386
, Issue.PART 2
, pp. 201-214
-
-
Zhao, Z.S.1
Manser, E.2
-
28
-
-
0034644603
-
Localized Rac activation dynamics visualized in living cells
-
Kraynov VS, et al. (2000) Localized Rac activation dynamics visualized in living cells. Science 290(5490): 333-337.
-
(2000)
Science
, vol.290
, Issue.5490
, pp. 333-337
-
-
Kraynov, V.S.1
-
29
-
-
77949321906
-
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein
-
Hundsrucker C, et al. (2010) Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem 285(8): 5507-5521.
-
(2010)
J Biol Chem
, vol.285
, Issue.8
, pp. 5507-5521
-
-
Hundsrucker, C.1
-
30
-
-
33750474414
-
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase
-
Kinderman FS, et al. (2006) A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell 24(3): 397-408.
-
(2006)
Mol Cell
, vol.24
, Issue.3
, pp. 397-408
-
-
Kinderman, F.S.1
-
31
-
-
0037447227
-
Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring
-
Alto NM, et al. (2003) Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci USA 100(8): 4445-4450.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.8
, pp. 4445-4450
-
-
Alto, N.M.1
-
32
-
-
2342418629
-
Rho-family GTPases: It's not only Rac and Rho (and i like it)
-
Wennerberg K, Der CJ (2004) Rho-family GTPases: It's not only Rac and Rho (and I like it). J Cell Sci 117(Pt 8): 1301-1312.
-
(2004)
J Cell Sci
, vol.117
, Issue.PART 8
, pp. 1301-1312
-
-
Wennerberg, K.1
Der, C.J.2
-
33
-
-
36749104291
-
Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo
-
Stefan E, et al. (2007) Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo. Proc Natl Acad Sci USA 104(43): 16916-16921.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.43
, pp. 16916-16921
-
-
Stefan, E.1
-
34
-
-
0032511882
-
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
-
King AJ, et al. (1998) The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 396(6707): 180-183.
-
(1998)
Nature
, vol.396
, Issue.6707
, pp. 180-183
-
-
King, A.J.1
-
35
-
-
12544256298
-
Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation
-
Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM (2005) Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation. J Biol Chem 280(3): 2055-2064.
-
(2005)
J Biol Chem
, vol.280
, Issue.3
, pp. 2055-2064
-
-
Sundberg-Smith, L.J.1
Doherty, J.T.2
MacK, C.P.3
Taylor, J.M.4
-
36
-
-
0036333485
-
Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1- ERK complexes
-
Eblen ST, Slack JK, Weber MJ, Catling AD (2002) Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1- ERK complexes. Mol Cell Biol 22(17): 6023-6033.
-
(2002)
Mol Cell Biol
, vol.22
, Issue.17
, pp. 6023-6033
-
-
Eblen, S.T.1
Slack, J.K.2
Weber, M.J.3
Catling, A.D.4
-
37
-
-
0030613761
-
Switching of the coupling of the beta2- adrenergic receptor to different G proteins by protein kinase A
-
Daaka Y, Luttrell LM, Lefkowitz RJ (1997) Switching of the coupling of the beta2- adrenergic receptor to different G proteins by protein kinase A. Nature 390(6655): 88-91.
-
(1997)
Nature
, vol.390
, Issue.6655
, pp. 88-91
-
-
Daaka, Y.1
Luttrell, L.M.2
Lefkowitz, R.J.3
-
39
-
-
0037805583
-
Serine phosphorylation negatively regulates RhoA in vivo
-
Ellerbroek SM, Wennerberg K, Burridge K (2003) Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem 278(21): 19023-19031.
-
(2003)
J Biol Chem
, vol.278
, Issue.21
, pp. 19023-19031
-
-
Ellerbroek, S.M.1
Wennerberg, K.2
Burridge, K.3
-
40
-
-
0028078824
-
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
-
Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367(6458): 40-46.
-
(1994)
Nature
, vol.367
, Issue.6458
, pp. 40-46
-
-
Manser, E.1
Leung, T.2
Salihuddin, H.3
Zhao, Z.S.4
Lim, L.5
-
41
-
-
0034282225
-
Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
-
Howe AK, Juliano RL (2000) Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat Cell Biol 2(9): 593-600.
-
(2000)
Nat Cell Biol
, vol.2
, Issue.9
, pp. 593-600
-
-
Howe, A.K.1
Juliano, R.L.2
-
42
-
-
84860369376
-
Structural basis for the regulation of protein kinase A by activation loop phosphorylation
-
Steichen JM, et al. (2012) Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem 287(18): 14672-14680.
-
(2012)
J Biol Chem
, vol.287
, Issue.18
, pp. 14672-14680
-
-
Steichen, J.M.1
-
43
-
-
0032748298
-
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity
-
Zenke FT, King CC, Bohl BP, Bokoch GM (1999) Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem 274(46): 32565-32573.
-
(1999)
J Biol Chem
, vol.274
, Issue.46
, pp. 32565-32573
-
-
Zenke, F.T.1
King, C.C.2
Bohl, B.P.3
Bokoch, G.M.4
-
44
-
-
84877633978
-
P21-Activated kinase 4 promotes prostate cancer progression through CREB
-
June 18, 10.1038/onc.2012.255.
-
Park MH, et al. (June 18, 2012) p21-Activated kinase 4 promotes prostate cancer progression through CREB. Oncogene, 10.1038/onc.2012.255.
-
(2012)
Oncogene
-
-
Park, M.H.1
-
45
-
-
78649880786
-
P21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients
-
Siu MK, et al. (2010) p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients. Proc Natl Acad Sci USA 107(43): 18622-18627.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.43
, pp. 18622-18627
-
-
Siu, M.K.1
-
46
-
-
80054124577
-
Expression and function of androgen receptor coactivator p44/ Mep50/WDR77 in ovarian cancer
-
Ligr M, et al. (2011) Expression and function of androgen receptor coactivator p44/ Mep50/WDR77 in ovarian cancer. PLoS ONE 6(10):e26250.
-
(2011)
PLoS ONE
, vol.6
, Issue.10
-
-
Ligr, M.1
-
47
-
-
84857774190
-
Molecular pathways: Beta-adrenergic signaling in cancer
-
Cole SW, Sood AK (2012) Molecular pathways: Beta-adrenergic signaling in cancer. Clin Cancer Res 18(5): 1201-1206.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.5
, pp. 1201-1206
-
-
Cole, S.W.1
Sood, A.K.2
-
48
-
-
79959345328
-
Anchored protein kinase A recruitment of active Rac GTPase
-
Logue JS, Whiting JL, Tunquist B, Langeberg LK, Scott JD (2011) Anchored protein kinase A recruitment of active Rac GTPase. J Biol Chem 286(25): 22113-22121.
-
(2011)
J Biol Chem
, vol.286
, Issue.25
, pp. 22113-22121
-
-
Logue, J.S.1
Whiting, J.L.2
Tunquist, B.3
Langeberg, L.K.4
Scott, J.D.5
-
49
-
-
65249146677
-
VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells
-
Schlegel N, Waschke J (2009) VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells. Am J Physiol Cell Physiol 296(3):C453-C462.
-
(2009)
Am J Physiol Cell Physiol
, vol.296
, Issue.3
-
-
Schlegel, N.1
Waschke, J.2
-
50
-
-
34250177621
-
Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
-
Birukova AA, et al. (2007) Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res 313(11): 2504-2520.
-
(2007)
Exp Cell Res
, vol.313
, Issue.11
, pp. 2504-2520
-
-
Birukova, A.A.1
-
51
-
-
26444593916
-
Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration
-
Howe AK, Baldor LC, Hogan BP (2005) Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration. Proc Natl Acad Sci USA 102(40): 14320-14325.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.40
, pp. 14320-14325
-
-
Howe, A.K.1
Baldor, L.C.2
Hogan, B.P.3
-
52
-
-
77949538387
-
Epac: Defining a new mechanism for cAMP action
-
Gloerich M, Bos JL (2010) Epac: Defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol 50: 355-375.
-
(2010)
Annu Rev Pharmacol Toxicol
, vol.50
, pp. 355-375
-
-
Gloerich, M.1
Bos, J.L.2
-
53
-
-
15044353649
-
Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes
-
Baillie GS, Houslay MD (2005) Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes. Curr Opin Cell Biol 17(2): 129-134.
-
(2005)
Curr Opin Cell Biol
, vol.17
, Issue.2
, pp. 129-134
-
-
Baillie, G.S.1
Houslay, M.D.2
|