-
1
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
BRIM-3 Study Group
-
Chapman PB, Hauschild A, Robert C, et al.; BRIM-3 Study Group. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364(26):2507-2516.
-
(2011)
N Engl J Med.
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
2
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363(9):809-819.
-
(2010)
N Engl J Med.
, vol.363
, Issue.9
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
3
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G, Hirth P, Tsai J, et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010;467(7315):596-599.
-
(2010)
Nature
, vol.467
, Issue.7315
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
-
4
-
-
34248563299
-
Role of mitogen-activated protein kinase kinase kinases in signal integration
-
Cuevas BD, Abell AN, Johnson GL. Role of mitogen-activated protein kinase kinase kinases in signal integration. Oncogene. 2007;26(22):3159-3171.
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3159-3171
-
-
Cuevas, B.D.1
Abell, A.N.2
Johnson, G.L.3
-
5
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R, Shi H, Wang Q, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature. 2010;468(7326):973-977.
-
(2010)
Nature
, vol.468
, Issue.7326
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
-
6
-
-
80051625929
-
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
-
Wagle N, Emery C, Berger MF, et al. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol. 2011;29(22):3085-3096.
-
(2011)
J Clin Oncol.
, vol.29
, Issue.22
, pp. 3085-3096
-
-
Wagle, N.1
Emery, C.2
Berger, M.F.3
-
7
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen CM, Boehm JS, Kim SY, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010;468(7326):968- 972.
-
(2010)
Nature
, vol.468
, Issue.7326
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
-
8
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva J, Vultur A, Lee JT, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell. 2010;18(6):683-695.
-
(2010)
Cancer Cell.
, vol.18
, Issue.6
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
-
9
-
-
77950193693
-
An oncogenic role for ETV1 in melanoma
-
Jané-Valbuena J, Widlund HR, Perner S, et al. An oncogenic role for ETV1 in melanoma. Cancer Res. 2010;70(5):2075-2084.
-
(2010)
Cancer Res.
, vol.70
, Issue.5
, pp. 2075-2084
-
-
Jané-Valbuena, J.1
Widlund, H.R.2
Perner, S.3
-
10
-
-
0242691046
-
AP-1: A double-edged sword in tumorigenesis
-
Eferl R, Wagner EF. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer. 2003;3(11):859-868.
-
(2003)
Nat Rev Cancer.
, vol.3
, Issue.11
, pp. 859-868
-
-
Eferl, R.1
Wagner, E.F.2
-
11
-
-
34247606483
-
Rewired ERK-JNK signaling pathways in melanoma
-
Lopez-Bergami P, Huang C, Goydos JS, et al. Rewired ERK-JNK signaling pathways in melanoma. Cancer Cell. 2007;11(5):447-460.
-
(2007)
Cancer Cell.
, vol.11
, Issue.5
, pp. 447-460
-
-
Lopez-Bergami, P.1
Huang, C.2
Goydos, J.S.3
-
12
-
-
0029166667
-
A synthetic inhibitor of the mitogen- Activated protein kinase cascade
-
Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR. A synthetic inhibitor of the mitogen- activated protein kinase cascade. Proc Natl Acad Sci U S A. 1995;92(17):7686-7689.
-
(1995)
Proc Natl Acad Sci U S A.
, vol.92
, Issue.17
, pp. 7686-7689
-
-
Dudley, D.T.1
Pang, L.2
Decker, S.J.3
Bridges, A.J.4
Saltiel, A.R.5
-
13
-
-
0029012476
-
A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
-
Ham J, Babij C, Whitfield J, et al. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron. 1995;14(5):927-939.
-
(1995)
Neuron.
, vol.14
, Issue.5
, pp. 927-939
-
-
Ham, J.1
Babij, C.2
Whitfield, J.3
-
14
-
-
0035172076
-
Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin e kinase complexes
-
Hennigan RF, Stambrook PJ. Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes. Mol Biol Cell. 2001;12(8):2352-2363.
-
(2001)
Mol Biol Cell.
, vol.12
, Issue.8
, pp. 2352-2363
-
-
Hennigan, R.F.1
Stambrook, P.J.2
-
15
-
-
36749068064
-
Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression
-
Quereda V, Martinalbo J, Dubus P, Carnero A, Malumbres M. Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene. 2007;26(55):7665-7674.
-
(2007)
Oncogene
, vol.26
, Issue.55
, pp. 7665-7674
-
-
Quereda, V.1
Martinalbo, J.2
Dubus, P.3
Carnero, A.4
Malumbres, M.5
-
16
-
-
0032784037
-
CDKN2A (P16(INK4a)) and CDK4 mutation analysis in 131 Australian melanoma probands: Effect of family history and multiple primary melanomas
-
Holland EA, Schmid H, Kefford RF, Mann GJ. CDKN2A (P16(INK4a)) and CDK4 mutation analysis in 131 Australian melanoma probands: effect of family history and multiple primary melanomas. Genes Chromosomes Cancer. 1999;25(4):339-348.
-
(1999)
Genes Chromosomes Cancer
, vol.25
, Issue.4
, pp. 339-348
-
-
Holland, E.A.1
Schmid, H.2
Kefford, R.F.3
Mann, G.J.4
-
17
-
-
27844567142
-
Distinct sets of genetic alterations in melanoma
-
Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353(20):2135-2147.
-
(2005)
N Engl J Med.
, vol.353
, Issue.20
, pp. 2135-2147
-
-
Curtin, J.A.1
Fridlyand, J.2
Kageshita, T.3
-
18
-
-
0029805005
-
Cyclin kinase inhibitor p21WAF1/CIP1 in malignant melanoma: Reduced expression in metastatic lesions
-
Maelandsmo GM, Holm R, Fodstad O, Kerbel RS, Flørenes VA. Cyclin kinase inhibitor p21WAF1/CIP1 in malignant melanoma: reduced expression in metastatic lesions. Am J Pathol. 1996;149(6):1813-1822.
-
(1996)
Am J Pathol.
, vol.149
, Issue.6
, pp. 1813-1822
-
-
Maelandsmo, G.M.1
Holm, R.2
Fodstad, O.3
Kerbel, R.S.4
Flørenes, V.A.5
-
19
-
-
13944273767
-
Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
-
Carreira S, Goodall J, Aksan I, et al. Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature. 2005;433(7027):764-769.
-
(2005)
Nature
, vol.433
, Issue.7027
, pp. 764-769
-
-
Carreira, S.1
Goodall, J.2
Aksan, I.3
-
20
-
-
3142775003
-
Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c)
-
Matsuzaki Y, Takaoka Y, Hitomi T, Nishino H, Sakai T. Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c). Oncogene. 2004;23(31):5409-5414.
-
(2004)
Oncogene
, vol.23
, Issue.31
, pp. 5409-5414
-
-
Matsuzaki, Y.1
Takaoka, Y.2
Hitomi, T.3
Nishino, H.4
Sakai, T.5
-
21
-
-
33750442923
-
Genomewide analysis of estrogen receptor binding sites
-
Carroll JS, Meyer CA, Song J, et al. Genomewide analysis of estrogen receptor binding sites. Nat Genet. 2006;38(11):1289-1297.
-
(2006)
Nat Genet.
, vol.38
, Issue.11
, pp. 1289-1297
-
-
Carroll, J.S.1
Meyer, C.A.2
Song, J.3
-
23
-
-
33645510413
-
Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice
-
Hacker E, Muller HK, Irwin N, et al. Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Res. 2006;66(6):2946-2952.
-
(2006)
Cancer Res.
, vol.66
, Issue.6
, pp. 2946-2952
-
-
Hacker, E.1
Muller, H.K.2
Irwin, N.3
-
24
-
-
0032516238
-
Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1
-
Halaban R, Cheng E, Zhang Y, Mandigo CE, Miglarese MR. Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1. Oncogene. 1998;16(19):2489-2501.
-
(1998)
Oncogene
, vol.16
, Issue.19
, pp. 2489-2501
-
-
Halaban, R.1
Cheng, E.2
Zhang, Y.3
Mandigo, C.E.4
Miglarese, M.R.5
-
25
-
-
33644676352
-
Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: A possible role for survivin down-regulation
-
Pennati M, Campbell AJ, Curto M, et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005;4(9):1328-1337.
-
(2005)
Mol Cancer Ther.
, vol.4
, Issue.9
, pp. 1328-1337
-
-
Pennati, M.1
Campbell, A.J.2
Curto, M.3
-
26
-
-
15444355744
-
CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation
-
Brooks EE, Gray NS, Joly A, et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J Biol Chem. 1997;272(46):29207-29211.
-
(1997)
J Biol Chem.
, vol.272
, Issue.46
, pp. 29207-29211
-
-
Brooks, E.E.1
Gray, N.S.2
Joly, A.3
-
27
-
-
0033386504
-
The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4
-
Kubo A, Nakagawa K, Varma RK, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999;5(12):4279-4286.
-
(1999)
Clin Cancer Res.
, vol.5
, Issue.12
, pp. 4279-4286
-
-
Kubo, A.1
Nakagawa, K.2
Varma, R.K.3
-
28
-
-
0037573393
-
Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors
-
Zhu G, Conner SE, Zhou X, et al. Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. J Med Chem. 2003;46(11):2027-2030.
-
(2003)
J Med Chem.
, vol.46
, Issue.11
, pp. 2027-2030
-
-
Zhu, G.1
Conner, S.E.2
Zhou, X.3
-
29
-
-
66149126085
-
Antitumor efficacy of the novel RAF inhibitor GDC- 0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression
-
Hoeflich KP, Herter S, Tien J, et al. Antitumor efficacy of the novel RAF inhibitor GDC- 0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Res. 2009;69(7):3042-3051.
-
(2009)
Cancer Res.
, vol.69
, Issue.7
, pp. 3042-3051
-
-
Hoeflich, K.P.1
Herter, S.2
Tien, J.3
-
30
-
-
0032984348
-
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
-
Sebolt-Leopold JS, Dudley DT, Herrera R, et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med. 1999;5(7):810-816.
-
(1999)
Nat Med.
, vol.5
, Issue.7
, pp. 810-816
-
-
Sebolt-Leopold, J.S.1
Dudley, D.T.2
Herrera, R.3
-
31
-
-
0032552994
-
MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
-
Duncia JV, Santella JB III, Higley CA, et al. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett. 1998;8(20):2839-2844.
-
(1998)
Bioorg Med Chem Lett.
, vol.8
, Issue.20
, pp. 2839-2844
-
-
Duncia, J.V.1
Santella III, J.B.2
Higley, C.A.3
|