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Volumn 1, Issue 1, 2015, Pages 60-71

Chemopreventive Effects of Licorice and Its Components

Author keywords

Glycyrrhetic acid; Glycyrrhizic acid; Iso liquiritigenin; Isoangustone A; Licochalcone A; Licochalcone E

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; CASPASE 3; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE 1; FAS LIGAND; FLAVONOID; GLUTATHIONE; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 23; ISOANGUSTONE A; LICOCHALCONE A; LICOCHALCONE E; LIPID PEROXIDASE; LIPOPOLYSACCHARIDE; LIQUIRITIGENIN; MICROTUBULE ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PLANT MEDICINAL PRODUCT; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 85017046797     PISSN: None     EISSN: 2198641X     Source Type: Journal    
DOI: 10.1007/s40495-014-0015-5     Document Type: Review
Times cited : (40)

References (117)
  • 1
    • 0033785922 scopus 로고    scopus 로고
    • A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice
    • COI: 1:CAS:528:DC%2BD3cXnt1Kqu7w%3D, PID: 11082698
    • Shibata S. A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi. 2000;120(10):849–62.
    • (2000) Yakugaku Zasshi , vol.120 , Issue.10 , pp. 849-862
    • Shibata, S.1
  • 2
    • 0017993703 scopus 로고
    • Glycyrrhiza in old and new perspectives
    • COI: 1:CAS:528:DyaE1cXkvF2nsr4%3D, PID: 353426
    • Gibson MR. Glycyrrhiza in old and new perspectives. Lloydia. 1978;41(4):348–54.
    • (1978) Lloydia , vol.41 , Issue.4 , pp. 348-354
    • Gibson, M.R.1
  • 4
    • 77349123814 scopus 로고    scopus 로고
    • Glycyrrhizic acid toxicity caused by consumption of licorice candy cigars
    • PID: 19166646
    • Johns C. Glycyrrhizic acid toxicity caused by consumption of licorice candy cigars. Cjem. 2009;11(1):94–6.
    • (2009) Cjem , vol.11 , Issue.1 , pp. 94-96
    • Johns, C.1
  • 5
    • 0025677127 scopus 로고
    • The determination of glycyrrhizin in selected UK liquorice product
    • COI: 1:CAS:528:DyaK3MXitVGkurw%3D, PID: 2079112
    • Spinks EA, Fenwick GR. The determination of glycyrrhizin in selected UK liquorice product. Food Addit Contam. 1990;7(6):769–78.
    • (1990) Food Addit Contam , vol.7 , Issue.6 , pp. 769-778
    • Spinks, E.A.1    Fenwick, G.R.2
  • 6
    • 0019794745 scopus 로고
    • Liquorice consumption and its influence on blood pressure in Danish school-children
    • COI: 1:STN:280:DyaL38%2FgtlGjsQ%3D%3D, PID: 7273867
    • Ibsen KK. Liquorice consumption and its influence on blood pressure in Danish school-children. Dan Med Bull. 1981;28(3):124–6.
    • (1981) Dan Med Bull , vol.28 , Issue.3 , pp. 124-126
    • Ibsen, K.K.1
  • 7
    • 0027071656 scopus 로고
    • Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone
    • COI: 1:CAS:528:DyaK3sXhsVCrsb4%3D, PID: 1476186
    • Gomez-Sanchez EP, Gomez-Sanchez CE. Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone. Am J Physiol. 1992;263(6 Pt 1):E1125–30.
    • (1992) Am J Physiol , vol.263 , Issue.6 , pp. E1125-E1130
    • Gomez-Sanchez, E.P.1    Gomez-Sanchez, C.E.2
  • 9
    • 0037047461 scopus 로고    scopus 로고
    • Anti-Helicobacter pylori flavonoids from licorice extract
    • COI: 1:CAS:528:DC%2BD38Xlt12rsr8%3D, PID: 12127165
    • Fukai T, Marumo A, Kaitou K, Kanda T, Terada S, Nomura T. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 2002;71(12):1449–63.
    • (2002) Life Sci , vol.71 , Issue.12 , pp. 1449-1463
    • Fukai, T.1    Marumo, A.2    Kaitou, K.3    Kanda, T.4    Terada, S.5    Nomura, T.6
  • 10
    • 0034819068 scopus 로고    scopus 로고
    • Licorice and cancer
    • COI: 1:CAS:528:DC%2BD3MXnsVCntbs%3D, PID: 11588889
    • Wang ZY, Nixon DW. Licorice and cancer. Nutr Cancer. 2001;39(1):1–11.
    • (2001) Nutr Cancer , vol.39 , Issue.1 , pp. 1-11
    • Wang, Z.Y.1    Nixon, D.W.2
  • 11
    • 0036193981 scopus 로고    scopus 로고
    • Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure
    • COI: 1:CAS:528:DC%2BD38Xhs1ylsLc%3D, PID: 11882402
    • Fuhrman B, Volkova N, Kaplan M, Presser D, Attias J, Hayek T, et al. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure. Nutrition. 2002;18(3):268–73.
    • (2002) Nutrition , vol.18 , Issue.3 , pp. 268-273
    • Fuhrman, B.1    Volkova, N.2    Kaplan, M.3    Presser, D.4    Attias, J.5    Hayek, T.6
  • 12
    • 46849110600 scopus 로고    scopus 로고
    • Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
    • COI: 1:CAS:528:DC%2BD1cXpsVCqu7s%3D, PID: 18446848
    • Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res. 2008;22(6):709–24.
    • (2008) Phytother Res , vol.22 , Issue.6 , pp. 709-724
    • Asl, M.N.1    Hosseinzadeh, H.2
  • 13
    • 36649036991 scopus 로고    scopus 로고
    • Skin lightening preparations and the hydroquinone controversy
    • PID: 18045355
    • Draelos ZD. Skin lightening preparations and the hydroquinone controversy. Dermatol Ther. 2007;20(5):308–13.
    • (2007) Dermatol Ther , vol.20 , Issue.5 , pp. 308-313
    • Draelos, Z.D.1
  • 14
    • 0025794373 scopus 로고
    • Inhibition of adenosine 3′,5′-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins
    • COI: 1:CAS:528:DyaK3MXkvVyisLg%3D, PID: 1654220
    • Kusano A, Nikaido T, Kuge T, Ohmoto T, Delle Monache G, Botta B, et al. Inhibition of adenosine 3′,5′-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins. Chem Pharm Bull. 1991;39(4):930–3.
    • (1991) Chem Pharm Bull , vol.39 , Issue.4 , pp. 930-933
    • Kusano, A.1    Nikaido, T.2    Kuge, T.3    Ohmoto, T.4    Delle Monache, G.5    Botta, B.6
  • 15
    • 0030959281 scopus 로고    scopus 로고
    • Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation
    • COI: 1:CAS:528:DyaK2sXktFOnurc%3D, PID: 9199893
    • Vaya J, Belinky PA, Aviram M. Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Free Radic Biol Med. 1997;23(2):302–13.
    • (1997) Free Radic Biol Med , vol.23 , Issue.2 , pp. 302-313
    • Vaya, J.1    Belinky, P.A.2    Aviram, M.3
  • 16
    • 0033776850 scopus 로고    scopus 로고
    • Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus
    • COI: 1:CAS:528:DC%2BD3cXmsVeku7s%3D, PID: 10993226
    • Hatano T, Shintani Y, Aga Y, Shiota S, Tsuchiya T, Yoshida T. Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull. 2000;48(9):1286–92.
    • (2000) Chem Pharm Bull , vol.48 , Issue.9 , pp. 1286-1292
    • Hatano, T.1    Shintani, Y.2    Aga, Y.3    Shiota, S.4    Tsuchiya, T.5    Yoshida, T.6
  • 17
    • 0031612262 scopus 로고    scopus 로고
    • Phenolic constituents of licorice (Glycyrrhiza species)
    • COI: 1:CAS:528:DyaK1cXhslGitrk%3D, PID: 9545874
    • Nomura T, Fukai T. Phenolic constituents of licorice (Glycyrrhiza species). Fortschr Chem Org Naturst. 1998;73:1–158.
    • (1998) Fortschr Chem Org Naturst , vol.73 , pp. 1-158
    • Nomura, T.1    Fukai, T.2
  • 18
    • 0021957586 scopus 로고
    • Metabolism of glycyrrhizin by human intestinal flora. II. Isolation and characterization of human intestinal bacteria capable of metabolizing glycyrrhizin and related compounds
    • COI: 1:CAS:528:DyaL2MXhs1enur4%3D, PID: 4006016
    • Hattori M, Sakamoto T, Yamagishi T, Sakamoto K, Konishi K, Kobashi K, et al. Metabolism of glycyrrhizin by human intestinal flora. II. Isolation and characterization of human intestinal bacteria capable of metabolizing glycyrrhizin and related compounds. Chem Pharm Bull. 1985;33(1):210–7.
    • (1985) Chem Pharm Bull , vol.33 , Issue.1 , pp. 210-217
    • Hattori, M.1    Sakamoto, T.2    Yamagishi, T.3    Sakamoto, K.4    Konishi, K.5    Kobashi, K.6
  • 19
    • 0023242981 scopus 로고
    • Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
    • COI: 1:CAS:528:DyaL1cXlsVGlsw%3D%3D, PID: 2889032
    • Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR. Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet. 1987;2(8563):821–4.
    • (1987) Lancet , vol.2 , Issue.8563 , pp. 821-824
    • Stewart, P.M.1    Wallace, A.M.2    Valentino, R.3    Burt, D.4    Shackleton, C.H.5    Edwards, C.R.6
  • 20
    • 0027175394 scopus 로고
    • Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action
    • COI: 1:CAS:528:DyaK3sXltV2htLk%3D, PID: 8504732
    • Whorwood CB, Sheppard MC, Stewart PM. Licorice inhibits 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels and potentiates glucocorticoid hormone action. Endocrinology. 1993;132(6):2287–92.
    • (1993) Endocrinology , vol.132 , Issue.6 , pp. 2287-2292
    • Whorwood, C.B.1    Sheppard, M.C.2    Stewart, P.M.3
  • 21
    • 0032753750 scopus 로고    scopus 로고
    • Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial
    • PID: 10574137
    • van Rossum TG, Vulto AG, Hop WC, Brouwer JT, Niesters HG, Schalm SW. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo-controlled phase I/II trial. J Gastroenterol Hepatol. 1999;14(11):1093–9.
    • (1999) J Gastroenterol Hepatol , vol.14 , Issue.11 , pp. 1093-1099
    • van Rossum, T.G.1    Vulto, A.G.2    Hop, W.C.3    Brouwer, J.T.4    Niesters, H.G.5    Schalm, S.W.6
  • 22
    • 14644419026 scopus 로고    scopus 로고
    • Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes
    • COI: 1:CAS:528:DC%2BD2MXit1emtrw%3D, PID: 15765147
    • Curreli F, Friedman-Kien AE, Flore O. Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes. J Clin Invest. 2005;115(3):642–52.
    • (2005) J Clin Invest , vol.115 , Issue.3 , pp. 642-652
    • Curreli, F.1    Friedman-Kien, A.E.2    Flore, O.3
  • 23
    • 0038047657 scopus 로고    scopus 로고
    • Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
    • COI: 1:CAS:528:DC%2BD3sXksF2hu78%3D, PID: 12814717
    • Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr HW. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet. 2003;361(9374):2045–6.
    • (2003) Lancet , vol.361 , Issue.9374 , pp. 2045-2046
    • Cinatl, J.1    Morgenstern, B.2    Bauer, G.3    Chandra, P.4    Rabenau, H.5    Doerr, H.W.6
  • 24
    • 13944251304 scopus 로고    scopus 로고
    • Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus
    • COI: 1:CAS:528:DC%2BD2MXksVyqtw%3D%3D, PID: 15715493
    • Hoever G, Baltina L, Michaelis M, Kondratenko R, Tolstikov GA, Doerr HW, et al. Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus. J Med Chem. 2005;48(4):1256–9.
    • (2005) J Med Chem , vol.48 , Issue.4 , pp. 1256-1259
    • Hoever, G.1    Baltina, L.2    Michaelis, M.3    Kondratenko, R.4    Tolstikov, G.A.5    Doerr, H.W.6
  • 25
    • 35348993141 scopus 로고    scopus 로고
    • Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice
    • COI: 1:CAS:528:DC%2BD2sXhtl2jtLfM, PID: 17917259
    • Lee CH, Park SW, Kim YS, Kang SS, Kim JA, Lee SH, et al. Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. Biol Pharm Bull. 2007;30(10):1898–904.
    • (2007) Biol Pharm Bull , vol.30 , Issue.10 , pp. 1898-1904
    • Lee, C.H.1    Park, S.W.2    Kim, Y.S.3    Kang, S.S.4    Kim, J.A.5    Lee, S.H.6
  • 26
    • 0344825278 scopus 로고    scopus 로고
    • Glycyrrhizin enhances interleukin-10 production by liver dendritic cells in mice with hepatitis
    • COI: 1:CAS:528:DC%2BD3sXovVKmsr4%3D, PID: 14614603
    • Abe M, Akbar F, Hasebe A, Horiike N, Onji M. Glycyrrhizin enhances interleukin-10 production by liver dendritic cells in mice with hepatitis. J Gastroenterol. 2003;38(10):962–7.
    • (2003) J Gastroenterol , vol.38 , Issue.10 , pp. 962-967
    • Abe, M.1    Akbar, F.2    Hasebe, A.3    Horiike, N.4    Onji, M.5
  • 27
    • 15444365508 scopus 로고    scopus 로고
    • Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes
    • COI: 1:CAS:528:DC%2BD2MXit1ersb4%3D, PID: 15642733
    • Gumpricht E, Dahl R, Devereaux MW, Sokol RJ. Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. J Biol Chem. 2005;280(11):10556–63.
    • (2005) J Biol Chem , vol.280 , Issue.11 , pp. 10556-10563
    • Gumpricht, E.1    Dahl, R.2    Devereaux, M.W.3    Sokol, R.J.4
  • 28
    • 0022622839 scopus 로고
    • Enhancement of interferon-gamma production in glycyrrhizin-treated human peripheral lymphocytes in response to concanavalin A and to surface antigen of hepatitis B virus
    • COI: 1:CAS:528:DyaL28Xhs1Wqsb0%3D, PID: 3080754
    • Shinada M, Azuma M, Kawai H, Sazaki K, Yoshida I, Yoshida T, et al. Enhancement of interferon-gamma production in glycyrrhizin-treated human peripheral lymphocytes in response to concanavalin A and to surface antigen of hepatitis B virus. Proc Soc Exp Biol Med. 1986;181(2):205–10.
    • (1986) Proc Soc Exp Biol Med , vol.181 , Issue.2 , pp. 205-210
    • Shinada, M.1    Azuma, M.2    Kawai, H.3    Sazaki, K.4    Yoshida, I.5    Yoshida, T.6
  • 29
    • 33748531846 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappaB is associated with neuroprotective effects of glycyrrhizic acid on glutamate-induced excitotoxicity in primary neurons
    • COI: 1:CAS:528:DC%2BD28Xps1OmtLw%3D, PID: 16952351
    • Cherng JM, Lin HJ, Hung MS, Lin YR, Chan MH, Lin JC. Inhibition of nuclear factor kappaB is associated with neuroprotective effects of glycyrrhizic acid on glutamate-induced excitotoxicity in primary neurons. Eur J Pharmacol. 2006;547(1–3):10–21.
    • (2006) Eur J Pharmacol , vol.547 , Issue.1-3 , pp. 10-21
    • Cherng, J.M.1    Lin, H.J.2    Hung, M.S.3    Lin, Y.R.4    Chan, M.H.5    Lin, J.C.6
  • 30
    • 0025800623 scopus 로고
    • Inhibition of mouse skin tumor-initiating activity of DMBA by chronic oral feeding of glycyrrhizin in drinking water
    • COI: 1:CAS:528:DyaK3MXlsV2rt7c%3D, PID: 1907733
    • Agarwal R, Wang ZY, Mukhtar H. Inhibition of mouse skin tumor-initiating activity of DMBA by chronic oral feeding of glycyrrhizin in drinking water. Nutr Cancer. 1991;15(3–4):187–93.
    • (1991) Nutr Cancer , vol.15 , Issue.3-4 , pp. 187-193
    • Agarwal, R.1    Wang, Z.Y.2    Mukhtar, H.3
  • 31
    • 79952440733 scopus 로고    scopus 로고
    • Glycyrrhiza flavescens subsp. antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-alpha and IFN-alpha levels
    • COI: 1:CAS:528:DC%2BC3MXjsFCiu7g%3D, PID: 21145935
    • Aydemir EA, Oz ES, Gokturk RS, Ozkan G, Fiskin K. Glycyrrhiza flavescens subsp. antalyensis exerts antiproliferative effects on melanoma cells via altering TNF-alpha and IFN-alpha levels. Food Chem Toxicol. 2011;49(4):820–8.
    • (2011) Food Chem Toxicol , vol.49 , Issue.4 , pp. 820-828
    • Aydemir, E.A.1    Oz, E.S.2    Gokturk, R.S.3    Ozkan, G.4    Fiskin, K.5
  • 32
    • 0036875843 scopus 로고    scopus 로고
    • Inhibitory effect of glycyrrhizin on experimental pulmonary metastasis in mice inoculated with B16 melanoma
    • COI: 1:CAS:528:DC%2BD3sXhtFGnu78%3D, PID: 12553032
    • Kobayashi M, Fujita K, Katakura T, Utsunomiya T, Pollard RB, Suzuki F. Inhibitory effect of glycyrrhizin on experimental pulmonary metastasis in mice inoculated with B16 melanoma. Anticancer Res. 2002;22(6C):4053–8.
    • (2002) Anticancer Res , vol.22 , Issue.6C , pp. 4053-4058
    • Kobayashi, M.1    Fujita, K.2    Katakura, T.3    Utsunomiya, T.4    Pollard, R.B.5    Suzuki, F.6
  • 33
    • 79961051534 scopus 로고    scopus 로고
    • Cherng JM, Tsai KD, Yu YW, Lin JC. Molecular mechanisms underlying chemopreventive activities of glycyrrhizic acid against UVB-radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. 2011;176(2):177–86. 21545294. Epub 2011/05/07. Eng. This group showed that ingesting orally licorice compounds could prevent UVB induced skin cancer, making it more applicable to the human condition
    • Cherng JM, Tsai KD, Yu YW, Lin JC. Molecular mechanisms underlying chemopreventive activities of glycyrrhizic acid against UVB-radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Radiat Res. 2011;176(2):177–86. PubMed PMID: 21545294. Epub 2011/05/07. Eng. This group showed that ingesting orally licorice compounds could prevent UVB induced skin cancer, making it more applicable to the human condition.
    • (2011) Radiat Res.
  • 34
    • 59249091038 scopus 로고    scopus 로고
    • Glycyrrhizin induces apoptosis in prostate cancer cell lines DU-145 and LNCaP
    • COI: 1:CAS:528:DC%2BD1MXjs1Ghtg%3D%3D, PID: 19020719
    • Thirugnanam S, Xu L, Ramaswamy K, Gnanasekar M. Glycyrrhizin induces apoptosis in prostate cancer cell lines DU-145 and LNCaP. Oncol Rep. 2008;20(6):1387–92.
    • (2008) Oncol Rep , vol.20 , Issue.6 , pp. 1387-1392
    • Thirugnanam, S.1    Xu, L.2    Ramaswamy, K.3    Gnanasekar, M.4
  • 35
    • 32944470031 scopus 로고    scopus 로고
    • Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells
    • COI: 1:CAS:528:DC%2BD2MXnslykt74%3D, PID: 16012754
    • Hibasami H, Iwase H, Yoshioka K, Takahashi H. Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells. Int J Mol Med. 2005;16(2):233–6.
    • (2005) Int J Mol Med , vol.16 , Issue.2 , pp. 233-236
    • Hibasami, H.1    Iwase, H.2    Yoshioka, K.3    Takahashi, H.4
  • 36
    • 33644866837 scopus 로고    scopus 로고
    • Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells
    • COI: 1:CAS:528:DC%2BD28XhsVems74%3D, PID: 16391818
    • Hibasami H, Iwase H, Yoshioka K, Takahashi H. Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells. Int J Mol Med. 2006;17(2):215–9.
    • (2006) Int J Mol Med , vol.17 , Issue.2 , pp. 215-219
    • Hibasami, H.1    Iwase, H.2    Yoshioka, K.3    Takahashi, H.4
  • 37
    • 84897376193 scopus 로고    scopus 로고
    • Involvement of BID translocation in glycyrrhetinic acid and 11-deoxy glycyrrhetinic acid-induced attenuation of gastric cancer growth
    • COI: 1:CAS:528:DC%2BC2cXjt1aqu7k%3D, PID: 24547973
    • Lin D, Zhong W, Li J, Zhang B, Song G, Hu T. Involvement of BID translocation in glycyrrhetinic acid and 11-deoxy glycyrrhetinic acid-induced attenuation of gastric cancer growth. Nutr Cancer. 2014;66(3):463–73.
    • (2014) Nutr Cancer , vol.66 , Issue.3 , pp. 463-473
    • Lin, D.1    Zhong, W.2    Li, J.3    Zhang, B.4    Song, G.5    Hu, T.6
  • 38
    • 34247897118 scopus 로고    scopus 로고
    • Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice
    • COI: 1:CAS:528:DC%2BD2sXivF2gsr0%3D, PID: 17273742
    • Niwa K, Lian Z, Onogi K, Yun W, Tang L, Mori H, et al. Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice. Oncol Rep. 2007;17(3):617–22.
    • (2007) Oncol Rep , vol.17 , Issue.3 , pp. 617-622
    • Niwa, K.1    Lian, Z.2    Onogi, K.3    Yun, W.4    Tang, L.5    Mori, H.6
  • 39
    • 84893698554 scopus 로고    scopus 로고
    • 18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway
    • COI: 1:CAS:528:DC%2BC3sXhslSlsLfL, PID: 24162829
    • Wang D, Wong HK, Feng YB, Zhang ZJ. 18beta-glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway. J Neurooncol. 2014;116(2):221–30.
    • (2014) J Neurooncol , vol.116 , Issue.2 , pp. 221-230
    • Wang, D.1    Wong, H.K.2    Feng, Y.B.3    Zhang, Z.J.4
  • 40
    • 0344010967 scopus 로고    scopus 로고
    • Selectivity of action of glycyrrhizin derivatives on the growth of MCF-7 and HEP-2 cells
    • COI: 1:CAS:528:DC%2BD2cXkvFeg, PID: 14666682
    • Rossi T, Castelli M, Zandomeneghi G, Ruberto A, Benassi L, Magnoni C, et al. Selectivity of action of glycyrrhizin derivatives on the growth of MCF-7 and HEP-2 cells. Anticancer Res. 2003;23(5A):3813–8.
    • (2003) Anticancer Res , vol.23 , Issue.5A , pp. 3813-3818
    • Rossi, T.1    Castelli, M.2    Zandomeneghi, G.3    Ruberto, A.4    Benassi, L.5    Magnoni, C.6
  • 41
    • 84898827741 scopus 로고    scopus 로고
    • 18beta-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer
    • PID: 24695790
    • Huang RY, Chu YL, Huang QC, Chen XM, Jiang ZB, Zhang X, et al. 18beta-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer. PLoS ONE. 2014;9(4):e93690.
    • (2014) PLoS ONE , vol.9 , Issue.4
    • Huang, R.Y.1    Chu, Y.L.2    Huang, Q.C.3    Chen, X.M.4    Jiang, Z.B.5    Zhang, X.6
  • 42
    • 84893807583 scopus 로고    scopus 로고
    • Inhibition of protein kinase C alpha/betaII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells
    • COI: 1:CAS:528:DC%2BC2cXht1ylu7c%3D, PID: 24461294
    • Song J, Ko HS, Sohn EJ, Kim B, Kim JH, Kim HJ, et al. Inhibition of protein kinase C alpha/betaII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells. Bioorg Med Chem Lett. 2014;24(4):1188–91.
    • (2014) Bioorg Med Chem Lett , vol.24 , Issue.4 , pp. 1188-1191
    • Song, J.1    Ko, H.S.2    Sohn, E.J.3    Kim, B.4    Kim, J.H.5    Kim, H.J.6
  • 43
    • 84874007222 scopus 로고    scopus 로고
    • Glycyrrhizic acid suppresses the development of precancerous lesions via regulating the hyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats
    • COI: 1:CAS:528:DC%2BC3sXjtl2qurg%3D, PID: 23457494
    • Khan R, Khan AQ, Lateef A, Rehman MU, Tahir M, Ali F, et al. Glycyrrhizic acid suppresses the development of precancerous lesions via regulating the hyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats. PLoS ONE. 2013;8(2):e56020.
    • (2013) PLoS ONE , vol.8 , Issue.2
    • Khan, R.1    Khan, A.Q.2    Lateef, A.3    Rehman, M.U.4    Tahir, M.5    Ali, F.6
  • 44
    • 84868092973 scopus 로고    scopus 로고
    • Glycyrrhizic acid induces apoptosis in WEHI-3 mouse leukemia cells through the caspase- and mitochondria-dependent pathways
    • COI: 1:CAS:528:DC%2BC38XhvFShsr7O, PID: 22972479
    • Chueh FS, Hsiao YT, Chang SJ, Wu PP, Yang JS, Lin JJ, et al. Glycyrrhizic acid induces apoptosis in WEHI-3 mouse leukemia cells through the caspase- and mitochondria-dependent pathways. Oncol Rep. 2012;28(6):2069–76.
    • (2012) Oncol Rep , vol.28 , Issue.6 , pp. 2069-2076
    • Chueh, F.S.1    Hsiao, Y.T.2    Chang, S.J.3    Wu, P.P.4    Yang, J.S.5    Lin, J.J.6
  • 45
    • 0026537697 scopus 로고
    • Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of 2 cases and review of the literature
    • COI: 1:STN:280:DyaK383isFShsA%3D%3D, PID: 1563455
    • Shintani S, Murase H, Tsukagoshi H, Shiigai T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Report of 2 cases and review of the literature. Eur Neurol. 1992;32(1):44–51.
    • (1992) Eur Neurol , vol.32 , Issue.1 , pp. 44-51
    • Shintani, S.1    Murase, H.2    Tsukagoshi, H.3    Shiigai, T.4
  • 46
    • 0038726867 scopus 로고    scopus 로고
    • Licorice consumption causing severe hypokalemic paralysis
    • PID: 12934789
    • Elinav E, Chajek-Shaul T. Licorice consumption causing severe hypokalemic paralysis. Mayo Clin Proc. 2003;78(6):767–8.
    • (2003) Mayo Clin Proc , vol.78 , Issue.6 , pp. 767-768
    • Elinav, E.1    Chajek-Shaul, T.2
  • 47
    • 39749084600 scopus 로고    scopus 로고
    • Licorice-induced hypokalemia
    • PID: 17320224
    • Mumoli N, Cei M. Licorice-induced hypokalemia. Int J Cardiol. 2008;124(3):e42–4.
    • (2008) Int J Cardiol , vol.124 , Issue.3 , pp. e42-e44
    • Mumoli, N.1    Cei, M.2
  • 48
    • 84871570917 scopus 로고    scopus 로고
    • Licorice induced hypokalemia, edema, and thrombocytopenia
    • COI: 1:CAS:528:DC%2BC2cXhs1OisrzO, PID: 22653692
    • Celik MM, Karakus A, Zeren C, Demir M, Bayarogullari H, Duru M, et al. Licorice induced hypokalemia, edema, and thrombocytopenia. Hum Exp Toxicol. 2012;31(12):1295–8.
    • (2012) Hum Exp Toxicol , vol.31 , Issue.12 , pp. 1295-1298
    • Celik, M.M.1    Karakus, A.2    Zeren, C.3    Demir, M.4    Bayarogullari, H.5    Duru, M.6
  • 49
    • 34447095946 scopus 로고    scopus 로고
    • Final report on the safety assessment of glycyrrhetinic acid, potassium glycyrrhetinate, disodium succinoyl glycyrrhetinate, glyceryl glycyrrhetinate, glycyrrhetinyl stearate, stearyl glycyrrhetinate, glycyrrhizic acid, ammonium glycyrrhizate, dipotassium glycyrrhizate, disodium glycyrrhizate, trisodium glycyrrhizate, methyl glycyrrhizate, and potassium glycyrrhizinate. ;26 Suppl 2:79–112. 17613133. Epub 2007/12/06. eng
    • Final report on the safety assessment of glycyrrhetinic acid, potassium glycyrrhetinate, disodium succinoyl glycyrrhetinate, glyceryl glycyrrhetinate, glycyrrhetinyl stearate, stearyl glycyrrhetinate, glycyrrhizic acid, ammonium glycyrrhizate, dipotassium glycyrrhizate, disodium glycyrrhizate, trisodium glycyrrhizate, methyl glycyrrhizate, and potassium glycyrrhizinate. Int J Toxicol. 2007;26 Suppl 2:79–112. PubMed PMID: 17613133. Epub 2007/12/06. eng.
    • (2007) Int J Toxicol.
  • 50
    • 77949764073 scopus 로고    scopus 로고
    • Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice
    • COI: 1:CAS:528:DC%2BC3cXptFOisLs%3D
    • Cuendet M, Guo J, Luo Y, Chen S, Oteham CP, Moon RC, et al. Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. Cancer Prev Res (Phila). 2010;3(2):221–32.
    • (2010) Cancer Prev Res (Phila) , vol.3 , Issue.2 , pp. 221-232
    • Cuendet, M.1    Guo, J.2    Luo, Y.3    Chen, S.4    Oteham, C.P.5    Moon, R.C.6
  • 51
    • 58749093583 scopus 로고    scopus 로고
    • Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase
    • COI: 1:CAS:528:DC%2BD1MXhvFClsb4%3D, PID: 19065667
    • Ye L, Gho WM, Chan FL, Chen S, Leung LK. Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase. Int J Cancer. 2009;124(5):1028–36.
    • (2009) Int J Cancer , vol.124 , Issue.5 , pp. 1028-1036
    • Ye, L.1    Gho, W.M.2    Chan, F.L.3    Chen, S.4    Leung, L.K.5
  • 52
    • 84878446393 scopus 로고    scopus 로고
    • Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade
    • COI: 1:CAS:528:DC%2BC3sXos12gtL4%3D, PID: 23547785
    • Vandooren J, Van den Steen PE, Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade. Crit Rev Biochem Mol Biol. 2013;48(3):222–72.
    • (2013) Crit Rev Biochem Mol Biol , vol.48 , Issue.3 , pp. 222-272
    • Vandooren, J.1    Van den Steen, P.E.2    Opdenakker, G.3
  • 53
    • 84880822964 scopus 로고    scopus 로고
    • Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIF1alpha accumulation via increased production of reactive oxygen species
    • COI: 1:CAS:528:DC%2BC3sXht1Gks7rJ, PID: 23922721
    • Ma J, Zhang Q, Chen S, Fang B, Yang Q, Chen C, et al. Mitochondrial dysfunction promotes breast cancer cell migration and invasion through HIF1alpha accumulation via increased production of reactive oxygen species. PLoS ONE. 2013;8(7):e69485.
    • (2013) PLoS ONE , vol.8 , Issue.7
    • Ma, J.1    Zhang, Q.2    Chen, S.3    Fang, B.4    Yang, Q.5    Chen, C.6
  • 54
    • 85047694081 scopus 로고    scopus 로고
    • VEGF-targeted cancer therapeutics-paradoxical effects in endocrine organs
    • COI: 1:CAS:528:DC%2BC2cXht1Wls7zJ, PID: 25048037
    • Cao Y. VEGF-targeted cancer therapeutics-paradoxical effects in endocrine organs. Nat Rev Endocrinol. 2014;10(9):530–9.
    • (2014) Nat Rev Endocrinol , vol.10 , Issue.9 , pp. 530-539
    • Cao, Y.1
  • 55
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulators of the tumor microenvironment
    • COI: 1:CAS:528:DC%2BC3cXlsVSgtb4%3D, PID: 20371345
    • Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 2010;141(1):52–67.
    • (2010) Cell , vol.141 , Issue.1 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 56
    • 84875133881 scopus 로고    scopus 로고
    • Novel plant-derived target drugs: a step forward from licorice?
    • COI: 1:CAS:528:DC%2BC3sXktFSktrc%3D, PID: 23425066
    • Lorusso V, Marech I. Novel plant-derived target drugs: a step forward from licorice? Expert Opin Ther Targets. 2013;17(4):333–5.
    • (2013) Expert Opin Ther Targets , vol.17 , Issue.4 , pp. 333-335
    • Lorusso, V.1    Marech, I.2
  • 57
    • 71749083439 scopus 로고    scopus 로고
    • Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases
    • COI: 1:CAS:528:DC%2BD1MXhsV2ltbnP, PID: 19157825
    • Kang SW, Choi JS, Choi YJ, Bae JY, Li J, Kim DS, et al. Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases. J Nutr Biochem. 2010;21(1):55–65.
    • (2010) J Nutr Biochem , vol.21 , Issue.1 , pp. 55-65
    • Kang, S.W.1    Choi, J.S.2    Choi, Y.J.3    Bae, J.Y.4    Li, J.5    Kim, D.S.6
  • 58
    • 77952929257 scopus 로고    scopus 로고
    • The licorice flavonoid isoliquiritigenin suppresses phorbol ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line
    • COI: 1:CAS:528:DC%2BC3cXotlahsL8%3D, PID: 20033868
    • Lau GT, Ye L, Leung LK. The licorice flavonoid isoliquiritigenin suppresses phorbol ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line. Planta Med. 2010;76(8):780–5.
    • (2010) Planta Med , vol.76 , Issue.8 , pp. 780-785
    • Lau, G.T.1    Ye, L.2    Leung, L.K.3
  • 59
    • 3042545271 scopus 로고    scopus 로고
    • Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development
    • COI: 1:CAS:528:DC%2BD2cXltlaitbg%3D, PID: 15132774
    • Takahashi T, Takasuka N, Iigo M, Baba M, Nishino H, Tsuda H, et al. Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. Cancer Sci. 2004;95(5):448–53.
    • (2004) Cancer Sci , vol.95 , Issue.5 , pp. 448-453
    • Takahashi, T.1    Takasuka, N.2    Iigo, M.3    Baba, M.4    Nishino, H.5    Tsuda, H.6
  • 60
    • 84907176451 scopus 로고    scopus 로고
    • Zhao H, Zhang X, Chen X, Li Y, Ke Z, Tang T, et al. Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. 2014;279(3):311–21.25026504. Epub 2014/07/16. Eng. Showed different, interesting mechanism for the anticancer activity of iso-liquiritigenin
    • Zhao H, Zhang X, Chen X, Li Y, Ke Z, Tang T, et al. Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. Toxicol Appl Pharmacol. 2014;279(3):311–21. PubMed PMID: 25026504. Epub 2014/07/16. Eng. Showed different, interesting mechanism for the anticancer activity of iso-liquiritigenin.
    • (2014) Toxicol Appl Pharmacol.
  • 61
    • 84891954684 scopus 로고    scopus 로고
    • Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells
    • COI: 1:CAS:528:DC%2BC2cXpsFeiu7c%3D, PID: 24247527
    • Zhou Y, Ho WS. Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells. Oncol Rep. 2014;31(1):298–304.
    • (2014) Oncol Rep , vol.31 , Issue.1 , pp. 298-304
    • Zhou, Y.1    Ho, W.S.2
  • 62
    • 68149160590 scopus 로고    scopus 로고
    • Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells
    • COI: 1:CAS:528:DC%2BD1MXpsV2lurw%3D, PID: 19536869
    • Hsu YL, Chia CC, Chen PJ, Huang SE, Huang SC, Kuo PL. Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells. Mol Nutr Food Res. 2009;53(7):826–35.
    • (2009) Mol Nutr Food Res , vol.53 , Issue.7 , pp. 826-835
    • Hsu, Y.L.1    Chia, C.C.2    Chen, P.J.3    Huang, S.E.4    Huang, S.C.5    Kuo, P.L.6
  • 63
    • 84906491754 scopus 로고    scopus 로고
    • Zheng H, Li Y, Wang Y, Zhao H, Zhang J, Chai H, et al. Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. 2014;280(1):10–20. PubMed PMID: 25094029. Epub 2014/08/06. Eng. This paper present a unique mechansim for the anticancer activity of iso-liquiritigenin
    • Zheng H, Li Y, Wang Y, Zhao H, Zhang J, Chai H, et al. Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. Toxicol Appl Pharmacol. 2014;280(1):10–20. PubMed PMID: 25094029. Epub 2014/08/06. Eng. This paper present a unique mechansim for the anticancer activity of iso-liquiritigenin.
    • (2014) Toxicol Appl Pharmacol.
  • 64
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • COI: 1:CAS:528:DyaK2cXhtlSrsLo%3D, PID: 8106557
    • Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol. 1994;124(4):619–26.
    • (1994) J Cell Biol , vol.124 , Issue.4 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 65
    • 55949136859 scopus 로고    scopus 로고
    • Anoikis resistance and tumor metastasis
    • COI: 1:CAS:528:DC%2BD1cXhtlyhtr%2FJ, PID: 18579285
    • Simpson CD, Anyiwe K, Schimmer AD. Anoikis resistance and tumor metastasis. Cancer Lett. 2008;272(2):177–85.
    • (2008) Cancer Lett , vol.272 , Issue.2 , pp. 177-185
    • Simpson, C.D.1    Anyiwe, K.2    Schimmer, A.D.3
  • 66
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, CDKs and cancer: a changing paradigm
    • COI: 1:CAS:528:DC%2BD1MXit1ans78%3D, PID: 19238148
    • Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer. 2009;9(3):153–66.
    • (2009) Nat Rev Cancer , vol.9 , Issue.3 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 67
    • 0029071657 scopus 로고
    • D-type cyclins
    • COI: 1:CAS:528:DyaK2MXlslGns70%3D, PID: 7610482
    • Sherr CJ. D-type cyclins. Trends Biochem Sci. 1995;20(5):187–90.
    • (1995) Trends Biochem Sci , vol.20 , Issue.5 , pp. 187-190
    • Sherr, C.J.1
  • 68
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • COI: 1:CAS:528:DyaK28XntlyktLs%3D, PID: 8939849
    • Sherr CJ. Cancer cell cycles. Science. 1996;274(5293):1672–7.
    • (1996) Science , vol.274 , Issue.5293 , pp. 1672-1677
    • Sherr, C.J.1
  • 69
    • 84894265538 scopus 로고    scopus 로고
    • Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions
    • COI: 1:CAS:528:DC%2BC2cXmtlSrsL4%3D, PID: 24486984
    • Huang W, Tang S, Qiao X, Ma W, Ji S, Wang K, et al. Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions. Fitoterapia. 2014;94:36–47.
    • (2014) Fitoterapia , vol.94 , pp. 36-47
    • Huang, W.1    Tang, S.2    Qiao, X.3    Ma, W.4    Ji, S.5    Wang, K.6
  • 70
    • 77957085380 scopus 로고    scopus 로고
    • Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway
    • COI: 1:CAS:528:DC%2BC3cXhtFWqtb3E, PID: 20229524
    • Seon MR, Lim SS, Choi HJ, Park SY, Cho HJ, Kim JK, et al. Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway. Mol Nutr Food Res. 2010;54(9):1329–39.
    • (2010) Mol Nutr Food Res , vol.54 , Issue.9 , pp. 1329-1339
    • Seon, M.R.1    Lim, S.S.2    Choi, H.J.3    Park, S.Y.4    Cho, H.J.5    Kim, J.K.6
  • 71
    • 83355177774 scopus 로고    scopus 로고
    • Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells
    • COI: 1:CAS:528:DC%2BC3MXhs1Shur7F, PID: 21429724
    • Seon MR, Park SY, Kwon SJ, Lim SS, Choi HJ, Park H, et al. Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells. J Nutr Biochem. 2012;23(1):85–92.
    • (2012) J Nutr Biochem , vol.23 , Issue.1 , pp. 85-92
    • Seon, M.R.1    Park, S.Y.2    Kwon, S.J.3    Lim, S.S.4    Choi, H.J.5    Park, H.6
  • 72
    • 84882737116 scopus 로고    scopus 로고
    • Lee E, Son JE, Byun S, Lee SJ, Kim YA, Liu K, et al. CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth. 2013;272(1):12–20. 23707764. Epub 2013/05/28. eng. One of the first papers to show direct molecular targets of a specific licorice compound
    • Lee E, Son JE, Byun S, Lee SJ, Kim YA, Liu K, et al. CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth. Toxicol Appl Pharmacol. 2013;272(1):12–20. PubMed PMID: 23707764. Epub 2013/05/28. eng. One of the first papers to show direct molecular targets of a specific licorice compound.
    • (2013) Toxicol Appl Pharmacol.
  • 73
    • 0030847760 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    • COI: 1:CAS:528:DyaK2sXmsVGls7c%3D, PID: 9311993
    • Vlach J, Hennecke S, Amati B. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 1997;16(17):5334–44.
    • (1997) EMBO J , vol.16 , Issue.17 , pp. 5334-5344
    • Vlach, J.1    Hennecke, S.2    Amati, B.3
  • 74
    • 18644376449 scopus 로고    scopus 로고
    • PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
    • COI: 1:CAS:528:DC%2BD38XnsVGrt7s%3D, PID: 12244302
    • Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med. 2002;8(10):1153–60.
    • (2002) Nat Med , vol.8 , Issue.10 , pp. 1153-1160
    • Liang, J.1    Zubovitz, J.2    Petrocelli, T.3    Kotchetkov, R.4    Connor, M.K.5    Han, K.6
  • 75
    • 0032005978 scopus 로고    scopus 로고
    • Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma
    • COI: 1:CAS:528:DyaK1cXnsFehsg%3D%3D, PID: 9458103
    • Tsihlias J, Kapusta LR, DeBoer G, Morava-Protzner I, Zbieranowski I, Bhattacharya N, et al. Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. Cancer Res. 1998;58(3):542–8.
    • (1998) Cancer Res , vol.58 , Issue.3 , pp. 542-548
    • Tsihlias, J.1    Kapusta, L.R.2    DeBoer, G.3    Morava-Protzner, I.4    Zbieranowski, I.5    Bhattacharya, N.6
  • 76
    • 0031930822 scopus 로고    scopus 로고
    • Low p27 expression predicts poor disease-free survival in patients with prostate cancer
    • COI: 1:CAS:528:DyaK1cXmslOktr4%3D, PID: 9474188
    • Yang RM, Naitoh J, Murphy M, Wang HJ, Phillipson J, de Kernion JB, et al. Low p27 expression predicts poor disease-free survival in patients with prostate cancer. J Urol. 1998;159(3):941–5.
    • (1998) J Urol , vol.159 , Issue.3 , pp. 941-945
    • Yang, R.M.1    Naitoh, J.2    Murphy, M.3    Wang, H.J.4    Phillipson, J.5    de Kernion, J.B.6
  • 77
    • 85017655774 scopus 로고    scopus 로고
    • Song NR, Lee EJ, Byun S, Kim JE, Mottamal M, Park JH, et al. Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3-K, MKK4 and MKK7 in human melanoma. (Phila). Oct 8.24104352. Epub 2013/10/10. Eng. One of the first papers to report direct binding partners for a specific licorice compound
    • Song NR, Lee EJ, Byun S, Kim JE, Mottamal M, Park JH, et al. Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3-K, MKK4 and MKK7 in human melanoma. Cancer Prev Res (Phila). Oct 8. PubMed PMID: 24104352. Epub 2013/10/10. Eng. One of the first papers to report direct binding partners for a specific licorice compound.
    • Cancer Prev Res
  • 80
    • 84860863911 scopus 로고    scopus 로고
    • PI3K and mTOR signaling pathways in cancer: new data on targeted therapies
    • COI: 1:CAS:528:DC%2BC38Xjs1Okt7o%3D, PID: 22350330
    • Willems L, Tamburini J, Chapuis N, Lacombe C, Mayeux P, Bouscary D. PI3K and mTOR signaling pathways in cancer: new data on targeted therapies. Curr Oncol Rep. 2012;14(2):129–38.
    • (2012) Curr Oncol Rep , vol.14 , Issue.2 , pp. 129-138
    • Willems, L.1    Tamburini, J.2    Chapuis, N.3    Lacombe, C.4    Mayeux, P.5    Bouscary, D.6
  • 81
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: variations on a theme
    • COI: 1:CAS:528:DC%2BD1cXhtFWiurzI, PID: 18794884
    • Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene. 2008;27(41):5497–510.
    • (2008) Oncogene , vol.27 , Issue.41 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 82
    • 39049107744 scopus 로고    scopus 로고
    • GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy
    • COI: 1:CAS:528:DC%2BD1cXitVaqu7k%3D, PID: 18023328
    • Takahashi-Yanaga F, Sasaguri T. GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy. Cell Signal. 2008;20(4):581–9.
    • (2008) Cell Signal , vol.20 , Issue.4 , pp. 581-589
    • Takahashi-Yanaga, F.1    Sasaguri, T.2
  • 83
    • 79251600292 scopus 로고    scopus 로고
    • Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis
    • COI: 1:CAS:528:DC%2BC3MXhtlakurc%3D, PID: 21216524
    • Xiao XY, Hao M, Yang XY, Ba Q, Li M, Ni SJ, et al. Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis. Cancer Lett. 2011;302(1):69–75.
    • (2011) Cancer Lett , vol.302 , Issue.1 , pp. 69-75
    • Xiao, X.Y.1    Hao, M.2    Yang, X.Y.3    Ba, Q.4    Li, M.5    Ni, S.J.6
  • 84
    • 0033861361 scopus 로고    scopus 로고
    • Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid
    • COI: 1:CAS:528:DC%2BD3cXlvFGjtb0%3D, PID: 10953339
    • Rafi MM, Rosen RT, Vassil A, Ho CT, Zhang H, Ghai G, et al. Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid. Anticancer Res. 2000;20(4):2653–8.
    • (2000) Anticancer Res , vol.20 , Issue.4 , pp. 2653-2658
    • Rafi, M.M.1    Rosen, R.T.2    Vassil, A.3    Ho, C.T.4    Zhang, H.5    Ghai, G.6
  • 85
    • 84880974487 scopus 로고    scopus 로고
    • Kim YJ, Jung EB, Myung SC, Kim W, Lee CS. Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation. **;92(1–2):49–59. 23921841. Epub 2013/08/08. eng
    • Kim YJ, Jung EB, Myung SC, Kim W, Lee CS. Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation. Pharmacology. **;92(1–2):49–59. PubMed PMID: 23921841. Epub 2013/08/08. eng.
    • Pharmacology.
  • 86
    • 84860467105 scopus 로고    scopus 로고
    • Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways
    • COI: 1:CAS:528:DC%2BC38Xlt1Kms70%3D, PID: 22465181
    • Lee CS, Kwak SW, Kim YJ, Lee SA, Park ES, Myung SC, et al. Guanylate cyclase activator YC-1 potentiates apoptotic effect of licochalcone A on human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathways. Eur J Pharmacol. 2012;683(1–3):54–62.
    • (2012) Eur J Pharmacol , vol.683 , Issue.1-3 , pp. 54-62
    • Lee, C.S.1    Kwak, S.W.2    Kim, Y.J.3    Lee, S.A.4    Park, E.S.5    Myung, S.C.6
  • 88
    • 84902765959 scopus 로고    scopus 로고
    • Anti-carcinogenic effects of non-polar components containing licochalcone A in roasted licorice root
    • PID: 24944769
    • Park SY, Kim EJ, Choi HJ, Seon MR, Lim SS, Kang YH, et al. Anti-carcinogenic effects of non-polar components containing licochalcone A in roasted licorice root. Nutr Res Pract. 2014;8(3):257–66.
    • (2014) Nutr Res Pract , vol.8 , Issue.3 , pp. 257-266
    • Park, S.Y.1    Kim, E.J.2    Choi, H.J.3    Seon, M.R.4    Lim, S.S.5    Kang, Y.H.6
  • 89
    • 70349306540 scopus 로고    scopus 로고
    • Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway
    • COI: 1:CAS:528:DC%2BD1MXhtVGjtb3J, PID: 19711916
    • Yo YT, Shieh GS, Hsu KF, Wu CL, Shiau AL. Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway. J Agric Food Chem. 2009;57(18):8266–73.
    • (2009) J Agric Food Chem , vol.57 , Issue.18 , pp. 8266-8273
    • Yo, Y.T.1    Shieh, G.S.2    Hsu, K.F.3    Wu, C.L.4    Shiau, A.L.5
  • 90
    • 84892384187 scopus 로고    scopus 로고
    • Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway
    • COI: 1:CAS:528:DC%2BC2cXpsFegtL4%3D, PID: 24337492
    • Kim JS, Park MR, Lee SY, Kim K, Moon SM, Kim CS, et al. Licochalcone A induces apoptosis in KB human oral cancer cells via a caspase-dependent FasL signaling pathway. Oncol Rep. 2014;31(2):755–62.
    • (2014) Oncol Rep , vol.31 , Issue.2 , pp. 755-762
    • Kim, J.S.1    Park, M.R.2    Lee, S.Y.3    Kim, K.4    Moon, S.M.5    Kim, C.S.6
  • 91
    • 4143140833 scopus 로고    scopus 로고
    • Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells
    • COI: 1:CAS:528:DC%2BD2cXmslOhtb4%3D, PID: 15313200
    • Fu Y, Hsieh TC, Guo J, Kunicki J, Lee MY, Darzynkiewicz Z, et al. Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Biochem Biophys Res Commun. 2004;322(1):263–70.
    • (2004) Biochem Biophys Res Commun , vol.322 , Issue.1 , pp. 263-270
    • Fu, Y.1    Hsieh, T.C.2    Guo, J.3    Kunicki, J.4    Lee, M.Y.5    Darzynkiewicz, Z.6
  • 92
    • 55549112882 scopus 로고    scopus 로고
    • Anti-proliferative effect of licochalcone A on vascular smooth muscle cells
    • COI: 1:CAS:528:DC%2BD1MXjtFCltA%3D%3D, PID: 18981562
    • Park JH, Lim HJ, Lee KS, Lee S, Kwak HJ, Cha JH, et al. Anti-proliferative effect of licochalcone A on vascular smooth muscle cells. Biol Pharm Bull. 2008;31(11):1996–2000.
    • (2008) Biol Pharm Bull , vol.31 , Issue.11 , pp. 1996-2000
    • Park, J.H.1    Lim, H.J.2    Lee, K.S.3    Lee, S.4    Kwak, H.J.5    Cha, J.H.6
  • 93
    • 77956458323 scopus 로고    scopus 로고
    • Antitumor and antimetastatic effects of licochalcone A in mouse models
    • COI: 1:CAS:528:DC%2BC3cXos1aisLw%3D
    • Kim JK, Shin EK, Park JH, Kim YH. Antitumor and antimetastatic effects of licochalcone A in mouse models. J Mol Med (Berl). 2010;88(8):829–38.
    • (2010) J Mol Med (Berl) , vol.88 , Issue.8 , pp. 829-838
    • Kim, J.K.1    Shin, E.K.2    Park, J.H.3    Kim, Y.H.4
  • 94
    • 45749128172 scopus 로고    scopus 로고
    • Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice
    • COI: 1:CAS:528:DC%2BD1cXotlKisLY%3D, PID: 18484961
    • Lee CK, Son SH, Park KK, Park JH, Lim SS, Kim SH, et al. Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice. Basic Clin Pharmacol Toxicol. 2008;103(1):48–54.
    • (2008) Basic Clin Pharmacol Toxicol , vol.103 , Issue.1 , pp. 48-54
    • Lee, C.K.1    Son, S.H.2    Park, K.K.3    Park, J.H.4    Lim, S.S.5    Kim, S.H.6
  • 95
    • 54249164448 scopus 로고    scopus 로고
    • Licochalcone A isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice
    • COI: 1:CAS:528:DC%2BD1cXht1Kns7rJ
    • Kwon HS, Park JH, Kim DH, Kim YH, Shin HK, Kim JK. Licochalcone A isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice. J Mol Med (Berl). 2008;86(11):1287–95.
    • (2008) J Mol Med (Berl) , vol.86 , Issue.11 , pp. 1287-1295
    • Kwon, H.S.1    Park, J.H.2    Kim, D.H.3    Kim, Y.H.4    Shin, H.K.5    Kim, J.K.6
  • 96
    • 28644439905 scopus 로고    scopus 로고
    • Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts
    • COI: 1:CAS:528:DC%2BD28Xit1Kmsrk%3D, PID: 16354411
    • Furuhashi I, Iwata S, Shibata S, Sato T, Inoue H. Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts. J Pharm Pharmacol. 2005;57(12):1661–6.
    • (2005) J Pharm Pharmacol , vol.57 , Issue.12 , pp. 1661-1666
    • Furuhashi, I.1    Iwata, S.2    Shibata, S.3    Sato, T.4    Inoue, H.5
  • 97
    • 84891127997 scopus 로고    scopus 로고
    • Licochalcone A inhibiting proliferation of bladder cancer T24 cells by inducing reactive oxygen species production
    • COI: 1:CAS:528:DC%2BC3sXhslOmtb3M, PID: 24211992
    • Jiang J, Yuan X, Zhao H, Yan X, Sun X, Zheng Q. Licochalcone A inhibiting proliferation of bladder cancer T24 cells by inducing reactive oxygen species production. Biomed Mater Eng. 2014;24(1):1019–25.
    • (2014) Biomed Mater Eng , vol.24 , Issue.1 , pp. 1019-1025
    • Jiang, J.1    Yuan, X.2    Zhao, H.3    Yan, X.4    Sun, X.5    Zheng, Q.6
  • 98
    • 84880864440 scopus 로고    scopus 로고
    • Licochalcone A-induced human bladder cancer T24 cells apoptosis triggered by mitochondria dysfunction and endoplasmic reticulum stress
    • PID: 23936805
    • Yuan X, Li D, Zhao H, Jiang J, Wang P, Ma X, et al. Licochalcone A-induced human bladder cancer T24 cells apoptosis triggered by mitochondria dysfunction and endoplasmic reticulum stress. Biomed Res Int. 2013;2013:474272.
    • (2013) Biomed Res Int , vol.2013 , pp. 474272
    • Yuan, X.1    Li, D.2    Zhao, H.3    Jiang, J.4    Wang, P.5    Ma, X.6
  • 99
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: new discoveries and insights
    • COI: 1:CAS:528:DyaK28XitlCgtbc%3D, PID: 8717528
    • Baldwin Jr AS. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649–83.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 100
    • 0031463551 scopus 로고    scopus 로고
    • Regulation of NF-kappa B activation by MAP kinase cascades
    • COI: 1:STN:280:DyaK1c7gsVCmug%3D%3D, PID: 9442376
    • Schulze-Osthoff K, Ferrari D, Riehemann K, Wesselborg S. Regulation of NF-kappa B activation by MAP kinase cascades. Immunobiology. 1997;198(1–3):35–49.
    • (1997) Immunobiology , vol.198 , Issue.1-3 , pp. 35-49
    • Schulze-Osthoff, K.1    Ferrari, D.2    Riehemann, K.3    Wesselborg, S.4
  • 101
    • 0031573614 scopus 로고    scopus 로고
    • Clinically relevant findings
    • COI: 1:CAS:528:DyaK2sXotVykurk%3D, PID: 9399935
    • Gilmore TD. Clinically relevant findings. J Clin Invest. 1997;100(12):2935–6.
    • (1997) J Clin Invest , vol.100 , Issue.12 , pp. 2935-2936
    • Gilmore, T.D.1
  • 102
    • 0030800330 scopus 로고    scopus 로고
    • Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response
    • COI: 1:CAS:528:DyaK2sXls1Sgsrk%3D, PID: 9270030
    • Li JJ, Westergaard C, Ghosh P, Colburn NH. Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response. Cancer Res. 1997;57(16):3569–76.
    • (1997) Cancer Res , vol.57 , Issue.16 , pp. 3569-3576
    • Li, J.J.1    Westergaard, C.2    Ghosh, P.3    Colburn, N.H.4
  • 103
    • 0027436597 scopus 로고
    • Proposed NF-kappa B/I kappa B family nomenclature
    • COI: 1:STN:280:DyaK2c%2FktVOhug%3D%3D, PID: 8224837
    • Nabel GJ, Verma IM. Proposed NF-kappa B/I kappa B family nomenclature. Genes Dev. 1993;7(11):2063.
    • (1993) Genes Dev , vol.7 , Issue.11 , pp. 2063
    • Nabel, G.J.1    Verma, I.M.2
  • 104
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-kappaB: players, pathways, perspectives
    • COI: 1:CAS:528:DC%2BD28XhtFektL7E, PID: 17072321
    • Gilmore TD. Introduction to NF-kappaB: players, pathways, perspectives. Oncogene. 2006;25(51):6680–4.
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6680-6684
    • Gilmore, T.D.1
  • 105
    • 60549108717 scopus 로고    scopus 로고
    • Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276
    • COI: 1:CAS:528:DC%2BD1MXisFWjsb0%3D, PID: 19168128
    • Furusawa J, Funakoshi-Tago M, Tago K, Mashino T, Inoue H, Sonoda Y, et al. Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276. Cell Signal. 2009;21(5):778–85.
    • (2009) Cell Signal , vol.21 , Issue.5 , pp. 778-785
    • Furusawa, J.1    Funakoshi-Tago, M.2    Tago, K.3    Mashino, T.4    Inoue, H.5    Sonoda, Y.6
  • 106
    • 61649115375 scopus 로고    scopus 로고
    • Glycyrrhiza inflata-derived chalcones, licochalcone A, licochalcone B and licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway
    • COI: 1:CAS:528:DC%2BD1MXjt1SnsLk%3D, PID: 19291859
    • Furusawa J, Funakoshi-Tago M, Mashino T, Tago K, Inoue H, Sonoda Y, et al. Glycyrrhiza inflata-derived chalcones, licochalcone A, licochalcone B and licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol. 2009;9(4):499–507.
    • (2009) Int Immunopharmacol , vol.9 , Issue.4 , pp. 499-507
    • Furusawa, J.1    Funakoshi-Tago, M.2    Mashino, T.3    Tago, K.4    Inoue, H.5    Sonoda, Y.6
  • 107
    • 70349337442 scopus 로고    scopus 로고
    • Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation
    • COI: 1:CAS:528:DC%2BD1MXht1eitrjO, PID: 19592502
    • Funakoshi-Tago M, Tanabe S, Tago K, Itoh H, Mashino T, Sonoda Y, et al. Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation. Mol Pharmacol. 2009;76(4):745–53.
    • (2009) Mol Pharmacol , vol.76 , Issue.4 , pp. 745-753
    • Funakoshi-Tago, M.1    Tanabe, S.2    Tago, K.3    Itoh, H.4    Mashino, T.5    Sonoda, Y.6
  • 108
    • 84922393935 scopus 로고    scopus 로고
    • Antimetastatic effects of licochalcone A on oral cancer via regulating metastasis-associated proteases
    • COI: 1:CAS:528:DC%2BC2cXntlOhsrs%3D, PID: 24789273
    • Shen H, Zeng G, Tang G, Cai X, Bi L, Huang C, et al. Antimetastatic effects of licochalcone A on oral cancer via regulating metastasis-associated proteases. Tumour Biol. 2014;35(8):7467–74.
    • (2014) Tumour Biol , vol.35 , Issue.8 , pp. 7467-7474
    • Shen, H.1    Zeng, G.2    Tang, G.3    Cai, X.4    Bi, L.5    Huang, C.6
  • 109
    • 84899538692 scopus 로고    scopus 로고
    • Licochalcone A suppresses migration and invasion of human hepatocellular carcinoma cells through downregulation of MKK4/JNK via NF-kappaB mediated urokinase plasminogen activator expression
    • PID: 24466137
    • Tsai JP, Hsiao PC, Yang SF, Hsieh SC, Bau DT, Ling CL, et al. Licochalcone A suppresses migration and invasion of human hepatocellular carcinoma cells through downregulation of MKK4/JNK via NF-kappaB mediated urokinase plasminogen activator expression. PLoS ONE. 2014;9(1):e86537.
    • (2014) PLoS ONE , vol.9 , Issue.1
    • Tsai, J.P.1    Hsiao, P.C.2    Yang, S.F.3    Hsieh, S.C.4    Bau, D.T.5    Ling, C.L.6
  • 110
    • 84925282687 scopus 로고    scopus 로고
    • Huang HC, Tsai LL, Tsai JP, Hsieh SC, Yang SF, Hsueh JT, et al. Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression. 2014 Aug 23. PubMed PMID: 25149157. Epub 2014/08/26. Eng
    • Huang HC, Tsai LL, Tsai JP, Hsieh SC, Yang SF, Hsueh JT, et al. Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression. Tumour Biol. 2014 Aug 23. PubMed PMID: 25149157. Epub 2014/08/26. Eng.
    • (2014) Tumour Biol.
  • 111
    • 84892410391 scopus 로고    scopus 로고
    • Yao K, Chen H, Lee MH, Li H, Ma W, Peng C, et al. Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1. (Phila). 2014;7(1):139–49. 24253317. Epub 2013/11/21. Eng. First to report that licochalcone A directly bound to and inhibited JNK1
    • Yao K, Chen H, Lee MH, Li H, Ma W, Peng C, et al. Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1. Cancer Prev Res (Phila). 2014;7(1):139–49. PubMed PMID: 24253317. Epub 2013/11/21. Eng. First to report that licochalcone A directly bound to and inhibited JNK1.
    • (2014) Cancer Prev Res
  • 112
    • 67649311246 scopus 로고    scopus 로고
    • A selective small-molecule inhibitor of c-Jun N-terminal kinase 1
    • COI: 1:CAS:528:DC%2BD1MXotFyks78%3D, PID: 19527717
    • Yao K, Cho YY, Bode AM, Vummenthala A, Park JG, Liu K, et al. A selective small-molecule inhibitor of c-Jun N-terminal kinase 1. FEBS Lett. 2009;583(13):2208–12.
    • (2009) FEBS Lett , vol.583 , Issue.13 , pp. 2208-2212
    • Yao, K.1    Cho, Y.Y.2    Bode, A.M.3    Vummenthala, A.4    Park, J.G.5    Liu, K.6
  • 113
    • 36849082972 scopus 로고    scopus 로고
    • Induction of apoptosis by the licochalcone E in endothelial cells via modulation of NF-kappaB and Bcl-2 Family
    • COI: 1:CAS:528:DC%2BD1cXht1ymtLg%3D, PID: 18057714
    • Chang HJ, Yoon G, Park JS, Kim MH, Baek MK, Kim NH, et al. Induction of apoptosis by the licochalcone E in endothelial cells via modulation of NF-kappaB and Bcl-2 Family. Biol Pharm Bull. 2007;30(12):2290–3.
    • (2007) Biol Pharm Bull , vol.30 , Issue.12 , pp. 2290-2293
    • Chang, H.J.1    Yoon, G.2    Park, J.S.3    Kim, M.H.4    Baek, M.K.5    Kim, N.H.6
  • 114
    • 84878466075 scopus 로고    scopus 로고
    • Licochalcone E present in licorice suppresses lung metastasis in the 4T1 mammary orthotopic cancer model
    • COI: 1:CAS:528:DC%2BC3sXptVWmsb8%3D
    • Kwon SJ, Park SY, Kwon GT, Lee KW, Kang YH, Choi MS, et al. Licochalcone E present in licorice suppresses lung metastasis in the 4T1 mammary orthotopic cancer model. Cancer Prev Res (Phila). 2013;6(6):603–13.
    • (2013) Cancer Prev Res (Phila) , vol.6 , Issue.6 , pp. 603-613
    • Kwon, S.J.1    Park, S.Y.2    Kwon, G.T.3    Lee, K.W.4    Kang, Y.H.5    Choi, M.S.6
  • 115
    • 84865499490 scopus 로고    scopus 로고
    • Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease
    • COI: 1:CAS:528:DC%2BC38XhtlGqtbjL, PID: 22227268
    • Kim SS, Lim J, Bang Y, Gal J, Lee SU, Cho YC, et al. Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease. J Nutr Biochem. 2012;23(10):1314–23.
    • (2012) J Nutr Biochem , vol.23 , Issue.10 , pp. 1314-1323
    • Kim, S.S.1    Lim, J.2    Bang, Y.3    Gal, J.4    Lee, S.U.5    Cho, Y.C.6
  • 116
    • 84878435205 scopus 로고    scopus 로고
    • Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages
    • PID: 23708096
    • Lee HN, Cho HJ, Lim Do Y, Kang YH, Lee KW, Park JH. Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages. Int J Mol Sci. 2013;14(6):10926–43.
    • (2013) Int J Mol Sci , vol.14 , Issue.6 , pp. 10926-10943
    • Lee, H.N.1    Cho, H.J.2    Lim Do, Y.3    Kang, Y.H.4    Lee, K.W.5    Park, J.H.6
  • 117
    • 77955920339 scopus 로고    scopus 로고
    • Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B
    • COI: 1:CAS:528:DC%2BC3cXhtVKjtrrI, PID: 20601178
    • Cho YC, Lee SH, Yoon G, Kim HS, Na JY, Choi HJ, et al. Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B. Int Immunopharmacol. 2010;10(9):1119–26.
    • (2010) Int Immunopharmacol , vol.10 , Issue.9 , pp. 1119-1126
    • Cho, Y.C.1    Lee, S.H.2    Yoon, G.3    Kim, H.S.4    Na, J.Y.5    Choi, H.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.