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Volumn 110, Issue 21, 2013, Pages 8531-8536

Reciprocal regulation of PKA and Rac signaling

Author keywords

Cross talk; Signal transduction

Indexed keywords

BETA ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANOSINE TRIPHOSPHATASE; PROTEIN P21; RAC PROTEIN;

EID: 84878133783     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1215902110     Document Type: Article
Times cited : (42)

References (54)
  • 1
    • 70849112486 scopus 로고    scopus 로고
    • Cell signaling in space and time: Where proteins come together and when they're apart
    • Scott JD, Pawson T (2009) Cell signaling in space and time: Where proteins come together and when they're apart. Science 326(5957): 1220-1224.
    • (2009) Science , vol.326 , Issue.5957 , pp. 1220-1224
    • Scott, J.D.1    Pawson, T.2
  • 2
    • 38449087529 scopus 로고    scopus 로고
    • Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer
    • Bhola NE, Grandis JR (2008) Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer. Front Biosci 13: 1857-1865.
    • (2008) Front Biosci , vol.13 , pp. 1857-1865
    • Bhola, N.E.1    Grandis, J.R.2
  • 4
    • 1342322686 scopus 로고    scopus 로고
    • Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion
    • Schäfer B, Gschwind A, Ullrich A (2004) Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion. Oncogene 23(4): 991-999.
    • (2004) Oncogene , vol.23 , Issue.4 , pp. 991-999
    • Schäfer, B.1    Gschwind, A.2    Ullrich, A.3
  • 5
    • 36448956774 scopus 로고    scopus 로고
    • GPCR-jacking: From a new route in RTK signalling to a new concept in GPCR activation
    • Delcourt N, Bockaert J, Marin P (2007) GPCR-jacking: From a new route in RTK signalling to a new concept in GPCR activation. Trends Pharmacol Sci 28(12): 602-607.
    • (2007) Trends Pharmacol Sci , vol.28 , Issue.12 , pp. 602-607
    • Delcourt, N.1    Bockaert, J.2    Marin, P.3
  • 6
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam RT, Gutkind JS (2007) G-protein-coupled receptors and cancer. Nat Rev Cancer 7(2): 79-94.
    • (2007) Nat Rev Cancer , vol.7 , Issue.2 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 7
    • 38149061122 scopus 로고    scopus 로고
    • Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for drug design
    • Taylor SS, et al. (2008) Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for drug design. Biochim Biophys Acta 1784(1): 16-26.
    • (2008) Biochim Biophys Acta , vol.1784 , Issue.1 , pp. 16-26
    • Taylor, S.S.1
  • 8
    • 84856983194 scopus 로고    scopus 로고
    • Structure and allostery of the PKA RIIβ tetrameric holoenzyme
    • Zhang P, et al. (2012) Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science 335(6069): 712-716.
    • (2012) Science , vol.335 , Issue.6069 , pp. 712-716
    • Zhang, P.1
  • 9
    • 1842866233 scopus 로고    scopus 로고
    • AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes
    • Malbon CC, Tao J, Wang HY (2004) AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes. Biochem J 379(Pt 1): 1-9.
    • (2004) Biochem J , vol.379 , Issue.PART 1 , pp. 1-9
    • Malbon, C.C.1    Tao, J.2    Wang, H.Y.3
  • 10
    • 10044253425 scopus 로고    scopus 로고
    • AKAP signalling complexes: Focal points in space and time
    • Wong W, Scott JD (2004) AKAP signalling complexes: Focal points in space and time. Nat Rev Mol Cell Biol 5(12): 959-970.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , Issue.12 , pp. 959-970
    • Wong, W.1    Scott, J.D.2
  • 11
    • 46849106085 scopus 로고    scopus 로고
    • Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility
    • Gerits N, Kostenko S, Shiryaev A, Johannessen M, Moens U (2008) Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility. Cell Signal 20(9): 1592-1607.
    • (2008) Cell Signal , vol.20 , Issue.9 , pp. 1592-1607
    • Gerits, N.1    Kostenko, S.2    Shiryaev, A.3    Johannessen, M.4    Moens, U.5
  • 12
    • 22544463087 scopus 로고    scopus 로고
    • Integrating signals between cAMP and the RAS/RAF/MEK/ ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels
    • Dumaz N, Marais R (2005) Integrating signals between cAMP and the RAS/RAF/MEK/ ERK signalling pathways. Based on the anniversary prize of the Gesellschaft für Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS J 272(14): 3491-3504.
    • (2005) FEBS J , vol.272 , Issue.14 , pp. 3491-3504
    • Dumaz, N.1    Marais, R.2
  • 13
    • 0036607064 scopus 로고    scopus 로고
    • Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation
    • Stork PJ, Schmitt JM (2002) Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 12(6): 258-266.
    • (2002) Trends Cell Biol , vol.12 , Issue.6 , pp. 258-266
    • Stork, P.J.1    Schmitt, J.M.2
  • 14
    • 34248563299 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase kinase kinases in signal integration
    • Cuevas BD, Abell AN, Johnson GL (2007) Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene 26(22): 3159-3171.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3159-3171
    • Cuevas, B.D.1    Abell, A.N.2    Johnson, G.L.3
  • 15
    • 0036488510 scopus 로고    scopus 로고
    • RHO-GTPases and cancer
    • Sahai E, Marshall CJ (2002) RHO-GTPases and cancer. Nat Rev Cancer 2(2): 133-142.
    • (2002) Nat Rev Cancer , vol.2 , Issue.2 , pp. 133-142
    • Sahai, E.1    Marshall, C.J.2
  • 16
    • 77953480305 scopus 로고    scopus 로고
    • Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo
    • Wang Z, et al. (2010) Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo. Oncogene 29(23): 3362-3373.
    • (2010) Oncogene , vol.29 , Issue.23 , pp. 3362-3373
    • Wang, Z.1
  • 17
    • 0037417890 scopus 로고    scopus 로고
    • Beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi
    • Baillie GS, et al. (2003) beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proc Natl Acad Sci USA 100(3): 940-945.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.3 , pp. 940-945
    • Baillie, G.S.1
  • 18
    • 84455180792 scopus 로고    scopus 로고
    • PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades
    • Stefan E, et al. (2011) PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades. Nat Commun 2:598.
    • (2011) Nat Commun , vol.2 , pp. 598
    • Stefan, E.1
  • 19
    • 0028124505 scopus 로고
    • Mechanism of inhibition of Raf-1 by protein kinase A
    • Häfner S, et al. (1994) Mechanism of inhibition of Raf-1 by protein kinase A. Mol Cell Biol 14(10): 6696-6703.
    • (1994) Mol Cell Biol , vol.14 , Issue.10 , pp. 6696-6703
    • Häfner, S.1
  • 20
    • 0027716596 scopus 로고
    • Inhibition by cAMP of Ras-dependent activation of Raf
    • Cook SJ, McCormick F (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science 262(5136): 1069-1072.
    • (1993) Science , vol.262 , Issue.5136 , pp. 1069-1072
    • Cook, S.J.1    McCormick, F.2
  • 21
    • 78649832811 scopus 로고    scopus 로고
    • AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade
    • Smith FD, et al. (2010) AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol 12(12): 1242-1249.
    • (2010) Nat Cell Biol , vol.12 , Issue.12 , pp. 1242-1249
    • Smith, F.D.1
  • 22
    • 0033558010 scopus 로고    scopus 로고
    • The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579
    • Hoffmann R, Baillie GS, MacKenzie SJ, Yarwood SJ, Houslay MD (1999) The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579. EMBO J 18(4): 893-903.
    • (1999) EMBO J , vol.18 , Issue.4 , pp. 893-903
    • Hoffmann, R.1    Baillie, G.S.2    MacKenzie, S.J.3    Yarwood, S.J.4    Houslay, M.D.5
  • 23
    • 1642414254 scopus 로고    scopus 로고
    • Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: Dynamics and subcellular location
    • Nika K, et al. (2004) Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: Dynamics and subcellular location. Biochem J 378(Pt 2): 335-342.
    • (2004) Biochem J , vol.378 , Issue.PART 2 , pp. 335-342
    • Nika, K.1
  • 24
    • 33746851955 scopus 로고    scopus 로고
    • Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
    • Thaker PH, et al. (2006) Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12(8): 939-944.
    • (2006) Nat Med , vol.12 , Issue.8 , pp. 939-944
    • Thaker, P.H.1
  • 25
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • Jaffe AB, Hall A (2005) Rho GTPases: Biochemistry and biology. Annu Rev Cell Dev Biol 21: 247-269.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 27
    • 14844293207 scopus 로고    scopus 로고
    • PAK and other Rho-associated kinases - Effectors with surprisingly diverse mechanisms of regulation
    • Zhao ZS, Manser E (2005) PAK and other Rho-associated kinases - effectors with surprisingly diverse mechanisms of regulation. Biochem J 386(Pt 2): 201-214.
    • (2005) Biochem J , vol.386 , Issue.PART 2 , pp. 201-214
    • Zhao, Z.S.1    Manser, E.2
  • 28
    • 0034644603 scopus 로고    scopus 로고
    • Localized Rac activation dynamics visualized in living cells
    • Kraynov VS, et al. (2000) Localized Rac activation dynamics visualized in living cells. Science 290(5490): 333-337.
    • (2000) Science , vol.290 , Issue.5490 , pp. 333-337
    • Kraynov, V.S.1
  • 29
    • 77949321906 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein
    • Hundsrucker C, et al. (2010) Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem 285(8): 5507-5521.
    • (2010) J Biol Chem , vol.285 , Issue.8 , pp. 5507-5521
    • Hundsrucker, C.1
  • 30
    • 33750474414 scopus 로고    scopus 로고
    • A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase
    • Kinderman FS, et al. (2006) A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell 24(3): 397-408.
    • (2006) Mol Cell , vol.24 , Issue.3 , pp. 397-408
    • Kinderman, F.S.1
  • 31
    • 0037447227 scopus 로고    scopus 로고
    • Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring
    • Alto NM, et al. (2003) Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci USA 100(8): 4445-4450.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.8 , pp. 4445-4450
    • Alto, N.M.1
  • 32
    • 2342418629 scopus 로고    scopus 로고
    • Rho-family GTPases: It's not only Rac and Rho (and i like it)
    • Wennerberg K, Der CJ (2004) Rho-family GTPases: It's not only Rac and Rho (and I like it). J Cell Sci 117(Pt 8): 1301-1312.
    • (2004) J Cell Sci , vol.117 , Issue.PART 8 , pp. 1301-1312
    • Wennerberg, K.1    Der, C.J.2
  • 33
    • 36749104291 scopus 로고    scopus 로고
    • Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo
    • Stefan E, et al. (2007) Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo. Proc Natl Acad Sci USA 104(43): 16916-16921.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.43 , pp. 16916-16921
    • Stefan, E.1
  • 34
    • 0032511882 scopus 로고    scopus 로고
    • The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
    • King AJ, et al. (1998) The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 396(6707): 180-183.
    • (1998) Nature , vol.396 , Issue.6707 , pp. 180-183
    • King, A.J.1
  • 35
    • 12544256298 scopus 로고    scopus 로고
    • Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation
    • Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM (2005) Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation. J Biol Chem 280(3): 2055-2064.
    • (2005) J Biol Chem , vol.280 , Issue.3 , pp. 2055-2064
    • Sundberg-Smith, L.J.1    Doherty, J.T.2    MacK, C.P.3    Taylor, J.M.4
  • 36
    • 0036333485 scopus 로고    scopus 로고
    • Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1- ERK complexes
    • Eblen ST, Slack JK, Weber MJ, Catling AD (2002) Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1- ERK complexes. Mol Cell Biol 22(17): 6023-6033.
    • (2002) Mol Cell Biol , vol.22 , Issue.17 , pp. 6023-6033
    • Eblen, S.T.1    Slack, J.K.2    Weber, M.J.3    Catling, A.D.4
  • 37
    • 0030613761 scopus 로고    scopus 로고
    • Switching of the coupling of the beta2- adrenergic receptor to different G proteins by protein kinase A
    • Daaka Y, Luttrell LM, Lefkowitz RJ (1997) Switching of the coupling of the beta2- adrenergic receptor to different G proteins by protein kinase A. Nature 390(6655): 88-91.
    • (1997) Nature , vol.390 , Issue.6655 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 39
    • 0037805583 scopus 로고    scopus 로고
    • Serine phosphorylation negatively regulates RhoA in vivo
    • Ellerbroek SM, Wennerberg K, Burridge K (2003) Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem 278(21): 19023-19031.
    • (2003) J Biol Chem , vol.278 , Issue.21 , pp. 19023-19031
    • Ellerbroek, S.M.1    Wennerberg, K.2    Burridge, K.3
  • 40
    • 0028078824 scopus 로고
    • A brain serine/threonine protein kinase activated by Cdc42 and Rac1
    • Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367(6458): 40-46.
    • (1994) Nature , vol.367 , Issue.6458 , pp. 40-46
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Zhao, Z.S.4    Lim, L.5
  • 41
    • 0034282225 scopus 로고    scopus 로고
    • Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
    • Howe AK, Juliano RL (2000) Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat Cell Biol 2(9): 593-600.
    • (2000) Nat Cell Biol , vol.2 , Issue.9 , pp. 593-600
    • Howe, A.K.1    Juliano, R.L.2
  • 42
    • 84860369376 scopus 로고    scopus 로고
    • Structural basis for the regulation of protein kinase A by activation loop phosphorylation
    • Steichen JM, et al. (2012) Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem 287(18): 14672-14680.
    • (2012) J Biol Chem , vol.287 , Issue.18 , pp. 14672-14680
    • Steichen, J.M.1
  • 43
    • 0032748298 scopus 로고    scopus 로고
    • Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity
    • Zenke FT, King CC, Bohl BP, Bokoch GM (1999) Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem 274(46): 32565-32573.
    • (1999) J Biol Chem , vol.274 , Issue.46 , pp. 32565-32573
    • Zenke, F.T.1    King, C.C.2    Bohl, B.P.3    Bokoch, G.M.4
  • 44
    • 84877633978 scopus 로고    scopus 로고
    • P21-Activated kinase 4 promotes prostate cancer progression through CREB
    • June 18, 10.1038/onc.2012.255.
    • Park MH, et al. (June 18, 2012) p21-Activated kinase 4 promotes prostate cancer progression through CREB. Oncogene, 10.1038/onc.2012.255.
    • (2012) Oncogene
    • Park, M.H.1
  • 45
    • 78649880786 scopus 로고    scopus 로고
    • P21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients
    • Siu MK, et al. (2010) p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients. Proc Natl Acad Sci USA 107(43): 18622-18627.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.43 , pp. 18622-18627
    • Siu, M.K.1
  • 46
    • 80054124577 scopus 로고    scopus 로고
    • Expression and function of androgen receptor coactivator p44/ Mep50/WDR77 in ovarian cancer
    • Ligr M, et al. (2011) Expression and function of androgen receptor coactivator p44/ Mep50/WDR77 in ovarian cancer. PLoS ONE 6(10):e26250.
    • (2011) PLoS ONE , vol.6 , Issue.10
    • Ligr, M.1
  • 47
    • 84857774190 scopus 로고    scopus 로고
    • Molecular pathways: Beta-adrenergic signaling in cancer
    • Cole SW, Sood AK (2012) Molecular pathways: Beta-adrenergic signaling in cancer. Clin Cancer Res 18(5): 1201-1206.
    • (2012) Clin Cancer Res , vol.18 , Issue.5 , pp. 1201-1206
    • Cole, S.W.1    Sood, A.K.2
  • 49
    • 65249146677 scopus 로고    scopus 로고
    • VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells
    • Schlegel N, Waschke J (2009) VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells. Am J Physiol Cell Physiol 296(3):C453-C462.
    • (2009) Am J Physiol Cell Physiol , vol.296 , Issue.3
    • Schlegel, N.1    Waschke, J.2
  • 50
    • 34250177621 scopus 로고    scopus 로고
    • Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
    • Birukova AA, et al. (2007) Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res 313(11): 2504-2520.
    • (2007) Exp Cell Res , vol.313 , Issue.11 , pp. 2504-2520
    • Birukova, A.A.1
  • 51
    • 26444593916 scopus 로고    scopus 로고
    • Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration
    • Howe AK, Baldor LC, Hogan BP (2005) Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration. Proc Natl Acad Sci USA 102(40): 14320-14325.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.40 , pp. 14320-14325
    • Howe, A.K.1    Baldor, L.C.2    Hogan, B.P.3
  • 52
    • 77949538387 scopus 로고    scopus 로고
    • Epac: Defining a new mechanism for cAMP action
    • Gloerich M, Bos JL (2010) Epac: Defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol 50: 355-375.
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 355-375
    • Gloerich, M.1    Bos, J.L.2
  • 53
    • 15044353649 scopus 로고    scopus 로고
    • Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes
    • Baillie GS, Houslay MD (2005) Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes. Curr Opin Cell Biol 17(2): 129-134.
    • (2005) Curr Opin Cell Biol , vol.17 , Issue.2 , pp. 129-134
    • Baillie, G.S.1    Houslay, M.D.2


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